Arndt Borkhardt

Arndt Borkhardt

UNVERIFIED PROFILE

Are you Arndt Borkhardt?   Register this Author

Register author
Arndt Borkhardt

Arndt Borkhardt

Publications by authors named "Arndt Borkhardt"

Are you Arndt Borkhardt?   Register this Author

100Publications

3965Reads

34Profile Views

JAK2 p.G571S in B-cell precursor acute lymphoblastic leukemia: a synergizing germline susceptibility.

Leukemia 2019 Sep 9;33(9):2331-2335. Epub 2019 Apr 9.

Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine University Düsseldorf, Medical Faculty, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41375-019-0459-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756027PMC
September 2019

The preleukemic gene fusion can be generated in utero and is present in ≈0.6% of healthy newborns.

Blood 2019 Aug 21. Epub 2019 Aug 21.

Pediatric Oncology, Hematology and Clinical I, Heinrich-Heine-University Düsseldorf, Medical Faculty, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood.2019002215DOI Listing
August 2019

Interleukin-2-Inducible T-Cell Kinase Deficiency-New Patients, New Insight?

Front Immunol 2018 8;9:979. Epub 2018 May 8.

Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.00979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951928PMC
July 2019

Mutated SON putatively causes a cancer syndrome comprising high-risk medulloblastoma combined with café-au-lait spots.

Fam Cancer 2019 07;18(3):353-358

Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, University Children's Hospital, Heinrich-Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10689-019-00121-z
Publisher Site
http://dx.doi.org/10.1007/s10689-019-00121-zDOI Listing
July 2019

Medical history and clinical examinations are insufficient to exclude vertical human immunodeficiency virus transmission in healthy, at-risk adolescents.

Acta Paediatr 2019 Jun 11;108(6):994-997. Epub 2019 Apr 11.

Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/apa.14793
Publisher Site
http://dx.doi.org/10.1111/apa.14793DOI Listing
June 2019

Family-based germline sequencing in children with cancer.

Oncogene 2019 02 10;38(9):1367-1380. Epub 2018 Oct 10.

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-018-0520-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755997PMC
February 2019

Osteonecrosis in children with acute lymphoblastic leukemia at initial diagnosis and prior to any chemotherapy.

Leuk Lymphoma 2019 01 2;60(1):78-84. Epub 2018 May 2.

a Department of Pediatric Oncology, Hematology, and Clinical Immunology , Medical Faculty , Center for Child and Adolescent Health , University of Duesseldorf , Duesseldorf , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10428194.2018.1466292DOI Listing
January 2019

The association between birth order and childhood leukemia may be modified by paternal age and birth weight. Pooled results from the International Childhood Cancer Cohort Consortium (I4C).

Int J Cancer 2019 01 26;144(1):26-33. Epub 2018 Oct 26.

The George Institute for Global Health, Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.31635DOI Listing
January 2019

Penetrance and Expressivity in Inherited Cancer Predisposing Syndromes.

Trends Cancer 2018 11 20;4(11):718-728. Epub 2018 Sep 20.

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S24058033183019
Publisher Site
http://dx.doi.org/10.1016/j.trecan.2018.09.002DOI Listing
November 2018

Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor.

J Med Chem 2018 11 8;61(22):10299-10309. Epub 2018 Nov 8.

Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Medical Faculty , Leipzig University , Brüderstraße 34 , 04103 Leipzig , Germany.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01487
Publisher Site
http://dx.doi.org/10.1021/acs.jmedchem.8b01487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249066PMC
November 2018

Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling.

J Biol Chem 2018 10 20;293(40):15359-15369. Epub 2018 Aug 20.

From the Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Medical Faculty, Heinrich Heine University, Moorenstrasse 5, 40225 Düsseldorf, Germany,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA118.002243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177596PMC
October 2018

Corrigendum: Interleukin-2-Inducible T-Cell Kinase Deficiency-New Patients, New Insight?

Front Immunol 2018 1;9:2197. Epub 2018 Oct 1.

Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.02197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174291PMC
October 2018

T-cell leukemogenesis is an inappropriate lineage decision-making process: implications for precision oncology.

Mol Cell Oncol 2018 7;5(4):e1497860. Epub 2018 Aug 7.

Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC-USAL, Salamanca, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/23723556.2018.1497860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150050PMC
August 2018

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-018-0167-2DOI Listing
July 2018

Challenges of palliative care in children with inborn metabolic diseases.

Orphanet J Rare Dis 2018 07 9;13(1):112. Epub 2018 Jul 9.

