Arnold J Levine

Arnold J Levine

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Arnold J Levine

Publications by authors named "Arnold J Levine"

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Functional network analysis reveals an immune tolerance mechanism in cancer.

Proc Natl Acad Sci U S A 2020 Jun 29. Epub 2020 Jun 29.

Department of Computer Science, Stony Brook University, New York, NY 11794.

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http://dx.doi.org/10.1073/pnas.2002179117DOI Listing
June 2020

p53: 800 million years of evolution and 40 years of discovery.

Authors:
Arnold J Levine

Nat Rev Cancer 2020 May 13. Epub 2020 May 13.

Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ, USA.

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http://dx.doi.org/10.1038/s41568-020-0262-1DOI Listing
May 2020

Mdm2: Open questions.

Cancer Sci 2020 Apr 26. Epub 2020 Apr 26.

Institute for Advanced Study, Princeton, NJ, USA.

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http://dx.doi.org/10.1111/cas.14433DOI Listing
April 2020

Two well-differentiated pancreatic neuroendocrine tumor mouse models.

Cell Death Differ 2020 Jan 3;27(1):269-283. Epub 2019 Jun 3.

Raymond and Beverly Sackler Foundation Laboratory, New Brunswick, NJ, 08901, USA.

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http://dx.doi.org/10.1038/s41418-019-0355-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206057PMC
January 2020

P53 and The Immune Response: 40 Years of Exploration-A Plan for the Future.

Authors:
Arnold J Levine

Int J Mol Sci 2020 Jan 15;21(2). Epub 2020 Jan 15.

Simons Center for Systems Biology, Institute for Advanced, Study, Princeton, NJ 08540, USA.

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http://dx.doi.org/10.3390/ijms21020541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013403PMC
January 2020

Robust and interpretable PAM50 reclassification exhibits survival advantage for myoepithelial and immune phenotypes.

NPJ Breast Cancer 2019 9;5:30. Epub 2019 Sep 9.

3Departments of Computer Science & Applied Mathematics, Stony Brook University, Stony Brook, NY 11794 USA.

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http://dx.doi.org/10.1038/s41523-019-0124-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733897PMC
September 2019

The many faces of p53: something for everyone.

Authors:
Arnold J Levine

J Mol Cell Biol 2019 07;11(7):524-530

Institute for Advanced Study, Princeton, NJ 08540, USA.

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http://dx.doi.org/10.1093/jmcb/mjz026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736316PMC
July 2019

The Evolution of Tumor Formation in Humans and Mice with Inherited Mutations in the p53 Gene.

Authors:
Arnold J Levine

Curr Top Microbiol Immunol 2017;407:205-221

Institute for Advanced Study, Princeton, NJ, 08540, USA.

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http://dx.doi.org/10.1007/82_2017_5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383363PMC
June 2019

A tumor-specific endogenous repetitive element is induced by herpesviruses.

Nat Commun 2019 01 9;10(1):90. Epub 2019 Jan 9.

Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

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http://dx.doi.org/10.1038/s41467-018-07944-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327058PMC
January 2019

The Roles of Initiating Truncal Mutations in Human Cancers: The Order of Mutations and Tumor Cell Type Matters.

Cancer Cell 2019 01;35(1):10-15

Genetics Department, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.ccell.2018.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376970PMC
January 2019

The Evolution of Tumors in Mice and Humans with Germline p53 Mutations.

Cold Spring Harb Symp Quant Biol 2015 7;80:139-45. Epub 2015 Dec 7.

Grenoble Institute for Research on Cancer, Grenoble 38706, France.

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http://dx.doi.org/10.1101/sqb.2015.80.027631DOI Listing
January 2018

Why are there hotspot mutations in the TP53 gene in human cancers?

Cell Death Differ 2018 01 3;25(1):154-160. Epub 2017 Nov 3.

Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.

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http://dx.doi.org/10.1038/cdd.2017.180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729536PMC
January 2018

Reviewing the future of the P53 field.

Authors:
Arnold J Levine

Cell Death Differ 2018 01;25(1):1-2

Simons Center for Sysems Biology, Institute for Advanced Study, Princeton, NJ 08540, USA.

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http://dx.doi.org/10.1038/cdd.2017.181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729537PMC
January 2018

The interplay between epigenetic changes and the p53 protein in stem cells.

Genes Dev 2017 06;31(12):1195-1201

Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.298984.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558922PMC
June 2017

Structural Evolution and Dynamics of the p53 Proteins.

