Ashok R Venkitaraman

Ashok R Venkitaraman

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Ashok R Venkitaraman

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How do mutations affecting the breast cancer genes BRCA1 and BRCA2 cause cancer susceptibility?

DNA Repair (Amst) 2019 Jul 8:102668. Epub 2019 Jul 8.

Medical Research Council Cancer Unit, University of Cambridge, Box 197, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XZ, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2019.102668DOI Listing
July 2019

Enhancing Biochemical Resolution by Hyperdimensional Imaging Microscopy.

Biophys J 2019 May 22;116(10):1815-1822. Epub 2019 Apr 22.

Medical Research Council Cancer Unit, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/j.bpj.2019.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531829PMC
May 2019

Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling.

Cell Chem Biol 2018 06 29;25(6):677-690.e12. Epub 2018 Mar 29.

Center for Chemical Biology & Therapeutics, InSTEM, Bellary Road, Bangalore, Karnataka 560065, India; Medical Research Council Cancer Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015222PMC
June 2018

Single-molecule localization microscopy reveals molecular transactions during RAD51 filament assembly at cellular DNA damage sites.

Nucleic Acids Res 2018 03;46(5):2398-2416

The Medical Research Council Cancer Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK.

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http://dx.doi.org/10.1093/nar/gkx1303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861458PMC
March 2018

BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation.

Cell Rep 2018 01 28;22(4):1031-1039. Epub 2018 Jan 28.

Medical Research Council Cancer Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.12.086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846855PMC
January 2018

Impact of Alternative Splicing on the Human Proteome.

Cell Rep 2017 08;20(5):1229-1241

The Medical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK; RNA Biology and Cancer Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.07.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554779PMC
August 2017

High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy.

Nucleic Acids Res 2016 Nov 5;44(19):9017-9030. Epub 2016 Sep 5.

Medical Research Council Cancer Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK

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http://dx.doi.org/10.1093/nar/gkw783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100573PMC
November 2016

Specific inhibition of CK2α from an anchor outside the active site.

Chem Sci 2016 Nov 12;7(11):6839-6845. Epub 2016 Jul 12.

Department of Biochemistry , University of Cambridge , 80 Tennis Court Road , Cambridge CB2 1GA , UK . Email:

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http://dx.doi.org/10.1039/c6sc02335eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355960PMC
November 2016

Micro(mi) RNA-34a targets protein phosphatase (PP)1γ to regulate DNA damage tolerance.

Cell Cycle 2015 ;14(24):3830-41

a The Medical Research Council Cancer Unit; University of Cambridge ; Cambridge , UK.

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https://www.tandfonline.com/doi/full/10.1080/15384101.2015.1
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http://dx.doi.org/10.1080/15384101.2015.1064202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825746PMC
September 2016

Oncogenic KRAS triggers MAPK-dependent errors in mitosis and MYC-dependent sensitivity to anti-mitotic agents.

Sci Rep 2016 07 14;6:29741. Epub 2016 Jul 14.

The Medical Research Council Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, United Kingdom.

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http://dx.doi.org/10.1038/srep29741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944194PMC
July 2016

RNA Processing and Genome Stability: Cause and Consequence.

Mol Cell 2016 Feb;61(4):496-505

Medical Research Council Cancer Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905668PMC
February 2016

A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis.

Cell Cycle 2014 ;13(16):2554-63

a University of Cambridge ; Medical Research Council Cancer Unit; Hutchison/MRC Research Center ; Cambridge , UK.

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http://dx.doi.org/10.4161/15384101.2014.942204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614378PMC
August 2015

p53 shapes genome-wide and cell type-specific changes in microRNA expression during the human DNA damage response.

Cell Cycle 2014 ;13(16):2572-86

a University of Cambridge; Medical Research Council Cancer Unit; Hutchison/MRC Research Center ; Cambridge , UK.

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http://dx.doi.org/10.4161/15384101.2015.942209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601526PMC
August 2015

Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.

Chem Biol 2015 Jun;22(6):689-703

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK; Medical Research Council Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK; Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, 19 JJ Thomson Avenue, Cambridge CB3 0HE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2015.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518475PMC
June 2015

Synthesis of a novel polycyclic ring scaffold with antimitotic properties a selective domino Heck-Suzuki reaction.

Chem Sci 2015 Jan 9;6(1):390-396. Epub 2014 Sep 9.

Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge , CB2 1EW , UK . Email: ; ; Tel: +44 (0)1223 336498.

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http://dx.doi.org/10.1039/c4sc02547dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586250PMC
January 2015

Linear aliphatic dialkynes as alternative linkers for double-click stapling of p53-derived peptides.

Chembiochem 2014 Dec 29;15(18):2680-3. Epub 2014 Oct 29.

University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (UK).

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http://dx.doi.org/10.1002/cbic.201402374DOI Listing
December 2014

Maximizing the biochemical resolving power of fluorescence microscopy.

PLoS One 2013 28;8(10):e77392. Epub 2013 Oct 28.

Medical Research Council Cancer Unit, University of Cambridge, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077392PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810478PMC
August 2014

Investigating peptide sequence variations for 'double-click' stapled p53 peptides.

Org Biomol Chem 2014 Jun;12(24):4074-7

University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

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http://dx.doi.org/10.1039/c4ob00742eDOI Listing
June 2014

Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing.

Nat Commun 2014 Jun 4;5:4048. Epub 2014 Jun 4.

Medical Research Council Cancer Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK.

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http://dx.doi.org/10.1038/ncomms5048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059941PMC
June 2014

High content screening of diverse compound libraries identifies potent modulators of tubulin dynamics.

ACS Med Chem Lett 2014 May 24;5(5):598-603. Epub 2014 Feb 24.

Department of Chemistry, University of Cambridge , Cambridge CB2 1EW, U.K.

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http://dx.doi.org/10.1021/ml5000564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027768PMC
May 2014

Selective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP.

Nucleic Acids Res 2014 Apr 7;42(8):5059-71. Epub 2014 Feb 7.

MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Biomedical Campus, Cambridge CB2 0XZ, UK, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK, Wellcome Trust, Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK and Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.

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http://dx.doi.org/10.1093/nar/gku095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005691PMC
April 2014

Chromosome instability and carcinogenesis: insights from murine models of human pancreatic cancer associated with BRCA2 inactivation.

Mol Oncol 2014 Mar 6;8(2):161-8. Epub 2013 Nov 6.

University of Cambridge, Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, United Kingdom. Electronic address:

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http://doi.wiley.com/10.1016/j.molonc.2013.10.005
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http://dx.doi.org/10.1016/j.molonc.2013.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989051PMC
March 2014

Cancer suppression by the chromosome custodians, BRCA1 and BRCA2.

Science 2014 Mar;343(6178):1470-5

Medical Research Council Cancer Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK.

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http://dx.doi.org/10.1126/science.1252230DOI Listing
March 2014

Tumour suppressor mechanisms in the control of chromosome stability: insights from BRCA2.

Mol Cells 2014 Feb 19;37(2):95-9. Epub 2014 Feb 19.

University of Cambridge, Medical Research Council Cancer Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, United Kingdom.

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http://dx.doi.org/10.14348/molcells.2014.2346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935635PMC
February 2014

A-type lamins maintain the positional stability of DNA damage repair foci in mammalian nuclei.

PLoS One 2013 2;8(5):e61893. Epub 2013 May 2.

The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061893PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642183PMC
December 2013

Using a fragment-based approach to target protein-protein interactions.

Chembiochem 2013 Feb 23;14(3):332-42. Epub 2013 Jan 23.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

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http://dx.doi.org/10.1002/cbic.201200521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594973PMC
February 2013

Expression of LY6D is induced at the surface of MCF10A cells by X-ray irradiation.

FEBS J 2012 Dec 22;279(24):4479-91. Epub 2012 Nov 22.

Department of Biochemistry, Nagoya University School of Medicine, Japan.

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http://dx.doi.org/10.1111/febs.12034DOI Listing
December 2012

A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds.

Org Biomol Chem 2012 Oct;10(37):7545-51

Department of Chemistry, University of Cambridge, Cambridge, UK CB2 1EW.

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http://dx.doi.org/10.1039/c2ob26272jDOI Listing
October 2012

A DNA-damage selective role for BRCA1 E3 ligase in claspin ubiquitylation, CHK1 activation, and DNA repair.

Curr Biol 2012 Sep 2;22(18):1659-66. Epub 2012 Aug 2.

University of Cambridge, Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 OXZ, UK.

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http://dx.doi.org/10.1016/j.cub.2012.07.034DOI Listing
September 2012

Palladium-catalysed cross-coupling of vinyldisiloxanes with benzylic and allylic halides and sulfonates.

