Arvin C Dar

Arvin C Dar

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Arvin C Dar

Arvin C Dar

Publications by authors named "Arvin C Dar"

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Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network.

PLoS Comput Biol 2019 04 26;15(4):e1006878. Epub 2019 Apr 26.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1006878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506148PMC
April 2019

A whole-animal platform to advance a clinical kinase inhibitor into new disease space.

Nat Chem Biol 2018 03 22;14(3):291-298. Epub 2018 Jan 22.

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://dx.doi.org/10.1038/nchembio.2556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931369PMC
March 2018

Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling.

Nature 2016 09 24;537(7618):112-116. Epub 2016 Aug 24.

Department of Oncological Sciences, The Tisch Cancer Institute, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

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http://dx.doi.org/10.1038/nature19327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161575PMC
September 2016

CNS Anticancer Drug Discovery and Development Conference White Paper.

Neuro Oncol 2015 Nov;17 Suppl 6:vi1-26

Kaiser Permanente, Redwood City, California, USA (V.A.L.); University of Texas MD Anderson Cancer Center, Houston, TX, USA (V.A.L.); University of California, San Francisco, CA, USA (V.A.L.); SUNY Stony Brook University, Stony Brook, NY, USA (P.J.T.); Icahn School of Medicine at Mount Sinai, New York, NY, USA (J.M.G., M.R.B., A.C.D.); Columbia University Institute for Cancer Genetics, New York, NY, USA (A.I.); Fred Hutchinson Cancer Research Center, Seattle, WA, USA (P.J.P.); Genentech, Inc., South San Francisco, CA, USA (T.P.H.); University of Minnesota School of Pharmacy, Minneapolis, MN, USA (W.F.E.); Angiochem, Inc., Montreal, Quebec, Canada (J.E.L.); Pfizer Oncology, San Diego, CA, USA (T.W.J.); Massachusetts Institute of Technology, Cambridge, MA, USA (F.M.W.); US Food and Drug Administration, Silver Spring, MD, USA (J.S.); Texas Tech University School of Pharmacy, Amarillo, TX, USA (Q.R.S., R.S.); NewGen Therapeutics, Inc., Menlo Park, CA, USA (W.S.); Mayo Clinic, Rochester, MN, USA (J.N.S.); Dana-Farber Cancer Institute, Boston, MA, USA (P.Y.W.); University of Texas MD Anderson Cancer Center, Houston, TX, USA (D.A.B.); Celgene Avilomics Research, Bedford, MA, USA (R.C.P.).

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http://dx.doi.org/10.1093/neuonc/nov169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581696PMC
November 2015

Hepatitis C virus genetics affects miR-122 requirements and response to miR-122 inhibitors.

Nat Commun 2014 Nov 18;5:5408. Epub 2014 Nov 18.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1124, New York, New York 10029, USA.

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http://dx.doi.org/10.1038/ncomms6408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236719PMC
November 2014

Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology.

ACS Chem Biol 2013 Sep 23;8(9):1931-8. Epub 2013 Jul 23.

Howard Hughes Medical Institute and Department of Cellular & Molecular Pharmacology, University of California, San Francisco , San Francisco, California 94158, United States.

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http://dx.doi.org/10.1021/cb400376pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938192PMC
September 2013

A pickup in pseudokinase activity.

Authors:
Arvin C Dar

Biochem Soc Trans 2013 Aug;41(4):987-94

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY 10129, USA.

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http://dx.doi.org/10.1042/BST20130110DOI Listing
August 2013

Chemical genetic discovery of targets and anti-targets for cancer polypharmacology.

Nature 2012 Jun 6;486(7401):80-4. Epub 2012 Jun 6.

Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158, USA.

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http://www.nature.com/articles/nature11127
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http://dx.doi.org/10.1038/nature11127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703503PMC
June 2012

The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling.

Annu Rev Biochem 2011 ;80:769-95

Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1146/annurev-biochem-090308-173656DOI Listing
October 2011

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.

Nature 2011 Apr 27;472(7343):366-9. Epub 2011 Mar 27.

Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.

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http://www.nature.com/articles/nature09860
Publisher Site
http://dx.doi.org/10.1038/nature09860DOI Listing
April 2011

Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry.

Curr Protoc Chem Biol 2010 Mar;2(1):15-36

Chemistry and Chemical Biology Graduate Program, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1002/9780470559277.ch090201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894912PMC
March 2010

Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein.

Proc Natl Acad Sci U S A 2008 Nov 29;105(44):16894-9. Epub 2008 Oct 29.

Laboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0805524105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579349PMC
November 2008

Small molecule recognition of c-Src via the Imatinib-binding conformation.

Chem Biol 2008 Oct;15(10):1015-22

Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, Genentech Hall, 600 16(th) Street, University of California, San Francisco, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1016/j.chembiol.2008.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702663PMC
October 2008

Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR.

Cell 2005 Sep;122(6):887-900

Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.1016/j.cell.2005.06.044DOI Listing
September 2005

Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition.

Cell 2005 Sep;122(6):901-13

Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1016/j.cell.2005.06.041DOI Listing
September 2005

Formin leaky cap allows elongation in the presence of tight capping proteins.

Curr Biol 2003 Oct;13(20):1820-3

Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.cub.2003.09.057DOI Listing
October 2003

Slipped-strand DNAs formed by long (CAG)*(CTG) repeats: slipped-out repeats and slip-out junctions.

Nucleic Acids Res 2002 Oct;30(20):4534-47

Program of Genetics and Genomic Biology, The Hospital for Sick Children, 555 University Avenue, Elm Wing 11-135, Toronto, Ontario M5G 1X8, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC137136PMC
http://dx.doi.org/10.1093/nar/gkf572DOI Listing
October 2002

X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition.

Mol Cell 2002 Aug;10(2):295-305

Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/s1097-2765(02)00590-7DOI Listing
August 2002