Publications by authors named "Ashutosh Wechalekar"

100Publications

Wild-type transthyretin cardiac amyloidosis: When is a rare disease no longer a rare disease?

J Nucl Cardiol 2020 Jul 19. Epub 2020 Jul 19.

National Amyloidosis Centre, University College London, London, UK.

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http://dx.doi.org/10.1007/s12350-020-02275-1DOI Listing
July 2020

The diagnostic challenges of cardiac amyloidosis: A practical approach to the two main types.

Blood Rev 2020 Jun 23:100720. Epub 2020 Jun 23.

Department of Medicine, The John C Davis Myeloma and Amyloid Program, Tufts Medical Center, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.blre.2020.100720DOI Listing
June 2020

Confirming the Diagnosis of Amyloidosis.

Acta Haematol 2020 16;143(4):312-321. Epub 2020 Jun 16.

National Amyloidosis Centre, London, United Kingdom,

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http://dx.doi.org/10.1159/000508022DOI Listing
September 2020

The value of screening biopsies in light-chain (AL) and transthyretin (ATTR) amyloidosis.

Eur J Haematol 2020 Sep 23;105(3):352-356. Epub 2020 Jun 23.

National Amyloidosis Centre, Centre for Amyloidosis & Acute Phase Proteins, Division of Medicine, University College London, London, UK.

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http://dx.doi.org/10.1111/ejh.13458DOI Listing
September 2020

Two types of systemic amyloidosis in a single patient.

Amyloid 2020 May 6:1-2. Epub 2020 May 6.

National Amyloidosis Centre, University College London Medical School, Royal Free Hospital Campus, London, United Kingdom.

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http://dx.doi.org/10.1080/13506129.2020.1760238DOI Listing
May 2020

Epidemiologic and Survival Trends in Amyloidosis, 1987-2019.

N Engl J Med 2020 04;382(16):1567-1568

National Amyloidosis Centre, London, United Kingdom

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http://dx.doi.org/10.1056/NEJMc1917321DOI Listing
April 2020

Systemic amyloidosis: moving into the spotlight.

Leukemia 2020 05 9;34(5):1215-1228. Epub 2020 Apr 9.

National Amyloidosis Centre, University College London (Royal Free Campus), London, UK.

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http://dx.doi.org/10.1038/s41375-020-0802-4DOI Listing
May 2020

Noncontrast Magnetic Resonance for the Diagnosis of Cardiac Amyloidosis.

JACC Cardiovasc Imaging 2020 01 12;13(1 Pt 1):69-80. Epub 2019 Jun 12.

National Amyloidosis Centre, University College London, Royal Free Campus, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jcmg.2019.03.026DOI Listing
January 2020

Quantitation of Tc-DPD uptake in patients with transthyretin-related cardiac amyloidosis.

Amyloid 2018 Sep;25(3):203-210

a National Amyloidosis Centre , UCL Medical School (Royal Free Campus) , London , UK.

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http://dx.doi.org/10.1080/13506129.2018.1520087DOI Listing
September 2018

Real world outcomes of pomalidomide for treatment of relapsed light chain amyloidosis.

Br J Haematol 2018 11 10;183(4):557-563. Epub 2018 Aug 10.

National Amyloidosis Centre, University College London, London, UK.

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http://dx.doi.org/10.1111/bjh.15541DOI Listing
November 2018

Myocardial Edema and Prognosis in Amyloidosis.

J Am Coll Cardiol 2018 06;71(25):2919-2931

National Amyloidosis Centre, University College London, Royal Free Hospital, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom; Royal Free Hospital, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.03.536DOI Listing
June 2018

Treatment of IgM-associated immunoglobulin light-chain amyloidosis with rituximab-bendamustine.

Blood 2018 08 20;132(7):761-764. Epub 2018 Jun 20.

National Amyloidosis Centre, University College London (Royal Free Campus), Rowland Hill Street, London, United Kingdom.

