Asier Saez-Cirion

Asier Saez-Cirion

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Asier Saez-Cirion

Asier Saez-Cirion

Publications by authors named "Asier Saez-Cirion"

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HIV controllers: to treat or not to treat? Is that the right question?

Lancet HIV 2019 Oct 14. Epub 2019 Oct 14.

INSERM UMR 1184, Immunologie des Maladies Virales et Autoimmunes, Université Paris Sud, Le Kremlin Bicêtre, France; CEA, DSV/iMETI, Division of Immuno-Virology, IDMIT, Fontenay aux Roses, France; Assistance Publique-Hôpitaux de Paris, Service de Médecine Interne et Immunologie Clinique, CHU Bicêtre, Le Kremlin Bicêtre, France. Electronic address:

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http://dx.doi.org/10.1016/S2352-3018(19)30264-4DOI Listing
October 2019

HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry.

Cell Rep 2019 Sep;28(13):3381-3394.e7

Cell Death and Aging Team, Gustave Roussy, 114 rue Edouard Vaillant, F-94805 Villejuif, France; Laboratory of Molecular Radiotherapy, INSERM U1030, Gustave Roussy, 114 rue Edouard Vaillant, F-94805 Villejuif, France; Gustave Roussy, 114 rue Edouard Vaillant, F-94805 Villejuif, France; Université Paris Sud - Paris 11, 114 rue Edouard Vaillant, F-94805 Villejuif, France; Department of Biomedical Sciences, University of the Pacific, Arthur A. Dugoni School of Dentistry, 155 Fifth Street, San Francisco, CA 94103, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.02.095DOI Listing
September 2019

The Yellow Brick Road towards HIV Eradication.

Trends Immunol 2019 Jun 6;40(6):465-467. Epub 2019 May 6.

Institut Pasteur, HIV Inflammation and Persistence Unit, 75015 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.it.2019.04.006DOI Listing
June 2019

Cellular Determinants of HIV Persistence on Antiretroviral Therapy.

Adv Exp Med Biol 2018;1075:213-239

Unité HIV Inflammation and Persistence, Institut Pasteur, Paris Cedex 15, France.

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http://dx.doi.org/10.1007/978-981-13-0484-2_9DOI Listing
February 2019

Immune Responses to Retroviruses.

Annu Rev Immunol 2018 04 12;36:193-220. Epub 2018 Jan 12.

Immunity and Cancer Department, INSERM U932, Institut Curie, PSL Research University, 75005 Paris, France; email:

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http://dx.doi.org/10.1146/annurev-immunol-051116-052155DOI Listing
April 2018

A Subset of Extreme Human Immunodeficiency Virus (HIV) Controllers Is Characterized by a Small HIV Blood Reservoir and a Weak T-Cell Activation Level.

Open Forum Infect Dis 2017 3;4(2):ofx064. Epub 2017 Apr 3.

Assistance Publique-Hôpitaux de Paris (AP-HP), Service de Médecine Interne et Immunologie Clinique, Groupe Hospitalier Universitaire Paris Sud, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

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http://dx.doi.org/10.1093/ofid/ofx064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450900PMC
April 2017

Strong ifitm1 Expression in CD4 T Cells in HIV Controllers Is Correlated With Immune Activation.

J Acquir Immune Defic Syndr 2017 02;74(2):e56-e59

*INSERM U1184, Immunologie des infections virales et autoimmunité, Le Kremlin-Bicêtre, France †Université Paris Sud, Le Kremlin-Bicêtre, France ‡Assistance Publique-Hôpitaux de Paris, Service de Médecine Interne et Immunologie Clinique, Groupe Hospitalier Universitaire Paris Sud, Hôpital Bicêtre, Le Kremlin-Bicêtre, France §Division of Immuno-Virology, CEA, DSV/iMETI, IDMIT, France ‖INSERM U1018, Centre de recherche en Epidémiologie et Santé des Populations, Le Kremlin-Bicêtre, France ¶Assistance Publique-Hôpitaux de Paris, Département d'épidémiologie, Groupe Hospitalier Universitaire Paris Sud, Hôpital Bicêtre, Le Kremlin-Bicêtre, France **Institut Pasteur, Unité HIV inflammation et persistance, Paris, France.

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http://dx.doi.org/10.1097/QAI.0000000000001166DOI Listing
February 2017

Polyfunctional HIV-specific T cells in Post-Treatment Controllers.

