Aroona Razzaq

Aroona Razzaq

China

Main Specialties: Biochemical Genetics, Neurology

Additional Specialties: Visiting Lecture at The University of Faisalabad.


Top Author

Aroona Razzaq

Aroona Razzaq

Education

Oct 2019
Central South University, Changsha, Hunan, China
Researcher PhD Student (Biochemistry and Molecular Biology)
Dec 2018
GCUF, Pakistan
M.Phil/ Physiology
Jul 2016
GCUF, Pakistan
Bs (Hons)/ Physiology

Experience

Dec 2018
The University of Faisalabad, Pakistan
Lecturer
Worked as a visiting lecturer of Physiology at The University of Faisalabad
Dec 2018
GCUF, Pakistan
Lecturer
Work experience as a “Lecturer for undergraduates” as a part of my M. Phil tasks and internee in department of Physiology at Government College University Faisalabad.
Jun 2018
GCUF, Pakistan
Internee
Work experience as “Prime Minister Youth internee” for 1 year in department of Physiology at Government College University Faisalabad.
May 2016
PINUM Cancer Hospital, Faisalabad Pakistan
Internee
One month internship at PINUM Cancer Hospital in Ultrasound
May 2016
PINUM Cancer Hospital, Faisalabad Pakistan
Internee
One month internship at PINUM Cancer Hospital in Ultrasound
Apr 2016
Combined Military Hospital Lahore, Pakistan
Internee
One month internship in Chemical pathology department at Combined Military Hospital Lahore. Two weeks internship in Hematology and Serology Lab at Combined Military Hospital Lahore.
Jun 2014
Aziz Fatima hospital, millat chowk Faisalabad, Pakistan
Epidemiological researcher
Work experience in an epidemiological research project of Neurological disorders at Aziz Fatima hospital with 4 months duration.

Publications

8Publications

88Reads

31Profile Views

Foeniculum vulgare (Fennel) promotes functional recovery and ameliorates oxidative stress following a lesion to the sciatic nerve in mouse model.

J Food Biochem 2019 09 21;43(9):e12983. Epub 2019 Jul 21.

Neurochemicalbiology and Genetics Laboratory (NGL), Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad, Pakistan.

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http://dx.doi.org/10.1111/jfbc.12983DOI Listing
September 2019
0.741 Impact Factor

Putative Roles of Plant-Derived Tannins in Neurodegenerative and Neuropsychiatry Disorders: An Updated Review.

Molecules 2019 Jun 13;24(12). Epub 2019 Jun 13.

Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China.

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http://dx.doi.org/10.3390/molecules24122213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630756PMC
June 2019
16 Reads
2.416 Impact Factor

Supplementation of Cannabis sativa L. leaf powder accelerates functional recovery and ameliorates haemoglobin level following an induced injury to sciatic nerve in mouse model.

Pak J Pharm Sci 2019 Mar;32(2 (Supplementary)):785-792

Neurochemicalbiology and Genetics Laboratory (NGL), Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad, Pakistan.

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March 2019
3 Reads
0.950 Impact Factor

Role of cholesterol and sphingolipids in brain development and neurological diseases.

Lipids Health Dis 2019 Jan 25;18(1):26. Epub 2019 Jan 25.

Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, 361021, Fujian Province, China.

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https://lipidworld.biomedcentral.com/articles/10.1186/s12944
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http://dx.doi.org/10.1186/s12944-019-0965-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347843PMC
January 2019
31 Reads
2.219 Impact Factor

Lipids as Biomarkers of Brain Diseases

DOI: 10.1080/10408398.2018.1529653

Critical reviews in food science and nutrition

Brain is a central and pivotal organ of human body containing the highest lipids content next to adipose tissue. It works as a monitor for the whole body and needs an adequate supply of energy to maintain its physiological activities. This high demand of energy in the brain is chiefly maintained by the lipids along with its reservoirs. Thus, the lipid metabolism is also an important for the proper development and function of the brain. Being a prominent part of the brain, lipids play a vast number of physiological activities within the brain starting from the structural development, impulse conduction, insulation, neurogenesis, synaptogenesis, myelin sheath formation and finally to act as the signaling molecules. Interestingly, lipids bilayer also maintains the structural integrity for the physiological functions of protein. Thus, in light to all of these activities, lipids and its metabolism can be attributed pivotal for brain health and its activities. Decisively, the impaired/altered metabolism of lipids and its intermediates puts forward a key step in the progression of different brain ailments including neurodegenerative, neurological and neuropsychiatry disorders. Depending on their associated underlying pathways, they serve as the potential biomarkers of these disorders and are considered as necessary diagnostic tools. The present review discusses the role and level of altered lipids metabolism in brain diseases including neurodegenerative diseases, neurological diseases, and neuropsychiatric diseases. Moreover, the possible mechanisms of altered level of lipids and their metabolites have also been discussed in detail.

