Aslaug Jonasdottir

Aslaug Jonasdottir

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Aslaug Jonasdottir

Aslaug Jonasdottir

Publications by authors named "Aslaug Jonasdottir"

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A PRPH splice-donor variant associates with reduced sural nerve amplitude and risk of peripheral neuropathy.

Authors:
Gyda Bjornsdottir Erna V Ivarsdottir Kristbjorg Bjarnadottir Stefania Benonisdottir Sandra Sif Gylfadottir Gudny A Arnadottir Rafn Benediktsson Gisli Hreinn Halldorsson Anna Helgadottir Adalbjorg Jonasdottir Aslaug Jonasdottir Ingileif Jonsdottir Anna Margret Kristinsdottir Olafur Th Magnusson Gisli Masson Pall Melsted Thorunn Rafnar Asgeir Sigurdsson Gunnar Sigurdsson Astros Skuladottir Valgerdur Steinthorsdottir Unnur Styrkarsdottir Gudmundur Thorgeirsson Gudmar Thorleifsson Arnor Vikingsson Daniel F Gudbjartsson Hilma Holm Hreinn Stefansson Unnur Thorsteinsdottir Gudmundur L Norddahl Patrick Sulem Thorgeir E Thorgeirsson Kari Stefansson

Nat Commun 2019 04 16;10(1):1777. Epub 2019 Apr 16.

deCODE Genetics/Amgen, Inc., 101 Reykjavik, Iceland.

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http://dx.doi.org/10.1038/s41467-019-09719-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468012PMC
April 2019

Identification of Lynch syndrome risk variants in the Romanian population.

Authors:
Paul D Iordache Dana Mates Bjarni Gunnarsson Hannes P Eggertsson Patrick Sulem Stefania Benonisdottir Irma Eva Csiki Stefan Rascu Daniel Radavoi Radu Ursu Catalin Staicu Violeta Calota Angelica Voinoiu Mariana Jinga Gabriel Rosoga Razvan Danau Sorin Cristian Sima Daniel Badescu Nicoleta Suciu Viorica Radoi Ioan Nicolae Mates Mihai Dobra Camelia Nicolae Sigrun Kristjansdottir Jon G Jonasson Andrei Manolescu Gudny Arnadottir Brynjar Jensson Aslaug Jonasdottir Asgeir Sigurdsson Louise le Roux Hrefna Johannsdottir Thorunn Rafnar Bjarni V Halldorsson Viorel Jinga Kari Stefansson

J Cell Mol Med 2018 12 16;22(12):6068-6076. Epub 2018 Oct 16.

deCODE genetics/AMGEN, Reykjavik, Iceland.

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http://dx.doi.org/10.1111/jcmm.13881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237568PMC
December 2018

Multiple transmissions of de novo mutations in families.

Authors:
Hákon Jónsson Patrick Sulem Gudny A Arnadottir Gunnar Pálsson Hannes P Eggertsson Snaedis Kristmundsdottir Florian Zink Birte Kehr Kristjan E Hjorleifsson Brynjar Ö Jensson Ingileif Jonsdottir Sigurdur Einar Marelsson Sigurjon Axel Gudjonsson Arnaldur Gylfason Adalbjorg Jonasdottir Aslaug Jonasdottir Simon N Stacey Olafur Th Magnusson Unnur Thorsteinsdottir Gisli Masson Augustine Kong Bjarni V Halldorsson Agnar Helgason Daniel F Gudbjartsson Kari Stefansson

Nat Genet 2018 12 5;50(12):1674-1680. Epub 2018 Nov 5.

deCODE genetics/Amgen Inc., Reykjavik, Iceland.

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http://www.nature.com/articles/s41588-018-0259-9
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http://dx.doi.org/10.1038/s41588-018-0259-9DOI Listing
December 2018

Author Correction: The rate of meiotic gene conversion varies by sex and age.

Authors:
Bjarni V Halldorsson Marteinn T Hardarson Birte Kehr Unnur Styrkarsdottir Arnaldur Gylfason Gudmar Thorleifsson Florian Zink Adalbjorg Jonasdottir Aslaug Jonasdottir Patrick Sulem Gisli Masson Unnur Thorsteinsdottir Agnar Helgason Augustine Kong Daniel F Gudbjartsson Kari Stefansson

Nat Genet 2018 11;50(11):1616

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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http://www.nature.com/articles/s41588-018-0228-3
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http://dx.doi.org/10.1038/s41588-018-0228-3DOI Listing
November 2018

A homozygous loss-of-function mutation leading to CYBC1 deficiency causes chronic granulomatous disease.

Authors:
Gudny A Arnadottir Gudmundur L Norddahl Steinunn Gudmundsdottir Arna B Agustsdottir Snaevar Sigurdsson Brynjar O Jensson Kristbjorg Bjarnadottir Fannar Theodors Stefania Benonisdottir Erna V Ivarsdottir Asmundur Oddsson Ragnar P Kristjansson Gerald Sulem Kristjan F Alexandersson Thorhildur Juliusdottir Kjartan R Gudmundsson Jona Saemundsdottir Adalbjorg Jonasdottir Aslaug Jonasdottir Asgeir Sigurdsson Paolo Manzanillo Sigurjon A Gudjonsson Gudmundur A Thorisson Olafur Th Magnusson Gisli Masson Kjartan B Orvar Hilma Holm Sigurdur Bjornsson Reynir Arngrimsson Daniel F Gudbjartsson Unnur Thorsteinsdottir Ingileif Jonsdottir Asgeir Haraldsson Patrick Sulem Kari Stefansson

Nat Commun 2018 10 25;9(1):4447. Epub 2018 Oct 25.

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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http://www.nature.com/articles/s41467-018-06964-x
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http://dx.doi.org/10.1038/s41467-018-06964-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202333PMC
October 2018

MAP1B mutations cause intellectual disability and extensive white matter deficit.

Authors:
G Bragi Walters Omar Gustafsson Gardar Sveinbjornsson Valgerdur K Eiriksdottir Arna B Agustsdottir Gudrun A Jonsdottir Stacy Steinberg Arni F Gunnarsson Magnus I Magnusson Unnur Unnsteinsdottir Amy L Lee Adalbjorg Jonasdottir Asgeir Sigurdsson Aslaug Jonasdottir Astros Skuladottir Lina Jonsson Muhammad S Nawaz Patrick Sulem Mike Frigge Andres Ingason Askell Love Gudmundur L Norddhal Mark Zervas Daniel F Gudbjartsson Magnus O Ulfarsson Evald Saemundsen Hreinn Stefansson Kari Stefansson

Nat Commun 2018 08 27;9(1):3456. Epub 2018 Aug 27.

deCODE genetics/Amgen, Reykjavik, 101, Iceland.

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http://dx.doi.org/10.1038/s41467-018-05595-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110722PMC
August 2018

Variants in NKX2-5 and FLNC Cause Dilated Cardiomyopathy and Sudden Cardiac Death.

Authors:
Gardar Sveinbjornsson Eva F Olafsdottir Rosa B Thorolfsdottir Olafur B Davidsson Anna Helgadottir Adalbjorg Jonasdottir Aslaug Jonasdottir Eythor Bjornsson Brynjar O Jensson Gudny A Arnadottir Hallfridur Kristinsdottir Sigurdur S Stephensen Gylfi Oskarsson Tomas Gudbjartsson Emil L Sigurdsson Karl Andersen Ragnar Danielsen David O Arnar Ingileif Jonsdottir Unnur Thorsteinsdottir Patrick Sulem Gudmundur Thorgeirsson Daniel F Gudbjartsson Hilma Holm Kari Stefansson

Circ Genom Precis Med 2018 08;11(8):e002151

Adalbjorg Jonasdottir, Aslaug Jonasdottir, E.B., B.O.J., G.A.A., D.O.A., I.J., U.T., P.S., G.T., D.F.G., H.H., K.S.).

