Publications by authors named "Ashani T Weeraratna"

95Publications

Genetic screening for single-cell variability modulators driving therapy resistance.

Nat Genet 2021 Jan 4;53(1):76-85. Epub 2021 Jan 4.

Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA.

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January 2021

Completing the Great Unfinished Symphony of Cancer Together: The Importance of Immigrants in Cancer Research.

Cancer Cell 2020 Sep;38(3):301-305

The Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. Electronic address:

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September 2020

The Race toward Equity: Increasing Racial Diversity in Cancer Research and Cancer Care.

Cancer Discov 2020 Oct 18;10(10):1451-1454. Epub 2020 Aug 18.

Department of Biochemistry and Molecular Biology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

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October 2020

Preserve junior faculty in biomedical sciences during and after the pandemic.

Nat Med 2020 07;26(7):1003-1004

Department of Health Policy and Management and Department of Biochemistry and Molecular Biology, the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

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July 2020

How the ageing microenvironment influences tumour progression.

Nat Rev Cancer 2020 02 13;20(2):89-106. Epub 2019 Dec 13.

The Wistar Institute, Immunology, Microenvironment and Metastasis Program, Philadelphia, PA, USA.

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February 2020

Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma.

Mol Cell 2020 02 11;77(3):633-644.e5. Epub 2019 Dec 11.

Immunology, Microenvironment and Metastasis, The Wistar Institute, Philadelphia, PA, 19104, U.S.A.; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health and Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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February 2020

Tumour Dormancy and Reawakening: Opportunities and Challenges.

Trends Cancer 2019 12 25;5(12):762-765. Epub 2019 Nov 25.

Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA; Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Hospital, Baltimore, MD 21231, USA.

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December 2019

Normal Aging and Its Role in Cancer Metastasis.

Cold Spring Harb Perspect Med 2020 Sep 1;10(9). Epub 2020 Sep 1.

The Wistar Institute, Immunology, Microenvironment and Metastasis Program, Philadelphia, Pennsylvania 19104, USA.

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September 2020

Women in cancer research.

Nat Rev Cancer 2019 10 15;19(10):547-552. Epub 2019 Aug 15.

Department of Biochemistry and Molecular Biology, John Hopkins School of Public Health, Baltimore, MD, USA.

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October 2019

ER stress promotes antitumor effects in BRAFi/MEKi resistant human melanoma induced by natural compound 4-nerolidylcathecol (4-NC).

Pharmacol Res 2019 03 11;141:63-72. Epub 2018 Dec 11.

Skin Biology and Melanoma Lab, Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address:

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March 2019

Bad company: Microenvironmentally mediated resistance to targeted therapy in melanoma.

Pigment Cell Melanoma Res 2019 03 18;32(2):237-247. Epub 2018 Oct 18.

Immunology, Microenvironment Metastasis Program, Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania.

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March 2019

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.

Cell 2018 06 31;174(1):72-87.e32. Epub 2018 May 31.

Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; The Wistar Institute, Philadelphia, PA 19104, USA; Ludwig Institute for Cancer Research, New York, NY 10017, USA. Electronic address:

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June 2018

Modeling the two-way feedback between contractility and matrix realignment reveals a nonlinear mode of cancer cell invasion.

Proc Natl Acad Sci U S A 2017 02 14;114(9):E1617-E1626. Epub 2017 Feb 14.

Department of Materials Science and Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104;

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February 2017

UNRelenting Translation UNRestrains Melanoma Migration.

Cancer Cell 2016 11;30(5):655-657

Laboratory of Genetics and Genomics, National Institute on Aging-IRP, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address:

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November 2016

In the Wnt-er of life: Wnt signalling in melanoma and ageing.

Br J Cancer 2016 Nov 20;115(11):1273-1279. Epub 2016 Oct 20.

Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.

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November 2016

Response to Programmed Cell Death-1 Blockade in a Murine Melanoma Syngeneic Model Requires Costimulation, CD4, and CD8 T Cells.

Cancer Immunol Res 2016 10 2;4(10):845-857. Epub 2016 Sep 2.

