Publications by authors named "Arsen Ghasabyan"

22Publications

Tranexamic acid is associated with reduced complement activation in trauma patients with hemorrhagic shock and hyperfibrinolysis on thromboelastography.

Blood Coagul Fibrinolysis 2020 Jul 27. Epub 2020 Jul 27.

Departments of Biological Engineering and Biology, Center for Precision Cancer Medicine, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge.

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http://dx.doi.org/10.1097/MBC.0000000000000938DOI Listing
July 2020

Obesity is associated with postinjury hypercoagulability.

J Trauma Acute Care Surg 2019 10;87(4):876-882

From the Department of Surgery (J.M.S., J.R.C., J.J.S., A.B., A.S.), University of Colorado Denver; Department of Surgery (E.E.M., M.J.C., A.G., J.C.), Denver Health Medical Center; Department of Pediatrics (C.C.S.); and School of Public Health (A.S.), University of Colorado Aurora, Colorado.

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http://dx.doi.org/10.1097/TA.0000000000002414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773476PMC
October 2019

Variability in international normalized ratio and activated partial thromboplastin time after injury are not explained by coagulation factor deficits.

J Trauma Acute Care Surg 2019 09;87(3):582-589

From the Department of Surgery (G.R.S., E.E.M., H.B.M., G.R.N., J.R.C., A.C., M.J.C., C.C.S., A.B., A.S.), University of Colorado School of Medicine; Denver Health Medical Center (E.E.M., A.G., M.J.C.); Department of Pediatrics (C.C.S.), University of Colorado School of Medicine; Bonfils Blood Center (C.C.S.), and University of Colorado School of Public Health (A.S.). Denver, Colorado.

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http://dx.doi.org/10.1097/TA.0000000000002385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713266PMC
September 2019

Trauma Resuscitation Consideration: Sex Matters.

J Am Coll Surg 2019 05 21;228(5):760-768.e1. Epub 2019 Jan 21.

Department of Surgery, University of Colorado-Denver, Aurora, CO. Electronic address:

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http://dx.doi.org/10.1016/j.jamcollsurg.2019.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487203PMC
May 2019

Severe traumatic brain injury is associated with a unique coagulopathy phenotype.

J Trauma Acute Care Surg 2019 04;86(4):686-693

From the Department of Surgery (J.M.S., A.B., J.R.C.), University of Colorado Denver; Department of Surgery (E.E.M., M.J.C., A.G., J.C.), Denver Health Medical Center; Department of Pediatrics (C.C.S.), University of Colorado School of Public Health (A.S.), Aurora, CO.

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http://Insights.ovid.com/crossref?an=01586154-900000000-9844
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http://dx.doi.org/10.1097/TA.0000000000002173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682404PMC
April 2019

Empiric transfusion strategies during life-threatening hemorrhage.

Surgery 2018 08 27;164(2):306-311. Epub 2018 Apr 27.

University of Colorado School of Medicine Department of Surgery, Aurora, CO; University of Colorado School of Public Health, Aurora, CO.

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http://dx.doi.org/10.1016/j.surg.2018.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056322PMC
August 2018

Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator.

J Trauma Acute Care Surg 2017 12;83(6):1014-1022

From the Department of Surgery (H.B.M., E.E.M., B.R.H., M.D., G.R.S., G.R.N., P.J.L., A.B., C.S., A.S., K.C.H.), University of Colorado; Denver Health Medical Center (E.E.M., A.G., J.C.); and University of Colorado School of Public Health (A.S.), Denver, Colorado.

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http://dx.doi.org/10.1097/TA.0000000000001718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726780PMC
December 2017

All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock-A comparison in rodents, swine, nonhuman primates, and injured patients.

J Trauma Acute Care Surg 2018 03;84(3):537-541

From the Department of Biochemistry and Molecular Genetics (J.A.R., M.J.W., K.C.H., A.D.), University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado; Denver Health Hospital - (E.E.M., A.G., J.C.), Denver, Colorado; Department of Surgery (A.L.S., H.B.M., M.F., G.N., A.B.), University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado; Naval Medical Research Unit San Antonio (L.J.S., F.R.S.), JBSA-Ft. Sam Houston, Texas; Department of Paediatrics (C.C.S.), University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado; and Bonfils Blood Center (C.C.S.), Denver, Colorado.

