Arthur F J Ram

Institute of Biology Leiden, Leiden University, Molecular Microbiology and Biotechnology, Sylviusweg 72, 2333 BE Leiden, the Netherlands. Electronic address:

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June 2020

Rab GDP-dissociation inhibitor gdiA is an essential gene required for cell wall chitin deposition in Aspergillus niger.

Authors:

Tim M van Leeuwe Anne Gerritsen Mark Arentshorst Peter J Punt Arthur F J Ram

Fungal Genet Biol 2020 03 27;136:103319. Epub 2019 Dec 27.

Leiden University, Institute of Biology Leiden, Molecular Microbiology and Biotechnology, Sylviusweg 72, 2333 BE Leiden, the Netherlands. Electronic address:

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March 2020

Subpopulations of hyphae secrete proteins or resist heat stress in Aspergillus oryzae colonies.

Authors:

Martin Tegelaar Robert-Jan Bleichrodt Benjamin Nitsche Arthur F J Ram Han A B Wösten

Environ Microbiol 2020 01 24;22(1):447-455. Epub 2019 Nov 24.

Microbiology, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.

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January 2020

Efficient marker free CRISPR/Cas9 genome editing for functional analysis of gene families in filamentous fungi.

Authors:

Tim M van Leeuwe Mark Arentshorst Tim Ernst Ebru Alazi Peter J Punt Arthur F J Ram

Fungal Biol Biotechnol 2019 21;6:13. Epub 2019 Sep 21.

1Department Molecular Microbiology and Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands.

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September 2019

Aspergillus fumigatus establishes infection in zebrafish by germination of phagocytized conidia, while Aspergillus niger relies on extracellular germination.

Authors:

Bjørn E V Koch Natalia H Hajdamowicz Ellen Lagendijk Arthur F J Ram Annemarie H Meijer

Sci Rep 2019 09 5;9(1):12791. Epub 2019 Sep 5.

Institute of Biology Leiden, Leiden University, Leiden, The Netherlands.

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September 2019

Functional analysis of three putative galactofuranosyltransferases with redundant functions in galactofuranosylation in Aspergillus niger.

Authors:

Mark Arentshorst Davina de Lange Joohae Park Ellen L Lagendijk Ebru Alazi Cees A M J J van den Hondel Arthur F J Ram

Arch Microbiol 2020 Jan 1;202(1):197-203. Epub 2019 Aug 1.

Institute of Biology Leiden, Molecular Microbiology and Biotechnology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

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January 2020

Dynamic and Functional Profiling of Xylan-Degrading Enzymes in Secretomes Using Activity-Based Probes.

ACS Cent Sci 2019 Jun 24;5(6):1067-1078. Epub 2019 May 24.

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands.

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June 2019

Correction to: Mutations in AraR leading to constitutive expression of arabinolytic genes in Aspergillus niger under derepressing conditions.

Authors:

Jos Reijngoud Malte Deseke Elmar T M Halbesma Ebru Alazi Mark Arentshorst Peter J Punt Arthur F J Ram

Appl Microbiol Biotechnol 2019 06;103(12):5063

Molecular Microbiology and Biotechnology, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333, BE, Leiden, The Netherlands.

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June 2019

Mutations in AraR leading to constitutive expression of arabinolytic genes in Aspergillus niger under derepressing conditions [corrected].

Authors:

Jos Reijngoud Malte Deseke Elmar T M Halbesma Ebru Alazi Mark Arentshorst Peter J Punt Arthur F J Ram

Appl Microbiol Biotechnol 2019 05 8;103(10):4125-4136. Epub 2019 Apr 8.

Molecular Microbiology and Biotechnology, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

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May 2019

FlbA-Regulated Gene Is Involved in Stress Resistance and Impacts Protein Secretion when Is Grown on Xylose.

Authors:

David Aerts Stijn G van den Bergh Harm Post Maarten A F Altelaar Mark Arentshorst Arthur F J Ram Robin A Ohm Han A B Wösten

Appl Environ Microbiol 2019 01 9;85(2). Epub 2019 Jan 9.

Microbiology, Department of Biology, Utrecht University, Utrecht, The Netherlands

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January 2019

Modulating Transcriptional Regulation of Plant Biomass Degrading Enzyme Networks for Rational Design of Industrial Fungal Strains.

Authors:

Ebru Alazi Arthur F J Ram

Front Bioeng Biotechnol 2018 25;6:133. Epub 2018 Sep 25.

Molecular Microbiology and Biotechnology, Institute of Biology Leiden, Leiden University, Leiden, Netherlands.

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September 2018

W361R mutation in GaaR, the regulator of D-galacturonic acid-responsive genes, leads to constitutive production of pectinases in Aspergillus niger.