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http://dx.doi.org/10.1161/CIRCGEN.117.002151DOI Listing
August 2018

A rare missense variant in associates with lower cholesterol levels.

Authors:
Aimee M Deaton Patrick Sulem Paul Nioi Stefania Benonisdottir Lucas D Ward Olafur B Davidsson Socheata Lao Anna Helgadottir Fan Fan Brynjar O Jensson Gudmundur L Norddahl Aslaug Jonasdottir Adalbjorg Jonasdottir Asgeir Sigurdsson Ragnar P Kristjansson Asmundur Oddsson Gudny A Arnadottir Hakon Jonsson Isleifur Olafsson Gudmundur I Eyjolfsson Olof Sigurdardottir Einar S Bjornsson Sigurdur Olafsson Thora Steingrimsdottir Thorunn Rafnar Gudmundur Thorgeirsson Gisli Masson Gudmar Thorleifsson Daniel F Gudbjartsson Hilma Holm Unnur Thorsteinsdottir Kari Stefansson

Commun Biol 2018 8;1:14. Epub 2018 Feb 8.

deCODE Genetics/Amgen, Inc., Reykjavik, 101 Iceland.

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http://dx.doi.org/10.1038/s42003-018-0015-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123719PMC
February 2018

Graphtyper enables population-scale genotyping using pangenome graphs.

Authors:
Hannes P Eggertsson Hakon Jonsson Snaedis Kristmundsdottir Eirikur Hjartarson Birte Kehr Gisli Masson Florian Zink Kristjan E Hjorleifsson Aslaug Jonasdottir Adalbjorg Jonasdottir Ingileif Jonsdottir Daniel F Gudbjartsson Pall Melsted Kari Stefansson Bjarni V Halldorsson

Nat Genet 2017 Nov 25;49(11):1654-1660. Epub 2017 Sep 25.

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.3964DOI Listing
November 2017

COPA syndrome in an Icelandic family caused by a recurrent missense mutation in COPA.

Authors:
Brynjar O Jensson Sif Hansdottir Gudny A Arnadottir Gerald Sulem Ragnar P Kristjansson Asmundur Oddsson Stefania Benonisdottir Hakon Jonsson Agnar Helgason Jona Saemundsdottir Olafur T Magnusson Gisli Masson Gudmundur A Thorisson Adalbjorg Jonasdottir Aslaug Jonasdottir Asgeir Sigurdsson Ingileif Jonsdottir Vigdis Petursdottir Jon R Kristinsson Daniel F Gudbjartsson Unnur Thorsteinsdottir Reynir Arngrimsson Patrick Sulem Gunnar Gudmundsson Kari Stefansson

BMC Med Genet 2017 11 14;18(1):129. Epub 2017 Nov 14.

deCODE Genetics/Amgen, Inc, Sturlugata 8, 101, Reykjavik, Iceland.

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https://bmcmedgenet.biomedcentral.com/articles/10.1186/s1288
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http://dx.doi.org/10.1186/s12881-017-0490-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686906PMC
November 2017

Compound heterozygous mutations in UBA5 causing early-onset epileptic encephalopathy in two sisters.

Authors:
Gudny A Arnadottir Brynjar O Jensson Sigurdur E Marelsson Gerald Sulem Asmundur Oddsson Ragnar P Kristjansson Stefania Benonisdottir Sigurjon A Gudjonsson Gisli Masson Gudmundur A Thorisson Jona Saemundsdottir Olafur Th Magnusson Adalbjorg Jonasdottir Aslaug Jonasdottir Asgeir Sigurdsson Daniel F Gudbjartsson Unnur Thorsteinsdottir Reynir Arngrimsson Patrick Sulem Kari Stefansson

BMC Med Genet 2017 10 2;18(1):103. Epub 2017 Oct 2.

deCODE Genetics/Amgen, Inc., Sturlugata 8, 101, Reykjavik, Iceland.

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http://dx.doi.org/10.1186/s12881-017-0466-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623963PMC
October 2017

Whole genome characterization of sequence diversity of 15,220 Icelanders.

Authors:
Hákon Jónsson Patrick Sulem Birte Kehr Snaedis Kristmundsdottir Florian Zink Eirikur Hjartarson Marteinn T Hardarson Kristjan E Hjorleifsson Hannes P Eggertsson Sigurjon Axel Gudjonsson Lucas D Ward Gudny A Arnadottir Einar A Helgason Hannes Helgason Arnaldur Gylfason Adalbjorg Jonasdottir Aslaug Jonasdottir Thorunn Rafnar Soren Besenbacher Michael L Frigge Simon N Stacey Olafur Th Magnusson Unnur Thorsteinsdottir Gisli Masson Augustine Kong Bjarni V Halldorsson Agnar Helgason Daniel F Gudbjartsson Kari Stefansson

Sci Data 2017 09 21;4:170115. Epub 2017 Sep 21.

deCODE genetics/Amgen Inc., Sturlugata 8, Reykjavik 101, Iceland.

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http://dx.doi.org/10.1038/sdata.2017.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607473PMC
September 2017

Parental influence on human germline de novo mutations in 1,548 trios from Iceland.

Authors:
Hákon Jónsson Patrick Sulem Birte Kehr Snaedis Kristmundsdottir Florian Zink Eirikur Hjartarson Marteinn T Hardarson Kristjan E Hjorleifsson Hannes P Eggertsson Sigurjon Axel Gudjonsson Lucas D Ward Gudny A Arnadottir Einar A Helgason Hannes Helgason Arnaldur Gylfason Adalbjorg Jonasdottir Aslaug Jonasdottir Thorunn Rafnar Mike Frigge Simon N Stacey Olafur Th Magnusson Unnur Thorsteinsdottir Gisli Masson Augustine Kong Bjarni V Halldorsson Agnar Helgason Daniel F Gudbjartsson Kari Stefansson

Nature 2017 09 20;549(7673):519-522. Epub 2017 Sep 20.

deCODE genetics/Amgen Inc., 101 Reykjavik, Iceland.

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http://dx.doi.org/10.1038/nature24018DOI Listing
September 2017

Identification of sequence variants influencing immunoglobulin levels.

Authors:
Stefan Jonsson Gardar Sveinbjornsson Aitzkoa Lopez de Lapuente Portilla Bhairavi Swaminathan Rosina Plomp Gillian Dekkers Ram Ajore Mina Ali Arthur E H Bentlage Evelina Elmér Gudmundur I Eyjolfsson Sigurjon A Gudjonsson Urban Gullberg Arnaldur Gylfason Bjarni V Halldorsson Markus Hansson Hilma Holm Åsa Johansson Ellinor Johnsson Aslaug Jonasdottir Bjorn R Ludviksson Asmundur Oddsson Isleifur Olafsson Sigurgeir Olafsson Olof Sigurdardottir Asgeir Sigurdsson Lilja Stefansdottir Gisli Masson Patrick Sulem Manfred Wuhrer Anna-Karin Wihlborg Gudmar Thorleifsson Daniel F Gudbjartsson Unnur Thorsteinsdottir Gestur Vidarsson Ingileif Jonsdottir Björn Nilsson Kari Stefansson

Nat Genet 2017 Aug 19;49(8):1182-1191. Epub 2017 Jun 19.

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.3897DOI Listing
August 2017

Corrigendum: Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis.