Cold Spring Harb Perspect Med 2017 Apr 3;7(4). Epub 2017 Apr 3.

Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a028308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378015PMC
April 2017

US immigration order strikes against biotech.

Authors:
Jeremy M Levin Steven H Holtzman John Maraganore Paul J Hastings Ron Cohen Bassil Dahiyat Julian Adams Chris Adams Brett Ahrens Jeff Albers Mara G Aspinall James E Audia Martin Babler Peter Barrett Zoe Barry Nessan Bermingham Stephen Bloch Robert I Blum Paul B Bolno Michael W Bonney Bruce Booth Daniel M Bradbury Steven K Brauer Brook Byers Pablo J Cagnoni Brian M Cali Isaac Ciechanover Chip Clark Michael D Clayman Jeff L Cleland Paula Cobb Ron Cooper Mark G Currie John Diekman Eric L Dobmeier Doug Doerfler Elizabeth Lr Donley Deborah Dunsire Matthew During Jens W Eckstein Eric Elenko Neil A Exter Jonathan J Fleming Gregory J Flesher Jean-Francois Formela Robert Forrester Cedric Francois Heather Franklin Mason W Freeman Howard Furst Leonard Patrick Gage Nicholas Galakatos Brian M Gallagher James A Geraghty Simba Gill David V Goeddel Mark A Goldsmith Maxine Gowen Vikas Goyal Tom Graney David Grayzel Barry Greene Paul Grint J C Gutierrez-Ramos Bill Haney Tuan Ha-Ngoc Tim Harris Faheem Hasnain Yujiro Steve Hata Peter Hecht Leslie Henshaw Rich Heyman Herve Hoppenot H Robert Horvitz Thomas E Hughes Wende S Hutton Stephen T Isaacs Annalisa Jenkins Jeff Jonker Jeff Kaplan Perry Karsen Jeb Keiper Jean Kim Jeff Kindler Rachel King Vanessa King Nina Kjellson Scott Koenig Gerhard Koenig Peter Kolchinsky Paul Laikind Robert Bob Langer John J Lee Jonathan S Leff Bruce A Leicher Nick Leschly Andrew Levin Mark Levin Arnold J Levine Alan Levy David R Liu Harvey F Lodish Uri Lopatin Ted W Love Guy Macdonald Gail J Maderis Ankit Mahadevia Nagesh K Mahanthappa Joel F Martin Alex Martin W Eddie Martucci James G McArthur Corey M McCann Sean A McCarthy C Geoffrey McDonough John Mendlein Larry Miller Diego Miralles Kenneth I Moch Bob More Andrew G Myers Michael A Narachi Amir Nashat Wendy Nelson William J Newell Bernat Olle John E Osborn Julia C Owens Atul Pande Stelios Papadopoulos H Stewart Parker Kush M Parmar Matthew R Patterson Steve M Paul Rob Perez Matthew Perry Cary G Pfeffer Mike Powell Mark Pruzanski Dennis J Purcell Amit Rakhit Kartik Ramamoorthi William Rastetter Adrian Ad Rawcliffe Laurence E Reid Ron C Renaud Jason P Rhodes William J Rieflin Chad Robins Scott M Rocklage Michael Rosenblatt Jonathan G Rosin William J Rutter Saurabh Saha Camille Samuels Vicki L Sato George Scangos John A Scarlett David Schenkein Stuart L Schreiber Andrew Schwab Paul Sekhri Rajeev Shah Thomas Shenk Clay B Siegall Nick J Simon Nancy Simonian Jeff Stein Michael Su Mary T Szela Marco Taglietti Nina Tandon Henri Termeer Nancy A Thornberry Martin Tolar Richard Ulevitch Akshay K Vaishnaw Anne VanLent Martin Varsavsky George P Vlasuk Michel Vounatsos Samuel G Waksal Neil Warma Ryan J Watts Yaron Werber Christoph Westphal Wendell Wierenga Doug E Williams Lewis Rusty Williams Kleanthis G Xanthopoulos Daphne Zohar Sandford Sandy Zweifach

Nat Biotechnol 2017 03;35(3):204-206

Nuvelution Pharmaceuticals, Inc., South San Francisco, California, USA.

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http://dx.doi.org/10.1038/nbt.3824DOI Listing
March 2017

Insights into immune system development and function from mouse T-cell repertoires.

