Arthi Kanthasamy

Arthi Kanthasamy

UNVERIFIED PROFILE

Are you Arthi Kanthasamy?   Register this Author

Register author
Arthi Kanthasamy

Arthi Kanthasamy

Publications by authors named "Arthi Kanthasamy"

Are you Arthi Kanthasamy?   Register this Author

88Publications

1851Reads

6Profile Views

Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders.

J Neuroimmune Pharmacol 2019 Sep 31;14(3):423-435. Epub 2019 Jan 31.

Department of Biomedical Sciences, Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Iowa State University, Ames, IA, 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11481-019-09835-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669119PMC
September 2019

Exosomes as Mediators of Chemical-Induced Toxicity.

Curr Environ Health Rep 2019 Sep;6(3):73-79

Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, 1222 Veterinary Medicine Building, Ames, IA, 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40572-019-00233-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698419PMC
September 2019

MitoPark Transgenic Mouse Model Recapitulates the Gastrointestinal Dysfunction and Gut-Microbiome Changes of Parkinson's Disease.

Neurotoxicology 2019 Sep 7. Epub 2019 Sep 7.

Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University (ISU), Ames, IA, 50011. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2019.09.004DOI Listing
September 2019

Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson's disease.

Biochim Biophys Acta Mol Basis Dis 2019 Aug 20:165533. Epub 2019 Aug 20.

Department of Biomedical Sciences, Parkinson's Disorder Research Program, Iowa State University, Ames, IA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2019.165533DOI Listing
August 2019

Fyn amplifies NLRP3 inflammasome signaling in Parkinson's disease.

Aging (Albany NY) 2019 Aug 27;11(16):5871-5873. Epub 2019 Aug 27.

Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.102210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738402PMC
August 2019

Manganese-Induced Neurotoxicity: New Insights Into the Triad of Protein Misfolding, Mitochondrial Impairment, and Neuroinflammation.

Front Neurosci 2019 26;13:654. Epub 2019 Jun 26.

Department of Biomedical Sciences, Parkinson's Disorder Research Laboratory, Iowa State University, Ames, IA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnins.2019.00654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606738PMC
June 2019

Environmental neurotoxicant-induced dopaminergic neurodegeneration: a potential link to impaired neuroinflammatory mechanisms.

Pharmacol Ther 2019 May 22;197:61-82. Epub 2019 Jan 22.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01637258193000
Publisher Site
http://dx.doi.org/10.1016/j.pharmthera.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520143PMC
May 2019

Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein.

Sci Signal 2019 Mar 12;12(572). Epub 2019 Mar 12.

Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scisignal.aau4543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435331PMC
March 2019

Utilization of the CRISPR-Cas9 Gene Editing System to Dissect Neuroinflammatory and Neuropharmacological Mechanisms in Parkinson's Disease.

J Neuroimmune Pharmacol 2019 Mar 16. Epub 2019 Mar 16.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA, 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11481-019-09844-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746615PMC
March 2019

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells.

Sci Signal 2019 Jan 8;12(563). Epub 2019 Jan 8.

Department of Biomedical Sciences, Parkinson Disorders Research Laboratory, Iowa Center for Advanced Neurotoxicology, Iowa State University, 2062 Veterinary Medicine Building, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://stke.sciencemag.org/lookup/doi/10.1126/scisignal.aat9
Publisher Site
http://dx.doi.org/10.1126/scisignal.aat9900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420319PMC
January 2019

Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes.

Glia 2018 10 12;66(10):2137-2157. Epub 2018 Sep 12.

Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA, 50011.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/glia.23467
Publisher Site
http://dx.doi.org/10.1002/glia.23467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240381PMC
October 2018

Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinflammatory mechanisms during neurotoxic insults.

Neurotoxicology 2018 07 30;67:129-140. Epub 2018 May 30.

Parkinson Disorders Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, 2062 Veterinary Medicine Building, Iowa State University, Ames, IA, 50011, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2018.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091676PMC
July 2018

Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes.

Neurotoxicology 2018 01 21;64:204-218. Epub 2017 May 21.

Parkinson Disorders Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, 2062 Veterinary Medicine Building, Iowa State University, Ames, IA 50011, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2017.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698176PMC
January 2018

Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mouse model of Parkinson's disease: Relevance to gene and environment interactions in metal neurotoxicity.

Neurotoxicology 2018 01 20;64:240-255. Epub 2017 Jun 20.

Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2017.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736468PMC
January 2018

Involvement of c-Abl Kinase in Microglial Activation of NLRP3 Inflammasome and Impairment in Autolysosomal System.

J Neuroimmune Pharmacol 2017 Dec 2;12(4):624-660. Epub 2017 May 2.

Department of Biomedical Sciences, Iowa Center for Advanced Neurotoxicology, Iowa State University, Ames, IA, 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11481-017-9746-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668207PMC
December 2017

Neurotoxicity of Vanadium.

Adv Neurobiol 2017 ;18:287-301

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, 2062 College of Veterinary Medicine Building, Ames, IA, 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-319-60189-2_14DOI Listing
December 2017

Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation.

Brain Res Bull 2017 Jul 16;133:60-70. Epub 2016 Dec 16.

Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainresbull.2016.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623095PMC
July 2017

Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease.

J Neurochem 2017 06 9;141(5):766-782. Epub 2017 May 9.

Department of Biomedical Sciences, Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Iowa State University, Ames, Iowa, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jnc.14033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643047PMC
June 2017

p73 gene in dopaminergic neurons is highly susceptible to manganese neurotoxicity.

Neurotoxicology 2017 03 20;59:231-239. Epub 2016 Apr 20.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, United States. Electronic address:

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073055PMC
http://dx.doi.org/10.1016/j.neuro.2016.04.012DOI Listing
March 2017

Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease.

Neurobiol Dis 2016 09 2;93:96-114. Epub 2016 May 2.

Parkinson Disorders Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2016.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995107PMC
September 2016

Acute hydrogen sulfide-induced neuropathology and neurological sequelae: challenges for translational neuroprotective research.