Chemistry 2012 Jul 8;18(28):8774-9. Epub 2012 Jun 8.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

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http://doi.wiley.com/10.1002/chem.201200431
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http://dx.doi.org/10.1002/chem.201200431DOI Listing
July 2012

Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity.

Org Biomol Chem 2012 Apr 23;10(13):2590-3. Epub 2012 Feb 23.

Institute of Pesticide Science, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi 712100, China.

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http://dx.doi.org/10.1039/c2ob25065aDOI Listing
April 2012

The breast cancer susceptibility gene BRCA2 is required for the maintenance of telomere homeostasis.

J Biol Chem 2012 Feb 20;287(7):5091-101. Epub 2011 Dec 20.

Department of Biological Sciences and the Institute of Molecular Biology and Genetics, Seoul National University, 599 Gwanak-Ro, Gwanak-Gu, Seoul 151-742, Korea.

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http://dx.doi.org/10.1074/jbc.M111.278994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281639PMC
February 2012

Pattern formation in centrosome assembly.

Curr Opin Cell Biol 2012 Feb 13;24(1):14-23. Epub 2012 Jan 13.

The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge, CB2 OXZ, United Kingdom.

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http://dx.doi.org/10.1016/j.ceb.2011.12.012DOI Listing
February 2012

Genome instability mechanisms and the structure of cancer genomes.

Curr Opin Genet Dev 2012 Feb 25;22(1):10-3. Epub 2012 Feb 25.

University of Cambridge, Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, United Kingdom.

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http://dx.doi.org/10.1016/j.gde.2012.02.003DOI Listing
February 2012

Beyond cancer genomics: after the end of the beginning.

Curr Opin Genet Dev 2012 Feb 6;22(1):1-2. Epub 2012 Mar 6.

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http://dx.doi.org/10.1016/j.gde.2012.02.010DOI Listing
February 2012

Cancer: Let sleeping DNA lie.

Nature 2011 Sep 7;477(7363):169-70. Epub 2011 Sep 7.

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http://dx.doi.org/10.1038/477169aDOI Listing
September 2011

Continuous polo-like kinase 1 activity regulates diffusion to maintain centrosome self-organization during mitosis.

Proc Natl Acad Sci U S A 2011 May 16;108(22):9310-5. Epub 2011 May 16.

Medical Research Council Cancer Cell Unit, Hutchison/Medical Research Council Research Centre and Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 OXZ, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1101112108
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http://dx.doi.org/10.1073/pnas.1101112108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107272PMC
May 2011

Context dependence of checkpoint kinase 1 as a therapeutic target for pancreatic cancers deficient in the BRCA2 tumor suppressor.

Mol Cancer Ther 2011 Apr 2;10(4):670-8. Epub 2011 Feb 2.

Department of Oncology and the Medical Research Council Cancer Cell Unit, University of Cambridge, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-10-0781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087888PMC
April 2011

From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1.

Angew Chem Int Ed Engl 2011 Apr 29;50(17):4003-6. Epub 2011 Mar 29.

University Chemical Laboratory, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK.

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http://dx.doi.org/10.1002/anie.201008019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555362PMC
April 2011

Does metabolite deficiency mark oncogenic cell cycles?

Cell 2011 Apr;145(3):337-8

University of Cambridge, Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, UK.

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http://dx.doi.org/10.1016/j.cell.2011.04.003DOI Listing
April 2011

Rational methods for the selection of diverse screening compounds.

ACS Chem Biol 2011 Mar 15;6(3):208-17. Epub 2011 Feb 15.

TCM Group, Cavendish Laboratory, University of Cambridge, United Kingdom.

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http://dx.doi.org/10.1021/cb100420rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765079PMC
March 2011

A vertebrate N-end rule degron reveals that Orc6 is required in mitosis for daughter cell abscission.

J Cell Biol 2011 Mar;192(6):969-78

Medical Research Council Research Centre, Cambridge CB2 0XZ, England, UK.

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http://dx.doi.org/10.1083/jcb.201008125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063140PMC
March 2011

Design and application of a confocal microscope for spectrally resolved anisotropy imaging.

Opt Express 2011 Jan;19(3):2546-55

The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK.

