Arnold Ganser

Arnold Ganser

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Arnold Ganser

Arnold Ganser

Publications by authors named "Arnold Ganser"

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Monocytes reprogrammed with lentiviral vectors co-expressing GM-CSF, IFN-α2 and antigens for personalized immune therapy of acute leukemia pre- or post-stem cell transplantation.

Cancer Immunol Immunother 2019 Nov 18;68(11):1891-1899. Epub 2019 Oct 18.

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s00262-019-02406-9DOI Listing
November 2019

Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in Patients Age >69 Years with Acute Myelogenous Leukemia: On Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.

Biol Blood Marrow Transplant 2019 Oct 7;25(10):1975-1983. Epub 2019 Jun 7.

European Society for Blood and Marrow Transplantation, Paris study office/CEREST-TC, Paris, France; Hematology Division and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Israel.

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http://dx.doi.org/10.1016/j.bbmt.2019.05.037DOI Listing
October 2019

Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo.

Ann Hematol 2019 Aug 18;98(8):1905-1918. Epub 2019 May 18.

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Strasse 1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s00277-019-03713-yDOI Listing
August 2019

MN1 is indispensable for MLL-rearranged acute myeloid leukemia.

Haematologica 2019 Aug 14. Epub 2019 Aug 14.

Hannover Medical School, Hannover, Germany;

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http://dx.doi.org/10.3324/haematol.2018.211201DOI Listing
August 2019

Cumulative dosages of chemotherapy and radiotherapy exposure, and risk of secondary malignancies after allogeneic hematopoietic stem cell transplantation.

Bone Marrow Transplant 2019 Apr 18;54(4):635-640. Epub 2018 Oct 18.

Hematology, Hemostasis, Oncology and Stem-Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://www.nature.com/articles/s41409-018-0359-2
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http://dx.doi.org/10.1038/s41409-018-0359-2DOI Listing
April 2019

miR-125b regulates chemotaxis and survival of bone marrow derived granulocytes in vitro and in vivo.

PLoS One 2018 4;13(10):e0204942. Epub 2018 Oct 4.

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204942PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171867PMC
March 2019

Spatiotemporally Skewed Activation of Programmed Cell Death Receptor 1-Positive T Cells after Epstein-Barr Virus Infection and Tumor Development in Long-Term Fully Humanized Mice.

Am J Pathol 2019 03 26;189(3):521-539. Epub 2018 Dec 26.

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany; Laboratory of Regenerative Immune Therapies Applied, Excellence Cluster REBIRTH and German Centre for Infection Research, Partner Site Hannover, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.11.014DOI Listing
March 2019

Diagnostic value of highly-sensitive chimerism analysis after allogeneic stem cell transplantation.

Bone Marrow Transplant 2018 11 2;53(11):1457-1465. Epub 2018 May 2.

Dept. of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1038/s41409-018-0176-7DOI Listing
November 2018

Improved short- and long-term outcome of allogeneic stem cell recipients admitted to the intensive care unit: a retrospective longitudinal analysis of 942 patients.

Intensive Care Med 2018 Sep 23;44(9):1483-1492. Epub 2018 Aug 23.

Department for Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1007/s00134-018-5347-xDOI Listing
September 2018

Flow cytometric characterization of acute leukemia reveals a distinctive "blast gate" of murine T-lymphoblastic leukemia/lymphoma.

Oncotarget 2018 Jan 18;9(2):2320-2328. Epub 2017 Dec 18.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.18632/oncotarget.23410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788642PMC
January 2018

Pyrimethamine as a Potent and Selective Inhibitor of Acute Myeloid Leukemia Identified by High-throughput Drug Screening.

Curr Cancer Drug Targets 2016 ;16(9):818-828

Department of Hematology, Hemostasis, Oncology and Stem cell Transplantation, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.2174/1568009616666160617103301DOI Listing
October 2017

Predicting death in patients with acute graft-versus-host disease after reduced-intensity conditioning.

Lancet Haematol 2017 09;4(9):e400-e401

Hannover Medical School, Hematology/Oncology, Hannover 30625, Germany.