Ann N Y Acad Sci 2016 08 21;1378(1):5-16. Epub 2016 Jul 21.

Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063677PMC
http://dx.doi.org/10.1111/nyas.13148DOI Listing
August 2016

Alterations in mitochondrial dynamics induced by tebufenpyrad and pyridaben in a dopaminergic neuronal cell culture model.

Neurotoxicology 2016 Mar 2;53:302-313. Epub 2015 Jul 2.

Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2015.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698251PMC
March 2016

Molecular cloning, epigenetic regulation, and functional characterization of Prkd1 gene promoter in dopaminergic cell culture models of Parkinson's disease.

J Neurochem 2015 Oct 28;135(2):402-15. Epub 2015 Aug 28.

Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa Center for Advanced Neurotoxicology, Iowa State University, Ames, Iowa, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jnc.13261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839478PMC
October 2015

Targeted toxicants to dopaminergic neuronal cell death.

Methods Mol Biol 2015 ;1254:239-52

Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, IA Center for Advanced Neurotoxicology, Iowa State University, 1600 S. 16th Street, Ames, IA, 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-2152-2_18DOI Listing
July 2015

α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's disease.

Toxicol Sci 2015 Feb 21;143(2):454-68. Epub 2014 Nov 21.

Department of Biomedical Sciences, Iowa Center for Advanced Neurotoxicology, Iowa State University, Ames, Iowa 50011

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/toxsci/kfu247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306724PMC
February 2015

Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes.

Biochim Biophys Acta 2014 Aug 20;1842(8):1282-94. Epub 2013 Sep 20.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2013.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961561PMC
August 2014

Vanadium exposure induces olfactory dysfunction in an animal model of metal neurotoxicity.

Neurotoxicology 2014 Jul 18;43:73-81. Epub 2013 Dec 18.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2013.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062607PMC
July 2014

N-Acetyl Cysteine Protects against Methamphetamine-Induced Dopaminergic Neurodegeneration via Modulation of Redox Status and Autophagy in Dopaminergic Cells.

Parkinsons Dis 2012 27;2012:424285. Epub 2012 Sep 27.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2012/424285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465903PMC
October 2012

Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease.

J Neuroinflammation 2012 Oct 23;9:241. Epub 2012 Oct 23.

Department of Biomedical Sciences, Iowa Center for Advanced Neurotoxicology, Iowa State University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1742-2094-9-241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488558PMC
October 2012

Emerging neurotoxic mechanisms in environmental factors-induced neurodegeneration.

Neurotoxicology 2012 Aug 7;33(4):833-7. Epub 2012 Feb 7.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2012.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377824PMC
August 2012

Proteolytic activation of proapoptotic kinase protein kinase Cδ by tumor necrosis factor α death receptor signaling in dopaminergic neurons during neuroinflammation.

J Neuroinflammation 2012 Apr 27;9:82. Epub 2012 Apr 27.

Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://jneuroinflammation.biomedcentral.com/articles/10.1186
Publisher Site
http://dx.doi.org/10.1186/1742-2094-9-82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419619PMC
April 2012

Guidelines for the use and interpretation of assays for monitoring autophagy.