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http://dx.doi.org/10.1182/blood-2018-04-846493DOI Listing
August 2018

Successful treatment of systemic AA amyloidosis associated with underlying Hodgkin lymphoma.

Br J Haematol 2018 09 16;182(5):619. Epub 2018 May 16.

National Amyloidosis Centre, University College London (Royal Free Campus), London, UK.

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http://dx.doi.org/10.1111/bjh.15269DOI Listing
September 2018

Extracardiac F-florbetapir imaging in patients with systemic amyloidosis: more than hearts and minds.

Eur J Nucl Med Mol Imaging 2018 07 12;45(7):1129-1138. Epub 2018 Apr 12.

National Amyloidosis Centre, University College London (Royal Free Campus), Rowland Hill Street, NW3 2PF, London, UK.

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http://dx.doi.org/10.1007/s00259-018-3995-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953997PMC
July 2018

[F]Florbetaben PET-CT confirms AL amyloidosis in a patient with Waldenström's Macroglobulinemia.

Haematologica 2018 07 12;103(7):e322-e324. Epub 2018 Apr 12.

University College Hospitals NHS Foundation Trust, London

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http://dx.doi.org/10.3324/haematol.2017.184515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029523PMC
July 2018

Biomarkers in AL amyloidosis: is the summit in sight?

Blood 2018 04;131(14):1502-1503

University College London Medical School.

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http://dx.doi.org/10.1182/blood-2018-02-832113DOI Listing
April 2018

Diagnosis, pathogenesis and outcome in leucocyte chemotactic factor 2 (ALECT2) amyloidosis.

Nephrol Dial Transplant 2018 02;33(2):241-247

National Amyloidosis Centre, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, Royal Free Campus, University College London, London, UK.

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http://dx.doi.org/10.1093/ndt/gfw375DOI Listing
February 2018

Repeat doses of antibody to serum amyloid P component clear amyloid deposits in patients with systemic amyloidosis.

Sci Transl Med 2018 01;10(422)

National Health Service National Amyloidosis Centre, Centre for Amyloidosis and Acute Phase Proteins, University College London and Royal Free Hospital, London NW3 2PF, UK.

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http://dx.doi.org/10.1126/scitranslmed.aan3128DOI Listing
January 2018

Role of Tc-DPD scintigraphy in imaging extra-cardiac light chain (AL) amyloidosis.

Br J Haematol 2018 11 30;183(3):506-509. Epub 2017 Oct 30.

Center for Amyloidosis and Acute Phase Proteins, University College London Medical School, London, UK.

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http://dx.doi.org/10.1111/bjh.14988DOI Listing
November 2018

Immunoparesis defined by heavy+light chain suppression is a novel marker of long-term outcomes in cardiac AL amyloidosis.

Br J Haematol 2017 11 8;179(4):575-585. Epub 2017 Oct 8.

Centre for Amyloidosis and Acute Phase Proteins, University College London (Royal Free Campus), London, UK.

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http://dx.doi.org/10.1111/bjh.14908DOI Listing
November 2017

Challenging Occam's Razor: An Unusual Combination of Sarcoidosis and Amyloidosis. The Value of Cardiac Magnetic Resonance Imaging in Infiltrative Cardiomyopathies.

Can J Cardiol 2017 10 18;33(10):1335.e9-1335.e11. Epub 2017 Jul 18.

Department of Cardiovascular Magnetic Resonance, Royal Brompton and Harefield NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College, London, United Kingdom.

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http://dx.doi.org/10.1016/j.cjca.2017.07.004DOI Listing
October 2017

Real world data of the impact of first cycle daratumumab on multiple myeloma and AL amyloidosis services.

Br J Haematol 2018 09 18;182(6):936-939. Epub 2017 Aug 18.

University College London Hospitals NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1111/bjh.14897DOI Listing
September 2018

Safety and efficacy of empirical interleukin-1 inhibition using anakinra in AA amyloidosis of uncertain aetiology.

