Arne Klungland

Arne Klungland

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Arne Klungland

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"Too much guts and not enough brains": (epi)genetic mechanisms and future therapies of Hirschsprung disease - a review.

Clin Epigenetics 2019 Sep 13;11(1):135. Epub 2019 Sep 13.

Clinic for Diagnostics and Intervention and Institute of Medical Microbiology, Oslo University Hospital, Rikshospitalet, 0027, Oslo, Norway.

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http://dx.doi.org/10.1186/s13148-019-0718-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743154PMC
September 2019

Excision of uracil from DNA by hSMUG1 includes strand incision and processing.

Nucleic Acids Res 2019 01;47(2):779-793

Department of Chemistry, Bioscience and Environmental Technology-Centre for Organelle Research, Faculty of Science and Technology, University of Stavanger, P.O. Box 8600 Forus, N-4021 Stavanger, Norway.

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http://dx.doi.org/10.1093/nar/gky1184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344882PMC
January 2019

Differential mA, mA, and mA Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.

Mol Cell 2018 09 6;71(6):973-985.e5. Epub 2018 Sep 6.

Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57 Street, Chicago, IL 60637, USA; Howard Hughes Medical Institute, The University of Chicago, 929 East 57 Street, Chicago, IL 60637, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765183064
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http://dx.doi.org/10.1016/j.molcel.2018.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151148PMC
September 2018

Excision of the doubly methylated base ,5-dimethylcytosine from DNA by Nei and Fpg proteins.

Philos Trans R Soc Lond B Biol Sci 2018 06;373(1748)

Department of Chemistry, Bioscience and Environmental Technology-Centre for Organelle Research, Faculty of Science and Technology, University of Stavanger, PO Box 8600 Forus, 4021 Stavanger, Norway

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http://dx.doi.org/10.1098/rstb.2017.0337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915725PMC
June 2018

Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA.

Mitochondrion 2018 05 8;40:16-28. Epub 2017 Sep 8.

Department of Medical Biochemistry, University of Oslo, Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2017.09.002DOI Listing
May 2018

RNA mA methylation participates in regulation of postnatal development of the mouse cerebellum.

Genome Biol 2018 05 31;19(1):68. Epub 2018 May 31.

Department of Pathology, Institute of Basic Medical Sciences Chinese Academy of Medical Science, School of Basic Medicine Peking Union Medical College; Neuroscience Center, Chinese Academy of Medical Sciences, Beijing, 100005, China.

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http://dx.doi.org/10.1186/s13059-018-1435-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984455PMC
May 2018

ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells.

Proc Natl Acad Sci U S A 2018 01 26;115(2):E325-E333. Epub 2017 Dec 26.

Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557;

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http://dx.doi.org/10.1073/pnas.1717794115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777073PMC
January 2018

Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes.

DNA Repair (Amst) 2017 10 12;58:13-20. Epub 2017 Aug 12.

Institute of Pharmacy and Biochemistry, University of Mainz, Staudingerweg 5, D-55099 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2017.08.005DOI Listing
October 2017

Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy.

PLoS One 2017 13;12(3):e0168182. Epub 2017 Mar 13.

Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168182PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347998PMC
September 2017

Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine.

Free Radic Biol Med 2017 06 24;107:62-68. Epub 2016 Nov 24.

Institute of Medical Microbiology, Oslo University Hospital, Rikshospitalet, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.11.038DOI Listing
June 2017

NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.

Cell Rep 2017 01;18(1):82-92

Research Institute of Internal Medicine, Oslo University Hospital and University of Oslo, 0424 Oslo, Norway; Department of Cardiology, Oslo University Hospital and University of Oslo, 0424 Oslo, Norway; Center for Heart Failure Research, University of Oslo, 0317 Oslo, Norway.

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http://dx.doi.org/10.1016/j.celrep.2016.12.009DOI Listing
January 2017

TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity.

Proc Natl Acad Sci U S A 2017 01 17;114(5):1039-1044. Epub 2017 Jan 17.

Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, NO-0379 Oslo, Norway;

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http://dx.doi.org/10.1073/pnas.1615093114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293095PMC
January 2017

A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain.

Neurobiol Aging 2016 12 18;48:34-47. Epub 2016 Aug 18.