Authors:
Unnur Styrkarsdottir Hannes Helgason Asgeir Sigurdsson Gudmundur L Norddahl Arna B Agustsdottir Louise N Reynard Amanda Villalvilla Gisli H Halldorsson Aslaug Jonasdottir Audur Magnusdottir Asmundur Oddson Gerald Sulem Florian Zink Gardar Sveinbjornsson Agnar Helgason Hrefna S Johannsdottir Anna Helgadottir Hreinn Stefansson Solveig Gretarsdottir Thorunn Rafnar Ina S Almdahl Anne Brækhus Tormod Fladby Geir Selbæk Farhad Hosseinpanah Fereidoun Azizi Jung Min Koh Nelson L S Tang Maryams Danesphour Jose I Mayordomo Corrine Welt Peter S Braund Nilesh J Samani Lambertus A Kiemeney L Stefan Lohmander Claus Christiansen Ole A Andreassen arcOGEN Consortium Olafur Magnusson Gisli Masson Augustine Kong Ingileif Jonsdottir Daniel Gudbjartsson Patrick Sulem Helgi Jonsson John Loughlin Thorvaldur Ingvarsson Unnur Thorsteinsdottir Kari Stefansson

Nat Genet 2017 07;49(8):1286

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http://dx.doi.org/10.1038/ng0817-1286bDOI Listing
July 2017

A rare splice donor mutation in the haptoglobin gene associates with blood lipid levels and coronary artery disease.

Authors:
Eythor Bjornsson Hannes Helgason Gisli Halldorsson Anna Helgadottir Arnaldur Gylfason Birte Kehr Adalbjorg Jonasdottir Aslaug Jonasdottir Asgeir Sigurdsson Asmundur Oddsson Gudmar Thorleifsson Olafur Th Magnusson Solveig Gretarsdottir Florian Zink Ragnar P Kristjansson Margret Asgeirsdottir Dorine W Swinkels Lambertus A Kiemeney Gudmundur I Eyjolfsson Olof Sigurdardottir Gisli Masson Isleifur Olafsson Gudmundur Thorgeirsson Hilma Holm Unnur Thorsteinsdottir Daniel F Gudbjartsson Patrick Sulem Kari Stefansson

Hum Mol Genet 2017 06;26(12):2364-2376

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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http://dx.doi.org/10.1093/hmg/ddx123DOI Listing
June 2017

Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis.

Authors:
Unnur Styrkarsdottir Hannes Helgason Asgeir Sigurdsson Gudmundur L Norddahl Arna B Agustsdottir Louise N Reynard Amanda Villalvilla Gisli H Halldorsson Aslaug Jonasdottir Audur Magnusdottir Asmundur Oddson Gerald Sulem Florian Zink Gardar Sveinbjornsson Agnar Helgason Hrefna S Johannsdottir Anna Helgadottir Hreinn Stefansson Solveig Gretarsdottir Thorunn Rafnar Ina S Almdahl Anne Brækhus Tormod Fladby Geir Selbæk Farhad Hosseinpanah Fereidoun Azizi Jung Min Koh Nelson L S Tang Maryam S Daneshpour Jose I Mayordomo Corrine Welt Peter S Braund Nilesh J Samani Lambertus A Kiemeney L Stefan Lohmander Claus Christiansen Ole A Andreassen Olafur Magnusson Gisli Masson Augustine Kong Ingileif Jonsdottir Daniel Gudbjartsson Patrick Sulem Helgi Jonsson John Loughlin Thorvaldur Ingvarsson Unnur Thorsteinsdottir Kari Stefansson

Nat Genet 2017 May 20;49(5):801-805. Epub 2017 Mar 20.

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.3816DOI Listing
May 2017

Diversity in non-repetitive human sequences not found in the reference genome.

Authors:
Birte Kehr Anna Helgadottir Pall Melsted Hakon Jonsson Hannes Helgason Adalbjörg Jonasdottir Aslaug Jonasdottir Asgeir Sigurdsson Arnaldur Gylfason Gisli H Halldorsson Snaedis Kristmundsdottir Gudmundur Thorgeirsson Isleifur Olafsson Hilma Holm Unnur Thorsteinsdottir Patrick Sulem Agnar Helgason Daniel F Gudbjartsson Bjarni V Halldorsson Kari Stefansson

Nat Genet 2017 Apr 27;49(4):588-593. Epub 2017 Feb 27.

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.3801DOI Listing
April 2017

A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma.

Authors:
Dirk Smith Hannes Helgason Patrick Sulem Unnur Steina Bjornsdottir Ai Ching Lim Gardar Sveinbjornsson Haruki Hasegawa Michael Brown Randal R Ketchem Monica Gavala Logan Garrett Adalbjorg Jonasdottir Aslaug Jonasdottir Asgeir Sigurdsson Olafur T Magnusson Gudmundur I Eyjolfsson Isleifur Olafsson Pall Torfi Onundarson Olof Sigurdardottir David Gislason Thorarinn Gislason Bjorn Runar Ludviksson Dora Ludviksdottir H Marike Boezen Andrea Heinzmann Marcus Krueger Celeste Porsbjerg Tarunveer S Ahluwalia Johannes Waage Vibeke Backer Klaus A Deichmann Gerard H Koppelman Klaus Bønnelykke Hans Bisgaard Gisli Masson Unnur Thorsteinsdottir Daniel F Gudbjartsson James A Johnston Ingileif Jonsdottir Kari Stefansson

PLoS Genet 2017 03 8;13(3):e1006659. Epub 2017 Mar 8.

deCODE genetics / Amgen Inc., Reykjavík, Iceland.

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http://dx.doi.org/10.1371/journal.pgen.1006659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362243PMC
March 2017

The rate of meiotic gene conversion varies by sex and age.

Authors:
Bjarni V Halldorsson Marteinn T Hardarson Birte Kehr Unnur Styrkarsdottir Arnaldur Gylfason Gudmar Thorleifsson Florian Zink Adalbjorg Jonasdottir Aslaug Jonasdottir Patrick Sulem Gisli Masson Unnur Thorsteinsdottir Agnar Helgason Augustine Kong Daniel F Gudbjartsson Kari Stefansson

Nat Genet 2016 11 19;48(11):1377-1384. Epub 2016 Sep 19.

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083143PMC
http://dx.doi.org/10.1038/ng.3669DOI Listing
November 2016

Multi-nucleotide de novo Mutations in Humans.

Authors:
Søren Besenbacher Patrick Sulem Agnar Helgason Hannes Helgason Helgi Kristjansson Aslaug Jonasdottir Adalbjorg Jonasdottir Olafur Th Magnusson Unnur Thorsteinsdottir Gisli Masson Augustine Kong Daniel F Gudbjartsson Kari Stefansson

PLoS Genet 2016 Nov 15;12(11):e1006315. Epub 2016 Nov 15.

deCODE genetics/Amgen, Inc., Iceland.

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http://dx.doi.org/10.1371/journal.pgen.1006315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147774PMC
November 2016

Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease.

Authors:
Anna Helgadottir Solveig Gretarsdottir Gudmar Thorleifsson Eirikur Hjartarson Asgeir Sigurdsson Audur Magnusdottir Aslaug Jonasdottir Helgi Kristjansson Patrick Sulem Asmundur Oddsson Gardar Sveinbjornsson Valgerdur Steinthorsdottir Thorunn Rafnar Gisli Masson Ingileif Jonsdottir Isleifur Olafsson Gudmundur I Eyjolfsson Olof Sigurdardottir Maryam S Daneshpour Davood Khalili Fereidoun Azizi Dorine W Swinkels Lambertus Kiemeney Arshed A Quyyumi Allan I Levey Riyaz S Patel Salim S Hayek Ingibjorg J Gudmundsdottir Gudmundur Thorgeirsson Unnur Thorsteinsdottir Daniel F Gudbjartsson Hilma Holm Kari Stefansson

Nat Genet 2016 06 2;48(6):634-9. Epub 2016 May 2.

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.3561DOI Listing
June 2016

Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease.