Amyloid 2017 Sep 26;24(3):189-193. Epub 2017 Jul 26.

a National Amyloidosis Centre, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London , London , UK.

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http://dx.doi.org/10.1080/13506129.2017.1352503DOI Listing
September 2017

High prevalence of recurrent nocturnal desaturations in systemic AL amyloidosis: a cross-sectional pilot study.

Sleep Med 2017 Apr 21;32:191-197. Epub 2016 Dec 21.

National Amyloidosis Centre, Division of Medicine, Royal Free Hospital Campus, University College of London Medical School, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2016.11.021DOI Listing
April 2017

Monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM): a practical guide to management.

Hematol Oncol 2017 Dec 2;35(4):432-439. Epub 2016 Nov 2.

Department of Haematology, Cancer Institute, University College London, London, UK.

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http://doi.wiley.com/10.1002/hon.2345
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http://dx.doi.org/10.1002/hon.2345DOI Listing
December 2017

Diagnosing Light Chain Amyloidosis on Temporal Artery Biopsies for Suspected Giant Cell Arteritis.

J Neuroophthalmol 2017 03;37(1):34-39

Haematology (RG), Severn Deanery, Bristol, United Kingdom; National Amyloidosis Centre (SM, AW), University College London, London, United Kingdom; Departments of Histopathology (PM), Ophthalmology (SW), and Haematology (SM), Royal United Hospital Bath, Bath, United Kingdom.

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http://dx.doi.org/10.1097/WNO.0000000000000447DOI Listing
March 2017

Comparison of Free Light Chain Assays:  Freelite and N Latex in Diagnosis, Monitoring, and Predicting Survival in Light Chain Amyloidosis.

Am J Clin Pathol 2016 Jul 27;146(1):78-85. Epub 2016 Jun 27.

From the National Amyloidosis Centre, University College London Medical School, Royal Free Hospital Campus, London, United Kingdom

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http://dx.doi.org/10.1093/ajcp/aqw079DOI Listing
July 2016

Autosomal dominant familial Mediterranean fever in Northern European Caucasians associated with deletion of p.M694 residue-a case series and genetic exploration.

Rheumatology (Oxford) 2017 02 5;56(2):209-213. Epub 2016 May 5.

National Amyloidosis Centre, Centre for Amyloidosis and Acute Phase Proteins, University College London Medical School, London, UK.

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http://dx.doi.org/10.1093/rheumatology/kew058DOI Listing
February 2017

Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis.

Circulation 2016 Jun 22;133(24):2404-12. Epub 2016 Apr 22.

From National Amyloidosis Centre, Division of Medicine (J.D.G., A.D.W., C.C.Q., H.J.L., T.R., M.F., K.F., T.L., F.W.V., C.J.W., D.F.H., P.N.H.) and Barts Heart Centre, Institute of Cardiovascular Science (J.C.M.), University College London, UK; Clinical Cardiovascular Research Laboratory for the Elderly, Columbia University Medical Center, New York (M.S.M., S.B., A.C.); Department of Cardiology and Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (R.H.F., S.D.); Amyloidosis Research and Treatment Center, Foundation Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, and Department of Molecular Medicine, University of Pavia, Italy (G.M., G.P., P.M.); Department of Cardiology, University Hospital Henri Mondor, Amyloidosis Mondor Network, Creteil, France (T.D.); Division of Hematology, Division of Cardiovascular Diseases, and Department of Radiology, Division of Nuclear Medicine, Department of Medicine, Mayo Clinic, Rochester, MN (A.D., M.G., G.B.J.); Amyloidosis Center, Boston University School of Medicine and Boston Medical Center, MA (J.L.B., F.L.R.); Departments of Nuclear Medicine and Molecular Imaging (A.W.J.M.G.) and Rheumatology and Clinical Immunology (B.P.H.), University of Groningen, University Medical Center Groningen, The Netherlands; Department of Nuclear Medicine, S. Orsola-Malpighi Hospital, and Cardiology Unit, Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater-University of Bologna, Italy (P.L.G., C.R.); and Yale University School of Medicine, Section of Cardiovascular Medicine, New Haven, CT (E.J.M.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.021612DOI Listing
June 2016

European Collaborative Study Defining Clinical Profile Outcomes and Novel Prognostic Criteria in Monoclonal Immunoglobulin M-Related Light Chain Amyloidosis.