Division of Hematology/Oncology, Department of Medicine, University of California (UCLA), Los Angeles, California. Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California. Jonsson Comprehensive Cancer Center (JCCC) at UCLA, Los Angeles, California. Division of Surgical Oncology, Department of Surgery, UCLA, Los Angeles, California.

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October 2016

Autophagy- An emerging target for melanoma therapy.

F1000Res 2016 29;5. Epub 2016 Jul 29.

Melanoma Research Center, Wistar Institute, Philadelphia, PA, USA.

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September 2016

The Wnts of change: How Wnts regulate phenotype switching in melanoma.

Biochim Biophys Acta 2015 Dec 4;1856(2):244-51. Epub 2015 Nov 4.

Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA. Electronic address:

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December 2015

Genetically-defined ovarian cancer mouse models.

J Pathol 2016 Jan;238(2):180-4

Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.

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January 2016

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion.

Proc Natl Acad Sci U S A 2015 Jul 29;112(28):8638-43. Epub 2015 Jun 29.

Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, PA 19104; Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104;

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July 2015

UV-Induced Wnt7a in the Human Skin Microenvironment Specifies the Fate of Neural Crest-Like Cells via Suppression of Notch.

J Invest Dermatol 2015 Jun 23;135(6):1521-1532. Epub 2015 Feb 23.

Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA. Electronic address:

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June 2015

Bisphosphonamidate clodronate prodrug exhibits selective cytotoxic activity against melanoma cell lines.

Mol Cancer Ther 2014 Feb 5;13(2):297-306. Epub 2013 Dec 5.

Corresponding Authors: Caren L. Freel Meyers, WBSB 307B, 725 N. Wolfe St., Baltimore, MD 21205.

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February 2014

Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2.

Cancer Discov 2013 Dec 8;3(12):1378-93. Epub 2013 Oct 8.

1Tumor Metastasis and Microenvironment Program and 2Molecular and Cellular Oncogenesis Program, The Wistar Institute; 3Abramson Cancer Center, University of Pennsylvania, Philadelphia; 4Lehigh Valley Health Network, Allentown, Pennsylvania; 5The National Institute on Aging, NIH, Baltimore, Maryland; and 6Dana-Farber/Harvard Cancer Center, Boston, Massachusetts.

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December 2013

Change is in the air: the hypoxic induction of phenotype switching in melanoma.

J Invest Dermatol 2013 Oct;133(10):2316-2317

Tumor Metastasis and Microenvironment Program, The Wistar Institute, Philadelphia, Pennsylvania, USA. Electronic address:

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October 2013

A Wnt-er migration: the confusing role of β-catenin in melanoma metastasis.

Sci Signal 2013 Mar 26;6(268):pe11. Epub 2013 Mar 26.

Tumor Metastasis and Microenvironment Program, The Wistar Institute, Philadelphia, PA 19104, USA.

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March 2013

Automatic detection of melanoma progression by histological analysis of secondary sites.

Cytometry A 2012 May 29;81(5):364-73. Epub 2012 Mar 29.

National Institution on Aging, NIH, Laboratory of Genetics, Baltimore, Maryland, USA.

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May 2012

Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility.

Pigment Cell Melanoma Res 2011 Feb 1;24(1):175-86. Epub 2010 Dec 1.

Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.

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February 2011

Striking the target in Wnt-y conditions: intervening in Wnt signaling during cancer progression.

Biochem Pharmacol 2010 Sep 6;80(5):702-11. Epub 2010 Mar 6.

Laboratory of Immunology and Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

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September 2010

Hear the Wnt Ror: how melanoma cells adjust to changes in Wnt.

Pigment Cell Melanoma Res 2009 Dec 25;22(6):724-39. Epub 2009 Aug 25.

Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore MD, USA.

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December 2009

Heparan sulfate proteoglycan modulation of Wnt5A signal transduction in metastatic melanoma cells.

J Biol Chem 2009 Oct 20;284(42):28704-12. Epub 2009 Aug 20.

Laboratory of Immunology, Research Resources Branch, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA.

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October 2009

NRG1 / ERBB3 signaling in melanocyte development and melanoma: inhibition of differentiation and promotion of proliferation.

Pigment Cell Melanoma Res 2009 Dec 30;22(6):773-84. Epub 2009 Jul 30.

Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

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December 2009

Transcriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression.

