Publications by authors named "Arthur Weiss"

100Publications

How the T cell signaling network processes information to discriminate between self and agonist ligands.

Proc Natl Acad Sci U S A 2020 Oct 5;117(42):26020-26030. Epub 2020 Oct 5.

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.2008303117DOI Listing
October 2020

CD45 functions as a signaling gatekeeper in T cells.

Sci Signal 2019 10 22;12(604). Epub 2019 Oct 22.

Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1126/scisignal.aaw8151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948007PMC
October 2019

Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination.

Nat Immunol 2019 11 14;20(11):1481-1493. Epub 2019 Oct 14.

Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41590-019-0502-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858552PMC
November 2019

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis.

Proc Natl Acad Sci U S A 2019 09 27;116(37):18517-18527. Epub 2019 Aug 27.

Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143;

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http://dx.doi.org/10.1073/pnas.1904271116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744919PMC
September 2019

Adaptation by naïve CD4 T cells to self-antigen-dependent TCR signaling induces functional heterogeneity and tolerance.

Proc Natl Acad Sci U S A 2019 07 8;116(30):15160-15169. Epub 2019 Jul 8.

Department of Medicine, Division of Immunology, Lowance Center for Human Immunology, Emory University, Atlanta, GA 30322;

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http://dx.doi.org/10.1073/pnas.1904096116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660790PMC
July 2019

Switch-like activation of Bruton's tyrosine kinase by membrane-mediated dimerization.

Proc Natl Acad Sci U S A 2019 05 10;116(22):10798-10803. Epub 2019 May 10.

Department of Chemistry, University of California, Berkeley, CA 94720;

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http://dx.doi.org/10.1073/pnas.1819309116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561188PMC
May 2019

CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic.

J Cell Biol 2019 05 27;218(5):1619-1633. Epub 2019 Feb 27.

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA

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http://dx.doi.org/10.1083/jcb.201806097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504896PMC
May 2019

Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT.

Nat Immunol 2018 07 18;19(7):733-741. Epub 2018 Jun 18.

Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41590-018-0131-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202249PMC
July 2018

Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen.

Elife 2018 03 16;7. Epub 2018 Mar 16.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.

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http://dx.doi.org/10.7554/eLife.35190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889215PMC
March 2018

TCR Signaling: Mechanisms of Initiation and Propagation.

Trends Biochem Sci 2018 02 18;43(2):108-123. Epub 2017 Dec 18.

Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Howard Hughes Medical Institute (HHMI), San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2017.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801066PMC
February 2018

IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4 and CD8 T cells.

Sci Signal 2017 Dec 19;10(510). Epub 2017 Dec 19.

Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://stke.sciencemag.org/lookup/doi/10.1126/scisignal.aan4
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http://dx.doi.org/10.1126/scisignal.aan4931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741096PMC
December 2017

ZAP-70 in Signaling, Biology, and Disease.

Annu Rev Immunol 2018 04 13;36:127-156. Epub 2017 Dec 13.

Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, California 94143, USA; email: ,

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http://dx.doi.org/10.1146/annurev-immunol-042617-053335DOI Listing
April 2018

A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.

Mol Cell 2017 Aug 20;67(3):498-511.e6. Epub 2017 Jul 20.

Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; The Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 04143, USA. Electronic address:

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http://www.cell.com/molecular-cell/pdf/S1097-2765(17)30458-6
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http://linkinghub.elsevier.com/retrieve/pii/S109727651730458
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http://dx.doi.org/10.1016/j.molcel.2017.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558854PMC
August 2017

IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level.

J Immunol 2017 03 3;198(6):2445-2456. Epub 2017 Feb 3.

The Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143;

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http://dx.doi.org/10.4049/jimmunol.1601453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340617PMC
March 2017

Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness.

J Exp Med 2017 03 3;214(3):833-849. Epub 2017 Feb 3.

Department of Medicine, Rosalind Russell and Ephraim Engleman Rheumatology Research Center, University of California, San Francisco, CA 94143

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http://dx.doi.org/10.1084/jem.20161575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339679PMC
March 2017

Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells.

J Immunol 2017 01 9;198(2):657-668. Epub 2016 Dec 9.

The Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Division of Rheumatology, Department of Medicine, and the Howard Hughes Medical Institute at the University of California, San Francisco, San Francisco, CA 94143

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1601301
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http://dx.doi.org/10.4049/jimmunol.1601301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224971PMC
January 2017

Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen.

SLAS Discov 2017 03 13;22(3):324-331. Epub 2016 Dec 13.

1 Department of Molecular and Cell Biology and Department of Chemistry, California Institute of Quantitative Biosciences and Howard Hughes Medical Institute, University of California, Berkeley, CA, USA.

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http://dx.doi.org/10.1177/1087057116681407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491343PMC
March 2017

Positive Regulation of Lyn Kinase by CD148 Is Required for B Cell Receptor Signaling in B1 but Not B2 B Cells.

Immunity 2016 12 23;45(6):1232-1244. Epub 2016 Nov 23.

Howard Hughes Medical Institute, Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Departments of Medicine and of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143-0795, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903562PMC
December 2016

Phosphorylation of a Tyrosine Residue on Zap70 by Lck and Its Subsequent Binding via an SH2 Domain May Be a Key Gatekeeper of T Cell Receptor Signaling In Vivo.

Mol Cell Biol 2016 09 26;36(18):2396-402. Epub 2016 Aug 26.

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA

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http://dx.doi.org/10.1128/MCB.00165-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007795PMC
September 2016

CD28 Costimulation: From Mechanism to Therapy.

Immunity 2016 05;44(5):973-88

Diabetes Center and Department of Medicine, University of California, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932896PMC
May 2016

A CRISPR-Based Toolbox for Studying T Cell Signal Transduction.

Biomed Res Int 2016 1;2016:5052369. Epub 2016 Feb 1.

School of Life Science and Technology, ShanghaiTech University, Shanghai 200031, China.

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http://downloads.hindawi.com/journals/bmri/2016/5052369.pdf
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http://www.hindawi.com/journals/bmri/2016/5052369/
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http://dx.doi.org/10.1155/2016/5052369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753324PMC
December 2016

Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling.

Nat Chem Biol 2016 May 28;12(5):373-9. Epub 2016 Mar 28.

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/nchembio.2056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837022PMC
May 2016

An extracatalytic function of CD45 in B cells is mediated by CD22.

Proc Natl Acad Sci U S A 2015 Nov 11;112(47):E6515-24. Epub 2015 Nov 11.

Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California, San Francisco, CA 94143;

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http://www.pnas.org/content/112/47/E6515.full.pdf
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http://www.pnas.org/lookup/doi/10.1073/pnas.1519925112
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http://dx.doi.org/10.1073/pnas.1519925112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664364PMC
November 2015

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.

Elife 2015 Oct 30;4. Epub 2015 Oct 30.

Russell/Engleman Rheumatology Research Center, Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, United States.

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http://elifesciences.org/content/elife/4/e09183.full.pdf
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http://elifesciences.org/lookup/doi/10.7554/eLife.09183
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http://dx.doi.org/10.7554/eLife.09183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626889PMC
October 2015

Small molecule inhibition of Csk alters affinity recognition by T cells.

Elife 2015 Aug 24;4. Epub 2015 Aug 24.

Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, United States.

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http://dx.doi.org/10.7554/eLife.08088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568592PMC
August 2015

Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor.

Proc Natl Acad Sci U S A 2015 Mar 17;112(13):E1594-603. Epub 2015 Mar 17.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8.

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http://dx.doi.org/10.1073/pnas.1503286112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386406PMC
March 2015

Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation.

J Clin Immunol 2015 Feb 28;35(2):135-46. Epub 2015 Jan 28.

Department of Pediatrics, University of California San Francisco School of Medicine, and UCSF Benioff Children's Hospital, Box 0519, 513 Parnassus Avenue, HSE-301A, San Francisco, CA, 94143-0519, USA.

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http://dx.doi.org/10.1007/s10875-014-0125-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352191PMC
February 2015

Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.

Biochem J 2015 Jan;465(1):149-61

*Department of Molecular and Cell Biology and Department of Chemistry, California Institute of Quantitative Biosciences and Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, U.S.A.

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http://dx.doi.org/10.1042/BJ20140793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410814PMC
January 2015

Insights into the initiation of TCR signaling.