Medical Faculty, Department of Paediatric Oncology, Haematology and Clinical Immunology, Centre for Child and Adolescent Health, University of Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13023-018-0868-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038293PMC
July 2018

Epigenetic Priming in Cancer Initiation.

Trends Cancer 2018 06;4(6):408-417

Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain; Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca, Campus M. de Unamuno s/n, 37007 Salamanca, Spain; Equal senior author. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.trecan.2018.04.007DOI Listing
June 2018

IKZF1 Defines a New Minimal Residual Disease-Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia.

J Clin Oncol 2018 04 2;36(12):1240-1249. Epub 2018 Mar 2.

Martin Stanulla, Elif Dagdan, Stefanie V. Junk, Laura Hinze, Norman Klein, Christian P. Kratz, Petra Dörge, Doris Steinemann, and Martin Zimmermann, Hannover Medical School; Petra Dörge, German Center for Infection Research, Hannover; Anja Möricke, Kirsten Bleckmann, Denis Schewe, Gunnar Cario, and Martin Schrappe, University Hospital Schleswig-Holstein; Britt-Sabina Petersen and Andre Franke, Kiel University, Kiel; Cornelia Eckert and Stefanie Groeneveld-Krentz, Charité University Hospital; Wolf-Dieter Ludwig, HELIOS-Clinic Berlin-Buch, Berlin; Rolf Koehler, Claus R. Bartram, Andreas Kulozik, and Martina U. Muckenthaler, University of Heidelberg, Heidelberg; Arndt Borkhardt, Heinrich-Heine University, Düsseldorf, Germany; Marketa Zaliova, Charles University and University Hospital Motol, Prague, Czech Republic; Chiara Palmi, Giovanni Cazzaniga, and Andrea Biondi, Azienda Ospedaliera San Gerardo; Maria Grazia Valsecchi, University of Milano-Bicocca, Monza; Geertruy te Kronnie and Giuseppe Basso, University of Padova, Padua, Italy; Jean-Pierre Bourquin and Beat Bornhauser, University Children's Hospital Zurich, Zurich, Switzerland; Shai Izraeli, Sheba Medical Center Tel-Hashomer and Tel Aviv University, Tel Aviv, Israel; Oskar A. Haas and Renate Panzer-Grümayer, St Anna Kinderkrebsforschung and Medical University Vienna, Vienna, Austria; Hélène Cavé, Robert Debré Hospital and Paris-Diderot University, Paris, France; and Richard S. Houlston, The Institute of Cancer Research, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2017.74.3617DOI Listing
April 2018

Trio sequencing in pediatric cancer and clinical implications.

EMBO Mol Med 2018 04;10(4)

Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/emmm.201708641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887902PMC
April 2018

Advance care planning and outcome in pediatric palliative home care.

Oncotarget 2018 Apr 3;9(25):17867-17875. Epub 2018 Apr 3.

University of Duesseldorf, Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Duesseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.24929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915160PMC
April 2018

Significance of Frequencies, Compositions, and/or Antileukemic Activity of (DC-stimulated) Invariant NKT, NK and CIK Cells on the Outcome of Patients With AML, ALL and CLL.

J Immunother 2017 Jul/Aug;40(6):224-248

*Department of Hematopoetic Cell Transplantation, Medicine Department 3, University Hospital of Munich, Munich †Department of Hematology and Oncology, University Hospital of Tuebingen, Tuebingen ‡Department of Pediatric Hematology, Oncology and Clinical Immunology, University Hospital of Duesseldorf, Duesseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CJI.0000000000000171DOI Listing
March 2018

Diagnostic challenges in a child with early onset desmoplastic medulloblastoma and homozygous variants in MSH2 and MSH6.

Eur J Hum Genet 2018 03 4;26(3):440-444. Epub 2018 Jan 4.

Department of Paediatric Oncology, Haematology and Clinical Immunology, University Children´s Hospital, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41431-017-0071-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839041PMC
March 2018

The landscape of genomic alterations across childhood cancers.

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature25480DOI Listing
March 2018

Lymphnode tuberculosis in a 4-year-old boy with relapsed ganglioneuroblastoma: a case report.

BMC Infect Dis 2018 03 5;18(1):105. Epub 2018 Mar 5.

Department of Paediatric Oncology, Medical Faculty, Haematology and Clinical Immunology, Centre for Child and Adolescent Health, University of Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-018-3016-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839039PMC
March 2018

Five percent of healthy newborns have an fusion as revealed by DNA-based GIPFEL screening.