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http://dx.doi.org/10.1364/OE.19.002546DOI Listing
January 2011

DNA damage regulates the mobility of Brca2 within the nucleoplasm of living cells.

Proc Natl Acad Sci U S A 2010 Dec 22;107(50):21937-42. Epub 2010 Nov 22.

The Medical Research Council Cancer Cell Unit, Hutchison/Medical Research Council Research Centre, Cambridge CB2 0XZ, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1009577107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003017PMC
December 2010

Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer.

Cancer Cell 2010 Nov 4;18(5):499-509. Epub 2010 Nov 4.

Department of Oncology and the Medical Research Council Cancer Cell Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK.

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http://dx.doi.org/10.1016/j.ccr.2010.10.015DOI Listing
November 2010

Recruitment of phosphorylated NPM1 to sites of DNA damage through RNF8-dependent ubiquitin conjugates.

Cancer Res 2010 Sep 16;70(17):6746-56. Epub 2010 Aug 16.

Department of Translational Oncology, St. Marianna University Graduate School of Medicine, Kawasaki, Japan.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-10-0382DOI Listing
September 2010

HERC2 is an E3 ligase that targets BRCA1 for degradation.

Cancer Res 2010 Aug 14;70(15):6384-92. Epub 2010 Jul 14.

Division of Breast and Endocrine Surgery, Department of Surgery, St. Marianna University School of Medicine, Kawasaki, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1304DOI Listing
August 2010

A mitotic role for the DNA damage-responsive CHK2 kinase.

Nat Cell Biol 2010 May;12(5):424-5

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http://dx.doi.org/10.1038/ncb0510-424DOI Listing
May 2010

Modifying chromatin architecture during the response to DNA breakage.

Crit Rev Biochem Mol Biol 2010 Feb;45(1):2-13

University of Cambridge, Department of Oncology & The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, UK.

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http://dx.doi.org/10.3109/10409230903325446DOI Listing
February 2010

Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase.

Nucleic Acids Res 2010 Jan 29;38(1):82-96. Epub 2009 Oct 29.

The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge, UK.

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http://dx.doi.org/10.1093/nar/gkp873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800230PMC
January 2010

UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit.

Nat Cell Biol 2009 Nov 11;11(11):1363-9. Epub 2009 Oct 11.

University of Cambridge, Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge, CB2 OXZ, UK.

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http://www.nature.com/articles/ncb1983
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http://dx.doi.org/10.1038/ncb1983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875106PMC
November 2009

Mobilization and recruitment of HP1: a bimodal response to DNA breakage.

Cell Cycle 2009 Sep;8(18):2945-50

The Medical Research Council Cancer Cell Unit, Cambridge, UK.

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September 2009

Targeting the molecular defect in BRCA-deficient tumors for cancer therapy.

Cancer Cell 2009 Aug;16(2):89-90

The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge, UK.

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http://dx.doi.org/10.1016/j.ccr.2009.07.011DOI Listing
August 2009

The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry.

Curr Biol 2009 Jul 18;19(13):1075-85. Epub 2009 Jun 18.

Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK.

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http://dx.doi.org/10.1016/j.cub.2009.05.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719694PMC
July 2009

Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment.

Annu Rev Pathol 2009 ;4:461-87

Department of Oncology, University of Cambridge, and the Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Center, Cambridge, UK.

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http://dx.doi.org/10.1146/annurev.pathol.3.121806.151422DOI Listing
May 2009

c-ABL tyrosine kinase stabilizes RAD51 chromatin association.

Biochem Biophys Res Commun 2009 May 11;382(2):286-91. Epub 2009 Mar 11.

Department of Molecular Pathology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2009.03.020DOI Listing
May 2009

Paving the way for H2AX phosphorylation: chromatin changes in the DNA damage response.

Cell Cycle 2009 May 20;8(10):1494-500. Epub 2009 May 20.

The Medical Research Council Cancer Cell Unit, Cambridge, UK.

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http://dx.doi.org/10.4161/cc.8.10.8501DOI Listing
May 2009

Cell-cycle coordination between DNA replication and recombination revealed by a vertebrate N-end rule degron-Rad51.

Nat Struct Mol Biol 2008 Oct 14;15(10):1049-58. Epub 2008 Sep 14.

The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK.

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http://dx.doi.org/10.1038/nsmb.1490DOI Listing
October 2008

HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response.

Nature 2008 May 27;453(7195):682-6. Epub 2008 Apr 27.