J Clin Oncol 2016 06 25;34(17):2037-45. Epub 2016 Apr 25.

Sajitha Sachchithanantham, Murielle Roussel, Shameem Mahmood, Julian Gillmore, Helen Lachmann, Philip N. Hawkins, and Ashutosh D. Wechalekar, University College London Medical School, London, United Kingdom; Murielle Roussel, Centre Hospitalier Universitaire (CHU) Purpan, Toulouse; Arnaud Jaccard, CHU Limoges, Limoges, France; Giovanni Palladini and Giampaolo Merlini, University of Pavia; Catherine Klersy, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy; Christopher Paul Venner, University of Alberta, Edmonton, Alberta, Canada; and Simon Gibbs, Westmead Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1200/JCO.2015.63.3123DOI Listing
June 2016

(99m)Tc-DPD scintigraphy as a novel imaging modality for identification of skeletal muscle amyloid deposition in light-chain amyloidosis.

Amyloid 2016 Jun 16;23(2):134-5. Epub 2016 Mar 16.

a Division of Medicine (Royal Free Campus) , National Amyloidosis Centre, University College London , London , UK and.

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http://dx.doi.org/10.3109/13506129.2016.1158160DOI Listing
June 2016

Systemic amyloidosis.

Lancet 2016 Jun 21;387(10038):2641-2654. Epub 2015 Dec 21.

National Amyloidosis Centre, University College London (Royal Free Campus), London, UK.

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http://dx.doi.org/10.1016/S0140-6736(15)01274-XDOI Listing
June 2016

Role of imaging in cardiac amyloidosis: An ongoing challenge.

J Nucl Cardiol 2016 12 5;23(6):1364-1367. Epub 2015 Nov 5.

National Amyloidosis Centre, University College London (Royal Free Campus), Rowland Hill Street, London, NW3 2PF, United Kingdom.

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http://dx.doi.org/10.1007/s12350-015-0295-0DOI Listing
December 2016

Prognostic Value of Late Gadolinium Enhancement Cardiovascular Magnetic Resonance in Cardiac Amyloidosis.

Circulation 2015 Oct 11;132(16):1570-9. Epub 2015 Sep 11.

From Heart Hospital, London, UK (M.F., S.P., P.R., A.A.-G., T.A.T., S.M.B., V.M., S.R., H.B., A.S.H., C.H.M., J.C.M.); Institute of Cardiovascular Science (M.F., A.A.-G., T.A.T., S.M.B., H.B., J.C.M.) and Department of Statistical Science (W.B.), University College London, UK; National Amyloidosis Centre, University College London, Royal Free Hospital, London, UK (M.F., S.M.B., R.H.S., K.P., S.M., C.J.W., H.J.L., A.D.W., J.D.G., P.N.H.); Bristol Heart Institute, University of Bristol, UK (C.B.-D.); University of Pittsburgh School of Medicine, PA (E.B.S.); and National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (P.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.016567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606985PMC
October 2015

Time to redefine Myeloma.

Br J Haematol 2015 Oct 27;171(1):1-10. Epub 2015 Jul 27.

Department of Haematology, University Hospitals Bristol Foundation Trust, Bristol, UK.

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http://dx.doi.org/10.1111/bjh.13620DOI Listing
October 2015

Therapeutic blockade of interleukin-6 by tocilizumab in the management of AA amyloidosis and chronic inflammatory disorders: a case series and review of the literature.