Authors:
Daniel J Klionsky Fabio C Abdalla Hagai Abeliovich Robert T Abraham Abraham Acevedo-Arozena Khosrow Adeli Lotta Agholme Maria Agnello Patrizia Agostinis Julio A Aguirre-Ghiso Hyung Jun Ahn Ouardia Ait-Mohamed Slimane Ait-Si-Ali Takahiko Akematsu Shizuo Akira Hesham M Al-Younes Munir A Al-Zeer Matthew L Albert Roger L Albin Javier Alegre-Abarrategui Maria Francesca Aleo Mehrdad Alirezaei Alexandru Almasan Maylin Almonte-Becerril Atsuo Amano Ravi Amaravadi Shoba Amarnath Amal O Amer Nathalie Andrieu-Abadie Vellareddy Anantharam David K Ann Shailendra Anoopkumar-Dukie Hiroshi Aoki Nadezda Apostolova Giuseppe Arancia John P Aris Katsuhiko Asanuma Nana Y O Asare Hisashi Ashida Valerie Askanas David S Askew Patrick Auberger Misuzu Baba Steven K Backues Eric H Baehrecke Ben A Bahr Xue-Yuan Bai Yannick Bailly Robert Baiocchi Giulia Baldini Walter Balduini Andrea Ballabio Bruce A Bamber Edward T W Bampton Gábor Bánhegyi Clinton R Bartholomew Diane C Bassham Robert C Bast Henri Batoko Boon-Huat Bay Isabelle Beau Daniel M Béchet Thomas J Begley Christian Behl Christian Behrends Soumeya Bekri Bryan Bellaire Linda J Bendall Luca Benetti Laura Berliocchi Henri Bernardi Francesca Bernassola Sébastien Besteiro Ingrid Bhatia-Kissova Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Lawrence H Boise Paolo Bonaldo David L Boone Beat C Bornhauser Karina R Bortoluci Ioannis Bossis Frédéric Bost Jean-Pierre Bourquin Patricia Boya Michaël Boyer-Guittaut Peter V Bozhkov Nathan R Brady Claudio Brancolini Andreas Brech Jay E Brenman Ana Brennand Emery H Bresnick Patrick Brest Dave Bridges Molly L Bristol Paul S Brookes Eric J Brown John H Brumell Nicola Brunetti-Pierri Ulf T Brunk Dennis E Bulman Scott J Bultman Geert Bultynck Lena F Burbulla Wilfried Bursch Jonathan P Butchar Wanda Buzgariu Sergio P Bydlowski Ken Cadwell Monika Cahová Dongsheng Cai Jiyang Cai Qian Cai Bruno Calabretta Javier Calvo-Garrido Nadine Camougrand Michelangelo Campanella Jenny Campos-Salinas Eleonora Candi Lizhi Cao Allan B Caplan Simon R Carding Sandra M Cardoso Jennifer S Carew Cathleen R Carlin Virginie Carmignac Leticia A M Carneiro Serena Carra Rosario A Caruso Giorgio Casari Caty Casas Roberta Castino Eduardo Cebollero Francesco Cecconi Jean Celli Hassan Chaachouay Han-Jung Chae Chee-Yin Chai David C Chan Edmond Y Chan Raymond Chuen-Chung Chang Chi-Ming Che Ching-Chow Chen Guang-Chao Chen Guo-Qiang Chen Min Chen Quan Chen Steve S-L Chen WenLi Chen Xi Chen Xiangmei Chen Xiequn Chen Ye-Guang Chen Yingyu Chen Yongqiang Chen Yu-Jen Chen Zhixiang Chen Alan Cheng Christopher H K Cheng Yan Cheng Heesun Cheong Jae-Ho Cheong Sara Cherry Russ Chess-Williams Zelda H Cheung Eric Chevet Hui-Ling Chiang Roberto Chiarelli Tomoki Chiba Lih-Shen Chin Shih-Hwa Chiou Francis V Chisari Chi Hin Cho Dong-Hyung Cho Augustine M K Choi DooSeok Choi Kyeong Sook Choi Mary E Choi Salem Chouaib Divaker Choubey Vinay Choubey Charleen T Chu Tsung-Hsien Chuang Sheau-Huei Chueh Taehoon Chun Yong-Joon Chwae Mee-Len Chye Roberto Ciarcia Maria R Ciriolo Michael J Clague Robert S B Clark Peter G H Clarke Robert Clarke Patrice Codogno Hilary A Coller María I Colombo Sergio Comincini Maria Condello Fabrizio Condorelli Mark R Cookson Graham H Coombs Isabelle Coppens Ramon Corbalan Pascale Cossart Paola Costelli Safia Costes Ana Coto-Montes Eduardo Couve Fraser P Coxon James M Cregg José L Crespo Marianne J Cronjé Ana Maria Cuervo Joseph J Cullen Mark J Czaja Marcello D'Amelio Arlette Darfeuille-Michaud Lester M Davids Faith E Davies Massimo De Felici John F de Groot Cornelis A M de Haan Luisa De Martino Angelo De Milito Vincenzo De Tata Jayanta Debnath Alexei Degterev Benjamin Dehay Lea M D Delbridge Francesca Demarchi Yi Zhen Deng Jörn Dengjel Paul Dent Donna Denton Vojo Deretic Shyamal D Desai Rodney J Devenish Mario Di Gioacchino Gilbert Di Paolo Chiara Di Pietro Guillermo Díaz-Araya Inés Díaz-Laviada Maria T Diaz-Meco Javier Diaz-Nido Ivan Dikic Savithramma P Dinesh-Kumar Wen-Xing Ding Clark W Distelhorst Abhinav Diwan Mojgan Djavaheri-Mergny Svetlana Dokudovskaya Zheng Dong Frank C Dorsey Victor Dosenko James J Dowling Stephen Doxsey Marlène Dreux Mark E Drew Qiuhong Duan Michel A Duchosal Karen Duff Isabelle Dugail Madeleine Durbeej Michael Duszenko Charles L Edelstein Aimee L Edinger Gustavo Egea Ludwig Eichinger N Tony Eissa Suhendan Ekmekcioglu Wafik S El-Deiry Zvulun Elazar Mohamed Elgendy Lisa M Ellerby Kai Er Eng Anna-Mart Engelbrecht Simone Engelender Jekaterina Erenpreisa Ricardo Escalante Audrey Esclatine Eeva-Liisa Eskelinen Lucile Espert Virginia Espina Huizhou Fan Jia Fan Qi-Wen Fan Zhen Fan Shengyun Fang Yongqi Fang Manolis Fanto Alessandro Fanzani Thomas Farkas Jean-Claude Farré Mathias Faure Marcus Fechheimer Carl G Feng Jian Feng Qili Feng Youji Feng László Fésüs Ralph Feuer Maria E Figueiredo-Pereira Gian Maria Fimia Diane C Fingar Steven Finkbeiner Toren Finkel