Proc Natl Acad Sci U S A 2017 02 14;114(9):2253-2258. Epub 2017 Feb 14.

Laboratoire de Physique Théorique, UMR8549, CNRS, École Normale Supérieure, 75005 Paris, France.

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http://dx.doi.org/10.1073/pnas.1700241114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338539PMC
February 2017

Corrigendum to "Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer" [Drug Discov. Today 20 (11) (2015) 1391-1397].

Drug Discov Today 2016 10 29;21(10):1728. Epub 2016 Jul 29.

Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA; Department of Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2016.07.012DOI Listing
October 2016

The Role of the p53 Protein in Stem-Cell Biology and Epigenetic Regulation.

Cold Spring Harb Perspect Med 2016 Sep 1;6(9). Epub 2016 Sep 1.

Grenoble Institute for Research on Cancer, Grenoble, France.

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http://dx.doi.org/10.1101/cshperspect.a026153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008064PMC
September 2016

Inference of Ancestral Recombination Graphs through Topological Data Analysis.

PLoS Comput Biol 2016 08 17;12(8):e1005071. Epub 2016 Aug 17.

Department of Systems Biology and Department of Biomedical Informatics, Columbia University College of Physicians and Surgeons, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1005071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988722PMC
August 2016

Lysine methylation represses p53 activity in teratocarcinoma cancer cells.

Proc Natl Acad Sci U S A 2016 08 17;113(35):9822-7. Epub 2016 Aug 17.

Epigenetics Program, Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

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http://dx.doi.org/10.1073/pnas.1610387113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024588PMC
August 2016

Topological Data Analysis Generates High-Resolution, Genome-wide Maps of Human Recombination.

Cell Syst 2016 07 23;3(1):83-94. Epub 2016 Jun 23.

Department of Systems Biology, Columbia University College of Physicians and Surgeons, 1130 St. Nicholas Avenue, New York, NY 10032, USA; Department of Biomedical Informatics, Columbia University College of Physicians and Surgeons, 1130 St. Nicholas Avenue, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2016.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965322PMC
July 2016

P53 and the defenses against genome instability caused by transposons and repetitive elements.

Bioessays 2016 06 13;38(6):508-13. Epub 2016 May 13.

Department of Medicine, Hematology, and Medical Oncology, and Pathology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031199PMC
http://dx.doi.org/10.1002/bies.201600031DOI Listing
June 2016

Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells.

Proc Natl Acad Sci U S A 2015 Dec 2;112(49):15154-9. Epub 2015 Nov 2.

Tisch Cancer Institute, Department of Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; The Simons Center for Systems Biology, School of Natural Sciences, Institute for Advanced Study, Princeton, NJ 08540; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029

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http://dx.doi.org/10.1073/pnas.1517584112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679042PMC
December 2015

Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer.

Drug Discov Today 2015 11 20;20(11):1391-7. Epub 2015 Jul 20.

Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA; Department of Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2015.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922747PMC
November 2015

Stem cells, aging and cancers.

Authors:
Arnold J Levine

Aging (Albany NY) 2015 Jul;7(7):457-8

Institute for Advanced Study, Princeton, NJ 08540, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543030PMC
http://dx.doi.org/10.18632/aging.100776DOI Listing
July 2015

TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation.

Proc Natl Acad Sci U S A 2015 Jan 22;112(1):226-31. Epub 2014 Dec 22.

Medical Research Council Toxicology Unit, Leicester LE1 9HN, United Kingdom; Department of Experimental Medicine and Surgery, Biochemistry Istituto Dermopatico dell'Immacolata Laboratory, University of Rome Tor Vergata, 00133 Rome, Italy

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http://www.pnas.org/lookup/doi/10.1073/pnas.1410609111
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http://dx.doi.org/10.1073/pnas.1410609111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291637PMC
January 2015

The evolution of thymic lymphomas in p53 knockout mice.

Genes Dev 2014 Dec;28(23):2613-20

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08901, USA; Simons Center for Systems Biology, School of Natural Sciences, Institute for Advanced Study, Princeton, New Jersey 08540, USA

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http://dx.doi.org/10.1101/gad.252148.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248292PMC
December 2014

Whole-genome sequencing analysis of phenotypic heterogeneity and anticipation in Li-Fraumeni cancer predisposition syndrome.

Proc Natl Acad Sci U S A 2014 Oct 13;111(43):15497-501. Epub 2014 Oct 13.

Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901; Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08903

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http://dx.doi.org/10.1073/pnas.1417322111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217424PMC
October 2014

Genomic complexity: a call to action.

Sci Transl Med 2014 Sep;6(255):255cm10

Institute for Advanced Studies, Princeton, New Jersey and The Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA.

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http://dx.doi.org/10.1126/scitranslmed.3009148DOI Listing
September 2014

Tumour-associated mutant p53 drives the Warburg effect.

Nat Commun 2013 ;4:2935

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers State University of New Jersey, New Brunswick, New Jersey 08902, USA.

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http://dx.doi.org/10.1038/ncomms3935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969270PMC
July 2014

High-throughput image analysis of tumor spheroids: a user-friendly software application to measure the size of spheroids automatically and accurately.

J Vis Exp 2014 Jul 8(89). Epub 2014 Jul 8.

Raymond and Beverly Sackler Foundation, New Jersey; Rutgers Cancer Institute of New Jersey, Rutgers University;

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http://dx.doi.org/10.3791/51639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212916PMC
July 2014

Quantitative theory of entropic forces acting on constrained nucleotide sequences applied to viruses.

Proc Natl Acad Sci U S A 2014 Apr 17;111(13):5054-9. Epub 2014 Mar 17.

The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ 08540.

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http://dx.doi.org/10.1073/pnas.1402285111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977288PMC
April 2014

Dipeptide analysis of p53 mutations and evolution of p53 family proteins.

Biochim Biophys Acta 2014 Jan 10;1844(1 Pt B):198-206. Epub 2013 Apr 10.

State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China.

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http://dx.doi.org/10.1016/j.bbapap.2013.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429922PMC
January 2014

The maintenance of epigenetic states by p53: the guardian of the epigenome.

Oncotarget 2012 Dec;3(12):1503-4

Institute for Advanced Study, Einstein Road, Princeton, NJ, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681489PMC
http://dx.doi.org/10.18632/oncotarget.780DOI Listing
December 2012

Multiple roles of p53-related pathways in somatic cell reprogramming and stem cell differentiation.

Cancer Res 2012 Nov 10;72(21):5635-45. Epub 2012 Sep 10.

The Cancer Institute of New Jersey, Institute for Advanced Study, Princeton, New Jersey 08540, USA.

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http://cancerres.aacrjournals.org/content/72/21/5635.full.pd
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-12-1451DOI Listing
November 2012

A cell-penetrating bispecific antibody for therapeutic regulation of intracellular targets.

Mol Cancer Ther 2012 Oct 3;11(10):2169-73. Epub 2012 Aug 3.

Veterans Affairs Greater Los Angeles Health Care System, 161111 Plummer St., Sepulveda, CA 91343, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-12-0476-TDOI Listing
October 2012

Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6.

Clin Cancer Res 2012 Sep 3;18(17):4612-20. Epub 2012 Jul 3.

Departments of Pathology and Surgery, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, New York, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-3264DOI Listing
September 2012

Company Profile: Selventa, Inc.

Per Med 2012 Aug;9(6):579-583

Selventa, Inc., One Alewife Center, Cambridge, MA 02140, USA.

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http://dx.doi.org/10.2217/pme.12.59DOI Listing
August 2012

Chronic restraint stress attenuates p53 function and promotes tumorigenesis.

Proc Natl Acad Sci U S A 2012 May 16;109(18):7013-8. Epub 2012 Apr 16.

Department of Radiation Oncology and Department of Pediatrics, Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.1073/pnas.1203930109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345015PMC
May 2012

Allele-specific p53 mutant reactivation.

Cancer Cell 2012 May;21(5):614-25

The Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.03.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366694PMC
May 2012

The Regulation of Multiple p53 Stress Responses is Mediated through MDM2.

Genes Cancer 2012 Mar;3(3-4):199-208

Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA.

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http://dx.doi.org/10.1177/1947601912454734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494373PMC
March 2012

Viral reassortment as an information exchange between viral segments.

Proc Natl Acad Sci U S A 2012 Feb 13;109(9):3341-6. Epub 2012 Feb 13.

The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ 08540, USA.

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http://dx.doi.org/10.1073/pnas.1113300109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295259PMC
February 2012

The evolution of the p53 family of genes.

Authors:
Arnold J Levine

Cell Cycle 2012 Jan 15;11(2):214-5. Epub 2012 Jan 15.

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http://dx.doi.org/10.4161/cc.11.2.18899DOI Listing
January 2012

Molecular classification of prostate cancer using curated expression signatures.