Authors:
Paul Nioi Asgeir Sigurdsson Gudmar Thorleifsson Hannes Helgason Arna B Agustsdottir Gudmundur L Norddahl Anna Helgadottir Audur Magnusdottir Aslaug Jonasdottir Solveig Gretarsdottir Ingileif Jonsdottir Valgerdur Steinthorsdottir Thorunn Rafnar Dorine W Swinkels Tessel E Galesloot Niels Grarup Torben Jørgensen Henrik Vestergaard Torben Hansen Torsten Lauritzen Allan Linneberg Nele Friedrich Nikolaj T Krarup Mogens Fenger Ulrik Abildgaard Peter R Hansen Anders M Galløe Peter S Braund Christopher P Nelson Alistair S Hall Michael J A Williams Andre M van Rij Gregory T Jones Riyaz S Patel Allan I Levey Salim Hayek Svati H Shah Muredach Reilly Gudmundur I Eyjolfsson Olof Sigurdardottir Isleifur Olafsson Lambertus A Kiemeney Arshed A Quyyumi Daniel J Rader William E Kraus Nilesh J Samani Oluf Pedersen Gudmundur Thorgeirsson Gisli Masson Hilma Holm Daniel Gudbjartsson Patrick Sulem Unnur Thorsteinsdottir Kari Stefansson

N Engl J Med 2016 Jun 18;374(22):2131-41. Epub 2016 May 18.

From deCODE Genetics-Amgen (P.N., A.S., G. Thorleifsson, H. Helgason, A.B.A., G.L.N., A.H., A.M., A.J., S.G., I.J., V.S., T.R., G.M., H. Holm, D.G., P.S., U.T., K.S.), Faculty of Medicine (A.H., I.J., G. Thorgeirsson, U.T., K.S.) and School of Engineering and Natural Sciences (H. Helgason, D.G.), University of Iceland, the Laboratory in Mjodd (G.I.E.), and the Department of Clinical Biochemistry (I.O.) and Division of Cardiology, Department of Internal Medicine (G. Thorgeirsson, H. Holm), Landspitali, National University Hospital of Iceland, Reykjavik, and the Department of Clinical Biochemistry, Akureyri Hospital, Akureyri (O.S.) - all in Iceland; Radboud Institute for Molecular Life Sciences, Department of Laboratory Medicine (D.W.S.), Radboud Institute for Health Sciences (T.E.G., L.A.K.), and the Department of Health Evidence (L.A.K.), Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics (N.G., H.V., T.H., N.T.K., O.P.), and Institute of Public Health, Faculty of Health and Medical Science (T.J., A.L.), University of Copenhagen, and Research Center for Prevention and Health, Capital Region of Denmark (T.J., A.L.), Copenhagen, Faculty of Medicine, University of Aalborg, Aalborg (T.J.), Faculty of Health Sciences, University of Southern Denmark, Odense (T.H.), Department of Public Health, Section of General Practice, University of Aarhus, Aarhus (T.L.), Department of Clinical Experimental Research, Rigshospitalet, Glostrup (A.L.), Department of Clinical Biochemistry, University Hospital of Copenhagen at Hvidovre, Hvidovre (M.F.), Department of Cardiology, Gentofte University Hospital, Hellerup (U.A., P.R.H., A.M.G.), and Department of Cardiology, Roskilde Hospital, Roskilde (A.M.G.) - all in Denmark; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany (N.F.); Department of Cardiovascular Sciences, Uni

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http://dx.doi.org/10.1056/NEJMoa1508419DOI Listing
June 2016

Insertion of an SVA-E retrotransposon into the CASP8 gene is associated with protection against prostate cancer.

Authors:
Simon N Stacey Birte Kehr Julius Gudmundsson Florian Zink Aslaug Jonasdottir Sigurjon A Gudjonsson Asgeir Sigurdsson Bjarni V Halldorsson Bjarni A Agnarsson Kristrun R Benediktsdottir Katja K H Aben Sita H Vermeulen Ruben G Cremers Angeles Panadero Brian T Helfand Phillip R Cooper Jenny L Donovan Freddie C Hamdy Viorel Jinga Ichiro Okamoto Jon G Jonasson Laufey Tryggvadottir Hrefna Johannsdottir Anna M Kristinsdottir Gisli Masson Olafur T Magnusson Paul D Iordache Agnar Helgason Hannes Helgason Patrick Sulem Daniel F Gudbjartsson Augustine Kong Eirikur Jonsson Rosa B Barkardottir Gudmundur V Einarsson Thorunn Rafnar Unnur Thorsteinsdottir Ioan N Mates David E Neal William J Catalona José I Mayordomo Lambertus A Kiemeney Gudmar Thorleifsson Kari Stefansson

Hum Mol Genet 2016 Mar 5;25(5):1008-18. Epub 2016 Jan 5.

deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland, Faculty of Medicine,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754045PMC
March 2016

HLA class II sequence variants influence tuberculosis risk in populations of European ancestry.

Authors:
Gardar Sveinbjornsson Daniel F Gudbjartsson Bjarni V Halldorsson Karl G Kristinsson Magnus Gottfredsson Jeffrey C Barrett Larus J Gudmundsson Kai Blondal Arnaldur Gylfason Sigurjon Axel Gudjonsson Hafdis T Helgadottir Adalbjorg Jonasdottir Aslaug Jonasdottir Ari Karason Ljiljana Bulat Kardum Jelena Knežević Helgi Kristjansson Mar Kristjansson Arthur Love Yang Luo Olafur T Magnusson Patrick Sulem Augustine Kong Gisli Masson Unnur Thorsteinsdottir Zlatko Dembic Sergey Nejentsev Thorsteinn Blondal Ingileif Jonsdottir Kari Stefansson

Nat Genet 2016 Mar 1;48(3):318-22. Epub 2016 Feb 1.

deCODE genetics/Amgen Inc., Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.3498DOI Listing
March 2016

Common and rare variants associating with serum levels of creatine kinase and lactate dehydrogenase.

Authors:
Ragnar P Kristjansson Asmundur Oddsson Hannes Helgason Gardar Sveinbjornsson Gudny A Arnadottir Brynjar O Jensson Aslaug Jonasdottir Adalbjorg Jonasdottir G Bragi Walters Gerald Sulem Arna Oskarsdottir Stefania Benonisdottir Olafur B Davidsson Gisli Masson Olafur Th Magnusson Hilma Holm Olof Sigurdardottir Ingileif Jonsdottir Gudmundur I Eyjolfsson Isleifur Olafsson Daniel F Gudbjartsson Unnur Thorsteinsdottir Patrick Sulem Kari Stefansson

Nat Commun 2016 Feb 3;7:10572. Epub 2016 Feb 3.

deCODE genetics/Amgen, Inc., 101 Reykjavik, Iceland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742860PMC
February 2016

Identification of a large set of rare complete human knockouts.

Authors:
Patrick Sulem Hannes Helgason Asmundur Oddson Hreinn Stefansson Sigurjon A Gudjonsson Florian Zink Eirikur Hjartarson Gunnar Th Sigurdsson Adalbjorg Jonasdottir Aslaug Jonasdottir Asgeir Sigurdsson Olafur Th Magnusson Augustine Kong Agnar Helgason Hilma Holm Unnur Thorsteinsdottir Gisli Masson Daniel F Gudbjartsson Kari Stefansson

Nat Genet 2015 May 25;47(5):448-52. Epub 2015 Mar 25.

1] deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. [2] Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.3243DOI Listing
May 2015

Rare mutations associating with serum creatinine and chronic kidney disease.