Kim D Finley Filomena Fiorito Edward A Fisher Paul B Fisher Marc Flajolet Maria L Florez-McClure Salvatore Florio Edward A Fon Francesco Fornai Franco Fortunato Rati Fotedar Daniel H Fowler Howard S Fox Rodrigo Franco Lisa B Frankel Marc Fransen José M Fuentes Juan Fueyo Jun Fujii Kozo Fujisaki Eriko Fujita Mitsunori Fukuda Ruth H Furukawa Matthias Gaestel Philippe Gailly Malgorzata Gajewska Brigitte Galliot Vincent Galy Subramaniam Ganesh Barry Ganetzky Ian G Ganley Fen-Biao Gao George F Gao Jinming Gao Lorena Garcia Guillermo Garcia-Manero Mikel Garcia-Marcos Marjan Garmyn Andrei L Gartel Evelina Gatti Mathias Gautel Thomas R Gawriluk Matthew E Gegg Jiefei Geng Marc Germain Jason E Gestwicki David A Gewirtz Saeid Ghavami Pradipta Ghosh Anna M Giammarioli Alexandra N Giatromanolaki Spencer B Gibson Robert W Gilkerson Michael L Ginger Henry N Ginsberg Jakub Golab Michael S Goligorsky Pierre Golstein Candelaria Gomez-Manzano Ebru Goncu Céline Gongora Claudio D Gonzalez Ramon Gonzalez Cristina González-Estévez Rosa Ana González-Polo Elena Gonzalez-Rey Nikolai V Gorbunov Sharon Gorski Sandro Goruppi Roberta A Gottlieb Devrim Gozuacik Giovanna Elvira Granato Gary D Grant Kim N Green Aleš Gregorc Frédéric Gros Charles Grose Thomas W Grunt Philippe Gual Jun-Lin Guan Kun-Liang Guan Sylvie M Guichard Anna S Gukovskaya Ilya Gukovsky Jan Gunst Asa B Gustafsson Andrew J Halayko Amber N Hale Sandra K Halonen Maho Hamasaki Feng Han Ting Han Michael K Hancock Malene Hansen Hisashi Harada Masaru Harada Stefan E Hardt J Wade Harper Adrian L Harris James Harris Steven D Harris Makoto Hashimoto Jeffrey A Haspel Shin-ichiro Hayashi Lori A Hazelhurst Congcong He You-Wen He Marie-Joseé Hébert Kim A Heidenreich Miep H Helfrich Gudmundur V Helgason Elizabeth P Henske Brian Herman Paul K Herman Claudio Hetz Sabine Hilfiker Joseph A Hill Lynne J Hocking Paul Hofman Thomas G Hofmann Jörg Höhfeld Tessa L Holyoake Ming-Huang Hong David A Hood Gökhan S Hotamisligil Ewout J Houwerzijl Maria Høyer-Hansen Bingren Hu Chien-An A Hu Hong-Ming Hu Ya Hua Canhua Huang Ju Huang Shengbing Huang Wei-Pang Huang Tobias B Huber Won-Ki Huh Tai-Ho Hung Ted R Hupp Gang Min Hur James B Hurley Sabah N A Hussain Patrick J Hussey Jung Jin Hwang Seungmin Hwang Atsuhiro Ichihara Shirin Ilkhanizadeh Ken Inoki Takeshi Into Valentina Iovane Juan L Iovanna Nancy Y Ip Yoshitaka Isaka Hiroyuki Ishida Ciro Isidoro Ken-ichi Isobe Akiko Iwasaki Marta Izquierdo Yotaro Izumi Panu M Jaakkola Marja Jäättelä George R Jackson William T Jackson Bassam Janji Marina Jendrach Ju-Hong Jeon Eui-Bae Jeung Hong Jiang Hongchi Jiang Jean X Jiang Ming Jiang Qing Jiang Xuejun Jiang Xuejun Jiang Alberto Jiménez Meiyan Jin Shengkan Jin Cheol O Joe Terje Johansen Daniel E Johnson Gail V W Johnson Nicola L Jones Bertrand Joseph Suresh K Joseph Annie M Joubert Gábor Juhász Lucienne Juillerat-Jeanneret Chang Hwa Jung Yong-Keun Jung Kai Kaarniranta Allen Kaasik Tomohiro Kabuta Motoni Kadowaki Katarina Kagedal Yoshiaki Kamada Vitaliy O Kaminskyy Harm H Kampinga Hiromitsu Kanamori Chanhee Kang Khong Bee Kang Kwang Il Kang Rui Kang Yoon-A Kang Tomotake Kanki Thirumala-Devi Kanneganti Haruo Kanno Anumantha G Kanthasamy Arthi Kanthasamy Vassiliki Karantza Gur P Kaushal Susmita Kaushik Yoshinori Kawazoe Po-Yuan Ke John H Kehrl Ameeta Kelekar Claus Kerkhoff David H Kessel Hany Khalil Jan A K W Kiel Amy A Kiger Akio Kihara Deok Ryong Kim Do-Hyung Kim Dong-Hou Kim Eun-Kyoung Kim Hyung-Ryong Kim Jae-Sung Kim Jeong Hun Kim Jin Cheon Kim John K Kim Peter K Kim Seong Who Kim Yong-Sun Kim Yonghyun Kim Adi Kimchi Alec C Kimmelman Jason S King Timothy J Kinsella Vladimir Kirkin Lorrie A Kirshenbaum Katsuhiko Kitamoto Kaio Kitazato Ludger Klein Walter T Klimecki Jochen Klucken Erwin Knecht Ben C B Ko Jan C Koch Hiroshi Koga Jae-Young Koh Young Ho Koh Masato Koike Masaaki Komatsu Eiki Kominami Hee Jeong Kong Wei-Jia Kong Viktor I Korolchuk Yaichiro Kotake Michael I Koukourakis Juan B Kouri Flores Attila L Kovács Claudine Kraft Dimitri Krainc Helmut Krämer Carole Kretz-Remy Anna M Krichevsky Guido Kroemer Rejko Krüger Oleg Krut Nicholas T Ktistakis Chia-Yi Kuan Roza Kucharczyk Ashok Kumar Raj Kumar Sharad Kumar Mondira Kundu Hsing-Jien Kung Tino Kurz Ho Jeong Kwon Albert R La Spada Frank Lafont Trond Lamark Jacques Landry Jon D Lane Pierre Lapaquette Jocelyn F Laporte Lajos László Sergio Lavandero Josée N Lavoie Robert Layfield Pedro A Lazo Weidong Le Laurent Le Cam Daniel J Ledbetter Alvin J X Lee Byung-Wan Lee Gyun Min Lee Jongdae Lee Ju-Hyun Lee Michael Lee Myung-Shik Lee Sug Hyung Lee Christiaan Leeuwenburgh Patrick Legembre Renaud Legouis Michael Lehmann Huan-Yao Lei Qun-Ying Lei David A Leib José Leiro John J Lemasters Antoinette Lemoine Maciej S Lesniak Dina Lev Victor V Levenson Beth Levine Efrat Levy Faqiang Li Jun-Lin Li Lian Li Sheng Li Weijie Li Xue-Jun Li Yan-bo Li Yi-Ping Li Chengyu Liang Qiangrong Liang