Publications by authors named "Asmae Belbachir"

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Isolation, characterization, and antimicrobial activity of communic acid from .

J Complement Integr Med 2021 Jul 29. Epub 2021 Jul 29.

Laboratory of Organic Synthesis, Extraction and Valorisation, Faculty of Sciences Aïn Chock, Hassan II University of Casablanca, BP. 20000, Casablanca, Morocco.

Objectives: A mixture of Z and E communic acid is isolated for the first time from the cones of Its biological activity was studied.

Methods: The plant material was extracted in a Soxhlet apparatus with -hexane, the resulting extract was subjected to column chromatography (CC) on silica gel. The structure elucidation of the constituents of the isolated fraction was identified by comparison of its spectroscopic properties H and C NMR data with those reported in the literature. The antimicrobial assay of hexanic extract and isolated compounds was carried out by the disc diffusion and micro-dilution methods.

Results: A mixture of two diterpene acids isomers was isolated, with a high yield (68%). Their chemical structures were confirmed after comparing their spectral data with published reports. These natural products exhibited a significant antibacterial and antifungal activity against the tested strains. Indeed, for , , and , the inhibition zone diameters (36-37 mm) was better than penicillin, novobiocin, and amoxicillin. For s activity, it show that the mixture possess an activity similar to that of Metrazol. Against , the inhibitory activity was found less than Amoxicillin. This is the first report of isolation of communic acid from .

Conclusions: These results showed that the cones of were an important source of communic acid, and its hexanic extract had the greatest potential antibacterial activity against both Gram-negative and Gram-positive bacteria and .
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July 2021