Authors:
Gardar Sveinbjornsson Evgenia Mikaelsdottir Runolfur Palsson Olafur S Indridason Hilma Holm Aslaug Jonasdottir Agnar Helgason Snaevar Sigurdsson Adalbjorg Jonasdottir Asgeir Sigurdsson Gudmundur Ingi Eyjolfsson Olof Sigurdardottir Olafur Th Magnusson Augustine Kong Gisli Masson Patrick Sulem Isleifur Olafsson Unnur Thorsteinsdottir Daniel F Gudbjartsson Kari Stefansson

Hum Mol Genet 2014 Dec 31;23(25):6935-43. Epub 2014 Jul 31.

deCODE Genetics, 101 Reykjavik, Iceland Faculty of Medicine

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December 2014

Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.

Authors:
Simon N Stacey Patrick Sulem Daniel F Gudbjartsson Aslaug Jonasdottir Gudmar Thorleifsson Sigurjon A Gudjonsson Gisli Masson Julius Gudmundsson Bardur Sigurgeirsson Kristrun R Benediktsdottir Kristin Thorisdottir Rafn Ragnarsson Victoria Fuentelsaz Cristina Corredera Matilde Grasa Dolores Planelles Onofre Sanmartin Peter Rudnai Eugene Gurzau Kvetoslava Koppova Kari Hemminki Bjørn A Nexø Anne Tjønneland Kim Overvad Hrefna Johannsdottir Hafdis T Helgadottir Unnur Thorsteinsdottir Augustine Kong Ulla Vogel Rajiv Kumar Eduardo Nagore José I Mayordomo Thorunn Rafnar Jon H Olafsson Kari Stefansson

Hum Mol Genet 2014 Jun 8;23(11):3045-53. Epub 2014 Jan 8.

deCODE Genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland.

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http://dx.doi.org/10.1093/hmg/ddt671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014188PMC
June 2014

Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.

Authors:
Unnur Styrkarsdottir Gudmar Thorleifsson Hafdis T Helgadottir Nils Bomer Sarah Metrustry S Bierma-Zeinstra Annelieke M Strijbosch Evangelos Evangelou Deborah Hart Marian Beekman Aslaug Jonasdottir Asgeir Sigurdsson Finnur F Eiriksson Margret Thorsteinsdottir Michael L Frigge Augustine Kong Sigurjon A Gudjonsson Olafur T Magnusson Gisli Masson Albert Hofman Nigel K Arden Thorvaldur Ingvarsson Stefan Lohmander Margreet Kloppenburg Fernando Rivadeneira Rob G H H Nelissen Tim Spector Andre Uitterlinden P Eline Slagboom Unnur Thorsteinsdottir Ingileif Jonsdottir Ana M Valdes Ingrid Meulenbelt Joyce van Meurs Helgi Jonsson Kari Stefansson

Nat Genet 2014 May 13;46(5):498-502. Epub 2014 Apr 13.

1] deCODE Genetics/Amgen, Reykjavik, Iceland. [2] Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.2957DOI Listing
May 2014

Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits.

Authors:
Unnur Styrkarsdottir Gudmar Thorleifsson Patrick Sulem Daniel F Gudbjartsson Asgeir Sigurdsson Aslaug Jonasdottir Adalbjorg Jonasdottir Asmundur Oddsson Agnar Helgason Olafur T Magnusson G Bragi Walters Michael L Frigge Hafdis T Helgadottir Hrefna Johannsdottir Kristin Bergsteinsdottir Margret H Ogmundsdottir Jacqueline R Center Tuan V Nguyen John A Eisman Claus Christiansen Erikur Steingrimsson Jon G Jonasson Laufey Tryggvadottir Gudmundur I Eyjolfsson Asgeir Theodors Thorvaldur Jonsson Thorvaldur Ingvarsson Isleifur Olafsson Thorunn Rafnar Augustine Kong Gunnar Sigurdsson Gisli Masson Unnur Thorsteinsdottir Kari Stefansson

Nature 2013 May 5;497(7450):517-20. Epub 2013 May 5.

deCODE Genetics/Amgen, 101 Reykjavik, Iceland.

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http://dx.doi.org/10.1038/nature12124DOI Listing
May 2013

Rate of de novo mutations and the importance of father's age to disease risk.

Authors:
Augustine Kong Michael L Frigge Gisli Masson Soren Besenbacher Patrick Sulem Gisli Magnusson Sigurjon A Gudjonsson Asgeir Sigurdsson Aslaug Jonasdottir Adalbjorg Jonasdottir Wendy S W Wong Gunnar Sigurdsson G Bragi Walters Stacy Steinberg Hannes Helgason Gudmar Thorleifsson Daniel F Gudbjartsson Agnar Helgason Olafur Th Magnusson Unnur Thorsteinsdottir Kari Stefansson

Nature 2012 Aug;488(7412):471-5

deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland.

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http://dx.doi.org/10.1038/nature11396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548427PMC
August 2012

Discovery of common variants associated with low TSH levels and thyroid cancer risk.

Authors:
Julius Gudmundsson Patrick Sulem Daniel F Gudbjartsson Jon G Jonasson Gisli Masson Huiling He Aslaug Jonasdottir Asgeir Sigurdsson Simon N Stacey Hrefna Johannsdottir Hafdis Th Helgadottir Wei Li Rebecca Nagy Matthew D Ringel Richard T Kloos Marieke C H de Visser Theo S Plantinga Martin den Heijer Esperanza Aguillo Angeles Panadero Enrique Prats Almudena Garcia-Castaño Ana De Juan Fernando Rivera G Bragi Walters Hjordis Bjarnason Laufey Tryggvadottir Gudmundur I Eyjolfsson Unnur S Bjornsdottir Hilma Holm Isleifur Olafsson Kristleifur Kristjansson Hoskuldur Kristvinsson Olafur T Magnusson Gudmar Thorleifsson Jeffrey R Gulcher Augustine Kong Lambertus A L M Kiemeney Thorvaldur Jonsson Hannes Hjartarson Jose I Mayordomo Romana T Netea-Maier Albert de la Chapelle Jon Hrafnkelsson Unnur Thorsteinsdottir Thorunn Rafnar Kari Stefansson

Nat Genet 2012 Jan 22;44(3):319-22. Epub 2012 Jan 22.

deCODE Genetics, Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.1046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655412PMC
January 2012

Mutations in BRIP1 confer high risk of ovarian cancer.

Authors:
Thorunn Rafnar Daniel F Gudbjartsson Patrick Sulem Aslaug Jonasdottir Asgeir Sigurdsson Adalbjorg Jonasdottir Soren Besenbacher Pär Lundin Simon N Stacey Julius Gudmundsson Olafur T Magnusson Louise le Roux Gudbjorg Orlygsdottir Hafdis T Helgadottir Hrefna Johannsdottir Arnaldur Gylfason Laufey Tryggvadottir Jon G Jonasson Ana de Juan Eugenia Ortega Jose M Ramon-Cajal Maria D García-Prats Carlos Mayordomo Angeles Panadero Fernando Rivera Katja K H Aben Anne M van Altena Leon F A G Massuger Mervi Aavikko Paula M Kujala Synnöve Staff Lauri A Aaltonen Kristrun Olafsdottir Johannes Bjornsson Augustine Kong Anna Salvarsdottir Hafsteinn Saemundsson Karl Olafsson Kristrun R Benediktsdottir Jeffrey Gulcher Gisli Masson Lambertus A Kiemeney Jose I Mayordomo Unnur Thorsteinsdottir Kari Stefansson

Nat Genet 2011 Oct 2;43(11):1104-7. Epub 2011 Oct 2.

deCODE genetics, Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.955DOI Listing
October 2011

A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.