Synaptic Neurochemistry Laboratory, Division of Anatomy and CMBN/SERTA Healthy Brain Ageing Centre, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Brain and Muscle Energy Group, Electron Microscopy Laboratory, Institute of Oral Biology, University of Oslo, Oslo, Norway; Center for Healthy Aging and Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629920PMC
December 2016

Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation.

Mol Cell Neurosci 2016 12 14;77:47-52. Epub 2016 Oct 14.

Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway; GliaLab and Letten Centre, Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway; Department of Neurology, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2016.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157926PMC
December 2016

Reversible RNA modifications in meiosis and pluripotency.

Nat Methods 2016 12;14(1):18-22

Department of Microbiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

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http://dx.doi.org/10.1038/nmeth.4111DOI Listing
December 2016

Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells.

Cell Physiol Biochem 2016 15;38(1):173-84. Epub 2016 Jan 15.

Clinic for Diagnostics and Intervention and Institute of Medical Microbiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

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http://dx.doi.org/10.1159/000438619DOI Listing
October 2016

ALKBH1-Mediated tRNA Demethylation Regulates Translation.

Cell 2016 Oct 13;167(3):816-828.e16. Epub 2016 Oct 13.

Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA; Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA; Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57(th) Street, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.09.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119773PMC
October 2016

ALKBHs-facilitated RNA modifications and de-modifications.

DNA Repair (Amst) 2016 08 17;44:87-91. Epub 2016 May 17.

Department of Microbiology, Division of Diagnostics and Intervention, Institute of Clinical Medicine, Oslo University Hospital, Rikshospitalet, Oslo NO-0027, Norway; Department of Molecular Medicine, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo NO-0027, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2016.05.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120542PMC
August 2016

DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates.

Biochem Biophys Rep 2016 Jul 22;6:9-15. Epub 2016 Feb 22.

Department of Microbiology, Division of diagnostics and intervention, Institute of Clinical Medicine, Oslo University Hospital, Rikshospitalet, NO-0027 Oslo, Norway.

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https://linkinghub.elsevier.com/retrieve/pii/S24055808163001
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http://dx.doi.org/10.1016/j.bbrep.2016.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600429PMC
July 2016

Endogenous DNA Damage and Repair Enzymes: -A short summary of the scientific achievements of Tomas Lindahl, Nobel Laureate in Chemistry 2015.

Genomics Proteomics Bioinformatics 2016 06 12;14(3):122-125. Epub 2015 Dec 12.

CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

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http://dx.doi.org/10.1016/j.gpb.2015.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936663PMC
June 2016

Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells.

Epigenetics Chromatin 2016 31;9:21. Epub 2016 May 31.

Nordic European Molecular Laboratory (EMBL) Partnership, Centre for Molecular Medicine Norway, University of Oslo, Blindern, P.O. Box 1137, 0318 Oslo, Norway ; Department of Haematology, Oslo University Hospital, Oslo, Norway ; Norwegian Center for Stem Cell Research, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1186/s13072-016-0070-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888655PMC
June 2016

Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations.

Fertil Steril 2016 05 25;105(5):1170-1179.e5. Epub 2016 Jan 25.

Department of Gynecology, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.fertnstert.2016.01.002DOI Listing
May 2016

Base-excision repair and beyond --A short summary attributed to scientific achievements of Tomas Lindahl, Nobel Prize Laureate in Chemistry 2015.

Sci China Life Sci 2016 Jan 16;59(1):89-92. Epub 2015 Dec 16.

Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, CAS Center for Excellence in Molecular Cell Science, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.

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http://dx.doi.org/10.1007/s11427-015-4983-4DOI Listing
January 2016

Non-homologous functions of the AlkB homologs.

J Mol Cell Biol 2015 Dec 23;7(6):494-504. Epub 2015 May 23.

Clinic for Diagnostics and Intervention and Institute of Medical Microbiology, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway

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http://dx.doi.org/10.1093/jmcb/mjv029DOI Listing
December 2015

Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.

Cell Rep 2015 Dec 17;13(12):2671-8. Epub 2015 Dec 17.

Department of Microbiology, Oslo University Hospital and University of Oslo, 0424 Oslo, Norway; Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247150141
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http://dx.doi.org/10.1016/j.celrep.2015.12.001DOI Listing
December 2015

A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.

Genes Dev 2015 Oct 24;29(19):2037-53. Epub 2015 Sep 24.

Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10065, USA; New York Genome Center, New York, New York 10013, USA;

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http://dx.doi.org/10.1101/gad.269415.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604345PMC
October 2015

Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure.

Am J Physiol Heart Circ Physiol 2015 Aug 8;309(3):H434-49. Epub 2015 Jun 8.

Department of Oral Biology, Brain and Muscle Energy Group, University of Oslo, Oslo, Norway; Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark;

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http://dx.doi.org/10.1152/ajpheart.00253.2014DOI Listing
August 2015

Micro chromatin immunoprecipitation (μChIP) from early mammalian embryos.

Methods Mol Biol 2015 ;1222:227-45

Institute of Clinical Medicine, Division of diagnostics and intervention, Department of Microbiology, Oslo university hospital, Rikshospitalet, NO-0027, Oslo, Norway,

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http://dx.doi.org/10.1007/978-1-4939-1594-1_17DOI Listing
June 2015

Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes.

Genome Res 2015 Jun 23;25(6):897-906. Epub 2015 Mar 23.

Institute of Microbiology, Clinic for Diagnostics and Intervention, Oslo University Hospital, N-0027 Oslo, Norway; University of Oslo, 0316 Oslo, Norway;

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http://dx.doi.org/10.1101/gr.185793.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448685PMC
June 2015

ALKBH4 depletion in mice leads to spermatogenic defects.

PLoS One 2014 25;9(8):e105113. Epub 2014 Aug 25.

Institute of Medical Microbiology, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, Norway; Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105113PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143218PMC
May 2015

Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination.

Nucleic Acids Res 2014 Dec 29;42(21):13280-93. Epub 2014 Oct 29.

Institute of Medical Microbiology, Oslo University Hospital, Rikshospitalet, Norway Institute of Basic Medical Sciences, University of Oslo, PO Box 1018 Blindern, N-0315 Oslo, Norway.

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http://academic.oup.com/nar/article/42/21/13280/2902637/Endo
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http://dx.doi.org/10.1093/nar/gku1032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245937PMC
December 2014

DNA metabolism: bases of DNA repair and regulation.

Nat Chem Biol 2014 Jul;10(7):487-8

Department of Microbiology, University of Oslo, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1038/nchembio.1553DOI Listing
July 2014

Dynamic RNA modifications in disease.

Curr Opin Genet Dev 2014 Jun 5;26:47-52. Epub 2014 Jul 5.

Clinic for Diagnostics and Intervention and Institute of Medical Microbiology, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, 0027 Oslo, Norway.

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http://dx.doi.org/10.1016/j.gde.2014.05.006DOI Listing
June 2014

ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.

Nat Commun 2013 ;4:1832

Genome Structure and Stability Group, BIG CAS-OSLO Genome Research Cooperation, Disease Genomics and Individualized Medicine Laboratory, Beijing Institute of Genomics, Chinese Academy of Sciences, No. 1-7 Beichen West Road, Chaoyang District, Beijing 100101, China.

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http://dx.doi.org/10.1038/ncomms2863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674258PMC
December 2013

Tzfp represses the androgen receptor in mouse testis.

PLoS One 2013 25;8(4):e62314. Epub 2013 Apr 25.

Centre for Molecular Biology and Neuroscience, Department of Microbiology, Oslo University Hospital, Oslo, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062314PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636255PMC
November 2013

Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells.

Stem Cell Res 2013 Nov 27;11(3):1264-71. Epub 2013 Aug 27.

Clinic for Diagnostics and Intervention and Institute of Medical Microbiology, Oslo University Hospital, Rikshospitalet and University of Oslo, NO-0027 Oslo, Norway.

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http://dx.doi.org/10.1016/j.scr.2013.08.010DOI Listing
November 2013

Deletion of mouse Alkbh7 leads to obesity.

J Mol Cell Biol 2013 Jun 8;5(3):194-203. Epub 2013 Apr 8.

Clinic for Diagnostics and Intervention and Institute of Medical Microbiology, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway.

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http://jmcb.oxfordjournals.org/content/early/2013/04/08/jmcb
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http://jmcb.oxfordjournals.org/content/5/3/194.full.pdf
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http://jmcb.oxfordjournals.org/cgi/doi/10.1093/jmcb/mjt012
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http://dx.doi.org/10.1093/jmcb/mjt012DOI Listing
June 2013

Sprouts of RNA epigenetics: the discovery of mammalian RNA demethylases.