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January 2019
3 Reads

Role of cholesterol and sphingolipids in brain development and neurological diseases

ttps://doi.org/10.1186/s12944-019-0965-z

Lipids in health and disease

AbstractBrain is a vital organ of the human body which performs very important functions such as analysis, processing, coordination, and execution of electrical signals. For this purpose, it depends on a complex network of nerves which are ensheathed in lipids tailored myelin; an abundant source of lipids in the body. The nervous system is enriched with important classes of lipids; sphingolipids and cholesterol which compose the major portion of the brain particularly in the form of myelin. Both cholesterol and sphingolipids are embedded in the microdomains of membrane rafts and are functional units of the neuronal cell membrane. These molecules serve as the signaling molecules; hold important roles in the neuronal differentiation, synaptogenesis, and many others. Thus, their adequate provision and active metabolism are of crucial importance in the maintenance of physiological functions of brain and body of an individual. In the present review, we have highlighted the physiological roles of cholesterol and sphingolipids in the development of the nervous system as well as the association of their altered metabolism to neurological and neurodegenerative diseases.

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January 2019
7 Reads

Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders

Int J Biol Sci. 2018 Mar 9;14(3):341-357. doi: 10.7150/ijbs.23247. eCollection 2018.

International Journal of Biological Sciences

Neurodegenerative diseases are conventionally demarcated as disorders with selective loss of neurons. Conventional as well as newer molecules have been tested but they offer just symptomatic advantages along with abundant side effects. The discovery of more compelling molecules that can halt the pathology of these diseases will be considered as a miracle of present time. Several synthetic compounds are available but they may cause several other health issues. Therefore, natural molecules from the plants and other sources are being discovered to replace available medicines. In conventional medicational therapies, several plants have been reported to bestow remedial effects. Phytochemicals from medicinal plants can provide a better and safer alternative to synthetic molecules. Many phytochemicals have been identified that cure the human body from a number of diseases. The present article reviews the potential efficacy of plant-derived alkaloids, which possess potential therapeutic effects against several NDDs including Alzheimer's disease (AD), Huntington disease (HD), Parkinson's disease (PD), Epilepsy, Schizophrenia, and stroke. Alkaloids include isoquinoline, indole, pyrroloindole, oxindole, piperidine, pyridine, aporphine, vinca, β-carboline, methylxanthene, lycopodium, and erythrine byproducts. Alkaloids constitute positive roles in ameliorating pathophysiology of these illnesses by functioning as muscarinic and adenosine receptors agonists, anti-oxidant, anti-amyloid and MAO inhibitors, acetylcholinestrase and butyrylcholinesterase inhibitor, inhibitor of α-synuclein aggregation, dopaminergic and nicotine agonist, and NMDA antagonist. KEYWORDS: Neurodegenerative diseases; Phytochemicals; Plant derived alkaloids; acetylcholinestrase; butyrylcholinesterase; monoamine oxidase.

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May 2018
6 Reads

Role of Plant-Derived Flavonoids and Their Mechanism in Attenuation of Alzheimer's and Parkinson's Diseases: An Update of Recent Data.

Molecules 2018 Apr 2;23(4). Epub 2018 Apr 2.

Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China.

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http://dx.doi.org/10.3390/molecules23040814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017497PMC
April 2018
38 Reads
2.420 Impact Factor

Top co-authors

Azhar Rasul
Azhar Rasul

Jilin University Bethune Second Hospital

5
Tao Sun
Tao Sun

State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy

5
Haseeb Anwar
Haseeb Anwar

University of Agriculture

5
Ghulam Hussain
Ghulam Hussain

Université de Strasbourg Strasbourg

5
Nimra Aziz
Nimra Aziz

Government College University

5
Ali Imran
Ali Imran

Dalhousie University

4
Asghar Shabbir
Asghar Shabbir

COMSATS Institute of Information Technology

3
Waseem Ahmad
Waseem Ahmad

Aligarh Muslim University

2