Publications by authors named "Asghar Bayati"

7 Publications

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Multiple sclerosis national registry system in Iran: Validity and reliability of a minimum data set.

Mult Scler Relat Disord 2019 Aug 9;33:158-161. Epub 2019 Jun 9.

Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: As the prevalence and incidence of Multiple Sclerosis (MS) are increasing remarkably in Iran, gathering standardized information regarding the individual's diagnosis, care, and outcomes through a uniform registry system would enable policy-makers to systematically plan for care quality improvements.

Objective: To design a valid and reliable Persian version of a minimum data set to be utilized and integrated into the national MS registry system of Iran.

Method: The minimum data set consisted of six domains including patient identification, family history of MS, diagnosis, disease course, disability status, and medications. The content validity was assessed based on 27 experts' opinions. Item-Content Validity Index (I-CVI) and Scale-Content Validity Index (S-CVI) were used to assess the questions and their validities. Reliability was evaluated using the intra-class correlation coefficient (ICC) of the test-retest results.

Results: For validity appraisal, 27 experts reviewed the developed minimum data set. All the items had I-CVI values higher than the critical value of 0.78 in terms of relevance, clarity, and simplicity, except for "medication start date" and "medication end date" in relevance (I-CVI = 0.75 and 0.73, respectively) and "MS type" in simplicity (I-CVI = 0.76). The total S-CVI scores for relevance, clarity, and simplicity were higher than 0.9. In reliability assessment, 27 patients (out of 74 interviewed patients) were re-interviewed to assess the test-retest reliability. All ICCs were higher than the critical value of 0.7 (in 14 items out of 16), except for "progression to secondary-progressive MS" with the ICC = 0.68 and "the reason for medication discontinuance" with the ICC = 0.64.

Conclusion: The use of standardized validated minimum data set has the potential to enable the researchers and policy-makers to systematically compare and analyze patient information. The Persian version of the minimum data set found to be valid and reliable in Iran.
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http://dx.doi.org/10.1016/j.msard.2019.06.009DOI Listing
August 2019

Human glutathione s-transferase enzyme gene variations and risk of multiple sclerosis in Iranian population cohort.

Mult Scler Relat Disord 2017 Oct 28;17:41-46. Epub 2017 Jun 28.

Department of Neurology, Shahrekord University of Medical Sciences and Health Services, Iran.

Multiple sclerosis (MS) is an inflammatory disease with unknown etiology. Oxidative stress has been demonstrated to play a role in pathological and inflammatory mechanisms of MS. Cells activate antioxidant processes in response to oxidative stress. Glutathione is one of the antioxidant agents in the brain and serves as a cofactor for glutathione s-transferase (GST) enzymes for detoxifying nerve cells. Among different classes of GST, GSTM1 and GSTT1 are associated with the loss of function due to structural homozygous deletion. The aim of this study is to investigate GSTM1 and GSTT1 null genotypes in an Iranian population. In this study, 270 patients and 250 healthy controls were investigated. Patient's disabilities were assessed by Kurtzke Expanded Disability Status Scale (EDSS) and genotypes were determined by multiplex PCR. Association between genotype and MS, type of MS, gender, and inability level were surveyed. The findings demonstrated a highly significant association between the null genotypes and MS (OR = 6.89 for M1/T1). The combination of two genotypes increased the risk of MS by 6.8 times. The null genotypes were found to be more frequent in women than in men. Moreover, a significant association was observed between the null genotype and EDSS 6-10 (OR = 3.199). No significant association was noticed between MS type and the studied genotypes. According to this study, it can be proposed that people with GSTM1 and GSTT1 deletions are at a higher risk for developing MS, which can be due to a decrease in enzymatic activity and their levels in nerve cells and the brain.
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http://dx.doi.org/10.1016/j.msard.2017.06.016DOI Listing
October 2017

Comparison of Lumbopelvic and Hip Movement Patterns During Passive Hip External Rotation in Two Groups of Low Back Pain Patients with and without Rotational Demand Activities.

Ortop Traumatol Rehabil 2015 Nov-Dec;17(6):611-8

Rheumatologist, Shahrekord University of Medical Sciences, Iran.

Background: Because different groups of people with low back pain (LBP) engage in different tasks, their lumbopelvic-hip complex may move in different ways in those groups. The purpose of this study was to quantify the differences in lumbopelvic movement pattern during the passive hip external rotation (PHER) test in LBP patients with and without rotational demand activities (RDA).

Material And Methods: A total of 30 subjects with LBP, including 15 patients with-RDA and 15 patients without-RDA were enrolled. A passive hip external rotation test was performed. Pelvic and hip rotation over the full range of the test, timing of hip and pelvic motion, and pelvic rotation in the first half of the movement were measured using a 3-D motion analysis system.

Results: Passive pelvic rotation during the test in the group with RDA was significantly greater than in the other group. However, there was no significant difference between the groups in other kinematic variables, including hip external rotation, timing of hip and pelvic motion and pelvic rotation in the first half of the movement (p > 0.05).

