Publications by authors named "Assam El-Osta"

100Publications

Targeting Treatment Refractory by EZH2 Inhibition in Postural Tachycardia Syndrome.

Circ Res 2020 04 3;126(8):1058-1060. Epub 2020 Mar 3.

From the Epigenetics in Human Health and Disease Laboratory (H.K., A.W.K., J.O., A.E.-O.), Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315654DOI Listing
April 2020

Chinese Famine and the diabetes mellitus epidemic.

Nat Rev Endocrinol 2020 02;16(2):123

Peking University Diabetes Center, Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China.

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http://dx.doi.org/10.1038/s41574-019-0300-9DOI Listing
February 2020

RNA-seq-based identification of Star upregulation by islet amyloid formation.

Protein Eng Des Sel 2019 12;32(2):67-76

Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, WA 98018, USA.

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http://dx.doi.org/10.1093/protein/gzz022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908819PMC
December 2019

Sex-Based Mhrt Methylation Chromatinizes MeCP2 in the Heart.

iScience 2019 Jul 27;17:288-301. Epub 2019 Jun 27.

Epigenetics in Human Health and Disease, Central Clinical School, Faculty of Medicine, Monash University, Melbourne, VIC 3004, Australia; Baker Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, VIC 3004, Australia; Department of Clinical Pathology, The University of Melbourne, Parkville, VIC 3010, Australia; Hong Kong Institute of Diabetes and Obesity, Prince of Wales Hospital, The Chinese University of Hong Kong, 3/F Lui Che Woo Clinical Sciences Building, 30-32 Ngan Shing Street, Sha Tin, Hong Kong SAR; University College Copenhagen, Faculty of Health, Department of Technology, Biomedical Laboratory Science, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.06.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639684PMC
July 2019

Evaluation of genomic methylation indices in juvenile myoclonic epilepsy.

Authors:
Assam El-Osta

Epilepsia 2019 05;60(5):e37-e39

Epigenetics in Human Health and Disease, Central Clinical School, Faculty of Medicine, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1111/epi.14740DOI Listing
May 2019

Digital expression explorer 2: a repository of uniformly processed RNA sequencing data.

Gigascience 2019 04;8(4)

Epigenetics in Human Health and Disease, Central Clinical School, Faculty of Medicine, Monash University, 99 Commercial Road, Melbourne, VIC 3004, Australia.

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http://dx.doi.org/10.1093/gigascience/giz022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446219PMC
April 2019

Author Correction: Epidemic T2DM, early development and epigenetics: implications of the Chinese Famine.

Nat Rev Endocrinol 2019 05;15(5):312

Peking University Diabetes Center, Director of Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China.

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http://dx.doi.org/10.1038/s41574-019-0199-1DOI Listing
May 2019

Epigenetics, cardiovascular disease, and cellular reprogramming.

J Mol Cell Cardiol 2019 03 25;128:129-133. Epub 2019 Jan 25.

Department of Diabetes, Epigenetics in Human Health and Disease Laboratory, Monash University, Melbourne, VIC, Australia; Hong Kong Institute of Diabetes and Obesity, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.

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http://dx.doi.org/10.1016/j.yjmcc.2019.01.019DOI Listing
March 2019

Epidemic T2DM, early development and epigenetics: implications of the Chinese Famine.

Nat Rev Endocrinol 2018 12;14(12):738-746

Peking University Diabetes Center, Director of Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China.

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http://dx.doi.org/10.1038/s41574-018-0106-1DOI Listing
December 2018

Age-Related Differential Structural and Transcriptomic Responses in the Hypertensive Heart.

Front Physiol 2018 9;9:817. Epub 2018 Jul 9.

Heart Failure Research Group, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.

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http://dx.doi.org/10.3389/fphys.2018.00817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046461PMC
July 2018

Diet during Pregnancy is Implicated in the Regulation of Hypothalamic RNA Methylation and Risk of Obesity in Offspring.

Mol Nutr Food Res 2018 Jun 7:e1800134. Epub 2018 Jun 7.

Central Clinical School, Faculty of Medicine, Monash University, Victoria, 3004, Australia.

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http://dx.doi.org/10.1002/mnfr.201800134DOI Listing
June 2018

Contemporary Trends Emerging in Epigenomics and Metabolism.

Authors:
Assam El-Osta

Antioxid Redox Signal 2018 10 22;29(11):1019-1022. Epub 2018 Jun 22.