Authors:
Simon N Stacey Patrick Sulem Aslaug Jonasdottir Gisli Masson Julius Gudmundsson Daniel F Gudbjartsson Olafur T Magnusson Sigurjon A Gudjonsson Bardur Sigurgeirsson Kristin Thorisdottir Rafn Ragnarsson Kristrun R Benediktsdottir Bjørn A Nexø Anne Tjønneland Kim Overvad Peter Rudnai Eugene Gurzau Kvetoslava Koppova Kari Hemminki Cristina Corredera Victoria Fuentelsaz Pilar Grasa Sebastian Navarrete Fernando Fuertes Maria D García-Prats Enrique Sanambrosio Angeles Panadero Ana De Juan Almudena Garcia Fernando Rivera Dolores Planelles Virtudes Soriano Celia Requena Katja K Aben Michelle M van Rossum Ruben G H M Cremers Inge M van Oort Dick-Johan van Spronsen Jack A Schalken Wilbert H M Peters Brian T Helfand Jenny L Donovan Freddie C Hamdy Daniel Badescu Ovidiu Codreanu Mariana Jinga Irma E Csiki Vali Constantinescu Paula Badea Ioan N Mates Daniela E Dinu Adrian Constantin Dana Mates Sjofn Kristjansdottir Bjarni A Agnarsson Eirikur Jonsson Rosa B Barkardottir Gudmundur V Einarsson Fridbjorn Sigurdsson Pall H Moller Tryggvi Stefansson Trausti Valdimarsson Oskar T Johannsson Helgi Sigurdsson Thorvaldur Jonsson Jon G Jonasson Laufey Tryggvadottir Terri Rice Helen M Hansen Yuanyuan Xiao Daniel H Lachance Brian Patrick O Neill Matthew L Kosel Paul A Decker Gudmar Thorleifsson Hrefna Johannsdottir Hafdis T Helgadottir Asgeir Sigurdsson Valgerdur Steinthorsdottir Annika Lindblom Robert S Sandler Temitope O Keku Karina Banasik Torben Jørgensen Daniel R Witte Torben Hansen Oluf Pedersen Viorel Jinga David E Neal William J Catalona Margaret Wrensch John Wiencke Robert B Jenkins Eduardo Nagore Ulla Vogel Lambertus A Kiemeney Rajiv Kumar José I Mayordomo Jon H Olafsson Augustine Kong Unnur Thorsteinsdottir Thorunn Rafnar Kari Stefansson

Nat Genet 2011 Sep 25;43(11):1098-103. Epub 2011 Sep 25.

deCODE genetics, Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263694PMC
September 2011

A rare variant in MYH6 is associated with high risk of sick sinus syndrome.

Authors:
Hilma Holm Daniel F Gudbjartsson Patrick Sulem Gisli Masson Hafdis Th Helgadottir Carlo Zanon Olafur Th Magnusson Agnar Helgason Jona Saemundsdottir Arnaldur Gylfason Hrafnhildur Stefansdottir Solveig Gretarsdottir Stefan E Matthiasson Gu Mundur Thorgeirsson Aslaug Jonasdottir Asgeir Sigurdsson Hreinn Stefansson Thomas Werge Thorunn Rafnar Lambertus A Kiemeney Babar Parvez Raafia Muhammad Dan M Roden Dawood Darbar Gudmar Thorleifsson G Bragi Walters Augustine Kong Unnur Thorsteinsdottir David O Arnar Kari Stefansson

Nat Genet 2011 Mar 6;43(4):316-20. Epub 2011 Mar 6.

deCODE Genetics, Sturlugata 8, Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066272PMC
March 2011

Fine-scale recombination rate differences between sexes, populations and individuals.

Authors:
Augustine Kong Gudmar Thorleifsson Daniel F Gudbjartsson Gisli Masson Asgeir Sigurdsson Aslaug Jonasdottir G Bragi Walters Adalbjorg Jonasdottir Arnaldur Gylfason Kari Th Kristinsson Sigurjon A Gudjonsson Michael L Frigge Agnar Helgason Unnur Thorsteinsdottir Kari Stefansson

Nature 2010 Oct;467(7319):1099-103

deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland.

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http://dx.doi.org/10.1038/nature09525DOI Listing
October 2010

A sequence variant on 17q21 is associated with age at onset and severity of asthma.

Authors:
Eva Halapi Daniel F Gudbjartsson Gudrun M Jonsdottir Unnur S Bjornsdottir Gudmar Thorleifsson Hafdis Helgadottir Carolyn Williams Gerard H Koppelman Andrea Heinzmann H Marike Boezen Aslaug Jonasdottir Thorarinn Blondal Sigurjon A Gudjonsson Adalbjorg Jonasdottir Theodora Thorlacius Amanda P Henry Janine Altmueller Marcus Krueger Hyoung Doo Shin Soo-Taek Uh Hyun Sub Cheong Brynja Jonsdottir Bjorn R Ludviksson Dora Ludviksdottir David Gislason Choon-Sik Park Klaus Deichmann Philip J Thompson Matthias Wjst Ian P Hall Dirkje S Postma Thorarinn Gislason Augustine Kong Ingileif Jonsdottir Unnur Thorsteinsdottir Kari Stefansson

Eur J Hum Genet 2010 Aug 7;18(8):902-8. Epub 2010 Apr 7.

Population Genomics, deCODE Genetics Inc., Sturlugata 8, Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ejhg.2010.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987388PMC
August 2010

Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.

Authors:
Solveig Gretarsdottir Annette F Baas Gudmar Thorleifsson Hilma Holm Martin den Heijer Jean-Paul P M de Vries Steef E Kranendonk Clark J A M Zeebregts Steven M van Sterkenburg Robert H Geelkerken Andre M van Rij Michael J A Williams Albert P M Boll Jelena P Kostic Adalbjorg Jonasdottir Aslaug Jonasdottir G Bragi Walters Gisli Masson Patrick Sulem Jona Saemundsdottir Magali Mouy Kristinn P Magnusson Gerard Tromp James R Elmore Natzi Sakalihasan Raymond Limet Jean-Olivier Defraigne Robert E Ferrell Antti Ronkainen Ynte M Ruigrok Cisca Wijmenga Diederick E Grobbee Svati H Shah Christopher B Granger Arshed A Quyyumi Viola Vaccarino Riyaz S Patel A Maziar Zafari Allan I Levey Harland Austin Domenico Girelli Pier Franco Pignatti Oliviero Olivieri Nicola Martinelli Giovanni Malerba Elisabetta Trabetti Lewis C Becker Diane M Becker Muredach P Reilly Daniel J Rader Thomas Mueller Benjamin Dieplinger Meinhard Haltmayer Sigitas Urbonavicius Bengt Lindblad Anders Gottsäter Eleonora Gaetani Roberto Pola Philip Wells Marc Rodger Melissa Forgie Nicole Langlois Javier Corral Vicente Vicente Jordi Fontcuberta Francisco España Niels Grarup Torben Jørgensen Daniel R Witte Torben Hansen Oluf Pedersen Katja K Aben Jacqueline de Graaf Suzanne Holewijn Lasse Folkersen Anders Franco-Cereceda Per Eriksson David A Collier Hreinn Stefansson Valgerdur Steinthorsdottir Thorunn Rafnar Einar M Valdimarsson Hulda B Magnadottir Sigurlaug Sveinbjornsdottir Isleifur Olafsson Magnus Karl Magnusson Robert Palmason Vilhelmina Haraldsdottir Karl Andersen Pall T Onundarson Gudmundur Thorgeirsson Lambertus A Kiemeney Janet T Powell David J Carey Helena Kuivaniemi Jes S Lindholt Gregory T Jones Augustine Kong Jan D Blankensteijn Stefan E Matthiasson Unnur Thorsteinsdottir Kari Stefansson

Nat Genet 2010 Aug 11;42(8):692-7. Epub 2010 Jul 11.