Yung-Feng Liao Pawel P Liberski Andrew Lieberman Hyunjung J Lim Kah-Leong Lim Kyu Lim Chiou-Feng Lin Fu-Cheng Lin Jian Lin Jiandie D Lin Kui Lin Wan-Wan Lin Weei-Chin Lin Yi-Ling Lin Rafael Linden Paul Lingor Jennifer Lippincott-Schwartz Michael P Lisanti Paloma B Liton Bo Liu Chun-Feng Liu Kaiyu Liu Leyuan Liu Qiong A Liu Wei Liu Young-Chau Liu Yule Liu Richard A Lockshin Chun-Nam Lok Sagar Lonial Benjamin Loos Gabriel Lopez-Berestein Carlos López-Otín Laura Lossi Michael T Lotze Peter Lőw Binfeng Lu Bingwei Lu Bo Lu Zhen Lu Frédéric Luciano Nicholas W Lukacs Anders H Lund Melinda A Lynch-Day Yong Ma Fernando Macian Jeff P MacKeigan Kay F Macleod Frank Madeo Luigi Maiuri Maria Chiara Maiuri Davide Malagoli May Christine V Malicdan Walter Malorni Na Man Eva-Maria Mandelkow Stéphen Manon Irena Manov Kai Mao Xiang Mao Zixu Mao Philippe Marambaud Daniela Marazziti Yves L Marcel Katie Marchbank Piero Marchetti Stefan J Marciniak Mateus Marcondes Mohsen Mardi Gabriella Marfe Guillermo Mariño Maria Markaki Mark R Marten Seamus J Martin Camille Martinand-Mari Wim Martinet Marta Martinez-Vicente Matilde Masini Paola Matarrese Saburo Matsuo Raffaele Matteoni Andreas Mayer Nathalie M Mazure David J McConkey Melanie J McConnell Catherine McDermott Christine McDonald Gerald M McInerney Sharon L McKenna BethAnn McLaughlin Pamela J McLean Christopher R McMaster G Angus McQuibban Alfred J Meijer Miriam H Meisler Alicia Meléndez Thomas J Melia Gerry Melino Maria A Mena Javier A Menendez Rubem F S Menna-Barreto Manoj B Menon Fiona M Menzies Carol A Mercer Adalberto Merighi Diane E Merry Stefania Meschini Christian G Meyer Thomas F Meyer Chao-Yu Miao Jun-Ying Miao Paul A M Michels Carine Michiels Dalibor Mijaljica Ana Milojkovic Saverio Minucci Clelia Miracco Cindy K Miranti Ioannis Mitroulis Keisuke Miyazawa Noboru Mizushima Baharia Mograbi Simin Mohseni Xavier Molero Bertrand Mollereau Faustino Mollinedo Takashi Momoi Iryna Monastyrska Martha M Monick Mervyn J Monteiro Michael N Moore Rodrigo Mora Kevin Moreau Paula I Moreira Yuji Moriyasu Jorge Moscat Serge Mostowy Jeremy C Mottram Tomasz Motyl Charbel E-H Moussa Sylke Müller Sylviane Muller Karl Münger Christian Münz Leon O Murphy Maureen E Murphy Antonio Musarò Indira Mysorekar Eiichiro Nagata Kazuhiro Nagata Aimable Nahimana Usha Nair Toshiyuki Nakagawa Kiichi Nakahira Hiroyasu Nakano Hitoshi Nakatogawa Meera Nanjundan Naweed I Naqvi Derek P Narendra Masashi Narita Miguel Navarro Steffan T Nawrocki Taras Y Nazarko Andriy Nemchenko Mihai G Netea Thomas P Neufeld Paul A Ney Ioannis P Nezis Huu Phuc Nguyen Daotai Nie Ichizo Nishino Corey Nislow Ralph A Nixon Takeshi Noda Angelika A Noegel Anna Nogalska Satoru Noguchi Lucia Notterpek Ivana Novak Tomoyoshi Nozaki Nobuyuki Nukina Thorsten Nürnberger Beat Nyfeler Keisuke Obara Terry D Oberley Salvatore Oddo Michinaga Ogawa Toya Ohashi Koji Okamoto Nancy L Oleinick F Javier Oliver Laura J Olsen Stefan Olsson Onya Opota Timothy F Osborne Gary K Ostrander Kinya Otsu Jing-hsiung James Ou Mireille Ouimet Michael Overholtzer Bulent Ozpolat Paolo Paganetti Ugo Pagnini Nicolas Pallet Glen E Palmer Camilla Palumbo Tianhong Pan Theocharis Panaretakis Udai Bhan Pandey Zuzana Papackova Issidora Papassideri Irmgard Paris Junsoo Park Ohkmae K Park Jan B Parys Katherine R Parzych Susann Patschan Cam Patterson Sophie Pattingre John M Pawelek Jianxin Peng David H Perlmutter Ida Perrotta George Perry Shazib Pervaiz Matthias Peter Godefridus J Peters Morten Petersen Goran Petrovski James M Phang Mauro Piacentini Philippe Pierre Valérie Pierrefite-Carle Gérard Pierron Ronit Pinkas-Kramarski Antonio Piras Natik Piri Leonidas C Platanias Stefanie Pöggeler Marc Poirot Angelo Poletti Christian Poüs Mercedes Pozuelo-Rubio Mette Prætorius-Ibba Anil Prasad Mark Prescott Muriel Priault Nathalie Produit-Zengaffinen Ann Progulske-Fox Tassula Proikas-Cezanne Serge Przedborski Karin Przyklenk Rosa Puertollano Julien Puyal Shu-Bing Qian Liang Qin Zheng-Hong Qin Susan E Quaggin Nina Raben Hannah Rabinowich Simon W Rabkin Irfan Rahman Abdelhaq Rami Georg Ramm Glenn Randall Felix Randow V Ashutosh Rao Jeffrey C Rathmell Brinda Ravikumar Swapan K Ray Bruce H Reed John C Reed Fulvio Reggiori Anne Régnier-Vigouroux Andreas S Reichert John J Reiners Russel J Reiter Jun Ren José L Revuelta Christopher J Rhodes Konstantinos Ritis Elizete Rizzo Jeffrey Robbins Michel Roberge Hernan Roca Maria C Roccheri Stephane Rocchi H Peter Rodemann Santiago Rodríguez de Córdoba Bärbel Rohrer Igor B Roninson Kirill Rosen Magdalena M Rost-Roszkowska Mustapha Rouis Kasper M A Rouschop Francesca Rovetta Brian P Rubin David C Rubinsztein Klaus Ruckdeschel Edmund B Rucker Assaf Rudich Emil Rudolf Nelson Ruiz-Opazo Rossella Russo Tor Erik Rusten Kevin M Ryan Stefan W Ryter David M Sabatini Junichi Sadoshima Tapas Saha Tatsuya Saitoh Hiroshi Sakagami Yasuyoshi Sakai Ghasem Hoseini Salekdeh Paolo