Blood 2018 02 8;131(7):821-826. Epub 2018 Jan 8.

Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2017-09-808402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909885PMC
February 2018

IL-2 Inducible Kinase ITK is Critical for HIV-1 Infection of Jurkat T-cells.

Sci Rep 2018 02 16;8(1):3217. Epub 2018 Feb 16.

Clinic for Gastroenterology, Hepatology and Infectiology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, 40225, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-21344-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816632PMC
February 2018

Genetic predisposition in children with cancer - affected families' acceptance of Trio-WES.

Eur J Pediatr 2018 Jan 19;177(1):53-60. Epub 2017 Sep 19.

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225, Duesseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00431-017-2997-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748429PMC
January 2018

Correction to: Genetic predisposition in children with cancer - affected families' acceptance of Trio-WES.

Eur J Pediatr 2018 01;177(1):61

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225, Duesseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00431-017-3033-6DOI Listing
January 2018

Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations.

Eur J Hum Genet 2018 01 11;26(1):137-142. Epub 2017 Dec 11.

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41431-017-0048-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839031PMC
January 2018

Smoldering Development of Acute Megakaryoblastic Leukemia with Clonal Evolution in an Infant without Down Syndrome.

Klin Padiatr 2017 11 13;229(6):352-354. Epub 2017 Nov 13.

Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine University of Duesseldorf, Duesseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0043-113446DOI Listing
November 2017

Modeling the process of childhood B-cell leukemias.

Oncotarget 2017 Nov 27;8(60):102674-102680. Epub 2017 Sep 27.

Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC/ Universidad de Salamanca, Campus M. de Unamuno s/n, Salamanca, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.21281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731989PMC
November 2017

Nobel Prize nominees hundred years ago: Abraham Jacobi (1830-1919) and Otto Heubner (1843-1926).

Eur J Pediatr 2017 Oct 13;176(10):1411-1413. Epub 2017 Aug 13.

Department for the History, Philosophy, and Ethics of Medicine, Medical Faculty Heinrich-Heine-University Duesseldorf, Universitätsstr. 1, 40225, Duesseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00431-017-2987-8DOI Listing
October 2017

Palliative care for children with a yet undiagnosed syndrome.

Eur J Pediatr 2017 Oct 14;176(10):1319-1327. Epub 2017 Aug 14.

Medical Faculty, Department of Paediatric Oncology, Haematology and Clinical Immunology, Centre for Child and Adolescent Health, University of Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00431-017-2991-zDOI Listing
October 2017

Autism spectrum disorder and Li-Fraumeni syndrome: purely coincidental or mechanistically associated?

Mol Cell Pediatr 2017 Oct 5;4(1). Epub 2017 Oct 5.

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225, Duesseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40348-017-0075-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629188PMC
October 2017

End-of-life care in children with hematologic malignancies.

Oncotarget 2017 Oct 23;8(52):89939-89948. Epub 2017 Sep 23.

Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Medical Faculty, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.21188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685721PMC
October 2017

Embryonal rhabdomyosarcoma in a patient with a heterozygous frameshift variant in the DICER1 gene and additional manifestations of the DICER1 syndrome.

Fam Cancer 2017 07;16(3):401-405

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10689-016-9958-5DOI Listing
July 2017

HIV-1 Subtype Diversity and Prevalence of Primary Drug Resistance in a Single-Center Pediatric Cohort in Germany.

Intervirology 2016 5;59(5-6):301-306. Epub 2017 Jul 5.

Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000477811DOI Listing
July 2017

Osteonecrosis in children and adolescents with acute lymphoblastic leukemia: a therapeutic challenge.

Blood Adv 2017 Jun 13;1(14):981-994. Epub 2017 Jun 13.

Department of Pediatric Oncology, Hematology, and Clinical Immunology, Center for Child and Adolescent Health, Medical Faculty, University of Duesseldorf, Duesseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/bloodadvances.2017007286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737600PMC
June 2017

Infection as a cause of childhood leukemia: virus detection employing whole genome sequencing.

Haematologica 2017 05 2;102(5):e179-e183. Epub 2017 Feb 2.

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2016.155382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685284PMC
May 2017

Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.