Proc Natl Acad Sci U S A 2011 Dec 28;108(52):21276-81. Epub 2011 Nov 28.

Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ 08540, USA.

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http://dx.doi.org/10.1073/pnas.1117029108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248553PMC
December 2011

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect.

Proc Natl Acad Sci U S A 2011 Sep 19;108(39):16259-64. Epub 2011 Sep 19.

Department of Radiation Oncology and Department of Pediatrics, Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.1073/pnas.1113884108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182683PMC
September 2011

Germline mutations and polymorphisms in the origins of cancers in women.

J Oncol 2010 10;2010:297671. Epub 2010 Jan 10.

The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08901, USA.

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http://dx.doi.org/10.1155/2010/297671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810468PMC
July 2011

Regulation of female reproduction by p53 and its family members.

FASEB J 2011 Jul 14;25(7):2245-55. Epub 2011 Mar 14.

Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA.

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http://dx.doi.org/10.1096/fj.10-180166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114525PMC
July 2011

A genetic variant in a PP2A regulatory subunit encoded by the PPP2R2B gene associates with altered breast cancer risk and recurrence.

Int J Cancer 2011 May;128(10):2335-43

Department of Radiation Oncology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

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http://dx.doi.org/10.1002/ijc.25582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902652PMC
May 2011

The p53 family: guardians of maternal reproduction.

Nat Rev Mol Cell Biol 2011 04;12(4):259-65

Institute for Advanced Studies, Princeton, New Jersey 08540, USA.

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http://www.nature.com/articles/nrm3086
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http://dx.doi.org/10.1038/nrm3086DOI Listing
April 2011

Topology based data analysis identifies a subgroup of breast cancers with a unique mutational profile and excellent survival.

Proc Natl Acad Sci U S A 2011 Apr 11;108(17):7265-70. Epub 2011 Apr 11.

Department of Mathematics, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1073/pnas.1102826108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084136PMC
April 2011

Monographs editor.

Authors:
Arnold J Levine

Genes Cancer 2011 Apr;2(4):381

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http://dx.doi.org/10.1177/1947601911413465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135648PMC
April 2011

Introduction: The Changing Directions of p53 Research.

Authors:
Arnold J Levine

Genes Cancer 2011 Apr;2(4):382-4

Institute for Advanced Study, Princeton, New Jersey, USA.

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http://dx.doi.org/10.1177/1947601911413463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135647PMC
April 2011

Polymorphic variants in TSC1 and TSC2 and their association with breast cancer phenotypes.

Breast Cancer Res Treat 2011 Feb 25;125(3):861-8. Epub 2010 Jul 25.

Department of Medicine, Division of Medical Oncology, The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.

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http://dx.doi.org/10.1007/s10549-010-1062-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876413PMC
February 2011

Sequences from ancestral single-stranded DNA viruses in vertebrate genomes: the parvoviridae and circoviridae are more than 40 to 50 million years old.

J Virol 2010 Dec 22;84(23):12458-62. Epub 2010 Sep 22.

Simons Center for Systems Biology, Institute for Advanced Study, Einstein Drive, Princeton, New Jersey 08540, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976387PMC
December 2010

The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes.

Science 2010 Dec;330(6009):1340-4

Institute for Advanced Study, Princeton, NJ 08540, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1193494
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December 2010

Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures.

Proc Natl Acad Sci U S A 2010 Dec 13;107(52):22745-50. Epub 2010 Dec 13.

The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ 08540, USA.

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http://dx.doi.org/10.1073/pnas.1017001108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012457PMC
December 2010

p53 and NF-κB: different strategies for responding to stress lead to a functional antagonism.

FASEB J 2010 Oct 8;24(10):3643-52. Epub 2010 Jun 8.

Institute for Advanced Study, Princeton, NJ 08540, USA.

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http://dx.doi.org/10.1096/fj.10-160549DOI Listing
October 2010

The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein.

Trends Cell Biol 2010 Jul;20(7):427-34

Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.1016/j.tcb.2010.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921989PMC
July 2010

Unexpected inheritance: multiple integrations of ancient bornavirus and ebolavirus/marburgvirus sequences in vertebrate genomes.

PLoS Pathog 2010 Jul 29;6(7):e1001030. Epub 2010 Jul 29.

Simons Center for Systems Biology, Institute for Advanced Study, Princeton, New Jersey, USA.

