Publications by authors named "Arun D V Silamkoti"

2 Publications

  • Page 1 of 1

Synthesis and optimization of novel and selective muscarinic M(3) receptor antagonists.

Bioorg Med Chem Lett 2007 Sep 30;17(18):5256-60. Epub 2007 Jun 30.

Ranbaxy Research Laboratories, New Drug Discovery Research, Department of Medicinal Chemistry, Gurgaon, Haryana 122 001, India.

A series of constrained piperidine analogues were synthesized as novel muscarinic M(3) receptor antagonists. Evaluation of these compounds in binding assays revealed that they not only have high affinity for the M(3) receptor but also have high selectivity over the M(2) receptor.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2007.06.081DOI Listing
September 2007

Design, synthesis and activity of novel derivatives of oxybutynin and tolterodine.

Bioorg Med Chem Lett 2005 Apr;15(8):2093-6

Ranbaxy Research Laboratories, New Drug Discovery Research, Department of Medicinal Chemistry, Gurgaon 122 001, Haryana, India.

Novel derivatives of Tolterodine (1) and Oxybutynin (2) have been designed using conformationally restricted azabicyclics as replacement for open-chain amines. The synthesis and structure-activity relationships are presented.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2005.02.036DOI Listing
April 2005