Ashok B Kulkarni

Ashok B Kulkarni

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Ashok B Kulkarni

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Unique molecular signature in mucolipidosis type IV microglia.

J Neuroinflammation 2019 Dec 28;16(1):276. Epub 2019 Dec 28.

Division of Translational Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, DHHS, 10CRC, Rm 5-2571, 10 Center Dr, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1186/s12974-019-1672-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935239PMC
December 2019

Overexpression of the Cdk5 inhibitory peptide in motor neurons rescue of amyotrophic lateral sclerosis phenotype in a mouse model.

Hum Mol Genet 2019 10;28(19):3175-3187

Neuronal Cytoskeletal Protein Regulation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/hmg/ddz118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859439PMC
October 2019

Blockade of TIGIT/CD155 Signaling Reverses T-cell Exhaustion and Enhances Antitumor Capability in Head and Neck Squamous Cell Carcinoma.

Cancer Immunol Res 2019 Oct 6;7(10):1700-1713. Epub 2019 Aug 6.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0725DOI Listing
October 2019

Etv1 Controls the Establishment of Non-overlapping Motor Innervation of Neighboring Facial Muscles during Development.

Cell Rep 2019 Oct;29(2):437-452.e4

Center for Motor Neuron Biology and Disease (MNC), Columbia University, New York, NY 10032, USA; Columbia Stem Cell Initiative (CSCI), Columbia University, New York, NY 10032, USA; Columbia Translational Neuroscience Initiative (CTNI), Columbia University, New York, NY 10032, USA; Department of Rehabilitation and Regenerative Medicine, Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University, New York, NY 10032, USA; Department of Neuroscience, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.celrep.2019.08.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032945PMC
October 2019

Genome Editing in Mice Using CRISPR/Cas9 Technology.

Curr Protoc Cell Biol 2018 12 4;81(1):e57. Epub 2018 Sep 4.

National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland.

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https://currentprotocols.onlinelibrary.wiley.com/doi/pdf/10.
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http://doi.wiley.com/10.1002/cpcb.57
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http://dx.doi.org/10.1002/cpcb.57DOI Listing
December 2018

Bi-allelic TMEM94 Truncating Variants Are Associated with Neurodevelopmental Delay, Congenital Heart Defects, and Distinct Facial Dysmorphism.

Am J Hum Genet 2018 12;103(6):948-967

Section of Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA; NIH Undiagnosed Diseases Program, NHGRI and the Common Fund, National Institutes of Health, Bethesda, MD 20892, USA; Office of the Clinical Director, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288279PMC
December 2018

TGF-β receptor 1 regulates progenitors that promote browning of white fat.

Mol Metab 2018 10 27;16:160-171. Epub 2018 Jul 27.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes & Digestive & Kidney Diseases, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778183041
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http://dx.doi.org/10.1016/j.molmet.2018.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158128PMC
October 2018

Specific blockade CD73 alters the "exhausted" phenotype of T cells in head and neck squamous cell carcinoma.

Int J Cancer 2018 09;143(6):1494-1504

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.

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http://doi.wiley.com/10.1002/ijc.31534
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http://dx.doi.org/10.1002/ijc.31534DOI Listing
September 2018

The expression of PD-1 and LAG-3 in periapical lesions.

Am J Transl Res 2018 15;10(8):2677-2684. Epub 2018 Aug 15.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedicine of Ministry of Education [KLOBM]), School and Hospital of Stomatology, Wuhan University Wuhan, Hubei, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129551PMC
August 2018

γ-Secretase inhibitor reduces immunosuppressive cells and enhances tumour immunity in head and neck squamous cell carcinoma.

Int J Cancer 2018 03 2;142(5):999-1009. Epub 2017 Nov 2.

The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.

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http://dx.doi.org/10.1002/ijc.31115DOI Listing
March 2018

Anti-CD47 treatment enhances anti-tumor T-cell immunity and improves immunosuppressive environment in head and neck squamous cell carcinoma.

Oncoimmunology 2018 13;7(4):e1397248. Epub 2018 Mar 13.