Int J Med Sci 2009 9;6(1):51-64. Epub 2009 Feb 9.

Laboratory of Immunology, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.

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April 2009

Filamin A modulates kinase activation and intracellular trafficking of epidermal growth factor receptors in human melanoma cells.

Endocrinology 2009 Jun 12;150(6):2551-60. Epub 2009 Feb 12.

Laboratories of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224-6825, USA.

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June 2009

Wnt5A activates the calpain-mediated cleavage of filamin A.

J Invest Dermatol 2009 Jul 29;129(7):1782-9. Epub 2009 Jan 29.

Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.

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July 2009

Assaying Wnt5A-mediated invasion in melanoma cells.

Methods Mol Biol 2008 ;468:243-53

Laboratory of Immunology, National Institutes of Health, National Institute on Aging, Gerontology Research Center, Baltimore, MD, USA.

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January 2009

Detecting PKC phosphorylation as part of the Wnt/calcium pathway in cutaneous melanoma.

Methods Mol Biol 2008 ;468:157-72

Laboratory of Immunology, National Institutes of Health, National Institute of Aging, Gerontology Research Center, Baltimore, MD, USA.

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January 2009

Ghrelin promotes thymopoiesis during aging.

J Clin Invest 2007 Oct;117(10):2778-90

Clinical Immunology Section, Laboratory of Immunology, Intramural Research Program, National Institute on Aging, NIH, Baltimore, Maryland, USA.

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October 2007

CXCL12-induced partitioning of flotillin-1 with lipid rafts plays a role in CXCR4 function.

Eur J Immunol 2007 Aug;37(8):2104-16

Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

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August 2007

Microarray data analysis: an overview of design, methodology, and analysis.

Methods Mol Biol 2007 ;377:1-16

Laboratory of Immunology, National Institutes of Health, National Institute on Aging, Gerontology Research Center, Baltimore, MD, USA.

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August 2007

P21 gene knock down does not identify genetic effectors seen with gene knock out.

Cancer Biol Ther 2007 Jul;6(7):1025-30

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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July 2007

Transcriptome analysis of age-, gender- and diet-associated changes in murine thymus.

Cell Immunol 2007 Jan 17;245(1):42-61. Epub 2007 May 17.

Laboratory of Immunology, National Institute on Aging-Intramural Research Program, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.

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January 2007

Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility.

J Biol Chem 2006 Jun 9;281(24):16681-90. Epub 2006 Mar 9.

Laboratory of Immunology, NIA Intramural Research Program, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.

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June 2006

Discovering causes and cures for cancer from gene expression analysis.

Ageing Res Rev 2005 Nov 21;4(4):548-63. Epub 2005 Oct 21.

Laboratory of Immunology, National Institutes of Health, National Institute on Aging, Gerontology Research Center, 5600 Nathan Shock Drive, Box 21, Baltimore, MD 21224, USA.

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November 2005

A Wnt-er wonderland--the complexity of Wnt signaling in melanoma.

Cancer Metastasis Rev 2005 Jun;24(2):237-50

Laboratory of Immunology, The National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.

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June 2005

Gene expression profiling: from microarrays to medicine.

J Clin Immunol 2004 May;24(3):213-24

Clinical Immunology Section, Laboratory of Immunology, Gerontology Research Center, National Institute on Aging, Nathan Shock Dr, Baltimore, Maryland, USA.

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May 2004

SAGE identification and fluorescence imaging analysis of genes and transcripts in melanomas and precursor lesions.

Cancer Biol Ther 2004 Jan 24;3(1):104-9. Epub 2004 Jan 24.

Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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January 2004

Serial analysis of gene expression (SAGE): advances, analysis and applications to pigment cell research.

Pigment Cell Res 2003 Jun;16(3):183-9

Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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June 2003

The APC tumor suppressor pathway.

Methods Mol Biol 2003 ;222:21-40

Laboratory of Biological Chemistry, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.

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June 2003

Wnt signaling in human cancer.

Cancer Treat Res 2003 ;115:169-87

Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.

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July 2003

Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma.

Cancer Cell 2002 Apr;1(3):279-88

National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Bethesda, MD 20892, USA.

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April 2002