Nat Immunol 2014 Sep;15(9):798-807

Rosalind Russell/Ephraim P. Engleman Rheumatology Research Center, Division of Rheumatology, Department of Medicine and the Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/ni.2940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226627PMC
September 2014

A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.

Proc Natl Acad Sci U S A 2014 Sep 18;111(35):E3679-88. Epub 2014 Aug 18.

Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Division of Rheumatology, Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143

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http://www.pnas.org/content/111/35/E3679.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.1413726111
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http://dx.doi.org/10.1073/pnas.1413726111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156735PMC
September 2014

Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns.

Proc Natl Acad Sci U S A 2014 Jun 9;111(25):E2550-8. Epub 2014 Jun 9.

Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200; and

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http://dx.doi.org/10.1073/pnas.1408482111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078834PMC
June 2014

Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.

Nat Immunol 2014 Jul 8;15(7):687-94. Epub 2014 Jun 8.

1] Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California, USA. [2] Rosalind Russell-Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, California, USA. [3] Department of Medicine, University of California, San Francisco, San Francisco, California, USA. [4] Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/ni.2918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095875PMC
July 2014

Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.

Elife 2014 May 13;3:e02270. Epub 2014 May 13.

Department of Medicine, Division of Rheumatology, University of California, San Francisco, San Francisco, United States Rosalind Russell Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017645PMC
http://dx.doi.org/10.7554/eLife.02270DOI Listing
May 2014

A clue to antigen receptor tails.

J Immunol 2014 May;192(9):4013-4

CytomX Therapeutics, Inc., South San Francisco, CA 94080;

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http://dx.doi.org/10.4049/jimmunol.1400660DOI Listing
May 2014

Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210.

Nat Immunol 2014 Apr 9;15(4):393-401. Epub 2014 Mar 9.

Departments of Medicine and of Microbiology & Immunology, the Rosalind Russell-Ephraim P. Engleman Medical Research Center for Arthritis, and the Howard Hughes Medical Institute, University of California, San Francisco, CA 94143.

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http://dx.doi.org/10.1038/ni.2846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996831PMC
April 2014

Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL.

Elife 2014 Mar 4;3:e01310. Epub 2014 Mar 4.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936284PMC
http://dx.doi.org/10.7554/eLife.01310DOI Listing
March 2014

Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling.

Nat Immunol 2014 Feb 8;15(2):186-94. Epub 2013 Dec 8.

1] Rosalind Russell-Ephraim P. Engleman Medical Research Center for Arthritis, Division of Rheumatology, Department of Medicine, University of California, San Francisco, California, USA. [2] Howard Hughes Medical Institute, Chevy Chase, Maryland, USA. [3] Department of Microbiology and Immunology, University of California, San Francisco, California, USA.

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http://www.nature.com/articles/ni.2772
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http://dx.doi.org/10.1038/ni.2772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946925PMC
February 2014

Tony Pawson: Modular protein domains and the links to intracellular signaling.

Authors:
Arthur Weiss

Proc Natl Acad Sci U S A 2013 Oct 17;110(44):17604-5. Epub 2013 Oct 17.

Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143.

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http://dx.doi.org/10.1073/pnas.1317096110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816486PMC
October 2013

Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45.

Cold Spring Harb Symp Quant Biol 2013 7;78:131-139. Epub 2013 Oct 7.

Division of Rheumatology, Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, UCSF, San Francisco, CA, 94143, USA.

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http://symposium.cshlp.org/content/early/2013/10/07/sqb.2013
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http://symposium.cshlp.org/cgi/doi/10.1101/sqb.2013.78.02034
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http://dx.doi.org/10.1101/sqb.2013.78.020347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039614PMC
March 2015

Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells.

Immunity 2013 Sep 29;39(3):560-72. Epub 2013 Aug 29.

Diabetes Center, University of California, San Francisco, San Francisco, CA 94143-0540, USA; Department of Surgery, University of California, San Francisco, San Francisco, CA 94143-0540, USA.

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http://dx.doi.org/10.1016/j.immuni.2013.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804105PMC
September 2013

The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.

J Clin Invest 2013 May 1;123(5):2037-48. Epub 2013 Apr 1.

Division of Rheumatology and Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco (UCSF), San Francisco, California, USA.

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http://dx.doi.org/10.1172/JCI66397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635736PMC
May 2013

The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.

J Immunol 2013 Mar 8;190(6):2527-35. Epub 2013 Feb 8.