The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK.

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http://www.nature.com/doifinder/10.1038/nature06875
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http://dx.doi.org/10.1038/nature06875DOI Listing
May 2008

Chromosomal instability in cancer: causality and interdependence.

Cell Cycle 2007 Oct 18;6(19):2341-3. Epub 2007 Jul 18.

University of Cambridge, Cancer Research UK Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge CB2 0XZ, UK.

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http://dx.doi.org/10.4161/cc.6.19.4753DOI Listing
October 2007

A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange.

Nucleic Acids Res 2006 16;34(14):4000-11. Epub 2006 Aug 16.

Cancer Research UK Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkl505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557805PMC
September 2006

Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations.

J Med Chem 2006 Aug;49(17):5141-53

Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge CB3 0HE, UK.

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http://dx.doi.org/10.1021/jm060190+DOI Listing
August 2006

Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome.

Cell 2005 Jun;121(6):887-98

Cancer Research UK Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674050049
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http://dx.doi.org/10.1016/j.cell.2005.05.015DOI Listing
June 2005

DUBing down a tumour suppressor.

Nat Cell Biol 2005 Apr;7(4):332-3

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http://dx.doi.org/10.1038/ncb0405-332DOI Listing
April 2005

Medicine: aborting the birth of cancer.

Nature 2005 Apr;434(7035):829-30

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http://dx.doi.org/10.1038/434829aDOI Listing
April 2005

DNA recombination, chromosomal stability and carcinogenesis: insights into the role of BRCA2.

DNA Repair (Amst) 2004 Aug-Sep;3(8-9):835-43

CR UK Department of Oncology and the Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK.

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http://dx.doi.org/10.1016/j.dnarep.2004.03.008DOI Listing
February 2005

PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein.

Nat Struct Mol Biol 2004 Nov 3;11(11):1114-21. Epub 2004 Oct 3.

University of Cambridge, Cancer Research UK Department of Oncology and The Medical Research Council Cancer Cell Unit, Hills Road, Cambridge CB2 2XZ, UK.

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http://dx.doi.org/10.1038/nsmb837DOI Listing
November 2004

Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2.

Science 2004 Oct 16;306(5697):876-9. Epub 2004 Sep 16.

University of Cambridge, Cancer Research UK, Department of Oncology and the Medical Research Council (MRC) Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK.

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http://dx.doi.org/10.1126/science.1102574DOI Listing
October 2004

Preface: chromosomal instability and breast cancer pathogenesis.

J Mammary Gland Biol Neoplasia 2004 Jul;9(3):217-20

University of Cambridge, CR UK Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison/ MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK.

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http://link.springer.com/10.1023/B:JOMG.0000048769.24125.64
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http://dx.doi.org/10.1023/B:JOMG.0000048769.24125.64DOI Listing
July 2004

Tracing the network connecting BRCA and Fanconi anaemia proteins.

Nat Rev Cancer 2004 Apr;4(4):266-76

University of Cambridge, CR UK Department of Oncology and the Medical Research Council Cancer Cell Unit, Hills Road, Cambridge CB2 2XZ, UK.

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http://dx.doi.org/10.1038/nrc1321DOI Listing
April 2004

Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression.

Oncogene 2004 Jan;23(4):865-72

CR UK Department of Oncology and the Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK.

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http://dx.doi.org/10.1038/sj.onc.1207223DOI Listing
January 2004

Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein.

Genes Dev 2003 Dec 17;17(24):3017-22. Epub 2003 Dec 17.

University of Cambridge, CR UK Department of Oncology, Hutchison/MRC Research Centre, Cambridge CB2 2XZ, UK.

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http://dx.doi.org/10.1101/gad.279003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC305253PMC
December 2003

Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2.

Mol Cell 2003 Oct;12(4):1029-41

CR UK Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom.

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http://dx.doi.org/10.1016/s1097-2765(03)00394-0DOI Listing
October 2003

Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer.

DNA Repair (Amst) 2003 Sep;2(9):1015-28

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK.

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September 2003

A growing network of cancer-susceptibility genes.

N Engl J Med 2003 May;348(19):1917-9

University of Cambridge, Cancer Research United Kingdom Department of Oncology, Medical Research Council Cancer Cell Unit, Cambridge, United Kingdom.

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http://dx.doi.org/10.1056/NEJMcibr023150DOI Listing
May 2003