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http://dx.doi.org/10.1016/S2352-3026(17)30142-4DOI Listing
September 2017

Activation of TRKA receptor elicits mastocytosis in mice and is involved in the development of resistance to KIT-targeted therapy.

Oncotarget 2017 Sep 19;8(43):73871-73883. Epub 2017 May 19.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.18632/oncotarget.18027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650308PMC
September 2017

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation.

N Engl J Med 2017 08 23;377(5):454-464. Epub 2017 Jun 23.

From the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston (R.M.S.); the Division of Biomedical Statistics and Informatics (S.J.M., K.L.) and the Alliance Statistics and Data Center (S.J.M., K.L., S.G.), Mayo Clinic, Rochester, MN; the Alliance Statistics and Data Center, Duke University, Durham, NC (B.L.S.); the Ohio State University Comprehensive Cancer Center, Columbus (S.G., C.D.B., T.W.P., G.M., R.B.K.); Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus der TU Dresden, Dresden (C.T., G.E.), Department of Internal Medicine III, University Hospital of Ulm, Ulm (K.D., R.F.S., H.D.), Hematology and Oncology, University of Leipzig, Leipzig (D.N.), Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover (J.K., A.G.), and Department of Medicine II, Hematology-Oncology, Goethe University Hospital Frankfurt, Frankfurt am Main (H.S.) - all in Germany; the Department of Biomedicine and Prevention, University Tor Vergata, Rome (F.L.-C., S.A.); the Department of Clinical Haematology, Alfred Hospital and Monash University, Melbourne, VIC, Australia (A.W.); Hospital de la Santa Creu i Sant Pau, Hematology Department, Autonomous University of Barcelona, Barcelona (J.S.), and Hospital Universitario la Fe, Hematology Department, Department of Medicine, University of Valencia, Valencia (M.A.S.) - both in Spain; the Department of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto (J.M.B.); Radboud Institute Molecular Studies, Radboud University Medical Center, Nijmegen, the Netherlands (T.W.); the Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle (F.R.A.); the Division of Hematology-Oncology, Stanford Comprehensive Cancer Center, Stanford University, Stanford, CA (B.C.M.); the Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York (M.S.T.); and the Department of Medicine, University of Chicago, Chicago (R.A.L.).

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http://dx.doi.org/10.1056/NEJMoa1614359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754190PMC
August 2017

Possible Impact of Cytomegalovirus-Specific CD8 T Cells on Immune Reconstitution and Conversion to Complete Donor Chimerism after Allogeneic Stem Cell Transplantation.

Biol Blood Marrow Transplant 2017 Jul 23;23(7):1046-1053. Epub 2017 Mar 23.

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2017.03.027DOI Listing
July 2017

Human Effector Memory T Helper Cells Engage with Mouse Macrophages and Cause Graft-versus-Host-Like Pathology in Skin of Humanized Mice Used in a Nonclinical Immunization Study.

Am J Pathol 2017 Jun 20;187(6):1380-1398. Epub 2017 Apr 20.

Regenerative Biology to Reconstructive Therapies (REBIRTH), Laboratory of Regenerative Immune Therapies Applied, Hannover Medical School, Hannover, Germany; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.02.015DOI Listing
June 2017

Treating acute promyelocytic leukaemia in Latin America: lessons from the International Consortium on Acute Leukaemia experience.

Br J Haematol 2017 06 3;177(6):979-983. Epub 2017 May 3.

Department of Internal Medicine, Medical School of Ribeirão Preto, and Centre for Cell-Based Therapy, University of São Paulo, Ribeirao Preto, SP, Brazil.

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http://dx.doi.org/10.1111/bjh.14589DOI Listing
June 2017

Therapy of Treatment-Related Hypertension in Metastatic Renal-Cell Cancer Patients Receiving Sunitinib.

Clin Genitourin Cancer 2017 04 19;15(2):280-290.e3. Epub 2016 Oct 19.

Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1016/j.clgc.2016.10.004DOI Listing
April 2017

Therapy-related myeloid neoplasms.

