Ashish R Kumar

Developmental Adaptive Immune Defects Associated with STAT5B Deficiency in Three Young Siblings.

Authors:

Corinne L Foley Sareea S Al Remeithi Christopher T Towe Andrew Dauber Philippe F Backeljauw Leah Tyzinski Ashish R Kumar Vivian Hwa

J Clin Immunol 2021 Jan 22;41(1):136-146. Epub 2020 Oct 22.

Cincinnati Center for Growth Disorders, Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

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January 2021

Experience with a Reduced Toxicity Allogeneic Transplant Regimen for Non-CGD Primary Immune Deficiencies Requiring Myeloablation.

Authors:

Sharat Chandra Shanmuganathan Chandrakasan Blachy J Dávila Saldaña Jack J Bleesing Michael B Jordan Ashish R Kumar Michael S Grimley Christa Krupski Stella M Davies Pooja Khandelwal Rebecca A Marsh

J Clin Immunol 2021 Jan 16;41(1):89-98. Epub 2020 Oct 16.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 7015, Cincinnati, OH, 45229, USA.

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January 2021

Publisher Correction: MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia.

Authors:

Svetlana S Itskovich Arun Gurunathan Jason Clark Matthew Burwinkel Mark Wunderlich Mikaela R Berger Aishwarya Kulkarni Kashish Chetal Meenakshi Venkatasubramanian Nathan Salomonis Ashish R Kumar Lynn H Lee

Nat Commun 2020 07 7;11(1):3468. Epub 2020 Jul 7.

Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH, 45229, USA.

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July 2020

MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia.

Authors:

Svetlana S Itskovich Arun Gurunathan Jason Clark Matthew Burwinkel Mark Wunderlich Mikaela R Berger Aishwarya Kulkarni Kashish Chetal Meenakshi Venkatasubramanian Nathan Salomonis Ashish R Kumar Lynn H Lee

Nat Commun 2020 05 12;11(1):2369. Epub 2020 May 12.

Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH, 45229, USA.

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May 2020

High-risk LCH in infants is serially transplantable in a xenograft model but responds durably to targeted therapy.

Authors:

Lynn H Lee Christa Krupski Jason Clark Mark Wunderlich Robert B Lorsbach Michael S Grimley Matthew Burwinkel Adam Nelson Ashish R Kumar

Blood Adv 2020 02;4(4):717-727

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH; and.

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February 2020

Limitations of HLH-2004 criteria in distinguishing malignancy-associated hemophagocytic lymphohistiocytosis.

Authors:

Arun Gurunathan Alexander A Boucher Melissa Mark Kristina M Prus Maureen M O'Brien Erin H Breese Benjamin E Mizukawa Michael J Absalon Adam S Nelson Michael B Jordan Michael S Grimley Robert B Lorsbach Seth J Rotz Reema Mathanda Ashish R Kumar

Pediatr Blood Cancer 2018 12 1;65(12):e27400. Epub 2018 Oct 1.

Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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December 2018

Hematopoietic stem cell transplantation rescues the hematological, immunological, and vascular phenotype in DADA2.

Blood 2017 12 3;130(24):2682-2688. Epub 2017 Oct 3.

Department of Pediatrics, Division of Immunology, University Hospitals of Leuven, Leuven, Belgium.

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December 2017

Low IgE Is Insufficiently Sensitive to Guide Genetic Testing of Gain-of-Function Mutations.

Authors:

Stuart G Tangye Lisa R Forbes Jennifer Leiding Kahn Preece Ashish R Kumar Eleonora Gambineri Joshua D Milner Megan A Cooper Mikko Seppänen

Clin Chem 2017 09 30;63(9):1539-1540. Epub 2017 Jun 30.

Adult Immunodeficiency Unit Infectious Diseases, Inflammation Center and Rare Diseases Center Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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September 2017

Ruxolitinib as Salvage Therapy in Steroid-Refractory Acute Graft-versus-Host Disease in Pediatric Hematopoietic Stem Cell Transplant Patients.

Authors:

Pooja Khandelwal Ashley Teusink-Cross Stella M Davies Adam S Nelson Christopher E Dandoy Javier El-Bietar Rebecca A Marsh Ashish R Kumar Michael S Grimley Sonata Jodele Kasiani C Myers

Biol Blood Marrow Transplant 2017 Jul 23;23(7):1122-1127. Epub 2017 Mar 23.

Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

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July 2017

Incidence and Outcomes of Central Nervous System Hemophagocytic Lymphohistiocytosis Relapse after Reduced-Intensity Conditioning Hematopoietic Stem Cell Transplantation.

Authors:

Dana T Lounder Pooja Khandelwal Sharat Chandra Michael B Jordan Ashish R Kumar Michael S Grimley Stella M Davies Jack J Bleesing Rebecca A Marsh

Biol Blood Marrow Transplant 2017 May 17;23(5):857-860. Epub 2017 Feb 17.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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May 2017

Real-time genomic profiling of histiocytoses identifies early-kinase domain BRAF alterations while improving treatment outcomes.

Authors:

Lynn H Lee Anjelika Gasilina Jayeeta Roychoudhury Jason Clark Francis X McCormack Joseph Pressey Michael S Grimley Robert Lorsbach Siraj Ali Mark Bailey Philip Stephens Jeffrey S Ross Vincent A Miller Nicolas N Nassar Ashish R Kumar

JCI Insight 2017 02 9;2(3):e89473. Epub 2017 Feb 9.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center.

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February 2017

A xenograft model of macrophage activation syndrome amenable to anti-CD33 and anti-IL-6R treatment.

Authors:

Mark Wunderlich Courtney Stockman Mahima Devarajan Navin Ravishankar Christina Sexton Ashish R Kumar Benjamin Mizukawa James C Mulloy

JCI Insight 2016 09 22;1(15):e88181. Epub 2016 Sep 22.

Division of Experimental Hematology and Cancer Biology and.

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September 2016

An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors.

Authors:

Ami V Patel Katherine E Chaney Kwangmin Choi David A Largaespada Ashish R Kumar Nancy Ratner

EBioMedicine 2016 Jul 4;9:110-119. Epub 2016 Jun 4.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229-0713, United States. Electronic address:

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July 2016

Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells.

Authors:

Xiongwei Cai Long Gao Li Teng Jingping Ge Zaw Min Oo Ashish R Kumar D Gary Gilliland Philip J Mason Kai Tan Nancy A Speck

Cell Stem Cell 2015 Aug 9;17(2):165-77. Epub 2015 Jul 9.

Abramson Family Cancer Research Institute, Institute for Regenerative Medicine and Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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August 2015

Experience with Alemtuzumab, Fludarabine, and Melphalan Reduced-Intensity Conditioning Hematopoietic Cell Transplantation in Patients with Nonmalignant Diseases Reveals Good Outcomes and That the Risk of Mixed Chimerism Depends on Underlying Disease, Stem Cell Source, and Alemtuzumab Regimen.

Authors:

Rebecca A Marsh Marepalli B Rao Aharon Gefen Denise Bellman Parinda A Mehta Pooja Khandelwal Sharat Chandra Sonata Jodele Kasiani C Myers Michael Grimley Christopher Dandoy Javier El-Bietar Ashish R Kumar Tom Leemhuis Kejian Zhang Jack J Bleesing Michael B Jordan Alexandra H Filipovich Stella M Davies

Biol Blood Marrow Transplant 2015 Aug 10;21(8):1460-70. Epub 2015 Apr 10.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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August 2015

MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia.

Authors:

Jayeeta Roychoudhury Jason P Clark Gabriel Gracia-Maldonado Zeenath Unnisa Mark Wunderlich Kevin A Link Nupur Dasgupta Bruce Aronow Gang Huang James C Mulloy Ashish R Kumar

Blood 2015 Apr 4;125(16):2544-52. Epub 2015 Mar 4.

Division of Bone Marrow Transplantation and Immune Deficiency.

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April 2015

Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype.

Authors:

Huie Jing Qian Zhang Yu Zhang Brenna J Hill Christopher G Dove Erwin W Gelfand T Prescott Atkinson Gulbu Uzel Helen F Matthews Peter J Mustillo David B Lewis Fotini D Kavadas I Celine Hanson Ashish R Kumar Raif S Geha Daniel C Douek Steven M Holland Alexandra F Freeman Helen C Su

J Allergy Clin Immunol 2014 Jun 3;133(6):1667-75. Epub 2014 May 3.

Laboratory of Host Defenses, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, Md. Electronic address:

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June 2014