Authors:

Ebru Alazi Jing Niu Simon B Otto Mark Arentshorst Thi T M Pham Adrian Tsang Arthur F J Ram

Microbiologyopen 2019 05 8;8(5):e00732. Epub 2018 Oct 8.

Molecular Microbiology and Biotechnology, Institute of Biology Leiden, Leiden University, Leiden, The Netherlands.

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May 2019

A community-driven reconstruction of the metabolic network.

Authors:

Julian Brandl Maria Victoria Aguilar-Pontes Paul Schäpe Anders Noerregaard Mikko Arvas Arthur F J Ram Vera Meyer Adrian Tsang Ronald P de Vries Mikael R Andersen

Fungal Biol Biotechnol 2018 26;5:16. Epub 2018 Sep 26.

1Technical University of Denmark, Soeltofts Plads, Building 223, 2800 Kongens Lyngby, Denmark.

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September 2018

Correction: Velvet domain protein VosA represses the zinc cluster transcription factor SclB regulatory network for Aspergillus nidulans asexual development, oxidative stress response and secondary metabolism.

Authors:

Karl G Thieme Jennifer Gerke Christoph Sasse Oliver Valerius Sabine Thieme Razieh Karimi Antje K Heinrich Florian Finkernagel Kristina Smith Helge B Bode Michael Freitag Arthur F J Ram Gerhard H Braus

PLoS Genet 2018 08 29;14(8):e1007638. Epub 2018 Aug 29.

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August 2018

Velvet domain protein VosA represses the zinc cluster transcription factor SclB regulatory network for Aspergillus nidulans asexual development, oxidative stress response and secondary metabolism.

Authors:

Karl G Thieme Jennifer Gerke Christoph Sasse Oliver Valerius Sabine Thieme Razieh Karimi Antje K Heinrich Florian Finkernagel Kristina Smith Helge B Bode Michael Freitag Arthur F J Ram Gerhard H Braus

PLoS Genet 2018 07 25;14(7):e1007511. Epub 2018 Jul 25.

Department of Molecular Microbiology and Genetics and Goettingen Center for Molecular Biosciences (GZMB), University of Goettingen, Goettingen, Germany.

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July 2018

Parasexual Crossings for Bulk Segregant Analysis in Aspergillus niger to Facilitate Mutant Identification Via Whole Genome Sequencing.

Authors:

Mark Arentshorst Arthur F J Ram

Methods Mol Biol 2018 ;1775:277-287

Molecular Microbiology and Biotechnology, Institute of Biology Leiden, Leiden University, Leiden, The Netherlands.

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February 2019

Inducer-independent production of pectinases in Aspergillus niger by overexpression of the D-galacturonic acid-responsive transcription factor gaaR.

Authors:

Ebru Alazi Tim Knetsch Marcos Di Falco Ian D Reid Mark Arentshorst Jaap Visser Adrian Tsang Arthur F J Ram

Appl Microbiol Biotechnol 2018 Mar 24;102(6):2723-2736. Epub 2018 Jan 24.

Molecular Microbiology and Biotechnology, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

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March 2018

The FlbA-regulated predicted transcription factor Fum21 of Aspergillus niger is involved in fumonisin production.

Authors:

David Aerts Esther E Hauer Robin A Ohm Mark Arentshorst Wieke R Teertstra Christopher Phippen Arthur F J Ram Jens C Frisvad Han A B Wösten

Antonie Van Leeuwenhoek 2018 Mar 30;111(3):311-322. Epub 2017 Sep 30.

Microbiology, Department of Biology, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.

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March 2018

Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio-economy: a white paper.

Authors:

Vera Meyer Mikael R Andersen Axel A Brakhage Gerhard H Braus Mark X Caddick Timothy C Cairns Ronald P de Vries Thomas Haarmann Kim Hansen Christiane Hertz-Fowler Sven Krappmann Uffe H Mortensen Miguel A Peñalva Arthur F J Ram Ritchie M Head

Fungal Biol Biotechnol 2016 31;3. Epub 2016 Aug 31.

Ceratium Limited, The Haven, West Kirby, CH48 8AP UK.

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August 2016

The pathway intermediate 2-keto-3-deoxy-L-galactonate mediates the induction of genes involved in D-galacturonic acid utilization in Aspergillus niger.

Authors:

Ebru Alazi Claire Khosravi Tim G Homan Saskia du Pré Mark Arentshorst Marcos Di Falco Thi T M Pham Mao Peng Maria Victoria Aguilar-Pontes Jaap Visser Adrian Tsang Ronald P de Vries Arthur F J Ram

FEBS Lett 2017 05 6;591(10):1408-1418. Epub 2017 May 6.