Clin Exp Rheumatol 2015 Nov-Dec;33(6 Suppl 94):S46-53. Epub 2015 Jun 29.

National Amyloidosis Centre, University College London Division of Medicine, London, UK.

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January 2016

Differential Myocyte Responses in Patients with Cardiac Transthyretin Amyloidosis and Light-Chain Amyloidosis: A Cardiac MR Imaging Study.

Radiology 2015 Nov 21;277(2):388-97. Epub 2015 May 21.

From the Imaging Centre, the Heart Hospital, 16-18 Westmoreland St, London W1G 8PH, England (M.F., S.M.B., T.A.T., A.A.B., V.M., A.S.H., J.C.M.); Institute of Cardiovascular Science, University College London, London, England (M.F., S.M.B., T.A.T., A.A.G., J.C.M.); and National Amyloidosis Centre, University College London, Royal Free Hospital, London, England (M.F., S.M.B., T.L., J.A.G., D.F.H., H.J.L., C.J.W., A.D.W., J.D.G., P.N.H.).

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http://dx.doi.org/10.1148/radiol.2015141744DOI Listing
November 2015

Unusual imaging findings in a patient with AL amyloidosis.

Br J Haematol 2015 Aug 7;170(3):289. Epub 2015 May 7.

National Amyloidosis Centre, Division of Medicine (Royal Free Campus), University College London, London, UK.

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http://dx.doi.org/10.1111/bjh.13491DOI Listing
August 2015

A comparison of immunohistochemistry and mass spectrometry for determining the amyloid fibril protein from formalin-fixed biopsy tissue.

J Clin Pathol 2015 Apr 30;68(4):314-7. Epub 2015 Jan 30.

National Amyloidosis Centre, Division of Medicine, University College London, London, UK.

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http://dx.doi.org/10.1136/jclinpath-2014-202722DOI Listing
April 2015

T1 mapping and survival in systemic light-chain amyloidosis.

Eur Heart J 2015 Jan 16;36(4):244-51. Epub 2014 Nov 16.

The Heart Hospital, 16-18 Westmoreland Street, London W1G 8PH, UK Institute of Cardiovascular Science, University College London, Gower Street, London WC1E 6BT, UK

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http://dx.doi.org/10.1093/eurheartj/ehu444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301598PMC
January 2015

Two types of amyloid in a single heart.

Blood 2014 Nov;124(19):3025-7

National Amyloidosis Centre, University College London Medical School, Royal Free Hospital Campus, London, United Kingdom.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-06-58
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http://dx.doi.org/10.1182/blood-2014-06-580720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224198PMC
November 2014

Guidelines on the diagnosis and investigation of AL amyloidosis.

Br J Haematol 2015 Jan 14;168(2):207-18. Epub 2014 Oct 14.

National Amyloidosis Centre, Division of Medicine, UCL, London, UK.

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http://dx.doi.org/10.1111/bjh.13156DOI Listing
January 2015

Guidelines on the management of AL amyloidosis.

Br J Haematol 2015 Jan 10;168(2):186-206. Epub 2014 Oct 10.

Division of Medicine, National Amyloidosis Centre, UCL, London, UK.

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http://dx.doi.org/10.1111/bjh.13155DOI Listing
January 2015

Thoracic amyloidomas: Two case reports of an evasive diagnosis.

JRSM Open 2014 Jun 6;5(6):2054270414527280. Epub 2014 May 6.

National Amyloidosis Centre, University College London Medical School, Royal Free Hospital Campus, London NW3 2PF, UK.

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http://dx.doi.org/10.1177/2054270414527280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100224PMC
June 2014

Online registry for mutations in hereditary amyloidosis including nomenclature recommendations.

Hum Mutat 2014 Sep 4;35(9):E2403-12. Epub 2014 Aug 4.

Centre for Amyloidosis and Acute Phase Proteins, University College London Medical School, London, UK.

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http://dx.doi.org/10.1002/humu.22619DOI Listing
September 2014