1 Department of Diabetes, Epigenetics in Human Health and Disease, Central Clinical School, Monash University , Melbourne, Australia .

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http://dx.doi.org/10.1089/ars.2017.7473DOI Listing
October 2018

Metabolic Karma-The Atherogenic Legacy of Diabetes: The 2017 Edwin Bierman Award Lecture.

Diabetes 2018 05;67(5):785-790

Department of Diabetes, Central Clinical School, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.2337/dbi18-0010DOI Listing
May 2018

Lipoxins Regulate the Early Growth Response-1 Network and Reverse Diabetic Kidney Disease.

J Am Soc Nephrol 2018 05 28;29(5):1437-1448. Epub 2018 Feb 28.

Juvenile Diabetes Research Foundation Danielle Alberti Memorial Centre for Diabetes Complications, Diabetes Division, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia;

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http://dx.doi.org/10.1681/ASN.2017101112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967780PMC
May 2018

Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury.

Acta Neuropathol Commun 2018 02 27;6(1):17. Epub 2018 Feb 27.

Epilepsy Research Laboratory, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, PO Box 1627, FIN-70211, Kuopio, Finland.

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http://dx.doi.org/10.1186/s40478-018-0519-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828078PMC
February 2018

MeCP2 interacts with chromosomal microRNAs in brain.

Epigenetics 2017 ;12(12):1028-1037

a Central Clinical School, Faculty of Medicine , Monash University , Victoria , Australia.

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http://dx.doi.org/10.1080/15592294.2017.1391429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810764PMC
December 2018

Epigenetic Contribution to the Development and Progression of Vascular Diabetic Complications.

Antioxid Redox Signal 2018 10 26;29(11):1074-1091. Epub 2018 Feb 26.

1 Epigenetics in Human Health and Disease Laboratory, Department of Diabetes, Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University , Melbourne, Australia .

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http://dx.doi.org/10.1089/ars.2017.7347DOI Listing
October 2018

Epigenetics in diabetic nephropathy, immunity and metabolism.

Diabetologia 2018 Jan 11;61(1):6-20. Epub 2017 Nov 11.

Central Clinical School, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.

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http://dx.doi.org/10.1007/s00125-017-4490-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448927PMC
January 2018

Epigenetics and precision medicine in cardiovascular patients: from basic concepts to the clinical arena.

Eur Heart J 2018 12;39(47):4150-4158

Center for Molecular Cardiology, University of Zürich, Wagistrasse 12, Schlieren, Zurich, Switzerland.

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http://dx.doi.org/10.1093/eurheartj/ehx568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293269PMC
December 2018

Epigenetic programming, early life nutrition and the risk of metabolic disease.

Atherosclerosis 2017 Nov 5;266:31-40. Epub 2017 Sep 5.

Epigenetics in Human Health and Disease Laboratory, Central Clinical School, Faculty of Medicine, Monash University, Victoria 3004, Australia; Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia; Hong Kong Institute of Diabetes and Obesity, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.09.003DOI Listing
November 2017

Systems approach to the pharmacological actions of HDAC inhibitors reveals EP300 activities and convergent mechanisms of regulation in diabetes.

Epigenetics 2017 ;12(11):991-1003

a Epigenetics in Human Health and Disease Laboratory, Department of Diabetes, Central Clinical School, Faculty of Medicine, Monash University , Melbourne , Victoria , Australia.

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http://dx.doi.org/10.1080/15592294.2017.1371892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788408PMC
December 2018

Multicellular Transcriptional Analysis of Mammalian Heart Regeneration.

Circulation 2017 Sep 21;136(12):1123-1139. Epub 2017 Jul 21.

From School of Biomedical Sciences, University of Queensland, Brisbane, Australia (G.A.Q.-R., C.B.S., J.E.H., E.R.P.); Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia (M.Z., A.K., H.R., A.E.-O.); Central Clinical School, Monash University, Melbourne, Victoria, Australia (M.Z., A.K., H.R., A.E.-O.); Australian Regenerative Medicine Institute, EMBL-Australia Collaborating Group, Systems Biology Institute Australia, Monash University, Melbourne, Victoria (M.R.); Hong Kong Institute of Diabetes and Obesity, Prince of Wales Hospital, Chinese University of Hong Kong (A.E.-O.); Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia (E.R.P.); and Department of Physiology, School of Biomedical Sciences, University of Melbourne, Victoria, Australia (E.R.P.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.028252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598916PMC
September 2017

silencing by in postural tachycardia syndrome.