Molecular Microbiology and Biotechnology, Institute of Biology Leiden, Leiden University, The Netherlands.

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May 2017

Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus.

Authors:

Ronald P de Vries Robert Riley Ad Wiebenga Guillermo Aguilar-Osorio Sotiris Amillis Cristiane Akemi Uchima Gregor Anderluh Mojtaba Asadollahi Marion Askin Kerrie Barry Evy Battaglia Özgür Bayram Tiziano Benocci Susanna A Braus-Stromeyer Camila Caldana David Cánovas Gustavo C Cerqueira Fusheng Chen Wanping Chen Cindy Choi Alicia Clum Renato Augusto Corrêa Dos Santos André Ricardo de Lima Damásio George Diallinas Tamás Emri Erzsébet Fekete Michel Flipphi Susanne Freyberg Antonia Gallo Christos Gournas Rob Habgood Matthieu Hainaut María Laura Harispe Bernard Henrissat Kristiina S Hildén Ryan Hope Abeer Hossain Eugenia Karabika Levente Karaffa Zsolt Karányi Nada Kraševec Alan Kuo Harald Kusch Kurt LaButti Ellen L Lagendijk Alla Lapidus Anthony Levasseur Erika Lindquist Anna Lipzen Antonio F Logrieco Andrew MacCabe Miia R Mäkelä Iran Malavazi Petter Melin Vera Meyer Natalia Mielnichuk Márton Miskei Ákos P Molnár Giuseppina Mulé Chew Yee Ngan Margarita Orejas Erzsébet Orosz Jean Paul Ouedraogo Karin M Overkamp Hee-Soo Park Giancarlo Perrone Francois Piumi Peter J Punt Arthur F J Ram Ana Ramón Stefan Rauscher Eric Record Diego Mauricio Riaño-Pachón Vincent Robert Julian Röhrig Roberto Ruller Asaf Salamov Nadhira S Salih Rob A Samson Erzsébet Sándor Manuel Sanguinetti Tabea Schütze Kristina Sepčić Ekaterina Shelest Gavin Sherlock Vicky Sophianopoulou Fabio M Squina Hui Sun Antonia Susca Richard B Todd Adrian Tsang Shiela E Unkles Nathalie van de Wiele Diana van Rossen-Uffink Juliana Velasco de Castro Oliveira Tammi C Vesth Jaap Visser Jae-Hyuk Yu Miaomiao Zhou Mikael R Andersen David B Archer Scott E Baker Isabelle Benoit Axel A Brakhage Gerhard H Braus Reinhard Fischer Jens C Frisvad Gustavo H Goldman Jos Houbraken Berl Oakley István Pócsi Claudio Scazzocchio Bernhard Seiboth Patricia A vanKuyk Jennifer Wortman Paul S Dyer Igor V Grigoriev

Genome Biol 2017 02 14;18(1):28. Epub 2017 Feb 14.

US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA, 94598, USA.

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February 2017

An Evolutionarily Conserved Transcriptional Activator-Repressor Module Controls Expression of Genes for D-Galacturonic Acid Utilization in Aspergillus niger.

Authors:

Jing Niu Ebru Alazi Ian D Reid Mark Arentshorst Peter J Punt Jaap Visser Adrian Tsang Arthur F J Ram

Genetics 2017 01 9;205(1):169-183. Epub 2016 Nov 9.

Molecular Microbiology and Biotechnology, Leiden University, Institute of Biology Leiden, 2333 BE Leiden, The Netherlands

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January 2017

Highly active promoters and native secretion signals for protein production during extremely low growth rates in Aspergillus niger.

Authors:

Franziska Wanka Mark Arentshorst Timothy C Cairns Thomas Jørgensen Arthur F J Ram Vera Meyer

Microb Cell Fact 2016 Aug 20;15(1):145. Epub 2016 Aug 20.

Department Applied and Molecular Microbiology, Institute of Biotechnology, Berlin University of Technology, Gustav-Meyer-Allee 25, 13355, Berlin, Germany.

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August 2016

Aspergillus fumigatus MADS-Box Transcription Factor rlmA Is Required for Regulation of the Cell Wall Integrity and Virulence.

Authors:

Marina Campos Rocha João Henrique Tadini Marilhano Fabri Krissia Franco de Godoy Patrícia Alves de Castro Juliana Issa Hori Anderson Ferreira da Cunha Mark Arentshorst Arthur F J Ram Cees A M J J van den Hondel Gustavo Henrique Goldman Iran Malavazi

G3 (Bethesda) 2016 09 8;6(9):2983-3002. Epub 2016 Sep 8.

Departamento de Genética e Evolução, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, 13565 São Carlos, São Paulo, Brazil

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September 2016

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