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http://dx.doi.org/10.1371/journal.ppat.1001030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912400PMC
July 2010

Higher order Boolean networks as models of cell state dynamics.

J Theor Biol 2010 Jun 18;264(3):945-51. Epub 2010 Mar 18.

Simons Center for Systems Biology, Institute for Advanced Study, 1 Einstein Dr, Princeton, NJ 08540, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00225193100013
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June 2010

The origins and evolution of the p53 family of genes.

Cold Spring Harb Perspect Biol 2010 Jun 16;2(6):a001198. Epub 2009 Dec 16.

Institute for Advanced Study, Princeton, NJ 08540, USA.

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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869528PMC
June 2010

Negative regulation of tumor suppressor p53 by microRNA miR-504.

Mol Cell 2010 Jun;38(5):689-99

Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900922PMC
June 2010

Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis.

FASEB J 2010 May 17;24(5):1347-53. Epub 2009 Dec 17.

Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA.

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http://www.fasebj.org/doi/10.1096/fj.09-146001
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May 2010

Fine-scale detection of population-specific linkage disequilibrium using haplotype entropy in the human genome.

BMC Genet 2010 Apr 23;11:27. Epub 2010 Apr 23.

The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, New Jersey, USA.

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http://dx.doi.org/10.1186/1471-2156-11-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873552PMC
April 2010

A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer.

Carcinogenesis 2009 Nov 16;30(11):1910-5. Epub 2009 Sep 16.

Department of Medicine-Division of Medical Oncology, The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.

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http://dx.doi.org/10.1093/carcin/bgp224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895963PMC
November 2009

The regulation of human reproduction by p53 and its pathway.

Cell Cycle 2009 Nov;8(22):3621-2

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http://dx.doi.org/10.4161/cc.8.22.9938DOI Listing
November 2009

The first 30 years of p53: growing ever more complex.

Nat Rev Cancer 2009 10;9(10):749-58

Arnold J. Levine is at the Institute for Advanced Study, School of Natural Sciences, Einstein Drive, Princeton, New Jersey 08540, USA.

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http://www.nature.com/articles/nrc2723
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771725PMC
October 2009

Stem cell biology meets p53.

Nat Biotechnol 2009 Oct;27(10):914-5

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http://dx.doi.org/10.1038/nbt1009-914DOI Listing
October 2009

One billion years of p53/p63/p73 evolution.

Proc Natl Acad Sci U S A 2009 Oct 13;106(42):17609-10. Epub 2009 Oct 13.

Institute for Advanced Study, Princeton, NJ 08540, USA.

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http://dx.doi.org/10.1073/pnas.0910634106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764953PMC
October 2009

Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans.

Proc Natl Acad Sci U S A 2009 Jun 22;106(24):9761-6. Epub 2009 May 22.

Center for Reproductive Medicine and Infertility, Weill Cornell Medical College, New York, NY 10021, USA.

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http://dx.doi.org/10.1073/pnas.0904280106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700980PMC
June 2009

The regulation of the endosomal compartment by p53 the tumor suppressor gene.

FEBS J 2009 Apr 3;276(8):2201-12. Epub 2009 Mar 3.

The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2009.06949.xDOI Listing
April 2009

The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53.

Authors:
Arnold J Levine

Virology 2009 Feb 11;384(2):285-93. Epub 2008 Dec 11.

Institute for Advanced Study, Princeton, NJ 08540, USA.

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http://dx.doi.org/10.1016/j.virol.2008.09.034DOI Listing
February 2009

Why do we not yet have a human immunodeficiency virus vaccine?

Authors:
Arnold J Levine

J Virol 2008 Dec 1;82(24):11998-2000. Epub 2008 Oct 1.

Institute for Advanced Study, Princeton, NJ 08540, USA.

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http://dx.doi.org/10.1128/JVI.01953-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593315PMC
December 2008

The genetics of the p53 pathway, apoptosis and cancer therapy.

Nat Rev Drug Discov 2008 Dec;7(12):979-87

The Institute for Advanced Study, Einstein Drive, Princeton, New Jersey, 08540, USA.

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http://dx.doi.org/10.1038/nrd2656DOI Listing
December 2008

P53 mutations in lymphomas: position matters.

Blood 2008 Oct;112(8):2997-8

Cancer Institute of New Jersey, Institute for Advanced Study, USA.

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http://dx.doi.org/10.1182/blood-2008-07-167718DOI Listing
October 2008