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http://dx.doi.org/10.1097/TA.0000000000001721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820217PMC
March 2018

Platelet adenosine diphosphate receptor inhibition provides no advantage in predicting need for platelet transfusion or massive transfusion.

Surgery 2017 12 28;162(6):1286-1294. Epub 2017 Sep 28.

Department of Surgery, University of Colorado School of Medicine, Denver, CO; Department of Health Systems, Management & Policy, University of Colorado School of Public Health, Denver, CO.

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http://dx.doi.org/10.1016/j.surg.2017.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694384PMC
December 2017

Goal-directed Hemostatic Resuscitation of Trauma-induced Coagulopathy: A Pragmatic Randomized Clinical Trial Comparing a Viscoelastic Assay to Conventional Coagulation Assays.

Ann Surg 2016 Jun;263(6):1051-9

*Department of Surgery, University of Colorado, Denver, CO†Department of Surgery, Denver Health Medical Center, Denver, CO‡Department of Pediatrics, University of Colorado, Denver, CO§Research Laboratory, Bonfils Blood Center, Denver, CO¶Colorado School of Public Health, University of Colorado, Denver, CO.

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http://pdfs.journals.lww.com/annalsofsurgery/2016/06000/Goal
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http://dx.doi.org/10.1097/SLA.0000000000001608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432433PMC
June 2016

Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients.

J Trauma Acute Care Surg 2016 Jan;80(1):16-23; discussion 23-5

From the Department of Surgery (M.P.C., E.E.M, H.B.M, E.G., F.G.S., J.G.C., S.M., A.G., T.L.C., A.S., A.B., C.C.S.), University of Colorado-Denver; Department of Surgery, Denver Health Medical Center (M.P.C., E.E.M., H.B.M. E.G., J.G.C. A.G., T.L.C., A.S.); Department of Surgery, Georgia Regents University (M.P.C.); Department of Hematology and Oncology (C.C.S.), Children's Hospital Colorado; and Bonfils Blood Center (C.C.S.), Denver, Colorado.

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http://dx.doi.org/10.1097/TA.0000000000000885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688194PMC
January 2016

The "Death Diamond": Rapid thrombelastography identifies lethal hyperfibrinolysis.

J Trauma Acute Care Surg 2015 Dec;79(6):925-9

From the Department of Surgery (M.P.C., E.E.M., J.C., C.D.F., H.B.M., E.G., A.P.M., A.G., C.C.S., A.B., A.S.), University of Colorado Denver; Department of Surgery, Denver Health Medical Center (M.P.C., E.E.M., J.C., C.D.F., H.B.M., E.G., A.P.M., A.G.), Denver; and Bonfils Blood Center (C.C.S.), and Department of Hematology and Oncology (C.C.S.), Children's Hospital Colorado, Aurora, Colorado; Department of Surgery, Georgia Regents University (M.P.C.), Augusta, Georgia.

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http://dx.doi.org/10.1097/TA.0000000000000871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684985PMC
December 2015

Postinjury hyperfibrinogenemia compromises efficacy of heparin-based venous thromboembolism prophylaxis.

Shock 2014 Jan;41(1):33-9

*Department of Surgery, University of Colorado Denver, Aurora; †Department of Surgery, Denver Health Medical Center, Denver; ‡Trauma Research Center and §Department of Pediatrics, University of Colorado Denver, Aurora; and ∥Research Department, Bonfils Blood Center, Denver, Colorado.

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http://dx.doi.org/10.1097/SHK.0000000000000067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902785PMC
January 2014

Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy.

J Trauma Acute Care Surg 2013 Dec;75(6):961-7; discussion 967

From the Department of Surgery (M.P.C., C.R.R., J.N.H., T.L.C., J.R.S., A.S., A.B.), University of Colorado-Denver; Denver Health Medical Center (M.P.C., E.E.M., C.R.R., A.G., J.N.H., T.L.C., J.R.S., A.S.); Medical College of Georgia (M.P.C.); and Bonfils Blood Center (C.C.S.), Denver, Colorado.

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http://dx.doi.org/10.1097/TA.0b013e3182aa9c9fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072127PMC
December 2013