Curr Opin Hematol 2017 03;24(2):152-158

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1097/MOH.0000000000000316DOI Listing
March 2017

Improved Outcomes With Retinoic Acid and Arsenic Trioxide Compared With Retinoic Acid and Chemotherapy in Non-High-Risk Acute Promyelocytic Leukemia: Final Results of the Randomized Italian-German APL0406 Trial.

J Clin Oncol 2017 Feb 31;35(6):605-612. Epub 2016 Oct 31.

Uwe Platzbecker, Christian Thiede, Christoph Röllig, and Gerhard Ehninger, Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden; Uwe Platzbecker and Gerhard Ehninger, Study Alliance Leukemia, Dresden; Walter Fiedler, University Hospital Hamburg-Eppendorf; Norbert Schmitz, Asklepios Klinik St Georg Hamburg, Hamburg; Peter Brossart, Innere Medizin mit deSchwerpunkten Onkologie, Haematollogie un Rheumatologie, Bonn; Bernd Hertenstein, Klinikum Bremen Mitte, Bremen; Helmut R. Salih, University Hospital Tubingen; Mohammed Wattad, Kliniken Essen Süd, Essen; Michael Lübbert, University Medical Center, Freiburg; Christian H. Brandts, Goethe University Frankfurt, Frankfurt; Mathias Hänel, Klinikum Chemnitz gGmbH, Chemnitz; Hartmut Link, Klinik für Innere Medizin I, Westpfalz-Klinikum, Kaiserslautern; Konstanze Döhner, Hartmut Döhner, and Richard F. Schlenk, University Hospital Ulm, Ulm; Arnold Ganser, Hannover Medical School, Hannover, Germany; Giuseppe Avvisati, University Campus Bio-Medico; Laura Cicconi, Mariadomenica Divona, Sergio Amadori, and Francesco Lo-Coco, University Tor Vergata; Francesca Paoloni, Marco Vignetti, Fabio Efficace, Paola Fazi, and Franco Mandelli, Gruppo Italiano Malattie Ematologiche dell'Adulto Central Office; Marco Vignetti and Massimo Breccia, Sapienza University, Rome; Felicetto Ferrara, Cardarelli Hospital, Naples; Francesco Albano, University of Bari, Bari; Marco Sborgia, U.O. di Ematologia Clinica, Pescara; Eros Di Bona, San Bortolo Hospital, Vicenza; Erika Borlenghi, U.O. di Ematologia, Spedali Civili, Brescia; Roberto Cairoli, Ospedale Niguarda, Ca' Granda, SC Ematologia; Agostino Cortelezzi, Foundation Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico and University of Milan, Milano; Alessandro Rambaldi, Azienda Opsedaliera Papa Giovanni XXIII, Bergamo; Lorella Melillo, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo; Giorgio La Nasa, Centro Trapianti Midollo Osseo, Ospedale R. Binaghi, Università di Cagliari, Cagliari; Chiara Frairia, Hematology, Città della Salute e della Scienza, Torino; Enrico Maria Pogliani, Ospedale San Gerardo, Università degli Studi Milano Bicocca, Monza; Claudio Fozza, University of Sassari, Sassari; Alfonso Maria D'Arco, U.O. Medicina Interna e Onco-Ematologica P.O. "Umberto I," Nocera Inferiore, Nocera Inferiore; Nicola Di Renzo, Ospedale Vito Fazzi, Lecce; and Francesco Fabbiano, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy.

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http://dx.doi.org/10.1200/JCO.2016.67.1982DOI Listing
February 2017

CT patterns of organizing pneumonia in patients treated with VEGF/mTOR inhibitors for metastatic renal cell cancer: an observational study.

Acta Radiol Open 2017 Feb 1;6(2):2058460117694216. Epub 2017 Feb 1.

Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1177/2058460117694216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347262PMC
February 2017

Successful use of extracorporeal membrane oxygenation during induction chemotherapy in a patient with mediastinal tumor mass of a T lymphoblastic lymphoma.