The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine, Ministry of Education, Wuhan, Hubei, China.

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http://dx.doi.org/10.1080/2162402X.2017.1397248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889284PMC
March 2018

Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372.

Pain 2017 Nov;158(11):2155-2168

aDepartment of Biomedical Sciences, Faculty of Medicine, Universidad Católica del Norte, Coquimbo, Chile bSection on Cellular Signaling, The Eunice Kennedy Shiver National Institute of Health and Human Development, National Institutes of Health, Bethesda, MD, USA cLaboratory of Molecular and Cellular Mechanisms of Pain, Department of Biology, Faculty of Science, Universidad de Chile, Santiago, Chile dFunctional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA eLaboratory of Cellular and Neuronal Dynamics, Department of Biology, Faculty of Science, Universidad de Chile, Santiago, Chile fCenter for Geroscience, Brain Health and Metabolism (GERO), Santiago, Chile gThe Buck Institute for Research on Aging, Novato, CA, USA.

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http://dx.doi.org/10.1097/j.pain.0000000000001021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640492PMC
November 2017

Selective blockade of B7-H3 enhances antitumour immune activity by reducing immature myeloid cells in head and neck squamous cell carcinoma.

J Cell Mol Med 2017 09 11;21(9):2199-2210. Epub 2017 Apr 11.

The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine, Ministry of Education, Wuhan University, Wuhan, China.

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http://dx.doi.org/10.1111/jcmm.13143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571514PMC
September 2017

Blockade of adenosine A2A receptor enhances CD8 T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma.

Mol Cancer 2017 06 7;16(1):99. Epub 2017 Jun 7.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan, Hubei Province, People's Republic of China, 430079.

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http://dx.doi.org/10.1186/s12943-017-0665-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461710PMC
June 2017

Inhibition of SRC family kinases reduces myeloid-derived suppressor cells in head and neck cancer.

Int J Cancer 2017 Mar 2;140(5):1173-1185. Epub 2016 Dec 2.

The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.

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http://dx.doi.org/10.1002/ijc.30493DOI Listing
March 2017

T-cell immunoglobulin mucin 3 blockade drives an antitumor immune response in head and neck cancer.

Mol Oncol 2017 02 19;11(2):235-247. Epub 2017 Jan 19.

The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, China.

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http://dx.doi.org/10.1002/1878-0261.12029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527458PMC
February 2017

LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma.

Oncoimmunology 2016 7;5(11):e1239005. Epub 2016 Oct 7.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China; Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, China; Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1080/2162402X.2016.1239005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139652PMC
October 2016

Targeted overexpression of tumor necrosis factor-α increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neurons.

Pain 2016 06;157(6):1346-62

aLaboratory of Molecular and Cellular Mechanisms of Pain, Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile bLaboratory of Cellular and Neuronal Dynamics, Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile cDepartment of Biology, Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago, Chile dFunctional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1097/j.pain.0000000000000527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868804PMC
June 2016

Targeting STAT3 signaling reduces immunosuppressive myeloid cells in head and neck squamous cell carcinoma.

Oncoimmunology 2016 May 19;5(5):e1130206. Epub 2016 Jan 19.

The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine, Ministry of Education, Wuhan, China; Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, China; Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1080/2162402X.2015.1130206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910719PMC
May 2016

NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell.

Sci Rep 2016 04 25;6:24704. Epub 2016 Apr 25.

The State Key Laboratory Breeding Base of Basic Science of Stomatology &Key Laboratory of Oral Biomedicine, Ministry of Education, Wuhan, China.

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http://dx.doi.org/10.1038/srep24704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842967PMC
April 2016

TRPV1 function is modulated by Cdk5-mediated phosphorylation: insights into the molecular mechanism of nociception.

Sci Rep 2016 Feb 23;6:22007. Epub 2016 Feb 23.

Molecular Neurosciences, Department of Psychiatry and Psychotherapy, University of Regensburg, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1038/srep22007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763283PMC
February 2016

Epidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-inducible factor-1α and Notch1 in head neck squamous cell carcinoma.