JCI Insight 2017 03 23;2(6):e90183. Epub 2017 Mar 23.

Central Clinical School, Faculty of Medicine, Monash University, Victoria, Australia.

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http://dx.doi.org/10.1172/jci.insight.90183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358482PMC
March 2017

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice.

Circulation 2017 Mar 7;135(10):964-977. Epub 2016 Dec 7.

From Heart Failure Research Group (F.Z.M., E.N., P.-Y.C., D.H., A.F., N.W.R., D.M.K.) and Human Epigenetics Group (M.Z., A.E.-O.), Baker Heart and Diabetes Institute, Melbourne, Australia; Central Clinical School, Faculty of Medicine Nursing and Health Sciences (F.Z.M., A.E.-O., D.M.K.), Infection and Immunity Program, Monash Biomedicine Discovery Institute (J.K.T., C.R.M.), Department of Biochemistry and Molecular Biology (J.K.T., S.K., C.R.M.), and Department of Physiology (N.W.R.), Monash University, Melbourne, Australia; Department of Pathology, University of Melbourne, Australia (A.E.-O.); and Institute the Heart Centre, Alfred Hospital, Melbourne, Australia (D.M.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024545DOI Listing
March 2017

Current perspectives in Set7 mediated stem cell differentiation.

Noncoding RNA 2016 Dec 4;2(4). Epub 2016 Dec 4.

Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia.

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http://dx.doi.org/10.3390/ncrna2040014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831927PMC
December 2016

Pharmacological Histone Deacetylation Distinguishes Transcriptional Regulators.

Curr Top Med Chem 2017 ;17(14):1611-1622

Epigenetics in Human Health and Disease, Baker IDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, Australia.

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http://dx.doi.org/10.2174/1568026617666161104104341DOI Listing
July 2017

Set7 mediated interactions regulate transcriptional networks in embryonic stem cells.

Nucleic Acids Res 2016 Nov 20;44(19):9206-9217. Epub 2016 Jul 20.

Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia

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http://dx.doi.org/10.1093/nar/gkw621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100561PMC
November 2016

Metabolism and chromatin dynamics in health and disease.

Mol Aspects Med 2017 04 30;54:1-15. Epub 2016 Sep 30.

Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, 75 Commercial Road, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia; Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia; Faculty of Medicine, Monash University, Melbourne, Victoria 3800, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2016.09.004DOI Listing
April 2017

Pharmacological inhibition of arginine and lysine methyltransferases induces nuclear abnormalities and suppresses angiogenesis in human endothelial cells.

Biochem Pharmacol 2016 Dec 19;121:18-32. Epub 2016 Sep 19.

Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart & Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia; Epigenomics Profiling Facility, Baker IDI Heart & Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia; Central Clinical School, Faculty of Medicine, Monash University, Victoria, Australia.

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http://dx.doi.org/10.1016/j.bcp.2016.09.013DOI Listing
December 2016

Gene name errors are widespread in the scientific literature.

Genome Biol 2016 08 23;17(1):177. Epub 2016 Aug 23.

Baker IDI Heart & Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, 3004, Australia.

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http://dx.doi.org/10.1186/s13059-016-1044-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994289PMC
August 2016

Epigenomic changes associated with impaired norepinephrine transporter function in postural tachycardia syndrome.

Neurosci Biobehav Rev 2017 Mar 23;74(Pt B):342-355. Epub 2016 Jun 23.

Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia; Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia; Central Clinical School, Faculty of Medicine, Monash University, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.neubiorev.2016.06.015DOI Listing
March 2017

Evaluation of microRNA alignment techniques.

RNA 2016 08 9;22(8):1120-38. Epub 2016 Jun 9.

Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, AustraliaEpigenomics Profiling Facility, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia.

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http://dx.doi.org/10.1261/rna.055509.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931105PMC
August 2016

Epigenetic Changes in Diabetes and Cardiovascular Risk.

Circ Res 2016 May;118(11):1706-22

From the Epigenetics in Human Health and Disease Laboratory (S.T.K., A.E.-O.) and Epigenomics Profiling Facility (A.E.-O.), Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.P.); Department of Pathology, The University of Melbourne, Victoria, Australia (A.E.-O.); and Central Clinical School, Department of Medicine, Monash University, Victoria, Australia (A.E.-O.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.306819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593074PMC
May 2016

HDAC Inhibition in Vascular Endothelial Cells Regulates the Expression of ncRNAs.

