Arul M Chinnaiyan

Arul M Chinnaiyan

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Arul M Chinnaiyan

Publications by authors named "Arul M Chinnaiyan"

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Translating Science to Medicine: When Will the Rubber Meet the Road?

Eur Urol 2019 Nov 8;76(5):560-561. Epub 2019 Sep 8.

Department of Urology, University of Michigan, Ann Arbor, MI, USA; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1016/j.eururo.2019.08.023DOI Listing
November 2019

Clinical Outcomes in Cyclin-dependent Kinase 12 Mutant Advanced Prostate Cancer.

Eur Urol 2019 Oct 20. Epub 2019 Oct 20.

Division of Hematology/Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.eururo.2019.09.036DOI Listing
October 2019

TERT- beyond the territory: Usage of PCR-based TERT promoter assay in defining urothelial carcinoma in a case of long-standing prostatic adenocarcinoma.

Pathol Res Pract 2019 Sep 21:152663. Epub 2019 Sep 21.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Michigan Center for Translational Pathology, Ann Arbor, MI, USA; Rogel Cancer Center, Michigan Medicine, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1016/j.prp.2019.152663DOI Listing
September 2019

Pediatric craniopharyngioma in association with familial adenomatous polyposis.

Fam Cancer 2019 07;18(3):327-330

Morgan Adams Neuro-Oncology Program, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA.

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http://link.springer.com/10.1007/s10689-019-00126-8
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http://dx.doi.org/10.1007/s10689-019-00126-8DOI Listing
July 2019

The utility of upper urinary tract urine cytology before and after application of the Paris system.

Diagn Cytopathol 2019 May 19;47(5):421-427. Epub 2018 Dec 19.

Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan.

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http://doi.wiley.com/10.1002/dc.24127
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http://dx.doi.org/10.1002/dc.24127DOI Listing
May 2019

Dynamic Recruitment of Single RNAs to Processing Bodies Depends on RNA Functionality.

Mol Cell 2019 05 2;74(3):521-533.e6. Epub 2019 Apr 2.

Single Molecule Analysis Group, Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765193017
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http://dx.doi.org/10.1016/j.molcel.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499680PMC
May 2019

Clinical utility and concordance of upper urinary tract cytology and biopsy in predicting clinicopathological features of upper urinary tract urothelial carcinoma.

Hum Pathol 2019 04 8;86:76-84. Epub 2018 Dec 8.

Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2018.11.021DOI Listing
April 2019

Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma.

Neoplasia 2019 03 21;21(3):322-330. Epub 2019 Feb 21.

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA; Department of Urology, University of Michigan, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384317PMC
March 2019

The Landscape of Circular RNA in Cancer.

Cell 2019 02;176(4):869-881.e13

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.12.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601354PMC
February 2019

Next-generation sequencing in precision oncology: Patient understanding and expectations.

Cancer Med 2019 01 1;8(1):227-237. Epub 2019 Jan 1.

Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan.

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http://dx.doi.org/10.1002/cam4.1947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346219PMC
January 2019

Genetic diversity of NDUFV1-dependent mitochondrial complex I deficiency.

Eur J Hum Genet 2018 11 5;26(11):1582-1587. Epub 2018 Jul 5.

Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1038/s41431-018-0209-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189076PMC
November 2018

MiPanda: A Resource for Analyzing and Visualizing Next-Generation Sequencing Transcriptomics Data.

Neoplasia 2018 11 27;20(11):1144-1149. Epub 2018 Sep 27.

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA; Department of Pathology, University of Michigan, Ann Arbor, MI, USA; Department of Computational Medicine and Bioinformatics, Ann Arbor, MI, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Urology, University of Michigan, Ann Arbor, MI, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14765586183030
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http://dx.doi.org/10.1016/j.neo.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171536PMC
November 2018

Somatic Bi-allelic Loss of TSC Genes in Eosinophilic Solid and Cystic Renal Cell Carcinoma.

Eur Urol 2018 10 23;74(4):483-486. Epub 2018 Jun 23.

Department of Pathology, University of Michigan, Ann Arbor, MI, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA; Howard Hughes Medical Institute, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2018.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390848PMC
October 2018

Frequent PD-L1 Protein Expression and Molecular Correlates in Urinary Bladder Squamous Cell Carcinoma.