RNA Biol 2013 Jun 17;10(6):915-8. Epub 2013 Apr 17.

Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.4161/rna.24711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904589PMC
June 2013

ALKBH1 is a histone H2A dioxygenase involved in neural differentiation.

Stem Cells 2012 Dec;30(12):2672-82

Centre for Molecular Biology and Neuroscience, Institute of Medical Microbiology, Oslo University Hospital, Rikshospitalet and University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1002/stem.1228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546389PMC
December 2012

Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice.

Hum Mol Genet 2012 Nov 21;21(22):4939-47. Epub 2012 Aug 21.

Institute of Medical Microbiology, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, Oslo, Norway.

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http://dx.doi.org/10.1093/hmg/dds337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607484PMC
November 2012

Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes.

Nucleic Acids Res 2012 Nov 10;40(21):10950-63. Epub 2012 Sep 10.

Department of Microbiology, Centre for Molecular Biology and Neuroscience, Oslo University Hospital, Rikshospitalet, PO Box 4950, Nydalen, NO-0424 Oslo, Norway.

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http://dx.doi.org/10.1093/nar/gks839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505970PMC
November 2012

Kinetics of endogenous mouse FEN1 in base excision repair.

Nucleic Acids Res 2012 Oct 18;40(18):9044-59. Epub 2012 Jul 18.

Centre for Molecular Biology and Neuroscience and Institute of Clinical Medicine, Oslo University Hospital, Rikshospitalet, Norway.

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http://dx.doi.org/10.1093/nar/gks673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467068PMC
October 2012

The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.

Nucleic Acids Res 2012 Aug 24;40(14):6620-31. Epub 2012 Apr 24.

Department of Molecular Biosciences, University of Oslo, P.O. Box 1041 Blindern, N-0316 Oslo, Norway.

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http://dx.doi.org/10.1093/nar/gks327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413135PMC
August 2012

Pull-down of 5-hydroxymethylcytosine DNA using JBP1-coated magnetic beads.

Nat Protoc 2012 Jan 26;7(2):340-50. Epub 2012 Jan 26.

Centre for Molecular Biology and Neuroscience, Institute of Medical Microbiology, Oslo University Hospital Rikshospitalet, Oslo, Norway.

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http://dx.doi.org/10.1038/nprot.2011.443DOI Listing
January 2012

Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human Kir4.1 gene (KCNJ10).

Glia 2011 Nov 11;59(11):1635-42. Epub 2011 Jul 11.

Centre for Molecular Biology and Neuroscience, Letten Centre, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

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http://doi.wiley.com/10.1002/glia.21205
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http://dx.doi.org/10.1002/glia.21205DOI Listing
November 2011

X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal-lysosomal dysfunction.

Brain 2011 Nov 29;134(Pt 11):3369-83. Epub 2011 Sep 29.

Dominick P. Purpura Department of Neuroscience, Rose F. Kennedy Centre, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1093/brain/awr250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212719PMC
November 2011

Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.

J Bacteriol 2011 Sep 10;193(17):4495-508. Epub 2011 Jun 10.

Faculty of Science and Technology, Department of Mathematics and Natural Sciences, University of Stavanger, N-4036 Stavanger, Norway.

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http://dx.doi.org/10.1128/JB.00233-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165510PMC
September 2011

Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond.

Mech Ageing Dev 2011 Aug 25;132(8-9):424-8. Epub 2011 Feb 25.

Centre for Molecular Biology and Neuroscience, Institute of Medical Microbiology, Oslo University Hospital and University of Oslo, NO-0027 Oslo, Norway.

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http://dx.doi.org/10.1016/j.mad.2011.02.006DOI Listing
August 2011

The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression.

Biochem Biophys Res Commun 2011 Jul 15;411(1):40-3. Epub 2011 Jun 15.

Centre for Molecular Biology and Neuroscience and Institute of Medical Microbiology, Oslo University Hospital, Rikshospitalet, Norway.

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http://dx.doi.org/10.1016/j.bbrc.2011.06.077DOI Listing
July 2011

Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses.

DNA Repair (Amst) 2011 Jun 7;10(6):639-53. Epub 2011 May 7.