Salomoni Paul M Salvaterra Guy Salvesen Rosa Salvioli Anthony M J Sanchez José A Sánchez-Alcázar Ricardo Sánchez-Prieto Marco Sandri Uma Sankar Poonam Sansanwal Laura Santambrogio Shweta Saran Sovan Sarkar Minnie Sarwal Chihiro Sasakawa Ausra Sasnauskiene Miklós Sass Ken Sato Miyuki Sato Anthony H V Schapira Michael Scharl Hermann M Schätzl Wiep Scheper Stefano Schiaffino Claudio Schneider Marion E Schneider Regine Schneider-Stock Patricia V Schoenlein Daniel F Schorderet Christoph Schüller Gary K Schwartz Luca Scorrano Linda Sealy Per O Seglen Juan Segura-Aguilar Iban Seiliez Oleksandr Seleverstov Christian Sell Jong Bok Seo Duska Separovic Vijayasaradhi Setaluri Takao Setoguchi Carmine Settembre John J Shacka Mala Shanmugam Irving M Shapiro Eitan Shaulian Reuben J Shaw James H Shelhamer Han-Ming Shen Wei-Chiang Shen Zu-Hang Sheng Yang Shi Kenichi Shibuya Yoshihiro Shidoji Jeng-Jer Shieh Chwen-Ming Shih Yohta Shimada Shigeomi Shimizu Takahiro Shintani Orian S Shirihai Gordon C Shore Andriy A Sibirny Stan B Sidhu Beata Sikorska Elaine C M Silva-Zacarin Alison Simmons Anna Katharina Simon Hans-Uwe Simon Cristiano Simone Anne Simonsen David A Sinclair Rajat Singh Debasish Sinha Frank A Sinicrope Agnieszka Sirko Parco M Siu Efthimios Sivridis Vojtech Skop Vladimir P Skulachev Ruth S Slack Soraya S Smaili Duncan R Smith Maria S Soengas Thierry Soldati Xueqin Song Anil K Sood Tuck Wah Soong Federica Sotgia Stephen A Spector Claudia D Spies Wolfdieter Springer Srinivasa M Srinivasula Leonidas Stefanis Joan S Steffan Ruediger Stendel Harald Stenmark Anastasis Stephanou Stephan T Stern Cinthya Sternberg Björn Stork Peter Strålfors Carlos S Subauste Xinbing Sui David Sulzer Jiaren Sun Shi-Yong Sun Zhi-Jun Sun Joseph J Y Sung Kuninori Suzuki Toshihiko Suzuki Michele S Swanson Charles Swanton Sean T Sweeney Lai-King Sy Gyorgy Szabadkai Ira Tabas Heinrich Taegtmeyer Marco Tafani Krisztina Takács-Vellai Yoshitaka Takano Kaoru Takegawa Genzou Takemura Fumihiko Takeshita Nicholas J Talbot Kevin S W Tan Keiji Tanaka Kozo Tanaka Daolin Tang Dingzhong Tang Isei Tanida Bakhos A Tannous Nektarios Tavernarakis Graham S Taylor Gregory A Taylor J Paul Taylor Lance S Terada Alexei Terman Gianluca Tettamanti Karin Thevissen Craig B Thompson Andrew Thorburn Michael Thumm FengFeng Tian Yuan Tian Glauco Tocchini-Valentini Aviva M Tolkovsky Yasuhiko Tomino Lars Tönges Sharon A Tooze Cathy Tournier John Tower Roberto Towns Vladimir Trajkovic Leonardo H Travassos Ting-Fen Tsai Mario P Tschan Takeshi Tsubata Allan Tsung Boris Turk Lorianne S Turner Suresh C Tyagi Yasuo Uchiyama Takashi Ueno Midori Umekawa Rika Umemiya-Shirafuji Vivek K Unni Maria I Vaccaro Enza Maria Valente Greet Van den Berghe Ida J van der Klei Wouter van Doorn Linda F van Dyk Marjolein van Egmond Leo A van Grunsven Peter Vandenabeele Wim P Vandenberghe Ilse Vanhorebeek Eva C Vaquero Guillermo Velasco Tibor Vellai Jose Miguel Vicencio Richard D Vierstra Miquel Vila Cécile Vindis Giampietro Viola Maria Teresa Viscomi Olga V Voitsekhovskaja Clarissa von Haefen Marcela Votruba Keiji Wada Richard Wade-Martins Cheryl L Walker Craig M Walsh Jochen Walter Xiang-Bo Wan Aimin Wang Chenguang Wang Dawei Wang Fan Wang Fen Wang Guanghui Wang Haichao Wang Hong-Gang Wang Horng-Dar Wang Jin Wang Ke Wang Mei Wang Richard C Wang Xinglong Wang Xuejun Wang Ying-Jan Wang Yipeng Wang Zhen Wang Zhigang Charles Wang Zhinong Wang Derick G Wansink Diane M Ward Hirotaka Watada Sarah L Waters Paul Webster Lixin Wei Conrad C Weihl William A Weiss Scott M Welford Long-Ping Wen Caroline A Whitehouse J Lindsay Whitton Alexander J Whitworth Tom Wileman John W Wiley Simon Wilkinson Dieter Willbold Roger L Williams Peter R Williamson Bradly G Wouters Chenghan Wu Dao-Cheng Wu William K K Wu Andreas Wyttenbach Ramnik J Xavier Zhijun Xi Pu Xia Gengfu Xiao Zhiping Xie Zhonglin Xie Da-zhi Xu Jianzhen Xu Liang Xu Xiaolei Xu Ai Yamamoto Akitsugu Yamamoto Shunhei Yamashina Michiaki Yamashita Xianghua Yan Mitsuhiro Yanagida Dun-Sheng Yang Elizabeth Yang Jin-Ming Yang Shi Yu Yang Wannian Yang Wei Yuan Yang Zhifen Yang Meng-Chao Yao Tso-Pang Yao Behzad Yeganeh Wei-Lien Yen Jia-jing Yin Xiao-Ming Yin Ook-Joon Yoo Gyesoon Yoon Seung-Yong Yoon Tomohiro Yorimitsu Yuko Yoshikawa Tamotsu Yoshimori Kohki Yoshimoto Ho Jin You Richard J Youle Anas Younes Li Yu Long Yu Seong-Woon Yu Wai Haung Yu Zhi-Min Yuan Zhenyu Yue Cheol-Heui Yun Michisuke Yuzaki Olga Zabirnyk Elaine Silva-Zacarin David Zacks Eldad Zacksenhaus Nadia Zaffaroni Zahra Zakeri Herbert J Zeh Scott O Zeitlin Hong Zhang Hui-Ling Zhang Jianhua Zhang Jing-Pu Zhang Lin Zhang Long Zhang Ming-Yong Zhang Xu Dong Zhang Mantong Zhao Yi-Fang Zhao Ying Zhao Zhizhuang J Zhao Xiaoxiang Zheng Boris Zhivotovsky Qing Zhong Cong-Zhao Zhou Changlian Zhu Wei-Guo Zhu Xiao-Feng Zhu Xiongwei Zhu Yuangang Zhu Teresa Zoladek Wei-Xing Zong Antonio Zorzano Jürgen Zschocke Brian Zuckerbraun