Population Genomics, deCODE Genetics, Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157066PMC
August 2010

Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus.

Authors:
Simon N Stacey Patrick Sulem Carlo Zanon Sigurjon A Gudjonsson Gudmar Thorleifsson Agnar Helgason Aslaug Jonasdottir Soren Besenbacher Jelena P Kostic James D Fackenthal Dezheng Huo Clement Adebamowo Temidayo Ogundiran Janet E Olson Zachary S Fredericksen Xianshu Wang Maxime P Look Anieta M Sieuwerts John W M Martens Isabel Pajares Maria D Garcia-Prats Jose M Ramon-Cajal Ana de Juan Angeles Panadero Eugenia Ortega Katja K H Aben Sita H Vermeulen Fatemeh Asadzadeh K C Anton van Engelenburg Sara Margolin Chen-Yang Shen Pei-Ei Wu Asta Försti Per Lenner Roger Henriksson Robert Johansson Kerstin Enquist Göran Hallmans Thorvaldur Jonsson Helgi Sigurdsson Kristin Alexiusdottir Julius Gudmundsson Asgeir Sigurdsson Michael L Frigge Larus Gudmundsson Kristleifur Kristjansson Bjarni V Halldorsson Unnur Styrkarsdottir Jeffrey R Gulcher Kari Hemminki Annika Lindblom Lambertus A Kiemeney Jose I Mayordomo John A Foekens Fergus J Couch Olufunmilayo I Olopade Daniel F Gudbjartsson Unnur Thorsteinsdottir Thorunn Rafnar Oskar T Johannsson Kari Stefansson

PLoS Genet 2010 Jul 22;6(7):e1001029. Epub 2010 Jul 22.

deCODE Genetics, Reykjavik, Iceland.

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http://dx.doi.org/10.1371/journal.pgen.1001029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908678PMC
July 2010

Several common variants modulate heart rate, PR interval and QRS duration.

Authors:
Hilma Holm Daniel F Gudbjartsson David O Arnar Gudmar Thorleifsson Gudmundur Thorgeirsson Hrafnhildur Stefansdottir Sigurjon A Gudjonsson Aslaug Jonasdottir Ellisiv B Mathiesen Inger Njølstad Audhild Nyrnes Tom Wilsgaard Erin M Hald Kristian Hveem Camilla Stoltenberg Maja-Lisa Løchen Augustine Kong Unnur Thorsteinsdottir Kari Stefansson

Nat Genet 2010 Feb 10;42(2):117-22. Epub 2010 Jan 10.

deCODE genetics, Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.511DOI Listing
February 2010

Parental origin of sequence variants associated with complex diseases.

Authors:
Augustine Kong Valgerdur Steinthorsdottir Gisli Masson Gudmar Thorleifsson Patrick Sulem Soren Besenbacher Aslaug Jonasdottir Asgeir Sigurdsson Kari Th Kristinsson Adalbjorg Jonasdottir Michael L Frigge Arnaldur Gylfason Pall I Olason Sigurjon A Gudjonsson Sverrir Sverrisson Simon N Stacey Bardur Sigurgeirsson Kristrun R Benediktsdottir Helgi Sigurdsson Thorvaldur Jonsson Rafn Benediktsson Jon H Olafsson Oskar Th Johannsson Astradur B Hreidarsson Gunnar Sigurdsson Anne C Ferguson-Smith Daniel F Gudbjartsson Unnur Thorsteinsdottir Kari Stefansson

Nature 2009 Dec;462(7275):868-74

deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland.

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http://dx.doi.org/10.1038/nature08625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746295PMC
December 2009

Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche.

Authors:
Patrick Sulem Daniel F Gudbjartsson Thorunn Rafnar Hilma Holm Elinborg J Olafsdottir Gudridur H Olafsdottir Thorvaldur Jonsson Peter Alexandersen Bjarke Feenstra Heather A Boyd Katja K Aben Andre L M Verbeek Nel Roeleveld Aslaug Jonasdottir Unnur Styrkarsdottir Valgerdur Steinthorsdottir Ari Karason Simon N Stacey Julius Gudmundsson Margret Jakobsdottir Gudmar Thorleifsson Gudmundur Hardarson Jeffrey Gulcher Augustine Kong Lambertus A Kiemeney Mads Melbye Claus Christiansen Laufey Tryggvadottir Unnur Thorsteinsdottir Kari Stefansson

Nat Genet 2009 Jun 17;41(6):734-8. Epub 2009 May 17.

deCODE Genetics, Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.383DOI Listing
June 2009

Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits.

Authors:
Simon N Stacey Daniel F Gudbjartsson Patrick Sulem Jon T Bergthorsson Rajiv Kumar Gudmar Thorleifsson Asgeir Sigurdsson Margret Jakobsdottir Bardur Sigurgeirsson Kristrun R Benediktsdottir Kristin Thorisdottir Rafn Ragnarsson Dominique Scherer Peter Rudnai Eugene Gurzau Kvetoslava Koppova Veronica Höiom Rafael Botella-Estrada Virtudes Soriano Pablo Juberías Matilde Grasa Francisco J Carapeto Pilar Tabuenca Yolanda Gilaberte Julius Gudmundsson Steinunn Thorlacius Agnar Helgason Theodora Thorlacius Aslaug Jonasdottir Thorarinn Blondal Sigurjon A Gudjonsson Gudbjörn F Jonsson Jona Saemundsdottir Kristleifur Kristjansson Gyda Bjornsdottir Steinunn G Sveinsdottir Magali Mouy Frank Geller Eduardo Nagore José I Mayordomo Johan Hansson Thorunn Rafnar Augustine Kong Jon H Olafsson Unnur Thorsteinsdottir Kari Stefansson

Nat Genet 2008 Nov 12;40(11):1313-8. Epub 2008 Oct 12.

deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.234DOI Listing
November 2008

Large recurrent microdeletions associated with schizophrenia.

Authors:
Hreinn Stefansson Dan Rujescu Sven Cichon Olli P H Pietiläinen Andres Ingason Stacy Steinberg Ragnheidur Fossdal Engilbert Sigurdsson Thordur Sigmundsson Jacobine E Buizer-Voskamp Thomas Hansen Klaus D Jakobsen Pierandrea Muglia Clyde Francks Paul M Matthews Arnaldur Gylfason Bjarni V Halldorsson Daniel Gudbjartsson Thorgeir E Thorgeirsson Asgeir Sigurdsson Adalbjorg Jonasdottir Aslaug Jonasdottir Asgeir Bjornsson Sigurborg Mattiasdottir Thorarinn Blondal Magnus Haraldsson Brynja B Magnusdottir Ina Giegling Hans-Jürgen Möller Annette Hartmann Kevin V Shianna Dongliang Ge Anna C Need Caroline Crombie Gillian Fraser Nicholas Walker Jouko Lonnqvist Jaana Suvisaari Annamarie Tuulio-Henriksson Tiina Paunio Timi Toulopoulou Elvira Bramon Marta Di Forti Robin Murray Mirella Ruggeri Evangelos Vassos Sarah Tosato Muriel Walshe Tao Li Catalina Vasilescu Thomas W Mühleisen August G Wang Henrik Ullum Srdjan Djurovic Ingrid Melle Jes Olesen Lambertus A Kiemeney Barbara Franke Chiara Sabatti Nelson B Freimer Jeffrey R Gulcher Unnur Thorsteinsdottir Augustine Kong Ole A Andreassen Roel A Ophoff Alexander Georgi Marcella Rietschel Thomas Werge Hannes Petursson David B Goldstein Markus M Nöthen Leena Peltonen David A Collier David St Clair Kari Stefansson

Nature 2008 Sep;455(7210):232-6

CNS Division, deCODE genetics, Sturlugata 8, IS-101 Reykjavík, Iceland.