Centre for Molecular Biology and Neuroscience, Institute of Medical Microbiology, Oslo University Hospital and University of Oslo, NO-0027 Oslo, Norway.

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http://dx.doi.org/10.1016/j.dnarep.2011.04.011DOI Listing
June 2011

A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.

Nucleic Acids Res 2011 Apr 7;39(8):e55. Epub 2011 Feb 7.

Centre for Molecular Biology and Neuroscience and Institute of Medical Microbiology, Oslo University Hospital, Rikshospitalet, Norway.

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http://dx.doi.org/10.1093/nar/gkr051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082876PMC
April 2011

ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.

Nat Commun 2011 Feb 1;2:172. Epub 2011 Feb 1.

Department of Molecular Biosciences, University of Oslo, PO Box 1041 Blindern, Oslo 0316, Norway.

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http://dx.doi.org/10.1038/ncomms1173DOI Listing
February 2011

Spontaneous mutagenesis in Csb(m/m)Ogg1⁻(/)⁻ mice is attenuated by dietary resveratrol.

Carcinogenesis 2011 Jan 9;32(1):80-5. Epub 2010 Nov 9.

Institute of Pharmacy and Biochemistry, University of Mainz, Germany.

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http://dx.doi.org/10.1093/carcin/bgq196DOI Listing
January 2011

Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.

Proc Natl Acad Sci U S A 2011 Jan 27;108(2):846-51. Epub 2010 Dec 27.

Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1073/pnas.1015217108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021020PMC
January 2011

Continuous and periodic expansion of CAG repeats in Huntington's disease R6/1 mice.

PLoS Genet 2010 Dec 9;6(12):e1001242. Epub 2010 Dec 9.

Centre for Molecular Biology and Neuroscience, Institute of Medical Microbiology, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1371/journal.pgen.1001242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000365PMC
December 2010

The hyperthermophilic euryarchaeon Archaeoglobus fulgidus repairs uracil by single-nucleotide replacement.

J Bacteriol 2010 Nov 7;192(21):5755-66. Epub 2010 May 7.

Faculty of Science and Technology, Department of Mathematics and Natural Sciences, University of Stavanger, N-4036 Stavanger, Norway.

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http://dx.doi.org/10.1128/JB.00135-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953685PMC
November 2010

Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects.

PLoS One 2010 Nov 3;5(11):e13827. Epub 2010 Nov 3.

Centre for Molecular Biology and Neuroscience, Institute of Medical Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013827PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972218PMC
November 2010

Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding.

Mol Cell Biol 2010 Apr 1;30(7):1814-27. Epub 2010 Feb 1.

Center for Molecular Biology and Neuroscience and Institute of Medical Microbiology, Oslo University Hospital, and Department of Molecular Biosciences, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1128/MCB.01602-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838068PMC
April 2010

Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior.

Mol Cell Biol 2010 Mar 11;30(6):1357-67. Epub 2010 Jan 11.

Centre for Molecular Biology and Neuroscience, Institute of Medical Microbiology, Oslo University Hospital and University of Oslo, NO-0027 Oslo, Norway.

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http://dx.doi.org/10.1128/MCB.01149-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832488PMC
March 2010

Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria.

Nucleic Acids Res 2009 Nov;37(21):7124-36

Department of Molecular Biosciences, University of Oslo, PO Box 1041 Blindern, 0316 Oslo, Norway.

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http://dx.doi.org/10.1093/nar/gkp774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790896PMC
November 2009

8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells.

Proc Natl Acad Sci U S A 2008 Dec 19;105(48):18877-82. Epub 2008 Nov 19.

Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1073/pnas.0806464105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596238PMC
December 2008

AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA.

Cancer Res 2008 Jun;68(11):4142-9

Centre for Molecular Biology and Neuroscience, Institute of Medical Microbiology, Rikshospitalet HF and University of Oslo, Blindern, Oslo, Norway.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-0796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725713PMC
June 2008

Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants.

Cancer Res 2008 Jun;68(12):4571-9

Centre for Molecular Biology and Neuroscience and Institute of Medical Microbiology, Rikshospitalet Medical Center and University of Oslo, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-0168DOI Listing
June 2008

[Nobel Prize for genetic modification].

Tidsskr Nor Laegeforen 2007 Nov;127(23):3054

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November 2007

Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol.