Authors:
Rhea van den Bruck Patrick P Weil Thomas Ziegenhals Philipp Schreiner Stefan Juranek Daniel Gödde Silvia Vogel Frauke Schuster Valerie Orth Johannes Dörner Daniel Pembaur Meike Röper Stefan Störkel Hubert Zirngibl Stefan Wirth Andreas C W Jenke Jan Postberg Nikolas Boy Jana Heringer Gisela Haege Esther M Glahn Georg F Hoffmann Sven F Garbade Peter Burgard Stefan Kölker Cho-Ming Chao Faady Yahya Alena Moiseenko Amit Shrestha Negah Ahmadvand Jennifer Quantius Jochen Wilhelm Elie El-Agha Klaus-Peter Zimmer Saverio Bellusci Christian Staufner Stefan Kölker Holger Prokisch Georg F Hoffmann Stephan Seeliger Matthias Müller Andreas Hippe Henrik Steinkraus Roland Wauer Burkhard Lachmann Sigrun R Hofmann Christian M Hedrich Jakob Zierk Farhad Arzideh Rainer Haeckel Wolfgang Rascher Manfred Rauh Markus Metzler Sebastian Thieme Joanna Bandoła Cornelia Richter Martin Ryser Arshad Jamal Michelle P Ashton Malte von Bonin Matthias Kuhn Christian M Hedrich Ezio Bonifacio Reinhard Berner Sebastian Brenner Johanna Hammersen Cristina Has Nora Naumann-Bartsch Daniel Stachel Dimitra Kiritsi Stephan Söder Mathilde Tardieu Markus Metzler Leena Bruckner-Tuderman Holm Schneider F Bohne D Langer R Cencic T Eggermann U Zechner J Pelletier F Zepp T Enklaar D Prawitt Martin Pech Markus Weckmann Femke-Anouska Heinsen Andre Franke Christine Happle Anna-Maria Dittrich Gesine Hansen Oliver Fuchs Erika von Mutius Brian G Oliver Matthias V Kopp Claudia Paret Alexandra Russo Johanna Theruvath Bettina Keller Khalifa El Malki Nadine Lehmann Arthur Wingerter Marie A Neu Gerhold-Ay Aslihan Wolfgang Wagner Clemens Sommer Torsten Pietsch Larissa Seidmann Jörg Faber Felix Schreiner Merle Ackermann Michael Michalik Eva Rother Andras Bilkei-Gorzo Ildiko Racz Laura Bindila Beat Lutz Jörg Dötsch Andreas Zimmer Joachim Woelfle Hendrik S Fischer Tim L Ullrich Christoph Bührer Christoph Czernik Gerd Schmalisch Robert Stein Sigrun R Hofmann Judith Hagenbuchner Ursula Kiechl-Kohlendorfer Petra Obexer Michael J Ausserlechner Niki T Loges Adrien Tobias Frommer Julia Wallmeier Heymut Omran Soner Öner-Sieben Martina Gimpfl Jan Rozman Martin Irmler Johannes Beckers Martin Hrabe De Angelis Adelbert Roscher Eckhard Wolf Regina Ensenauer Karolina Nemes Michael Frühwald Martin Hasselblatt Reiner Siebert Uwe Kordes Marcel Kool Haicui Wang Holly Hardy Osama Refai Katy E S Barwick Holly H Zimmerman Joachim Weis Emma L Baple Andrew H Crosby Sebahattin Cirak C Hellmuth O Uhl M Standl J Heinrich E Thiering B Koletzko Lena Blümel Kornelius Kerl Daniel Picard Michael C Frühwald Max C Liebau Guido Reifenberger Arndt Borkhardt Martin Hasselblatt Marc Remke D Tews M Wabitsch P Fischer-Posovszky Mike-Andrew Westhoff Lisa Nonnenmacher Julia Langhans Lukas Schneele Nancy Trenkler Klaus-Michael Debatin

Mol Cell Pediatr 2017 May;4(Suppl 1)

Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40348-017-0071-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435609PMC
May 2017

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.

Am J Med Genet A 2017 Apr 7;173(4):1017-1037. Epub 2017 Feb 7.

Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.a.38142DOI Listing
April 2017

T-cell acute lymphoblastic leukemia in infants has distinct genetic and epigenetic features compared to childhood cases.

Genes Chromosomes Cancer 2017 02 26;56(2):159-167. Epub 2016 Oct 26.

Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine-University, Medical Faculty, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/gcc.22423DOI Listing
February 2017

Human RAD52 - a novel player in DNA repair in cancer and immunodeficiency.

Haematologica 2017 02 15;102(2):e69-e72. Epub 2016 Dec 15.

Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2016.155838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286958PMC
February 2017

A novel homozygous mutation in UNC13D presenting as Epstein-Barr-virus-associated lymphoproliferative disease at 9 years of age.