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http://dx.doi.org/10.1038/nature07229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687075PMC
September 2008

Sequence variants in the RNF212 gene associate with genome-wide recombination rate.

Authors:
Augustine Kong Gudmar Thorleifsson Hreinn Stefansson Gisli Masson Agnar Helgason Daniel F Gudbjartsson Gudrun M Jonsdottir Sigurjon A Gudjonsson Sverrir Sverrisson Theodora Thorlacius Aslaug Jonasdottir Gudmundur A Hardarson Stefan T Palsson Michael L Frigge Jeffrey R Gulcher Unnur Thorsteinsdottir Kari Stefansson

Science 2008 Mar 31;319(5868):1398-401. Epub 2008 Jan 31.

deCODE Genetics Inc, 101 Reykjavik, Iceland.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1152422
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March 2008

Genetics of gene expression and its effect on disease.

Authors:
Valur Emilsson Gudmar Thorleifsson Bin Zhang Amy S Leonardson Florian Zink Jun Zhu Sonia Carlson Agnar Helgason G Bragi Walters Steinunn Gunnarsdottir Magali Mouy Valgerdur Steinthorsdottir Gudrun H Eiriksdottir Gyda Bjornsdottir Inga Reynisdottir Daniel Gudbjartsson Anna Helgadottir Aslaug Jonasdottir Adalbjorg Jonasdottir Unnur Styrkarsdottir Solveig Gretarsdottir Kristinn P Magnusson Hreinn Stefansson Ragnheidur Fossdal Kristleifur Kristjansson Hjortur G Gislason Tryggvi Stefansson Bjorn G Leifsson Unnur Thorsteinsdottir John R Lamb Jeffrey R Gulcher Marc L Reitman Augustine Kong Eric E Schadt Kari Stefansson

Nature 2008 Mar 16;452(7186):423-8. Epub 2008 Mar 16.

deCODE genetics, 101 Reykjavik, Iceland.

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March 2008

Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.

Authors:
Gudmar Thorleifsson Kristinn P Magnusson Patrick Sulem G Bragi Walters Daniel F Gudbjartsson Hreinn Stefansson Thorlakur Jonsson Adalbjorg Jonasdottir Aslaug Jonasdottir Gerdur Stefansdottir Gisli Masson Gudmundur A Hardarson Hjorvar Petursson Arsaell Arnarsson Mehdi Motallebipour Ola Wallerman Claes Wadelius Jeffrey R Gulcher Unnur Thorsteinsdottir Augustine Kong Fridbert Jonasson Kari Stefansson

Science 2007 Sep 9;317(5843):1397-400. Epub 2007 Aug 9.

deCODE genetics Inc, 101 Reykjavik, Iceland.

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September 2007

A common variant on chromosome 9p21 affects the risk of myocardial infarction.

Authors:
Anna Helgadottir Gudmar Thorleifsson Andrei Manolescu Solveig Gretarsdottir Thorarinn Blondal Aslaug Jonasdottir Adalbjorg Jonasdottir Asgeir Sigurdsson Adam Baker Arnar Palsson Gisli Masson Daniel F Gudbjartsson Kristinn P Magnusson Karl Andersen Allan I Levey Valgerdur M Backman Sigurborg Matthiasdottir Thorbjorg Jonsdottir Stefan Palsson Helga Einarsdottir Steinunn Gunnarsdottir Arnaldur Gylfason Viola Vaccarino W Craig Hooper Muredach P Reilly Christopher B Granger Harland Austin Daniel J Rader Svati H Shah Arshed A Quyyumi Jeffrey R Gulcher Gudmundur Thorgeirsson Unnur Thorsteinsdottir Augustine Kong Kari Stefansson

Science 2007 Jun 3;316(5830):1491-3. Epub 2007 May 3.

deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1142842
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June 2007

A genome wide linkage disequilibrium screen in Parkinson's disease.

Authors:
Thomas Foltynie Andrew Hicks Stephen Sawcer Aslaug Jonasdottir Efrosini Setakis Melanie Maranian Taiwai Yeo Simon Lewis Carol Brayne Kari Stefansson Alastair Compston Jeff Gulcher Roger A Barker

J Neurol 2005 May 23;252(5):597-602. Epub 2005 Feb 23.

Dept. of Neurology, University of Cambridge, Cambridge, CB2 2PY, UK.

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http://dx.doi.org/10.1007/s00415-005-0686-2DOI Listing
May 2005

A common inversion under selection in Europeans.

Authors:
Hreinn Stefansson Agnar Helgason Gudmar Thorleifsson Valgerdur Steinthorsdottir Gisli Masson John Barnard Adam Baker Aslaug Jonasdottir Andres Ingason Vala G Gudnadottir Natasa Desnica Andrew Hicks Arnaldur Gylfason Daniel F Gudbjartsson Gudrun M Jonsdottir Jesus Sainz Kari Agnarsson Birgitta Birgisdottir Shyamali Ghosh Adalheidur Olafsdottir Jean-Baptiste Cazier Kristleifur Kristjansson Michael L Frigge Thorgeir E Thorgeirsson Jeffrey R Gulcher Augustine Kong Kari Stefansson

Nat Genet 2005 Feb 16;37(2):129-37. Epub 2005 Jan 16.

deCODE Genetics, Sturlugata 8, 101 Reykjavík, Iceland.

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February 2005

A genome-wide screen for association in Hungarian multiple sclerosis.

Authors:
Cecilia Rajda Krisztina Bencsik Erika Seres Aslaug Jonasdottir Thomas Foltynie Stephen Sawcer Kjartan Benediktsson Ragnheidur Fossdal Efrosini Setakis Alastair Compston László Vécsei

J Neuroimmunol 2003 Oct;143(1-2):84-7

Department of Neurology, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary.

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http://dx.doi.org/10.1016/j.jneuroim.2003.08.017DOI Listing
October 2003

A whole genome association study in Icelandic multiple sclerosis patients with 4804 markers.

Authors:
Aslaug Jonasdottir Theodora Thorlacius Ragnheidur Fossdal Adalbjorg Jonasdottir Kjartan Benediktsson John Benedikz Hjortur H Jonsson Jesus Sainz Helga Einarsdottir Sonja Sigurdardottir Gudlaug Kristjansdottir Stephen Sawcer Alastair Compston Kari Stefansson Jeffrey Gulcher

J Neuroimmunol 2003 Oct;143(1-2):88-92

deCODE Genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.

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October 2003

A whole genome association study in multiple sclerosis patients from north Portugal.

Authors:
Berta Martins Silva Theodora Thorlacius Kjartan Benediktsson Clara Pereira Ragnheidur Fossdal Hjortur H Jonsson Ana Silva Isabel Leite J Cerqueira Paulo P Costa Monica Marta Thomas Foltynie Stephen Sawcer Alastair Compston Aslaug Jonasdottir

J Neuroimmunol 2003 Oct;143(1-2):116-9

Pathology and Molecular Immunology Department, Instituto Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1016/j.jneuroim.2003.08.024DOI Listing
October 2003

A genomic screen of Spanish multiple sclerosis patients reveals multiple loci associated with the disease.

Authors:
Robert Goertsches Pablo Villoslada Manuel Comabella Xavier Montalban Arcadi Navarro Emilio G de la Concha Rafael Arroyo Adolfo Lopez de Munain David Otaegui Ricardo Palacios Jordi Perez-Tur Aslaug Jonasdottir Kjartan Benediktsson Ragnheidur Fossdal Stephen Sawcer Efrosini Setakis Alastair Compston

J Neuroimmunol 2003 Oct;143(1-2):124-8

Neuroimmunology Unit, Hospital Vall d'Hebron, Barcelona, Spain.

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October 2003