FEMS Yeast Res 2007 Sep 16;7(6):848-59. Epub 2007 May 16.

Institute of Microbiology, Rikshospitalet-Radiumhospitalet Medical Center, University of Oslo, Centre for Molecular Biology and Neuroscience, Oslo, Norway.

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http://dx.doi.org/10.1111/j.1567-1364.2007.00248.xDOI Listing
September 2007

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells.

Nature 2007 May 22;447(7143):447-52. Epub 2007 Apr 22.

Department of Pharmacology and Experimental Therapeutics, Mayo Clinic and Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA.

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http://www.nature.com/doifinder/10.1038/nature05778
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http://dx.doi.org/10.1038/nature05778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681094PMC
May 2007

Oxidative damage to purines in DNA: role of mammalian Ogg1.

DNA Repair (Amst) 2007 Apr 28;6(4):481-8. Epub 2006 Nov 28.

Centre for Molecular Biology and Neuroscience and Institute of Medical Microbiology, Rikshospitalet-Radiumhospitalet HF, N-0027 Oslo, Norway.

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http://dx.doi.org/10.1016/j.dnarep.2006.10.012DOI Listing
April 2007

Repeated inhalations of diesel exhaust particles and oxidatively damaged DNA in young oxoguanine DNA glycosylase (OGG1) deficient mice.

Free Radic Res 2007 Feb;41(2):172-81

Department of Occupational and Environmental Health, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1080/10715760601024122DOI Listing
February 2007

Organ and cell specificity of base excision repair mutants in mice.

Mutat Res 2007 Jan;614(1-2):56-68

Centre for Molecular Biology and Neuroscience, Institute of Medical Microbiology, Rikshospitalet-Radiumhospitalet HF, 0027 Oslo, Norway.

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http://dx.doi.org/10.1016/j.mrfmmm.2006.01.023DOI Listing
January 2007

Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo.

Nucleic Acids Res 2005 19;33(15):4704-10. Epub 2005 Aug 19.

Centre for Molecular Biology and Neuroscience (CMBN), and Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo Oslo, Norway.

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http://dx.doi.org/10.1093/nar/gki785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188085PMC
September 2005

Substantial decrease of urinary 8-oxo-7,8-dihydroguanine, a product of the base excision repair pathway, in DNA glycosylase defective mice.

Int J Biochem Cell Biol 2005 Jun;37(6):1331-6

Department of Clinical Biochemistry, The Ludwik Rydygier Medical University in Bydgoszcz, Karlowicza 24, 85-092 Bydgoszcz, Poland.

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http://dx.doi.org/10.1016/j.biocel.2005.01.001DOI Listing
June 2005

Transcription activities at 8-oxoG lesions in DNA.

DNA Repair (Amst) 2004 Nov;3(11):1457-68

Centre for Molecular Biology and Neuroscience, Institute of Medical Microbiology, National Hospital, University of Oslo, 0027 Oslo, Norway.

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http://dx.doi.org/10.1016/j.dnarep.2004.06.008DOI Listing
November 2004

Urinary excretion of DNA repair products correlates with metabolic rates as well as with maximum life spans of different mammalian species.

Free Radic Biol Med 2004 Nov;37(9):1449-54

Department of Clinical Biochemistry, The Ludwik Rydygier Medical University in Bydgoszcz, Karlowicza 24, 85-092 Bydgoszcz, Poland.

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http://dx.doi.org/10.1016/j.freeradbiomed.2004.07.014DOI Listing
November 2004

Diet is not responsible for the presence of several oxidatively damaged DNA lesions in mouse urine.

Free Radic Res 2004 Nov;38(11):1201-5

Department of Clinical Biochemistry, The Ludwik Rydygier Medical University, Bydgoszcz, Karlowicza 24, 85-092, Bydgoszcz, Poland.

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http://dx.doi.org/10.1080/10715760400017350DOI Listing
November 2004

Better late than never for repair of miscoding lesions within a transcribed template.

Mol Cell 2003 Oct;12(4):799-800

Centre of Molecular Biology and Neuroscience and Department of Molecular Biology, Institute of Medical Microbiology, University of Oslo, The National Hospital, 0027 Oslo, , Norway.

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http://dx.doi.org/10.1016/s1097-2765(03)00403-9DOI Listing
October 2003