Eur Urol 2018 10 3;74(4):529-531. Epub 2018 Jul 3.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Rogel Cancer Center, Michigan Medicine, Ann Arbor, MI, USA; Michigan Center for Translational Pathology, Ann Arbor, MI, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838183044
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http://dx.doi.org/10.1016/j.eururo.2018.06.019DOI Listing
October 2018

Competing for enhancers: PVT1 fine-tunes MYC expression.

Cell Res 2018 08;28(8):785-786

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1038/s41422-018-0064-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082902PMC
August 2018

miR-34a directly targets tRNA precursors and affects cellular proliferation, cell cycle, and apoptosis.

Proc Natl Acad Sci U S A 2018 07 25;115(28):7392-7397. Epub 2018 Jun 25.

Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4;

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http://dx.doi.org/10.1073/pnas.1703029115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048500PMC
July 2018

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.

Cell 2018 07 19;174(3):758-769.e9. Epub 2018 Jul 19.

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA; Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA; Department of Radiation Oncology, UCSF, San Francisco, CA, USA; Department of Urology, UCSF, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.06.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425931PMC
July 2018

Comprehensive Evaluation of Programmed Death-Ligand 1 Expression in Primary and Metastatic Prostate Cancer.

Am J Pathol 2018 06 22;188(6):1478-1485. Epub 2018 Mar 22.

Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Maryland; Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Maryland; Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440173117
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http://dx.doi.org/10.1016/j.ajpath.2018.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971230PMC
June 2018

Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer.

Cell 2018 06;173(7):1770-1782.e14

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.04.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084431PMC
June 2018

Targeting Androgen Receptor and DNA Repair in Metastatic Castration-Resistant Prostate Cancer: Results From NCI 9012.

J Clin Oncol 2018 04 20;36(10):991-999. Epub 2017 Dec 20.

Maha Hussain, Robert H. Lurie Comprehensive Cancer Center, Northwestern University; Walter M. Stadler, University of Chicago, Chicago; Daniel H. Shevrin, NorthShore University Health System, Evanston, IL; Maha Hussain, Stephanie Daignault-Newton, Lakshmi P. Kunju, Javed Siddiqui, Yi-Mi Wu, Dan Robinson, Robert J. Lonigro, Xuhong Cao, Scott A. Tomlins, Rohit Mehra, David C. Smith, Megan V. Caram, and Arul M. Chinnaiyan, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; Przemyslaw W. Twardowski, City of Hope Cancer Center, Duarte; Felix Y. Feng, University of California San Francisco, San Francisco, CA; Costantine Albany, Simon Cancer Center, Indiana University, Indianapolis, IN; Mark N. Stein, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ; Kathleen A. Cooney, University of Utah, Salt Lake City, UT; Bruce Montgomery, University of Washington, Seattle, WA; Emmanuel S. Antonarakis, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Paul G. Corn, University of Texas MD Anderson Cancer Center, Houston, TX; Young E. Whang, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC; and Karen E. Knudsen, Thomas Jefferson University, Philadelphia, PA.

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http://dx.doi.org/10.1200/JCO.2017.75.7310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075827PMC
April 2018

Physician Experiences and Understanding of Genomic Sequencing in Oncology.

J Genet Couns 2018 02 24;27(1):187-196. Epub 2017 Aug 24.

Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109-5419, USA.

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http://dx.doi.org/10.1007/s10897-017-0134-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810555PMC
February 2018

Cancer transcriptome profiling at the juncture of clinical translation.

Nat Rev Genet 2018 02 27;19(2):93-109. Epub 2017 Dec 27.

Michigan Center for Translational Pathology, University of Michigan.

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http://www.nature.com/doifinder/10.1038/nrg.2017.96
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http://dx.doi.org/10.1038/nrg.2017.96DOI Listing
February 2018

The utility of SDHB and FH immunohistochemistry in patients evaluated for hereditary paraganglioma-pheochromocytoma syndromes.

Hum Pathol 2018 01 24;71:47-54. Epub 2017 Oct 24.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109; Comprehensive Cancer Center, Michigan Medicine, Ann Arbor, MI; Michigan Center for Translational Pathology, Ann Arbor, MI 48109. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00468177173038
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http://dx.doi.org/10.1016/j.humpath.2017.10.013DOI Listing
January 2018

Precision oncology in the age of integrative genomics.