AIDS 2016 09;30(15):2299-302

aINSERM U1135 CIMI bSorbonne Universités, UPMC Univ Paris 06, CIMI, Paris cInfectious and Tropical Diseases Department, Regional Hospital Center, Orléans dUnité HIV, Inflammation et Persistance, Institut Pasteur, Paris eFaculté de Médecine, Université Paris Descartes, Sorbonne Paris-Cité fLaboratoire de Virologie, AP-HP, Hôpital Necker Enfants-Malades gDépartement d'Immunologie, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1097/QAD.0000000000001195DOI Listing
September 2016

Immunologic and Virologic Progression in HIV Controllers: The Role of Viral "Blips" and Immune Activation in the ANRS CO21 CODEX Study.

PLoS One 2015 6;10(7):e0131922. Epub 2015 Jul 6.

UMR 1184, Immunologie des Maladies Virales et Autoimmunes (IMVA), Université Paris Sud, Le Kremlin Bicêtre, France; Assistance Publique-Hôpitaux de Paris, Service de Médecine Interne, Hôpitaux Universitaires Paris Sud, Le Kremlin-Bicêtre, France; Faculté de Médecine Paris Sud, Le Kremlin Bicêtre, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131922PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493076PMC
April 2016

Long-term control of simian immunodeficiency virus (SIV) in cynomolgus macaques not associated with efficient SIV-specific CD8+ T-cell responses.

J Virol 2015 Apr 14;89(7):3542-56. Epub 2015 Jan 14.

Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Division of Immuno-Virology, Institute of Emerging Diseases and Innovative Therapies, IDMIT Center, Fontenay-aux-Roses, France Université Paris-Sud, Unité Mixte de Recherche UMR-E01, Orsay, France

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http://jvi.asm.org/content/89/7/3542.full.pdf
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http://jvi.asm.org/lookup/doi/10.1128/JVI.03723-14
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http://dx.doi.org/10.1128/JVI.03723-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403397PMC
April 2015

Posttreatment controllers: what do they tell us?

Curr Opin HIV AIDS 2015 Jan;10(1):29-34

aCHU Necker, Laboratoire de Virologie, Université Paris Descartes, Paris bService des Maladies Infectieuses et Tropicales, CHR d'Orléans-La Source, Orléans cInstitut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France.

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http://dx.doi.org/10.1097/COH.0000000000000123DOI Listing
January 2015

HIV cure research: advances and prospects.

Virology 2014 Apr 11;454-455:340-52. Epub 2014 Mar 11.

Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 25-28 rue du Dr Roux, 75724 Paris Cedex 15, France. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2014.02.021DOI Listing
April 2014

Elevated IP10 levels are associated with immune activation and low CD4⁺ T-cell counts in HIV controller patients.

AIDS 2014 Feb;28(4):467-76

aINSERM U1012, Régulation de la réponse immune, infection VIH1 et autoimmunité, Université Paris Sud bAPHP, Service de Médecine Interne, Hôpitaux Universitaires Paris Sud cINSERM U1018, Centre de recherche en Epidémiologie et Santé des Populations, Université Paris Sud, Le Kremlin Bicêtre dInstitut Pasteur, Unité de régulation des infections rétrovirales, Paris eService de Microbiologie, CHU Carémeau fINSERM U1047, Centre National de Référence des Brucella (L.A.), UFR de Médecine Université Montpellier 1, Nîmes gFaculté de Médecine Paris Sud XI, Le Kremlin Bicêtre hAPHP, Laboratoire de Virologie, CHU Necker, Paris, France.

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http://dx.doi.org/10.1097/QAD.0000000000000174DOI Listing
February 2014

The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate.

AIDS 2014 Feb;28(4):477-86

aINSERM UMR S 945, Infections and Immunity, Université Pierre et Marie Curie-Paris6, Hôpital Pitié-Salpêtrière, Paris, France bInstitute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, Wales, UK cInstitut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France. *Anna Lissina and Solène Fastenackels contributed equally to this writing of this work. †Current address: Centro de Investigacion en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.

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http://dx.doi.org/10.1097/QAD.0000000000000175DOI Listing
February 2014

What is the significance of posttreatment control of HIV infection vis-à-vis functional cure?

AIDS 2014 Feb;28(4):603-5

aVirology Unit, Department of Biomedical Sciences bUnit of Epidemiology and Control of HIV/STD, Department of Public Health cHIV/STD Clinic, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium dVic Arendt, Sylvie Delhalle, Centre de Recherche Public de la Santé, Luxemburg, Luxemburg eUnité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1097/QAD.0000000000000147DOI Listing
February 2014

HIV controllers: a genetically determined or inducible phenotype?