PLoS One 2015 27;10(2):e0119723. Epub 2015 Feb 27.

The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, Wuhan University, Wuhan, China; Department of Oral and Maxillofacial-Head and Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119723PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344331PMC
January 2016

Adhesive and migratory effects of phosphophoryn are modulated by flanking peptides of the integrin binding motif.

PLoS One 2014 14;9(11):e112490. Epub 2014 Nov 14.

Section of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112490PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232355PMC
December 2015

PD-1 blockade attenuates immunosuppressive myeloid cells due to inhibition of CD47/SIRPα axis in HPV negative head and neck squamous cell carcinoma.

Oncotarget 2015 Dec;6(39):42067-80

The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine, Ministry of Education, Wuhan University, Wuhan, China.

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http://dx.doi.org/10.18632/oncotarget.5955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747210PMC
December 2015

Tracking endogenous amelogenin and ameloblastin in vivo.

PLoS One 2014 16;9(6):e99626. Epub 2014 Jun 16.

Laboratory of Molecular Oral Pathophysiology, INSERM UMRS 1138, Team Berdal, Cordeliers Research Center, Pierre and Marie Curie University - Paris 6, Paris Descartes University - Paris 5, Paris, France; Laboratory of Morphogenesis Molecular Genetics, Department of Developmental and Stem Cells Biology, Institut Pasteur, CNRS URA 2578, Paris, France.

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http://eprints.whiterose.ac.uk/80738/13/Tracking%20endogenou
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http://dx.plos.org/10.1371/journal.pone.0099626
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099626PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059656PMC
October 2015

Mouse genetic background influences the dental phenotype.

Cells Tissues Organs 2013 8;198(6):448-56. Epub 2014 Apr 8.

Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pa., USA.

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http://dx.doi.org/10.1159/000360157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079555PMC
August 2015

Regulation of Sox6 by cyclin dependent kinase 5 in brain.

PLoS One 2014 24;9(3):e89310. Epub 2014 Mar 24.

Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089310PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963837PMC
January 2015

TGF-ß regulates enamel mineralization and maturation through KLK4 expression.

PLoS One 2013 20;8(11):e82267. Epub 2013 Nov 20.

Gene Transfer Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082267PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835418PMC
August 2014

Inhibition of mTOR reduces anal carcinogenesis in transgenic mouse model.

PLoS One 2013 4;8(10):e74888. Epub 2013 Oct 4.

The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China ; Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074888PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790781PMC
July 2014

Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma.

Apoptosis 2014 Apr;19(4):748-58

The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, Department of Oral and Maxillofacial-Head and Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.

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http://dx.doi.org/10.1007/s10495-013-0960-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211076PMC
April 2014

Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist improves neuronal loss and early lethality.

J Neuroinflammation 2014 Feb 5;11:28. Epub 2014 Feb 5.

Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1186/1742-2094-11-28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931315PMC
February 2014

Activation of cyclin-dependent kinase 5 mediates orofacial mechanical hyperalgesia.

Mol Pain 2013 Dec 21;9:66. Epub 2013 Dec 21.

Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1186/1744-8069-9-66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882292PMC
December 2013

MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma.

Cancer Lett 2013 May 20;331(2):230-8. Epub 2013 Jan 20.

Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.canlet.2013.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660136PMC
May 2013

Cdk5 regulates Rap1 activity.

Neurochem Int 2013 May 13;62(6):848-53. Epub 2013 Feb 13.

Laboratory of Cellular and Neuronal Dynamics, Department of Biology, Faculty of Sciences, Universidad de Chile, Chile.

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http://dx.doi.org/10.1016/j.neuint.2013.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791512PMC
May 2013

TGF-β1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells.

Mol Pain 2013 May 13;9:24. Epub 2013 May 13.

Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Building 30, Room 130, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1186/1744-8069-9-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680294PMC
May 2013

Targeting of interleukin-13 receptor α2 for treatment of head and neck squamous cell carcinoma induced by conditional deletion of TGF-β and PTEN signaling.

J Transl Med 2013 Feb 19;11:45. Epub 2013 Feb 19.

Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Building 30, Room 130, Bethesda, MD, USA.

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http://dx.doi.org/10.1186/1479-5876-11-45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598213PMC
February 2013

Dentin sialophosphoprotein and dentin matrix protein-1: Two highly phosphorylated proteins in mineralized tissues.

Arch Oral Biol 2012 Sep 24;57(9):1165-75. Epub 2012 Apr 24.

Department of Dental Science for Health Promotion, Division of Cervico-Gnathostomatology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.

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http://dx.doi.org/10.1016/j.archoralbio.2012.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517212PMC
September 2012

Transforming growth factor-β1 regulates Cdk5 activity in primary sensory neurons.

J Biol Chem 2012 May 28;287(20):16917-29. Epub 2012 Mar 28.

Functional Genomics Section, Laboratory of Cell and Developmental Biology, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1074/jbc.M111.329979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351291PMC
May 2012

Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons.

Cell Cycle 2012 Apr 15;11(8):1603-10. Epub 2012 Apr 15.

Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.4161/cc.20009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341229PMC
April 2012

The role of amelogenin during enamel-crystallite growth and organization in vivo.

Eur J Oral Sci 2011 Dec;119 Suppl 1:65-9

Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1111/j.1600-0722.2011.00883.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293103PMC
December 2011

Rescue of the murine amelogenin null phenotype with two amelogenin transgenes.

Eur J Oral Sci 2011 Dec;119 Suppl 1:70-4

Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1111/j.1600-0722.2011.00882.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270886PMC
December 2011

Amelogenins: Multi-Functional Enamel Matrix Proteins and Their Binding Partners.

J Oral Biosci 2011 Aug;53(3):257-266

GCOE Program, International Research Center for Molecular Science in Tooth and Bone Diseases Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8549, Japan ; Maxillofacial Orthognathics, Department of Maxillofacial Reconstruction and Function Division of Maxillofacial/Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732036PMC
August 2011

Hypomyelination phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated Cdk5 conditional knockout mice.

Neurochem Res 2011 Jul 6;36(7):1293-303. Epub 2011 Jan 6.

Department of Life Science and Medical Bio-Science, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo, 162-8480, Japan.

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http://dx.doi.org/10.1007/s11064-010-0391-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431604PMC
July 2011

Resveratrol inhibits Cdk5 activity through regulation of p35 expression.

Mol Pain 2011 Jul 7;7:49. Epub 2011 Jul 7.

Functional Genomic Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA

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http://dx.doi.org/10.1186/1744-8069-7-49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212955PMC
July 2011

Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β.

Nat Immunol 2011 Apr 6;12(4):312-9. Epub 2011 Feb 6.

Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/ni.1997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062738PMC
April 2011

An amelogenin mutation leads to disruption of the odontogenic apparatus and aberrant expression of Notch1.

J Oral Pathol Med 2011 Mar 4;40(3):235-42. Epub 2010 Oct 4.

Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104-6030, USA.

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http://dx.doi.org/10.1111/j.1600-0714.2010.00940.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319078PMC
March 2011

A novel role of periostin in postnatal tooth formation and mineralization.

J Biol Chem 2011 Feb 3;286(6):4302-9. Epub 2010 Dec 3.

Department of Respiratory Medicine, Qilu Hospital, Shandong University, Jinan 250012, China.

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http://dx.doi.org/10.1074/jbc.M110.140202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039381PMC
February 2011

A method for rapid demineralization of teeth and bones.

Open Dent J 2010 Dec 15;4:223-9. Epub 2010 Dec 15.

Gene Targeting Facility, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.2174/1874210601004010223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040998PMC
December 2010

Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis.

J Exp Med 2010 Oct 11;207(11):2507-19. Epub 2010 Oct 11.

Division of Pediatric Hematology/Oncology, Department of Pediatrics, University Hospitals Case Medical Center and The Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1084/jem.20100876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964575PMC
October 2010

Extracellular heat shock protein HSP90beta secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-beta1.

Biochem Biophys Res Commun 2010 Jul 1;398(3):525-31. Epub 2010 Jul 1.

Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X1001252
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http://dx.doi.org/10.1016/j.bbrc.2010.06.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922109PMC
July 2010

Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function.

Lab Invest 2010 Apr 8;90(4):543-55. Epub 2010 Feb 8.

Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1038/labinvest.2010.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847636PMC
April 2010

Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration.

Am J Pathol 2010 Jan 30;176(1):320-9. Epub 2009 Nov 30.

Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.2353/ajpath.2010.081158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797893PMC
January 2010

Molecular Roles of Cdk5 in Pain Signaling.

Drug Discov Today Ther Strateg 2009 Sep;6(3):105-111

Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1016/j.ddstr.2009.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022326PMC
September 2009

Overview: generation of gene knockout mice.

Curr Protoc Cell Biol 2009 Sep;Chapter 19:Unit 19.12 19.12.1-17

Department of Health and Human Services, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/0471143030.cb1912s44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782548PMC
September 2009

Manipulation of mouse embryonic stem cells for knockout mouse production.

Curr Protoc Cell Biol 2009 Sep;Chapter 19:Unit 19.13 19.13.1-24

Department of Health and Human Services, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/0471143030.cb1913s44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759096PMC
September 2009

Generation of gene knockout mice by ES cell microinjection.

Curr Protoc Cell Biol 2009 Sep;Chapter 19:Unit 19.14 19.14.1-36

Department of Health and Human Services, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/0471143030.cb1914s44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759098PMC
September 2009

Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development.

Dev Biol 2009 Aug 6;332(2):325-38. Epub 2009 Jun 6.

Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4370, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00121606090091
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http://dx.doi.org/10.1016/j.ydbio.2009.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716725PMC
August 2009

Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway.

Cancer Res 2009 Jul 7;69(14):5918-26. Epub 2009 Jul 7.

Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4330, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758611PMC
July 2009

Dentin sialoprotein and dentin phosphoprotein have distinct roles in dentin mineralization.

Matrix Biol 2009 May 5;28(4):221-9. Epub 2009 Apr 5.

Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health/DHHS, 30 Convent Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.matbio.2009.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758621PMC
May 2009

Genetic evidence for key roles of decorin and biglycan in dentin mineralization.

Matrix Biol 2009 Apr 12;28(3):129-36. Epub 2009 Feb 12.

Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.matbio.2009.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683192PMC
April 2009

Overview: engineering transgenic constructs and mice.

Curr Protoc Cell Biol 2009 Mar;Chapter 19:Unit 19.10

National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/0471143030.cb1910s42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743315PMC
March 2009

Generation of transgenic mice.

Curr Protoc Cell Biol 2009 Mar;Chapter 19:Unit 19.11

National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/0471143030.cb1911s42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119260PMC
March 2009

The leucine-rich amelogenin peptide alters the amelogenin null enamel phenotype.

Cells Tissues Organs 2009 14;189(1-4):169-74. Epub 2008 Aug 14.

Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pa. 19104-6030, USA.

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http://dx.doi.org/10.1159/000151384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824192PMC
February 2009

DSPP effects on in vivo bone mineralization.

Bone 2008 Dec 16;43(6):983-90. Epub 2008 Aug 16.

Mineralized Tissue Laboratory, Musculoskeletal Integrity Program, Hospital for Special Surgery, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.bone.2008.08.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621360PMC
December 2008

A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells.

Nat Immunol 2008 Jun 27;9(6):632-40. Epub 2008 Apr 27.

Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ni.1607DOI Listing
June 2008

Partial rescue of the amelogenin null dental enamel phenotype.

J Biol Chem 2008 May 3;283(22):15056-62. Epub 2008 Apr 3.

Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, 240 S. 40th Street, Philadelphia, PA 19104-6030, USA.

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http://dx.doi.org/10.1074/jbc.M707992200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397487PMC
May 2008

Conditional deletion of cyclin-dependent kinase 5 in primary sensory neurons leads to atypical skin lesions.

