Publications by authors named "Asmaa Abd Elhameed"

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Low resting diffusion capacity, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease.

J Appl Physiol (1985) 2019 10 1;127(4):1107-1116. Epub 2019 Aug 1.

Department of Medicine and Queen's University and Kingston Health Sciences Centre, Kingston, Ontario, Canada.

The mechanisms linking reduced diffusing capacity of the lung for carbon monoxide (Dl) to dyspnea and exercise intolerance across the chronic obstructive pulmonary disease (COPD) continuum are poorly understood. COPD progression generally involves both Dl decline and worsening respiratory mechanics, and their relative contribution to dyspnea has not been determined. In a retrospective analysis of 300 COPD patients who completed symptom-limited incremental cardiopulmonary exercise tests, we tested the association between peak oxygen-uptake (V̇o), Dl, and other resting physiological measures. Then, we stratified the sample into tertiles of forced expiratory volume in 1 s (FEV) and inspiratory capacity (IC) and compared dyspnea ratings, pulmonary gas exchange, and respiratory mechanics during exercise in groups with normal and low Dl [i.e.,
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October 2019