Publications by authors named "Arshad Desai"

134Publications

A tripartite mechanism catalyzes Mad2-Cdc20 assembly at unattached kinetochores.

Science 2021 01;371(6524):64-67

Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.

View Article and Find Full Text PDF
January 2021

A Non-canonical BRCT-Phosphopeptide Recognition Mechanism Underlies RhoA Activation in Cytokinesis.

Curr Biol 2020 Aug 2;30(16):3101-3115.e11. Epub 2020 Jul 2.

Ludwig Institute for Cancer Research, La Jolla, CA 92093, USA; Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA. Electronic address:

View Article and Find Full Text PDF
August 2020

Rashomon at the kinetochore: Function(s) of the Mad1-cyclin B1 complex.

J Cell Biol 2020 Aug;219(8)

Department of Cellular and Molecular Medicine and Section of Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA.

View Article and Find Full Text PDF
August 2020

A Semi-high-throughput Imaging Method and Data Visualization Toolkit to Analyze C. elegans Embryonic Development.

J Vis Exp 2019 10 29(152). Epub 2019 Oct 29.

Ludwig Institute for Cancer Research, San Diego; Department of Cellular and Molecular Medicine, University of California, San Diego;

View Article and Find Full Text PDF
October 2019

The G2-to-M Transition Is Ensured by a Dual Mechanism that Protects Cyclin B from Degradation by Cdc20-Activated APC/C.

Dev Cell 2019 11 3;51(3):313-325.e10. Epub 2019 Oct 3.

Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA, USA; Department of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

View Article and Find Full Text PDF
November 2019

Unbiased Boolean analysis of public gene expression data for cell cycle gene identification.

Mol Biol Cell 2019 07 15;30(14):1770-1779. Epub 2019 May 15.

Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093.

View Article and Find Full Text PDF
July 2019

Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan.

Nat Chem Biol 2019 05 25;15(5):453-462. Epub 2019 Mar 25.

The Skaggs Institute for Chemical Biology, Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.

View Article and Find Full Text PDF
May 2019

A high-content imaging approach to profile embryonic development.

Development 2019 04 11;146(7). Epub 2019 Apr 11.

Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA

View Article and Find Full Text PDF
April 2019

The Kinetochore-Microtubule Coupling Machinery Is Repurposed in Sensory Nervous System Morphogenesis.

Dev Cell 2019 03 28;48(6):864-872.e7. Epub 2019 Feb 28.

Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA 92093, USA; Department of Cellular & Molecular Medicine, University of California, San Diego, San Diego, La Jolla, CA 92093, USA. Electronic address:

View Article and Find Full Text PDF
March 2019

CFI-400945 is not a selective cellular PLK4 inhibitor.

Proc Natl Acad Sci U S A 2018 11 30;115(46):E10808-E10809. Epub 2018 Oct 30.

Small Molecule Discovery Program, Ludwig Institute for Cancer Research, La Jolla, CA 92093

View Article and Find Full Text PDF
November 2018

Promoting an "Auteur Theory" for Young Scientists: Preserving Excitement and Creativity ….

Bioessays 2018 11 19;40(11):e1800147. Epub 2018 Sep 19.

Department of Physics and Section of Molecular Biology, Division of Biology, University of California San Diego, La Jolla, CA, 92093, USA.

View Article and Find Full Text PDF
November 2018

CYK-4 functions independently of its centralspindlin partner ZEN-4 to cellularize oocytes in germline syncytia.

Elife 2018 07 10;7. Epub 2018 Jul 10.

Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, United States.

View Article and Find Full Text PDF
July 2018

A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis in .

Elife 2018 07 2;7. Epub 2018 Jul 2.

Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, San Diego, United States.

View Article and Find Full Text PDF
July 2018

Employing the one-cell C. elegans embryo to study cell division processes.

Methods Cell Biol 2018 1;144:185-231. Epub 2018 May 1.

Ludwig Institute for Cancer Research, La Jolla, CA, United States; Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA, United States. Electronic address:

View Article and Find Full Text PDF
December 2018

Cdc73 suppresses genome instability by mediating telomere homeostasis.

PLoS Genet 2018 01 10;14(1):e1007170. Epub 2018 Jan 10.

Ludwig Institute for Cancer Research, San Diego Branch, San Diego, California, United States of America.

View Article and Find Full Text PDF
January 2018