Cell Cycle 2008 Mar;7(6):750-3

National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892-4395, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819189PMC
http://dx.doi.org/10.4161/cc.7.6.5494DOI Listing
March 2008

Naked plasmid DNA-based alpha-galactosidase A gene transfer partially reduces systemic accumulation of globotriaosylceramide in Fabry mice.

Mol Biotechnol 2008 Feb 13;38(2):109-19. Epub 2007 Oct 13.

Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan .

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http://link.springer.com/10.1007/s12033-007-9008-5
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February 2008

Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone.

J Neurosci 2007 Nov;27(47):12829-38

Department of Developmental and Regenerative Biology, Institute of Molecular Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.

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http://dx.doi.org/10.1523/JNEUROSCI.1014-07.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673299PMC
November 2007

Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1.

Neurosignals 2006-2007;15(4):157-73. Epub 2006 Aug 18.

Cytoskeletal Protein Regulation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1159/000095130DOI Listing
August 2007

TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma.

Cell Cycle 2007 Jun 5;6(11):1360-6. Epub 2007 Jun 5.

Functional Genomics Section, Laboratory of Cellular and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.4161/cc.6.11.4268DOI Listing
June 2007

Amelogenin- and enamelysin (Mmp-20)-deficient mice display altered birefringence in the secretory-stage enamel organic extracellular matrix.

Connect Tissue Res 2007 ;48(1):39-45

Department of Morphology, Piracicaba Dental School, State University of Campinas, Piracicaba, SP, Brazil.

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http://dx.doi.org/10.1080/03008200601059175DOI Listing
April 2007

Neuron-specific TGF-beta signaling deficiency results in retinal detachment and cataracts in mice.

Biochem Biophys Res Commun 2007 Jan 16;352(2):418-22. Epub 2006 Nov 16.

Functional Genomics Section, Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.bbrc.2006.11.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2062516PMC
January 2007

Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1.

Proc Natl Acad Sci U S A 2007 Jan 28;104(2):660-5. Epub 2006 Dec 28.

Functional Genomics Section, Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0609916104
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http://dx.doi.org/10.1073/pnas.0609916104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1752192PMC
January 2007

The use of animal models to explore amelogenin variants in amelogenesis imperfecta.

Cells Tissues Organs 2005 ;181(3-4):196-201

Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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https://www.karger.com/Article/FullText/91381
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June 2006

Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development.

Mol Cell Biol 2006 May;26(10):3835-41

Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.26.10.3835-3841.2006
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http://dx.doi.org/10.1128/MCB.26.10.3835-3841.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1488998PMC
May 2006

A developmental comparison of matrix metalloproteinase-20 and amelogenin null mouse enamel.

Eur J Oral Sci 2006 May;114 Suppl 1:18-23; discussion 39-41, 379

Department of Cytokine Biology, Forsyth Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1111/j.1600-0722.2006.00292.xDOI Listing
May 2006

Overexpression of transforming growth factor-beta1 in teeth results in detachment of ameloblasts and enamel defects.

Eur J Oral Sci 2006 May;114 Suppl 1:30-4; discussion 39-41, 379

Functional Genomics Section, Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1111/j.1600-0722.2006.00276.xDOI Listing
May 2006

Comparison of body weight and gene expression in amelogenin null and wild-type mice.

Eur J Oral Sci 2006 May;114 Suppl 1:190-3; discussion 201-2, 381

Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1111/j.1600-0722.2006.00286.xDOI Listing
May 2006

Cdk5: a new player in pain signaling.

Cell Cycle 2006 Mar 15;5(6):585-8. Epub 2006 Mar 15.

Functional Genomics Section, Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA.

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https://www.tandfonline.com/doi/full/10.4161/cc.5.6.2578
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March 2006

Cyclin-dependent kinase 5 activity regulates pain signaling.

Proc Natl Acad Sci U S A 2006 Jan 9;103(3):791-6. Epub 2006 Jan 9.

Functional Genomics Section, Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0510405103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1325969PMC
January 2006

The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium.

Nat Cell Biol 2005 May 17;7(5):474-82. Epub 2005 Apr 17.

Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1038/ncb1249DOI Listing
May 2005