Publications by authors named "Arne C Rufer"

20 Publications

  • Page 1 of 1

Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization.

Angew Chem Int Ed Engl 2021 Mar 19;60(10):5436-5442. Epub 2021 Jan 19.

Medicinal Chemistry, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland.

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March 2021

Small molecule AX-024 reduces T cell proliferation independently of CD3ϵ/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain.

J Biol Chem 2020 06 21;295(23):7849-7864. Epub 2020 Apr 21.

Therapeutic Modalities, Lead Discovery and Medicinal Chemistry, pRED Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland

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June 2020

Domain swap in the C-terminal ubiquitin-like domain of human doublecortin.

Acta Crystallogr D Struct Biol 2018 May 26;74(Pt 5):450-462. Epub 2018 Apr 26.

pRED, Therapeutic Modalities, F. Hoffmann-La Roche, 4070 Basel, Switzerland.

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May 2018

A Novel Selective Inverse Agonist of the CB Receptor as a Radiolabeled Tool Compound for Kinetic Binding Studies.

Mol Pharmacol 2017 10 26;92(4):389-400. Epub 2017 Jul 26.

Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (A.M., H.S., A.P.I., L.H.H.), and Department of Molecular Physiology, Leiden Institute of Chemistry (A.M., M.S.), Leiden University, Leiden, The Netherlands; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (A.M., A.C.R., U.G., C.U., T.H.); and Natural and Medical Sciences Institute, University of Tübingen, Reutlingen, Germany (J.F.)

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October 2017

Characterization of mAb dimers reveals predominant dimer forms common in therapeutic mAbs.

MAbs 2016 07 31;8(5):928-40. Epub 2016 Mar 31.

a Analytical Development and Quality Control, Pharmaceutical Technical Development Europe, F. Hoffmann-La Roche Ltd. , Basel , Switzerland.

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July 2016

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation.

Authors:
Huaying Zhao Rodolfo Ghirlando Carlos Alfonso Fumio Arisaka Ilan Attali David L Bain Marina M Bakhtina Donald F Becker Gregory J Bedwell Ahmet Bekdemir Tabot M D Besong Catherine Birck Chad A Brautigam William Brennerman Olwyn Byron Agnieszka Bzowska Jonathan B Chaires Catherine T Chaton Helmut Cölfen Keith D Connaghan Kimberly A Crowley Ute Curth Tina Daviter William L Dean Ana I Díez Christine Ebel Debra M Eckert Leslie E Eisele Edward Eisenstein Patrick England Carlos Escalante Jeffrey A Fagan Robert Fairman Ron M Finn Wolfgang Fischle José García de la Torre Jayesh Gor Henning Gustafsson Damien Hall Stephen E Harding José G Hernández Cifre Andrew B Herr Elizabeth E Howell Richard S Isaac Shu-Chuan Jao Davis Jose Soon-Jong Kim Bashkim Kokona Jack A Kornblatt Dalibor Kosek Elena Krayukhina Daniel Krzizike Eric A Kusznir Hyewon Kwon Adam Larson Thomas M Laue Aline Le Roy Andrew P Leech Hauke Lilie Karolin Luger Juan R Luque-Ortega Jia Ma Carrie A May Ernest L Maynard Anna Modrak-Wojcik Yee-Foong Mok Norbert Mücke Luitgard Nagel-Steger Geeta J Narlikar Masanori Noda Amanda Nourse Tomas Obsil Chad K Park Jin-Ku Park Peter D Pawelek Erby E Perdue Stephen J Perkins Matthew A Perugini Craig L Peterson Martin G Peverelli Grzegorz Piszczek Gali Prag Peter E Prevelige Bertrand D E Raynal Lenka Rezabkova Klaus Richter Alison E Ringel Rose Rosenberg Arthur J Rowe Arne C Rufer David J Scott Javier G Seravalli Alexandra S Solovyova Renjie Song David Staunton Caitlin Stoddard Katherine Stott Holger M Strauss Werner W Streicher John P Sumida Sarah G Swygert Roman H Szczepanowski Ingrid Tessmer Ronald T Toth Ashutosh Tripathy Susumu Uchiyama Stephan F W Uebel Satoru Unzai Anna Vitlin Gruber Peter H von Hippel Christine Wandrey Szu-Huan Wang Steven E Weitzel Beata Wielgus-Kutrowska Cynthia Wolberger Martin Wolff Edward Wright Yu-Sung Wu Jacinta M Wubben Peter Schuck

PLoS One 2015 21;10(5):e0126420. Epub 2015 May 21.

Dynamics of Macromolecular Assembly Section, Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, 20892, United States of America.

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February 2016

Real-time monitoring of binding events on a thermostabilized human A2A receptor embedded in a lipid bilayer by surface plasmon resonance.

Biochim Biophys Acta 2015 May 25;1848(5):1224-33. Epub 2015 Feb 25.

F. Hoffmann-La Roche, Pharma Research and Early Development (pRED), Molecular Design and Chemical Biology, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel CH4070, Switzerland.

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May 2015

Structure and function of purified monoclonal antibody dimers induced by different stress conditions.

Pharm Res 2012 Aug 5;29(8):2047-59. Epub 2012 Apr 5.

Pharma Technical Development Europe (Biologics) Analytics, F. Hoffmann-La Roche Ltd., 4070, Basel, Switzerland.

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August 2012

Isoform-selective interaction of the adaptor protein Tks5/FISH with Sos1 and dynamins.

J Mol Biol 2009 Jul 21;390(5):939-50. Epub 2009 May 21.

Department of Biomolecular Mechanisms, Max-Planck-Institute for Medical Research, Heidelberg, Germany.

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July 2009

Structural insight into function and regulation of carnitine palmitoyltransferase.

Cell Mol Life Sci 2009 Aug 9;66(15):2489-501. Epub 2009 May 9.

F. Hoffmann-La Roche AG, Pharma Research Discovery Technologies, 4070 Basel, Switzerland.

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August 2009

Carnitine palmitoyltransferase 2: analysis of membrane association and complex structure with a substrate analog.

FEBS Lett 2007 Jul 8;581(17):3247-52. Epub 2007 Jun 8.

F Hoffmann-La Roche AG, Pharma Research Discovery, Basel, Switzerland.

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July 2007