Nat Biotechnol 2018 01;36(1):46-60

Michigan Center for Translational Pathology, Ann Arbor, Michigan, USA.

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http://www.nature.com/articles/nbt.4017
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http://dx.doi.org/10.1038/nbt.4017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364676PMC
January 2018

Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA.

Cell 2017 Dec;171(7):1559-1572.e20

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA; Department of Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, USA; Department of Pathology, University of Michigan, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA; Department of Urology, University of Michigan, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.11.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734106PMC
December 2017

Programmed Death-ligand 1 Expression in Upper Tract Urothelial Carcinoma.

Eur Urol Focus 2017 10 13;3(4-5):502-509. Epub 2016 Dec 13.

Department of Pathology, University of Michigan Health System, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, MI, USA; Michigan Center for Translational Pathology, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.euf.2016.11.011DOI Listing
October 2017

Utility of ERG Immunohistochemistry for Evaluation of Lymphovascular Invasion in Testicular Germ Cell Tumors: A Retrospective Pilot Study.

Appl Immunohistochem Mol Morphol 2017 Sep 29. Epub 2017 Sep 29.

Departments of *Pathology †Urology §Radiation Oncology, University of Michigan Medical School ‡Comprehensive Cancer Center, University of Michigan Medical School ∥Michigan Center for Translational Pathology ¶Howard Hughes Medical Institute, Ann Arbor, MI.

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http://dx.doi.org/10.1097/PAI.0000000000000597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876063PMC
September 2017

Clinical characteristics and whole exome/transcriptome sequencing of coexisting chronic myeloid leukemia and myelofibrosis.

Am J Hematol 2017 Jun 2;92(6):555-561. Epub 2017 May 2.

Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, 48109, USA.

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http://dx.doi.org/10.1002/ajh.24728DOI Listing
June 2017

Development of Peptidomimetic Inhibitors of the ERG Gene Fusion Product in Prostate Cancer.

Cancer Cell 2017 04 23;31(4):532-548.e7. Epub 2017 Mar 23.

Michigan Center for Translational Pathology, University of Michigan, 1400 East Medical Center Drive, 5316 CCGC, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, 1400 East Medical Center Drive, 5316 CCGC, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, 1400 East Medical Center Drive, 5316 CCGC, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan, 1400 East Medical Center Drive, 5316 CCGC, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan, 1400 East Medical Center Drive, 5316 CCGC, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443258PMC
April 2017

Precision medicine in pediatric oncology: Lessons learned and next steps.

Pediatr Blood Cancer 2017 03 17;64(3). Epub 2016 Oct 17.

Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan.

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http://dx.doi.org/10.1002/pbc.26288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683396PMC
March 2017

The Emergence of Precision Urologic Oncology: A Collaborative Review on Biomarker-driven Therapeutics.

Eur Urol 2017 02 25;71(2):237-246. Epub 2016 Aug 25.

Department of Urology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center of Weill Cornell Medical College, New York, NY, USA; Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, NY, USA.

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http://dx.doi.org/10.1016/j.eururo.2016.08.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5195855PMC
February 2017

TACO produces robust multisample transcriptome assemblies from RNA-seq.

Nat Methods 2017 01 21;14(1):68-70. Epub 2016 Nov 21.

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1038/nmeth.4078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199618PMC
January 2017

Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer.

Cell Rep 2016 12;17(10):2620-2631

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147555PMC
December 2016

Prostatic Adenocarcinoma With Hormone Exposure Related Changes in a Patient With Hepatic Cirrhosis - Value of Autopsy in a Case Report.

Urol Case Rep 2016 Nov 23;9:37-40. Epub 2016 Sep 23.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037208PMC
http://dx.doi.org/10.1016/j.eucr.2016.08.004DOI Listing
November 2016

The bright side of dark matter: lncRNAs in cancer.

J Clin Invest 2016 08 1;126(8):2775-82. Epub 2016 Aug 1.

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http://dx.doi.org/10.1172/JCI84421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966302PMC
August 2016

Role of BET proteins in castration-resistant prostate cancer.

Drug Discov Today Technol 2016 Mar 30;19:29-38. Epub 2016 Jul 30.

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ddtec.2016.07.001DOI Listing
March 2016