Noncoding RNA 2016 May 25;2(2). Epub 2016 May 25.

Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, 75 Commercial Road, The Alfred Medical Research and Education Precinct, Melbourne, VIC 3004, Australia.

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http://dx.doi.org/10.3390/ncrna2020004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831901PMC
May 2016

Improving understanding of chromatin regulatory proteins and potential implications for drug discovery.

Expert Rev Proteomics 2016 17;13(4):435-45. Epub 2016 Mar 17.

a Epigenetics in Human Health and Disease Laboratory , Baker IDI Heart and Diabetes Institute , Melbourne , Victoria , Australia.

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http://dx.doi.org/10.1586/14789450.2016.1159960DOI Listing
December 2016

Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling.

Arterioscler Thromb Vasc Biol 2016 Feb 29;36(2):295-307. Epub 2015 Dec 29.

From the Diabetic Complications Laboratory (S.P.G., E.D.M., K.K., P.C., M.E.C., K.A.M.J.-D.), Epigenetics Laboratory (J.O., A.E.-O.), and Diabetes and Dyslipidaemia Group (A.C.C.), Baker IDI Heart and Diabetes Institute, Melbourne, Australia; Faculty of Medicine, Monash University, Melbourne, Australia (S.P.G., E.D.M., K.A.M.J.-D.); Department of Pathology, Maastricht University Medical Center, Maastricht, The Netherlands (E.A.L.B.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (R.M.T.); and Department of Pharmacology, Cardiovascular Research Institute Maastricht (CARIM), Faculty of Medicine, Health, and Life Science, Maastricht University, Maastricht, The Netherlands (H.H.H.W.S.).

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http://atvb.ahajournals.org/content/36/2/295.full.pdf
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http://atvb.ahajournals.org/lookup/doi/10.1161/ATVBAHA.115.3
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http://dx.doi.org/10.1161/ATVBAHA.115.307012DOI Listing
February 2016

RNA sequencing supports distinct reactive oxygen species-mediated pathways of apoptosis by high and low size mass fractions of Bay leaf (Lauris nobilis) in HT-29 cells.

Food Funct 2015 Aug 26;6(8):2507-24. Epub 2015 Jun 26.

Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1039/c5fo00467eDOI Listing
August 2015

HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes.

Epigenetics 2015 5;10(5):418-30. Epub 2015 May 5.

a Epigenetics in Human Health and Disease Laboratory; Baker IDI Heart and Diabetes Institute ; Melbourne , Victoria , Australia.

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http://dx.doi.org/10.1080/15592294.2015.1024406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622459PMC
January 2016

Pathological hypertrophy reverses β2-adrenergic receptor-induced angiogenesis in mouse heart.

Physiol Rep 2015 Mar;3(3)

Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia Central Clinical School, Monash University, Melbourne, Victoria, Australia

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http://dx.doi.org/10.14814/phy2.12340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393171PMC
March 2015

Epigenetics and metabolism.

Circ Res 2015 Feb;116(4):715-36

From the Epigenetics in Human Health and Disease Laboratory (S.T.K., A.E.-O.) and Epigenomics Profiling Facility (S.T.K., A.E.-O.), Baker IDI Heart & Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia; Department of Pathology, The University of Melbourne, Victoria, Australia (A.E.-O.); and Central Clinical School, Department of Medicine, Monash University, Melbourne, Victoria, Australia (A.E.-O.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.303936DOI Listing
February 2015

Epigenetic-mediated reprogramming of pancreatic endocrine cells.

Antioxid Redox Signal 2015 Jun 18;22(16):1483-95. Epub 2015 Mar 18.

1 Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct , Melbourne, Australia .

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http://dx.doi.org/10.1089/ars.2014.6103DOI Listing
June 2015

Dynamic changes in the cardiac methylome during postnatal development.

FASEB J 2015 Apr 9;29(4):1329-43. Epub 2014 Dec 9.

*School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia; and Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia

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http://aups.org.au/Proceedings/45/144P/144P.pdf
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http://www.fasebj.org/content/early/2014/12/07/fj.14-264093.
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http://www.fasebj.org/cgi/doi/10.1096/fj.14-264093
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http://dx.doi.org/10.1096/fj.14-264093DOI Listing
April 2015

Non-referenced genome assembly from epigenomic short-read data.

