Publications by authors named "Arvind Kumar Sharma"

4 Publications

  • Page 1 of 1

Characteristics and Outcomes of Hospitalized Young Adults with Mild Covid -19.

J Assoc Physicians India 2020 Aug;68(8):62-65

Department of Research, RUHS College of Medical Sciences, Rajasthan.

Background: Stormy course has been reported among hospitalized adults with COVID-19 in high- and middle-income countries. To assess clinical outcomes in consecutively hospitalized patients with mild covid-19 in India we performed a study.

Methods: We developed a case registry of successive patients admitted with suspected covid-19 infection to our hospital (n=501). Covid-19 was diagnosed using reverse transcriptase polymerase chain reaction (RT-PCR). Demographic, clinical, investigations details and outcomes were recorded. Descriptive statistics are presented.

Results: Covid-19 was diagnosed in 234 (46.7%) and data compared with 267 (53.3%) negative controls. Mean age of covid-19 patients was 35.1±16.6y, 59.4% were <40y and 64% men. Symptoms were in less than 10% and comorbidities were in 4-8%. History of BCG vaccination was in 49% cases vs 10% controls. Cases compared to controls had significantly greater white cell (6.96+1.89 vs 6.12+1.69x109 cells/L) and lower lymphocyte count (1.98+0.79 vs 2.32+0.91x109 cells/L). No radiological and electrocardiographic abnormality was observed. All these were isolated or quarantined in the hospital and observed. Covid-19 patients received hydroxychloroquine and azithromycin according to prevalent guidelines. One patient needed oxygen support while hospital course was uncomplicated in the rest. All were discharged alive. Conversion to virus negative status was in 10.2±6.4 days and was significantly lower in age >40y (9.1±5.2) compared to 40-59y (11.3±6.1) and ≥60y (16.4±13.3) (p=0.001).

Conclusions: This hospital-based registry shows that mildly symptomatic or asymptomatic young covid-19 patients have excellent prognosis.
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August 2020

Towards a comprehensive safety understanding of granulocyte-colony stimulating factor biosimilars in treating chemotherapy associated febrile neutropenia: Trends from decades of data.

Toxicol Appl Pharmacol 2020 05 25;395:114976. Epub 2020 Mar 25.

Indian Pharmacopoeia Commission, Ministry of Health & Family Welfare, Government of India, Sector-23, Raj Nagar, Ghaziabad 201002, Uttar Pradesh, India.

Filgrastim, a biopharmaceutical listed on WHO model list of essential medicines, was approved in USA in 1991 for patients with non-myeloid malignancies associated with severe neutropenia and fever. Several filgrastim biosimilars have now been approved in USA, Europe and elsewhere since 2008, based on the reference product which has lost patent exclusivity; however their immunogenicity and safety is controversial. We conducted a retrospective, post market study between 1991 and May 2018 using VigiBase®. The study included all adverse events with case reports ≥150. Overall, 11,183 adverse drugs reaction reports were identified during observation period; of which 5764; 51.5% reports concerned to Neupogen®, the originator, and rest consists of Leucostim® (N = 680), Zarzio® (N = 622), Grasin® (N = 545), Nivestim® (N = 359) and Tevagrastim® (N = 152) biosimilars. When compared with the originator, Grasin® was associated with higher reporting of pyrexia (11.5% vs 7.9%, ROR 1.52, IC 1.12), myalgia (37% vs 2.2%, ROR 25.94, IC 2.11) and back pain (11.3% vs 4%, ROR 3.09, IC 2.32). Zarzio® was associated with increased reporting of arthralgia (4.5% vs 2.9%, ROR 1.59, IC 1.25) and neutropenia (11.4% vs 4%, ROR 2.59, IC 3.07). Bone pain was reported more often with Nivestim® (14.4% vs 8.3%, ROR 1.87, IC 5.30). Drug ineffectiveness was reported in cases with Zarzio® (35.9%), Nivestim® (19.4%) and Tevagrastim® (42.2%). Authors observed significant differences among originator and biosimilars in particular to efficacy, adverse events reported and time to onset of occurrences. Large epidemiologic studies are needed to further confirm these finding and provide additional insights.
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http://dx.doi.org/10.1016/j.taap.2020.114976DOI Listing
May 2020

Studies on Antimicrobial and Immunomodulatory Effects of Hot Aqueous Extract of Acacia nilotica L. Leaves against Common Veterinary Pathogens.