Autophagy 2012 Apr;8(4):445-544

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

View Article

Download full-text PDF

Source
http://www.dwalab.ca/common/pdf/cdd200944a.pdf
Web Search
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404883PMC
http://dx.doi.org/10.4161/auto.19496DOI Listing
April 2012

Measurement of proteasomal dysfunction in cell models of dopaminergic degeneration.

Methods Mol Biol 2011 ;758:293-305

Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa Center for Advanced Neurotoxicology, Iowa State University, Ames, IA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-61779-170-3_20DOI Listing
November 2011

Dopaminergic neurotoxicant 6-OHDA induces oxidative damage through proteolytic activation of PKCδ in cell culture and animal models of Parkinson's disease.

Toxicol Appl Pharmacol 2011 Nov 6;256(3):314-23. Epub 2011 Aug 6.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.taap.2011.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205342PMC
November 2011

Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells.

Toxicol Appl Pharmacol 2011 Nov 5;256(3):227-40. Epub 2011 Aug 5.

Department of Biomedical Sciences, Iowa Center for Advanced Neurotoxicology, Iowa State University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.taap.2011.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205240PMC
November 2011

Infectious prion protein alters manganese transport and neurotoxicity in a cell culture model of prion disease.

Neurotoxicology 2011 Oct 19;32(5):554-62. Epub 2011 Aug 19.

Department of Biomedical Sciences, Iowa Center for Advanced Neurotoxicity, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2011.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205977PMC
October 2011

Effects of manganese on tyrosine hydroxylase (TH) activity and TH-phosphorylation in a dopaminergic neural cell line.

Toxicol Appl Pharmacol 2011 Jul 15;254(2):65-71. Epub 2011 Feb 15.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011-1250, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.taap.2010.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107879PMC
July 2011

Transcriptional regulation of pro-apoptotic protein kinase Cdelta: implications for oxidative stress-induced neuronal cell death.

J Biol Chem 2011 Jun 5;286(22):19840-59. Epub 2011 Apr 5.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M110.203687
Publisher Site
http://dx.doi.org/10.1074/jbc.M110.203687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103361PMC
June 2011

α-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity.

J Neurosci 2011 Feb;31(6):2035-51

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.5634-10.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041642PMC
February 2011

A simple magnetic separation method for high-yield isolation of pure primary microglia.

J Neurosci Methods 2011 Jan 11;194(2):287-96. Epub 2010 Nov 11.

Department of Biomedical Sciences, Iowa Center for Advanced Neurotoxicology, Iowa State University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jneumeth.2010.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205446PMC
January 2011

Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model.

Free Radic Biol Med 2010 Dec 7;49(11):1674-84. Epub 2010 Sep 7.

Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2010.08.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020411PMC
December 2010

Novel cell death signaling pathways in neurotoxicity models of dopaminergic degeneration: relevance to oxidative stress and neuroinflammation in Parkinson's disease.

Neurotoxicology 2010 Sep 11;31(5):555-61. Epub 2009 Dec 11.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2009.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888638PMC
September 2010

Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: relevance to role of metals in pathogenesis of prion disease.

Toxicol Sci 2010 Jun 22;115(2):535-46. Epub 2010 Feb 22.

Department of Biomedical Sciences, Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Iowa State University, Ames, Iowa 50011, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/toxsci/article/1731367/Manganese
Publisher Site
http://dx.doi.org/10.1093/toxsci/kfq049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871751PMC
June 2010

Vanadium induces dopaminergic neurotoxicity via protein kinase Cdelta dependent oxidative signaling mechanisms: relevance to etiopathogenesis of Parkinson's disease.

Toxicol Appl Pharmacol 2009 Oct 29;240(2):273-85. Epub 2009 Jul 29.

Department of Biomedical Sciences, Iowa Center for Advanced Neurotoxicology, Iowa State University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.taap.2009.07.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753722PMC
October 2009

Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys-48 and -63.

J Cell Mol Med 2009 Aug 11;13(8B):1632-43. Epub 2009 May 11.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1582-4934.2009.00775.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819597PMC
August 2009

Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCdelta proteolytic activation and mitochondrial translocation.