Epigenetics 2014 Oct;9(10):1329-38

a Epigenetics in Human Health and Disease Laboratory ; Baker IDI Heart and Diabetes Institute ; The Alfred Medical Research and Education Precinct ; Melbourne , Victoria , Australia ;

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http://dx.doi.org/10.4161/15592294.2014.969610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622496PMC
October 2014

Development of novel activin-targeted therapeutics.

Mol Ther 2015 Mar 17;23(3):434-44. Epub 2014 Nov 17.

1] MIMR-PHI Institute of Medical Research, Clayton, Australia [2] Department of Physiology, Monash University, Clayton, Australia [3] Department of Molecular and Translational Sciences, Monash University, Clayton, Australia.

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http://dx.doi.org/10.1038/mt.2014.221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351455PMC
March 2015

Genetic variants within the second intron of the KCNQ1 gene affect CTCF binding and confer a risk of Beckwith-Wiedemann syndrome upon maternal transmission.

J Med Genet 2014 Aug 4;51(8):502-11. Epub 2014 Jul 4.

Epigenetics in Human Health and Disease, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.

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http://jmg.bmj.com/lookup/doi/10.1136/jmedgenet-2014-102368
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http://dx.doi.org/10.1136/jmedgenet-2014-102368DOI Listing
August 2014

Deep sequencing reveals novel Set7 networks.

Cell Mol Life Sci 2014 Nov 30;71(22):4471-86. Epub 2014 May 30.

Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, VIC, 3004, Australia.

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http://dx.doi.org/10.1007/s00018-014-1651-yDOI Listing
November 2014

Endothelial transcriptome in response to pharmacological methyltransferase inhibition.

ChemMedChem 2014 Aug 21;9(8):1755-62. Epub 2014 May 21.

Epigenetics in Human Health & Disease Laboratory, Baker IDI Heart & Diabetes Institute, The Alfred Medical Research & Education Precinct, Melbourne, Victoria 3004 (Australia); Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria 3800 (Australia).

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http://dx.doi.org/10.1002/cmdc.201402091DOI Listing
August 2014

Chromatin modifications remodel cardiac gene expression.

Cardiovasc Res 2014 Jul 8;103(1):7-16. Epub 2014 May 8.

Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia Central Clinical School, Faculty of Medicine, Monash University, Victoria, Australia Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia

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http://dx.doi.org/10.1093/cvr/cvu122DOI Listing
July 2014

Vascular histone deacetylation by pharmacological HDAC inhibition.

Genome Res 2014 Aug 14;24(8):1271-84. Epub 2014 Apr 14.

Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia; Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia; Faculty of Medicine, Monash University, Victoria 3800, Australia

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http://dx.doi.org/10.1101/gr.168781.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120081PMC
August 2014

Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy.

J Am Soc Nephrol 2014 Jun 7;25(6):1237-54. Epub 2014 Feb 7.

Diabetic Complications Division, Juvenile Diabetes Research Foundation Danielle Alberti Memorial Centre for Diabetic Complications, Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia; Department of Medicine, Monash University, Melbourne, Victoria, Australia;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033375PMC
http://dx.doi.org/10.1681/ASN.2013070810DOI Listing
June 2014

Chromatin context and ncRNA highlight targets of MeCP2 in brain.

RNA Biol 2013 Nov 30;10(11):1741-57. Epub 2013 Oct 30.

Epigenetics in Human Health and Disease Laboratory; Baker IDI Heart and Diabetes Institute; The Alfred Medical Research and Education Precinct; Melbourne, VIC, Australia; Epigenomic Profiling Facility; Baker IDI Heart and Diabetes Institute; The Alfred Medical Research and Education Precinct; Melbourne, VIC, Australia; Department of Pathology; The University of Melbourne; Parkville, VIC, Australia; Faculty of Medicine, Nursing and Health Sciences; Monash University; VIC, Australia.

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http://dx.doi.org/10.4161/rna.26921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907483PMC
November 2013

Interplay of chromatin modifications and non-coding RNAs in the heart.

Epigenetics 2014 Jan 10;9(1):101-12. Epub 2013 Oct 10.

Epigenetics in Human Health and Disease Laboratory; Baker IDI Heart and Diabetes Institute; The Alfred Medical Research and Education Precinct; Melbourne, VIC Australia; Epigenomics Profiling Facility; Baker IDI Heart and Diabetes Institute; The Alfred Medical Research and Education Precinct; Melbourne, VIC Australia; Department of Pathology; The University of Melbourne; Melbourne, VIC Australia; Faculty of Medicine; Monash University; Melbourne, VIC Australia.