Ann Hematol 2016 Oct 21;95(10):1719-21. Epub 2016 Jun 21.

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://downloads.hindawi.com/journals/crim/2014/804917.pdf
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http://dx.doi.org/10.1007/s00277-016-2734-7DOI Listing
October 2016

Genomic Classification and Prognosis in Acute Myeloid Leukemia.

N Engl J Med 2016 Jun;374(23):2209-2221

Cancer Genome Project, Wellcome Trust Sanger Institute (E.P., M.G., N.D.R., N.B., G.G., P.V.L., I.M., L.M., S.M., S.O., K.R., D.R.J., J.W.T., A.P.B., P.J.C.), and the European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI) (M.G.), Hinxton, the Centre for Evolution and Cancer, Institute of Cancer Research, London (N.E.P., M.F.G.), and the Department of Haematology, University of Cambridge, Cambridge (N.B.) - all in the United Kingdom; the Departments of Epidemiology and Biostatistics and Cancer Biology, the Center for Molecular Oncology and the Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York (E.P.); the Department of Internal Medicine III, Ulm University, Ulm (L.B., V.I.G., P.P., K.D., R.F.S., H.D.), and the Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover (M.H., F.T., A.G.) - both in Germany; the Division of Hematology, Fondazione IRCCS, Istituto Nazionale dei Tumori, and Department of Oncology and Onco-Hematology, University of Milan, Milan (N.B.); the Department of Human Genetics, University of Leuven, Leuven, Belgium (P.V.L.); and the Department of Pathology, University of Otago, Christchurch, New Zealand (P.G., P.J.C.).

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http://dx.doi.org/10.1056/NEJMoa1516192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979995PMC
June 2016

miR-181a Expression in Donor T Cells Modulates Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation.

J Immunol 2016 05 23;196(9):3927-34. Epub 2016 Mar 23.

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, D-30625 Hannover, Germany; and Institute of Immunology, Hannover Medical School, D-30625 Hannover, Germany

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http://dx.doi.org/10.4049/jimmunol.1502152DOI Listing
May 2016

Clonal Hematopoiesis of Indeterminate Potential.

Dtsch Arztebl Int 2016 May;113(18):317-22

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School.

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http://dx.doi.org/10.3238/arztebl.2016.0317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961884PMC
May 2016

The stem cell zinc finger 1 (SZF1)/ZNF589 protein has a human-specific evolutionary nucleotide DNA change and acts as a regulator of cell viability in the hematopoietic system.

Exp Hematol 2016 Apr 29;44(4):257-68. Epub 2015 Dec 29.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1016/j.exphem.2015.12.005DOI Listing
April 2016

Leukemogenic potency of the novel FLT3-N676K mutant.

Ann Hematol 2016 Apr 19;95(5):783-91. Epub 2016 Feb 19.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s00277-016-2616-zDOI Listing
April 2016

Differential Effects of Gut-Homing Molecules CC Chemokine Receptor 9 and Integrin-β7 during Acute Graft-versus-Host Disease of the Liver.

Biol Blood Marrow Transplant 2015 Dec 5;21(12):2069-2078. Epub 2015 Sep 5.

Institute of Immunology, Hannover Medical School, Hannover, Germany; Department of Hematology, Hemostasis, Oncology and Stem-Cell Transplantation, Hannover Medical School, Hannover, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10838791150059
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http://dx.doi.org/10.1016/j.bbmt.2015.08.038DOI Listing
December 2015

Deletion or inhibition of Fc gamma receptor 2B (CD32) prevents FVIII-specific activation of memory B cells in vitro.

Thromb Haemost 2015 Nov 6;114(6):1127-35. Epub 2015 Aug 6.

Sonja Werwitzke, MD, PhD, Department of Haematology, Haemostasis,, Oncology and Stem Cell Transplantation, Hannover Medical School, D-30625 Hannover, Germany, Tel.: + 49 511 532 8377, Fax: + 49 511 18524, E-mail:

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http://dx.doi.org/10.1160/TH14-06-0535DOI Listing
November 2015