J Cell Mol Med 2008 Dec 24;12(6A):2467-81. Epub 2008 Feb 24.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1582-4934.2008.00293.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957660PMC
December 2008

Opposing roles of prion protein in oxidative stress- and ER stress-induced apoptotic signaling.

Free Radic Biol Med 2008 Dec 13;45(11):1530-41. Epub 2008 Sep 13.

Department of Biomedical Sciences, Iowa Center for Advanced Neurotoxicology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2008.08.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628483PMC
December 2008

Chronic low-dose oxidative stress induces caspase-3-dependent PKCdelta proteolytic activation and apoptosis in a cell culture model of dopaminergic neurodegeneration.

Ann N Y Acad Sci 2008 Oct;1139:197-205

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, and Department of Biomedical Sciences, Iowa State University, Ames, Iowa, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1196/annals.1432.020
Publisher Site
http://dx.doi.org/10.1196/annals.1432.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657189PMC
October 2008

Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.

J Pharmacol Exp Ther 2007 Sep 12;322(3):913-22. Epub 2007 Jun 12.

Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa Center for Advanced Neurotoxicology, Iowa State University, Ames, IA 50011-1250, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.107.124669DOI Listing
September 2007

Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells.

Neurotoxicology 2007 Sep 25;28(5):988-97. Epub 2007 Aug 25.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011-1250, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S0161813X0700172
Publisher Site
http://dx.doi.org/10.1016/j.neuro.2007.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140261PMC
September 2007

Normal cellular prion protein protects against manganese-induced oxidative stress and apoptotic cell death.

Toxicol Sci 2007 Aug 4;98(2):495-509. Epub 2007 May 4.

Neuroscience and Toxicology Graduate Programs, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/toxsci/article-lookup/doi/10.1093/t
Publisher Site
http://dx.doi.org/10.1093/toxsci/kfm099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407037PMC
August 2007

Environmental neurotoxic chemicals-induced ubiquitin proteasome system dysfunction in the pathogenesis and progression of Parkinson's disease.

Pharmacol Ther 2007 Jun 19;114(3):327-44. Epub 2007 Apr 19.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011-1250, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharmthera.2007.04.001DOI Listing
June 2007

Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: relevance to oxidative damage in Parkinson's disease.

Neurochem Int 2007 May 23;50(6):834-47. Epub 2007 Feb 23.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011-1250, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2007.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950670PMC
May 2007

Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons.

J Neurosci 2007 May;27(20):5349-62

Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.4107-06.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407040PMC
May 2007

A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models.

Free Radic Biol Med 2006 Nov 25;41(10):1578-89. Epub 2006 Aug 25.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, 2008 Veterinary Medicine Building, Iowa State University, Ames, IA 50011-1250, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2006.08.016DOI Listing
November 2006

Interaction of metals with prion protein: possible role of divalent cations in the pathogenesis of prion diseases.

Neurotoxicology 2006 Sep 18;27(5):777-87. Epub 2006 Jun 18.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, 2062 Veterinary Medicine Building, Ames, IA 50011-1250, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2006.06.004DOI Listing
September 2006

Proteasome inhibitor MG-132 induces dopaminergic degeneration in cell culture and animal models.

Neurotoxicology 2006 Sep 29;27(5):807-15. Epub 2006 Jun 29.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, 2062 Veterinary Medicine Building, Ames, IA 50011-1250, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2006.06.006DOI Listing
September 2006

Methamphetamine induces autophagy and apoptosis in a mesencephalic dopaminergic neuronal culture model: role of cathepsin-D in methamphetamine-induced apoptotic cell death.

Ann N Y Acad Sci 2006 Aug;1074:234-44

Parkinson Disorders Research Laboratory, Department of Biomedical Sciences, 2062 Veterinary Medicine Building, Iowa State University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1196/annals.1369.022DOI Listing
August 2006

Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death.

Brain Res Mol Brain Res 2005 Sep;139(1):137-52

Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, 2062, Veterinary Medicine Building, Iowa Sate University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molbrainres.2005.05.022DOI Listing
September 2005

Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells.

J Biol Chem 2005 Aug 16;280(31):28721-30. Epub 2005 Jun 16.

Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M501092200DOI Listing
August 2005

Dieldrin-induced neurotoxicity: relevance to Parkinson's disease pathogenesis.

Neurotoxicology 2005 Aug;26(4):701-19

Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011-1250, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2004.07.010DOI Listing
August 2005

Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells.

J Pharmacol Exp Ther 2005 Apr 17;313(1):46-55. Epub 2004 Dec 17.

Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, 2008 Veterinary Medicine Bldg., Iowa State University, Ames, IA 50011-1250, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.104.078469DOI Listing
April 2005

Activation of protein kinase C delta by proteolytic cleavage contributes to manganese-induced apoptosis in dopaminergic cells: protective role of Bcl-2.

Biochem Pharmacol 2005 Jan;69(1):133-46

Parkinson Disorders Research Laboratory, Department of Biomedical Sciences, Iowa State University, 2062 Vetmed, Ames, IA 50011-1250, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S000629520400616
Publisher Site
http://dx.doi.org/10.1016/j.bcp.2004.08.035DOI Listing
January 2005

Dieldrin promotes proteolytic cleavage of poly(ADP-ribose) polymerase and apoptosis in dopaminergic cells: protective effect of mitochondrial anti-apoptotic protein Bcl-2.

Neurotoxicology 2004 Jun;25(4):589-98

Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, 2062 Veterinary Medicine Building, Ames, IA 50011-1250 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2003.09.014DOI Listing
June 2004

Role of proteolytic activation of protein kinase Cdelta in oxidative stress-induced apoptosis.

Antioxid Redox Signal 2003 Oct;5(5):609-20

Parkinson's Disorders Research Program, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/152308603770310275DOI Listing
October 2003

Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration.

Eur J Neurosci 2003 Sep;18(6):1387-401

Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, 2062 Veterinary Medicine Building, Iowa Sate University, Ames, IA 50011, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1460-9568.2003.02864.xDOI Listing
September 2003