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http://dx.doi.org/10.4161/epi.26405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928172PMC
January 2014

The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart.

Nucleic Acids Res 2014 Jan 16;42(2):790-803. Epub 2013 Oct 16.

Epigenetics in Human Health and Disease Laboratory, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia, Experimental Cardiology, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia, Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia and Central Clinical School, Faculty of Medicine, Monash University, Victoria, Australia.

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http://dx.doi.org/10.1093/nar/gkt896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902903PMC
January 2014

Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation.

FASEB J 2013 Dec 4;27(12):4940-53. Epub 2013 Sep 4.

1Department of Comparative and Experimental Medicine, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.

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http://dx.doi.org/10.1096/fj.13-233528DOI Listing
December 2013

Deep sequencing reveals increased DNA methylation in chronic rat epilepsy.

Acta Neuropathol 2013 Nov 5;126(5):741-56. Epub 2013 Sep 5.

Department of Neuropathology, University Hospital Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany,

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http://dx.doi.org/10.1007/s00401-013-1168-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825532PMC
November 2013

Applicability of histone deacetylase inhibition for the treatment of spinal muscular atrophy.

Neurotherapeutics 2013 Oct;10(4):677-87

Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, VIC, 3004, Australia.

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http://dx.doi.org/10.1007/s13311-013-0209-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805858PMC
October 2013

The methylation hypothesis of pharmacoresistance in epilepsy.

Epilepsia 2013 May;54 Suppl 2:41-7

Department of Neuropathology, University Hospital Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.1111/epi.12183DOI Listing
May 2013

Glycemic memories and the epigenetic component of diabetic nephropathy.

Curr Diab Rep 2013 Aug;13(4):574-81

Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, 3004, Australia.

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http://dx.doi.org/10.1007/s11892-013-0383-yDOI Listing
August 2013

Motif analysis in DNAse hypersensitivity regions uncovers distal cis elements associated with gene expression.

Bioinformation 2013 21;9(4):212-5. Epub 2013 Feb 21.

Epigenetics in Human Health and Disease Laboratory ; Epigenomics Profiling Facility, Baker IDI Heart & Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia.

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http://www.bioinformation.net/009/97320630009212.pdf
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http://dx.doi.org/10.6026/97320630009212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602893PMC
March 2013

Transcriptional regulation by the Set7 lysine methyltransferase.

Epigenetics 2013 Apr 11;8(4):361-72. Epub 2013 Mar 11.

Epigenetics in Human Health and Disease Laboratory; Baker IDI Heart and Diabetes Institute; The Alfred Medical Research and Education Precinct; Melbourne, VIC Australia; Epigenomics Profiling Facility; Baker IDI Heart and Diabetes Institute; The Alfred Medical Research and Education Precinct; Melbourne, VIC Australia; Department of Pathology; The University of Melbourne; Melbourne, VIC Australia; Faculty of Medicine; Monash University; Melbourne, VIC Australia.

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http://www.tandfonline.com/doi/abs/10.4161/epi.24234
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http://dx.doi.org/10.4161/epi.24234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674045PMC
April 2013

Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis.

Pathobiol Aging Age Relat Dis 2012 22;2. Epub 2012 Feb 22.

Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, VIC., Australia.

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http://dx.doi.org/10.3402/pba.v2i0.11905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417697PMC
September 2012

Redox mediating epigenetic changes confer metabolic memories.

Authors:
Assam El-Osta

Circ Res 2012 Jul;111(3):262-4

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http://dx.doi.org/10.1161/CIRCRESAHA.112.274936DOI Listing
July 2012

Epigenetic mechanisms in the pathogenesis of diabetic foot ulcers.

J Diabetes Complications 2012 Nov-Dec;26(6):554-61. Epub 2012 Jun 26.

Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.jdiacomp.2012.05.015DOI Listing
April 2013

Epigenetic modification of the norepinephrine transporter gene in postural tachycardia syndrome.

Arterioscler Thromb Vasc Biol 2012 Aug 21;32(8):1910-6. Epub 2012 Jun 21.

Baker IDI Heart & Diabetes Institute, The University of Melbourne, Melbourne, Victoria 3004, Australia.