Division of Rheumatology, Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://www.jimmunol.org/content/190/6/2527.full.pdf
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1202928
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http://dx.doi.org/10.4049/jimmunol.1202928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593789PMC
March 2013

Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.

Sci Signal 2013 Jan 1;6(256):ra1. Epub 2013 Jan 1.

Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children's Hospital, Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA.

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http://dx.doi.org/10.1126/scisignal.2003220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742096PMC
January 2013

Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function.

J Clin Invest 2012 Dec 1;122(12):4592-605. Epub 2012 Nov 1.

Department of Medicine, Division of Rheumatology, UCSF, San Francisco, California, USA.

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http://dx.doi.org/10.1172/JCI60920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533532PMC
December 2012

Endogenous antigen tunes the responsiveness of naive B cells but not T cells.

Nature 2012 Sep;489(7414):160-4

Division of Rheumatology, Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/nature11311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438375PMC
September 2012

Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells.

Nature 2012 Aug;488(7411):384-8

Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1038/nature11259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422413PMC
August 2012

The membrane environment can promote or suppress bistability in cell signaling networks.

J Phys Chem B 2012 Mar 13;116(11):3630-40. Epub 2012 Mar 13.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1021/jp2102385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321252PMC
March 2012

Ca-dependent Ras/Erk signaling mediates negative selection of autoreactive B cells.

Small GTPases 2011 Sep 1;2(5):282-288. Epub 2011 Sep 1.

Department of Medicine; Howard Hughes Medical Institute; Rosalind Russell Medical Research Center for Arthritis; University of California at San Francisco; San Francisco, CA USA.

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http://dx.doi.org/10.4161/sgtp.2.5.17794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265820PMC
September 2011

Lymphocyte signaling: a Tuscan affair.

Nat Immunol 2011 Dec 16;13(1):3-6. Epub 2011 Dec 16.

Department of Evolutionary Biology, University of Siena, Siena, Italy.

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http://www.nature.com/ni/journal/v13/n1/pdf/ni.2185.pdf%3FWT
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http://www.nature.com/doifinder/10.1038/ni.2185
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http://dx.doi.org/10.1038/ni.2185DOI Listing
December 2011

Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival.

Proc Natl Acad Sci U S A 2012 Jan 30;109(1):E3-12. Epub 2011 Nov 30.

Division of Rheumatology, Department of Medicine, Rosalind Russell Medical Research Center for Arthritis and Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252956PMC
January 2012

Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease.

J Clin Invest 2011 Dec 14;121(12):4618-21. Epub 2011 Nov 14.

Division of Rheumatology, Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, UCSF, San Francisco, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226009PMC
December 2011

Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus.

Immunity 2011 Nov 10;35(5):757-69. Epub 2011 Nov 10.

Department of Medicine, Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.immuni.2011.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245876PMC
November 2011

Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression.

PLoS One 2011 26;6(9):e25540. Epub 2011 Sep 26.

Department of Anatomy, University of California San Francisco, San Francisco, California, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180458PMC
February 2012

Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling.

Sci Signal 2011 Sep;4(190):ra59

Rosalind Russell Medical Research Center for Arthritis, Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1126/scisignal.2001893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080844PMC
September 2011

Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148.

J Biol Chem 2011 Jun 4;286(25):22101-12. Epub 2011 May 4.

Institute of Molecular Genetics, Academy of Sciences of Czech Republic, 142 20 Prague, Czech Republic.

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http://dx.doi.org/10.1074/jbc.M110.196733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121354PMC
June 2011

STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development.

Nat Immunol 2011 May 27;12(5):425-33. Epub 2011 Mar 27.

Department of Medicine, Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, University of California at San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/ni.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623929PMC
May 2011

Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases.

Blood 2011 Mar 18;117(11):3087-95. Epub 2011 Jan 18.

Department of Microbiology and Immunology and the Cancer Research Institute, USA.

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http://dx.doi.org/10.1182/blood-2010-06-292219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062311PMC
March 2011

The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation.

J Immunol 2011 Feb 10;186(4):1923-33. Epub 2011 Jan 10.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.4049/jimmunol.0903292DOI Listing
February 2011

A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity.

Nat Immunol 2010 Dec 31;11(12):1085-92. Epub 2010 Oct 31.

Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, Department of Microbiology and Immunology, University of California-San Francisco, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711183PMC
December 2010

Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate.

Proc Natl Acad Sci U S A 2010 Sep 30;107(37):16234-9. Epub 2010 Aug 30.

Department of Medicine, Division of Rheumatology, The Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, and Graduate Program in Biomedical Sciences, University of California, San Francisco, CA 94143-0795, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941278PMC
September 2010

ZAP-70: an essential kinase in T-cell signaling.

Cold Spring Harb Perspect Biol 2010 May;2(5):a002279

Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA.

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May 2010

Regulation of thymocyte positive selection and motility by GIT2.

Nat Immunol 2010 Jun 2;11(6):503-11. Epub 2010 May 2.

Department of Medicine, University of California San Francisco, San Francisco, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620668PMC
June 2010

The right team at the right time to go for a home run: tyrosine kinase activation by the TCR.

Authors:
Arthur Weiss

Nat Immunol 2010 Feb;11(2):101-4

Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, Departments of Medicine and of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA.

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February 2010

Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response.

Proc Natl Acad Sci U S A 2009 Dec 17;106(49):20699-704. Epub 2009 Nov 17.

Department of Molecular and Cell Biology, California Institute of Quantitative Biosciences, University of California, Berkeley, CA 94720, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778570PMC
December 2009

SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking.

Immunol Rev 2009 Nov;232(1):218-28

National Jewish Health, Denver, CO 80206, USA.

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November 2009

A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity.

J Exp Med 2009 Oct 19;206(11):2527-41. Epub 2009 Oct 19.

Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California San Francisco Children's Hospital, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://www.jem.org/cgi/doi/10.1084/jem.20082902
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October 2009

TCR signal transduction: opening the black box.

Authors:
Arthur Weiss

J Immunol 2009 Oct;183(8):4821-7

Division of Rheumatology, Rosalind Russell Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA.

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October 2009

Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes.

Sci Signal 2009 Apr 14;2(66):pt2. Epub 2009 Apr 14.

Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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April 2009

Requirement for CD45 in fine-tuning mast cell responses mediated by different ligand-receptor systems.

Cell Signal 2009 Aug 27;21(8):1277-86. Epub 2009 Mar 27.

Molecular Immunology, Institute for Biology III, University of Freiburg & Max-Planck-Institute for Immunobiology, Freiburg, Germany.

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August 2009

The structure, regulation, and function of ZAP-70.

Immunol Rev 2009 Mar;228(1):41-57

Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143-0795, USA.

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March 2009

Kinases and phosphatases of the immune system.

Authors:
Arthur Weiss

Immunol Rev 2009 Mar;228(1):5-8

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March 2009

Antigen receptor signaling in the rheumatic diseases.

Arthritis Res Ther 2009 30;11(1):202. Epub 2009 Jan 30.

Division of Rheumatology, Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, 513 Parnassus Avenue San Francisco, CA 94143, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688213PMC
September 2009

Digital signaling and hysteresis characterize ras activation in lymphoid cells.

Cell 2009 Jan;136(2):337-51

Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662698PMC
January 2009

Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses.

Proc Natl Acad Sci U S A 2009 Jan 7;106(2):546-51. Epub 2009 Jan 7.

Department of Pediatrics, Medicine, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626740PMC
January 2009

Alternative splicing of CD45: the tip of the iceberg.

Immunity 2008 Dec;29(6):839-41

Division of Rheumatology, Rosalind Russell Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143, USA.

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December 2008

Origin of the sharp boundary that discriminates positive and negative selection of thymocytes.

Proc Natl Acad Sci U S A 2009 Jan 19;106(2):528-33. Epub 2008 Dec 19.

Departments of Chemical Engineering, Chemistry, and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626737PMC
January 2009

Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.

Proc Natl Acad Sci U S A 2008 Dec 17;105(48):18895-900. Epub 2008 Nov 17.

Diabetes Center and the Department of Medicine, University of California, San Francisco, CA 94143, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596241PMC
December 2008

B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency.

J Exp Med 2008 Nov 10;205(12):2755-61. Epub 2008 Nov 10.

Department of Medicine, Biomedical Sciences Graduate Program, Medical Scientist Training Program, University of California San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1084/jem.20081204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585841PMC
November 2008