Immunol Rev 2013 Jul;254(1):281-94

Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France.

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http://dx.doi.org/10.1111/imr.12076DOI Listing
July 2013

Will it be possible to live without antiretroviral therapy?

Curr Opin HIV AIDS 2013 May;8(3):196-203

Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France.

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http://dx.doi.org/10.1097/COH.0b013e32835f94d5DOI Listing
May 2013

Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency.

Immunol Lett 2013 Jan 13;149(1-2):119-22. Epub 2012 Oct 13.

INSERM UMR S 945, Infections and Immunity, Université Pierre et Marie Curie-Paris 6, Hôpital Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1016/j.imlet.2012.10.002DOI Listing
January 2013

Natural resistance to HIV infection: lessons learned from HIV‐exposed uninfected individuals.

J Infect Dis 2010 Nov;202 Suppl 3:S345-50

Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France.

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http://dx.doi.org/10.1086/655973DOI Listing
November 2010

Ex vivo T cell-based HIV suppression assay to evaluate HIV-specific CD8+ T-cell responses.

Nat Protoc 2010 Jun 13;5(6):1033-41. Epub 2010 May 13.

Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1038/nprot.2010.73DOI Listing
June 2010

Interfacial pre-transmembrane domains in viral proteins promoting membrane fusion and fission.

Biochim Biophys Acta 2008 Jul-Aug;1778(7-8):1624-39. Epub 2008 Jan 3.

Unidad de Biofísica CSIC-UPV/EHU, Universidad del País Vasco, Aptdo. 644, Bilbao, Spain.

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http://dx.doi.org/10.1016/j.bbamem.2007.12.018DOI Listing
August 2008

HIV controllers: how do they tame the virus?

Trends Immunol 2007 Dec 5;28(12):532-40. Epub 2007 Nov 5.

Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 25 rue du Dr Roux, 75725 Paris Cedex 15, France.

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http://dx.doi.org/10.1016/j.it.2007.09.002DOI Listing
December 2007

Quantitative real-time analysis of HIV-1 gene expression dynamics in single living primary cells.

Biotechnol J 2006 Jun;1(6):682-9

Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1002/biot.200600045DOI Listing
June 2006

Structural and functional roles of HIV-1 gp41 pretransmembrane sequence segmentation.

Biophys J 2003 Dec;85(6):3769-80

Unidad de Biofísica (CSIC-UPV/EHU) and Departamento de Bioquímica, Universidad del País Vasco, 48080 Bilbao, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1303679PMC
http://dx.doi.org/10.1016/S0006-3495(03)74792-4DOI Listing
December 2003

The hydrophobic internal region of bovine prion protein shares structural and functional properties with HIV type 1 fusion peptide.

AIDS Res Hum Retroviruses 2003 Nov;19(11):969-78

Unidad de Biofísica (CSIC-UPV/EHU), and Departamento de Bioquímica, Universidad del País Vasco, 48080 Bilbao, Spain.

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http://dx.doi.org/10.1089/088922203322588323DOI Listing
November 2003

Pre-transmembrane sequence of Ebola glycoprotein. Interfacial hydrophobicity distribution and interaction with membranes.

FEBS Lett 2003 Jan;533(1-3):47-53

Unidad de Biofísica (CSIC-UPV/EHU) and Departamento de Bioquímica, Universidad del País Vasco, Aptdo. 644, 48080, Bilbao, Spain.

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http://dx.doi.org/10.1016/s0014-5793(02)03747-xDOI Listing
January 2003

Conformational transitions of membrane-bound HIV-1 fusion peptide.

Biochim Biophys Acta 2002 Aug;1564(1):57-65

Unidad de Biofísica (CSIC-UPV/EHU) and Departamento de Bioquímica, Universidad del País Vasco, Aptdo. 644, 48080 Bilbao, Spain.

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http://dx.doi.org/10.1016/s0005-2736(02)00400-5DOI Listing
August 2002

Sphingomyelin and cholesterol promote HIV-1 gp41 pretransmembrane sequence surface aggregation and membrane restructuring.

J Biol Chem 2002 Jun 2;277(24):21776-85. Epub 2002 Apr 2.

Unidad de Biofísica (Centro Superior de Investigaciones Cientificas-Universidad del País Vasco) and Departamento de Bioquímica, Universidad del País Vasco, Apartado 644, 48080 Bilbao, Spain.

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http://dx.doi.org/10.1074/jbc.M202255200DOI Listing
June 2002