Conclusions: 1. A greater lumbopelvic rotation ROM during the PHER existed in LBP patients who regularly participated in RDA. 2. Different groups of patients with LBP who engage in different specific activities may have a specific lumbopelvic movement pattern impairment. Therefore, each group of LBP patients in regard to their specific activities may need a different, specific plan of treatment.
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http://dx.doi.org/10.5604/15093492.1193032DOI Listing
April 2017

Effect of IFN-beta therapy on the frequency and function of CD4(+)CD25(+) regulatory T cells and Foxp3 gene expression in relapsing-remitting multiple sclerosis (RRMS): a preliminary study.

J Neuroimmunol 2010 Jan 22;218(1-2):120-4. Epub 2009 Nov 22.

Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Interferon-beta (IFN-beta) is an immunomodulatory drug of choice to control relapsing-remitting multiple sclerosis (RR-MS), although its function is still unclear. A reduced suppressive function of CD4(+)CD25(+) regulatory T cells (T(reg)) has been shown in RR-MS patients. In this study, to understand the effect of IFN-ss on CD4(+)CD25(+) regulatory T cells, we analyzed the frequency and function of these cells and Foxp3 gene expression before and after treatment. We evaluated the frequency and function of CD4(+)CD25(+)Foxp3(+) regulatory T cells by flow cytometry and co-culture inhibition test respectively and gene expression of Foxp3 by real-time PCR in a longitudinal follow-up study in 18 relapsing-remitting MS patients. Our data revealed that IFN-beta significantly improved frequency and suppressive function of T(reg) cells (P<0.05) without any significant effect on gene expression of Foxp3 after 6 months. The results of the present study indicate that IFN-beta therapy in some of patients with RR-MS may restore function of regulatory T cells and control the unchecked immune cascade activity. Larger longitudinal studies on more MS patients are required to confirm our findings.
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http://dx.doi.org/10.1016/j.jneuroim.2009.10.013DOI Listing
January 2010

Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations.

Cell Mol Neurobiol 2009 May 14;29(3):341-6. Epub 2008 Nov 14.

Department of Neurology, Iranian Center of Neurological Research, Tehran University of Medical Sciences, Keshavarz Blvd., Tehran, Iran.

As multiple sclerosis (MS) has long been known to be associated with Leber, hereditary optic neuropathy (LHON), a disease caused by mitochondrial (mtDNA) mutations, in this study we assessed possible involvement of mtDNA point mutation in MS patients. Fifty-two MS patients whose disease was confirmed with revised McDonald criteria and referred to Iranian Center of Neurological Research of Imam Khomeini hospital during 2006-2007 entered the study. Secondary mtDNA mutations, age, gender, clinical disability according to expanded disability status scale (EDSS), course of the disease, and presenting symptoms were the variables investigated in this study. DNA purification was performed by Diatom DNA Extraction Kit. Analysis of data was done by SPSS V11.5. The prevalent mutations with frequency of 19.2% were J, L, and T haplogroups. Haplotype A was more prevalent in patients with younger age of onset (P-value = 0.012) and high proportion of haplogroup H was associated with optic nerve involvement (P-value = 0.015). No motor symptoms were seen in haplogroup H patients. There is no significant relationship between duration of the disease and EDSS in different mutation of mtDNA.
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http://dx.doi.org/10.1007/s10571-008-9325-7DOI Listing
May 2009

Analysis of HLA DR2&DQ6 (DRB1*1501, DQA1*0102, DQB1*0602) haplotypes in Iranian patients with multiple sclerosis.

Cell Mol Neurobiol 2009 Feb 26;29(1):109-14. Epub 2008 Aug 26.

Department of Neurology, Iranian Center of Neurological Research, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Multiple sclerosis (MS) is prototype of inflammatory demyelinating disease of the central nervous system .The etiology of MS remains unclear, but according to current data the disease develops in genetically susceptible individuals and may require additional environmental triggers. The human leukocyte antigen (HLA) class II alleles (DRB1*1501, DQA1*0102, DQB1*0602) may have the strongest genetic effect in MS. In this study, the role of these alleles were investigated in 183 Iranian patients with multiple sclerosis and compared with 100 healthy individuals. HLA typing for DRB1*1501, DQA1*0102, DQB1*0602 was performed by polymerase chain reaction (PCR) amplification with sequence-specific primers (PCR-SSP) method. The results show that, HLA DR B1*1501 was significantly more frequent among MS patients (46% vs. 20%, PV = 0.0006) but DQA1*0102 haplotype was negatively associated with MS (30% vs. 50%, PV = 0.0049) and no significant association was found with DQB1*0602 and MS patients in comparison with control group (24% and 30%, PV = 0.43). No significant correlation was observed among these alleles with sex, type of disease; initial symptoms, expanded disability status scale (EDSS), as well as age at onset and familial MS. This study therefore indicates that there is no association of above HLA haplotypes with clinical presentation, disease duration, and disability in Iranian patients with MS which is in line with other previous studies in different ethnic groups.
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http://dx.doi.org/10.1007/s10571-008-9302-1DOI Listing
February 2009