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http://dx.doi.org/10.1161/ATVBAHA.111.244343DOI Listing
August 2012

A pipeline for the identification and characterization of chromatin modifications derived from ChIP-Seq datasets.

Biochimie 2012 Nov 13;94(11):2353-9. Epub 2012 Jun 13.

Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia.

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http://dx.doi.org/10.1016/j.biochi.2012.06.002DOI Listing
November 2012

Effects of the histone deacetylase inhibitor, trichostatin A, in a chronic allergic airways disease model in mice.

Arch Immunol Ther Exp (Warsz) 2012 Aug 9;60(4):295-306. Epub 2012 Jun 9.

Allergy and Immune Disorders, Murdoch Children's Research Institute, Melbourne, VIC, Australia.

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August 2012

Chromatin modifications associated with diabetes.

J Cardiovasc Transl Res 2012 Aug 26;5(4):399-412. Epub 2012 May 26.

Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/s12265-012-9380-9DOI Listing
August 2012

Distinguishing hyperglycemic changes by Set7 in vascular endothelial cells.

Circ Res 2012 Apr 8;110(8):1067-76. Epub 2012 Mar 8.

Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1161/CIRCRESAHA.112.266171DOI Listing
April 2012

Microparticles: major transport vehicles for distinct microRNAs in circulation.

Cardiovasc Res 2012 Mar 18;93(4):633-44. Epub 2012 Jan 18.

Atherothrombosis and Vascular Biology, BakerIDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia.

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http://dx.doi.org/10.1093/cvr/cvs007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291092PMC
March 2012

Influence of natural and synthetic histone deacetylase inhibitors on chromatin.

Antioxid Redox Signal 2012 Jul 9;17(2):340-54. Epub 2012 Feb 9.

Allergy and Immune Disorders, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1089/ars.2011.4480DOI Listing
July 2012

Glycemic memory.

Authors:
Assam El-Osta

Curr Opin Lipidol 2012 Feb;23(1):24-9

Epigenetics in Human Health and Disease Laboratory, The University of Melbourne, Parkville, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1097/MOL.0b013e32834f319dDOI Listing
February 2012

Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease.

Epigenetics 2011 Dec;6(12):1463-70

Allergy and Immune Disorders, Murdoch Children's Research Institute, Parkville VIC, Australia.

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http://dx.doi.org/10.4161/epi.6.12.18396DOI Listing
December 2011

Investigation into the biological properties of the olive polyphenol, hydroxytyrosol: mechanistic insights by genome-wide mRNA-Seq analysis.

Genes Nutr 2012 Apr 28;7(2):343-55. Epub 2011 Sep 28.

Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 75 Commercial Road, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/s12263-011-0249-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316757PMC
April 2012

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells.

Genome Res 2011 Oct 2;21(10):1601-15. Epub 2011 Sep 2.

Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia.

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http://dx.doi.org/10.1101/gr.116095.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202278PMC
October 2011

Chromatin modifying agents - the cutting edge of anticancer therapy.

Drug Discov Today 2011 Jul 1;16(13-14):543-7. Epub 2011 Jun 1.

Epigenomic Medicine Laboratory, Baker IDI Heart & Diabetes Research Institute, 75 Commercial Road, Melbourne 3004, Australia.

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http://dx.doi.org/10.1016/j.drudis.2011.05.012DOI Listing
July 2011

Remodeling is at the heart of chromatin: the heartaches of chromatin.

Authors:
Assam El-Osta

Epigenetics 2011 Jul 1;6(7):884-7. Epub 2011 Jul 1.

Epigenetics in Human Health and Disease, Baker IDI Heart and Diabetes Institute, Melbourne, VIC, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154429PMC
http://dx.doi.org/10.4161/epi.6.7.16551DOI Listing
July 2011

Cardiac genes show contextual SWI/SNF interactions with distinguishable gene activities.

Epigenetics 2011 Jun 1;6(6):760-8. Epub 2011 Jun 1.

Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.4161/epi.6.6.16007DOI Listing
June 2011

Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes.

Cell Mol Life Sci 2011 Dec 17;68(24):4101-14. Epub 2011 May 17.

Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 75 Commercial Road, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/s00018-011-0727-1DOI Listing
December 2011

Molecular model of naphthalene-induced DNA damage in the murine lung.

Hum Exp Toxicol 2012 Jan 20;31(1):42-50. Epub 2011 Apr 20.

Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1177/0960327111407228DOI Listing
January 2012