Vet Med Int 2014 7;2014:747042. Epub 2014 Apr 7.

Department of Veterinary Pharmacology and Toxicology, College of Veterinary Sciences and Animal Husbandry, Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU), Mathura 281001, India.

Acacia nilotica is a plant species that is almost ubiquitously found in different parts of the world. Various preparations of it have been advocated in folk medicine for the treatment of tuberculosis, leprosy, smallpox, dysentery, cough, ophthalmia, toothache, skin cancer as astringent, antispasmodic, and aphrodisiac since immemorial times. The present study investigates the antibacterial, antifungal, antiviral, and immunomodulatory potential of hot aqueous extract (HAE) of Acacia nilotica leaves. On dry matter basis, the filtered HAE had a good extraction ratio (33.46%) and was found to have carbohydrates, glycosides, phytosterols, phenolic compounds, saponins, and flavonoids as major constituents. HAE produced dose dependent zone of inhibition against Klebsiella pneumoniae, Pseudomonas aeruginosa, E. coli, Bacillus cereus, Staphylococcus aureus, and Streptococcus uberis and fungal pathogens Aspergillus niger and Aspergillus fumigates; however, no antiviral activity was recorded against IBR virus. HAE of A. nilotica revealed both proliferative and inhibitory effects on the rat splenocytes and IL-10 release depending on the dose. Detailed studies involving wide spectrum of bacterial, fungal, and viral species are required to prove or know the exact status of each constituents of the plant extract.
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http://dx.doi.org/10.1155/2014/747042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996978PMC
May 2014

Isolation and antibiotic sensitivity of Streptococcus pneumoniae infections with involvement of multiple organs in lambs.

Pak J Biol Sci 2013 Dec;16(24):2021-5

Department of Veterinary Pharmacology and Toxicology, Uttar Pradesh Pandit Deen Dayal Uphadhayay Pashu Chikitsa Vigyan Vishwavidyalaya Evum Go-Anusandhan Sansthan (DUVASU), Mathura-281001 (U.P.), India.

Respiratory diseases particularly lamb pneumonia is a multifactorial disease involving the interaction between host, etiological agent and environment. The present study was carried out to determine the causative agent of an outbreak of pneumonia in a sheep flock and to establish its pathogenicity and public health importance. The incidence occurred in sheep unit at Madhurikund farm of University (DUVASU), Mathura, Uttar Pradesh, India. At the time of incidence, the population of sheep at the farm was 90. Affected animals were clinically examined and nasal swabs and blood samples were collected from live animals, while morbid materials were collected from dead animals after postmortem examination. The etiological agent was isolated and characterized with conventional microbiological and biochemical methods. Streptococcus pneumoniae was the bacteria isolated from blood, different organs and cerebrospinal fluid. The antibiotic sensitivity revealed resistant to multiple drugs viz., penicillin, tetracycline, erythromycin, chloramphenicol, enrofloxacin and ciprofloxacin. Pathological examination revealed multiple involvements of organs with different degrees of inflammation and haemorrhages of the lower respiratory tract, lungs, liver, heart and kidney. Further, its pathogenicity was established by histopathological examination. In conclusion, presence of multi drug resistant Streptococcus pneumoniae in weaning lambs with the involvement of multiple organs appears to be an emerging zoonotic threat to human particularly in shepherds. This seems to be the first report of isolation of multi drug resistant Streptococcus pneumoniae from outbreak in lambs with multiple organ involvement in India.
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http://dx.doi.org/10.3923/pjbs.2013.2021.2025DOI Listing
December 2013
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