Leuk Lymphoma 2016 12 28;57(12):2949-2951. Epub 2016 Apr 28.

a Pediatric Oncology, Hematology and Clinical Immunology , Heinrich Heine University Medical Center , Düsseldorf , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10428194.2016.1177724DOI Listing
December 2016

Transient spontaneous remission in congenital MLL-AF10 rearranged acute myeloid leukemia presenting with cardiorespiratory failure and meconium ileus.

Mol Cell Pediatr 2016 Dec 29;3(1):30. Epub 2016 Aug 29.

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225, Duesseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40348-016-0061-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002396PMC
December 2016

Phase I/Phase II Study of Blinatumomab in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia.

J Clin Oncol 2016 12 31;34(36):4381-4389. Epub 2016 Oct 31.

Arend von Stackelberg, Charité Campus Virchow, Berlin; Gerhard Zugmaier, Amgen Research (Munich), Munich; Rupert Handgretinger, University of Tübingen, Tübingen; Peter Bader, Hospital for Children and Adolescents III, University of Frankfurt, Frankfurt; Paul Gerhardt Schlegel, University Children's Hospital Würzburg, Würzburg; Arndt Borkhardt, University of Düsseldorf Medical Faculty, Düsseldorf, Germany; Franco Locatelli, Ospedale Pediatrico Bambino Gesù, Rome, University of Pavia, Pavia; Carmelo Rizzari, San Gerardo Hospital, University of Milano-Bicocca, Monza; Chiara Messina, Clinica di Oncoematologia Pediatrica, Università degli Studi di Padova, Padova, Italy; Benoît Brethon, Hôpital Robert Debré, Service Hématologie-Immunologie Pédiatrique, Paris; Gérard Michel, Hôpital de la Timone, Marseille, France; Christian M. Zwaan, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, Netherlands; Tanya M. Trippett, Memorial Sloan Kettering Cancer Center, New York, NY; Maureen M. O'Brien, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Deepa Bhojwani, Children's Hospital of Los Angeles; Kuolung Hu and Min Zhu, Amgen, Thousand Oaks, CA; Susan R. Rheingold, Children's Hospital of Philadelphia, Philadelphia, PA; Todd Michael Cooper, Seattle Children's Hospital, Seattle, WA; Phillip Barnette, Primary Children's Medical Center, Salt Lake City, UT; Steven G. DuBois, Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA; Lia Gore, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO; and James A. Whitlock, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://ascopubs.org/doi/10.1200/JCO.2016.67.3301
Publisher Site
http://dx.doi.org/10.1200/JCO.2016.67.3301DOI Listing
December 2016

Effective treatment of spasticity using dronabinol in pediatric palliative care.

Eur J Paediatr Neurol 2016 Nov 30;20(6):898-903. Epub 2016 Jul 30.

University of Dusseldorf, Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Moorenstr. 5, 40225 Dusseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejpn.2016.07.021DOI Listing
November 2016

Mouse models for pre-clinical drug testing in leukemia.

Expert Opin Drug Discov 2016 Nov 9;11(11):1081-1091. Epub 2016 Sep 9.

a Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty , Heinrich-Heine University Dusseldorf , Düsseldorf , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17460441.2016.1229297DOI Listing
November 2016

Osteonecrosis in children with acute lymphoblastic leukemia.

Haematologica 2016 11 14;101(11):1295-1305. Epub 2016 Oct 14.

University of Duesseldorf, Medical Faculty, Department of Pediatric Oncology, Hematology, and Clinical Immunology, Center for Child and Adolescent Health, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2016.147595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394877PMC
November 2016

Massively Distended Abdomen Caused by Fibromatosis Previously Misdiagnosed as Myxofibrosarcoma.

J Oncol Pract 2016 11 31;12(11):1192-1194. Epub 2016 Oct 31.

University Children's Hospital, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JOP.2016.014951DOI Listing
November 2016

Fatal Lymphoproliferative Disease in Two Siblings Lacking Functional FAAP24.

J Clin Immunol 2016 10 29;36(7):684-92. Epub 2016 Jul 29.

Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University, Moorenstrasse 5, 40225, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10875-016-0317-yDOI Listing
October 2016

The PARA-suite: PAR-CLIP specific sequence read simulation and processing.

PeerJ 2016 27;4:e2619. Epub 2016 Oct 27.

Department for Algorithmic Bioinformatics, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany; Computational Biology of Infection Research, Helmholtz Center for Infection Research, Braunschweig, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7717/peerj.2619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088580PMC
October 2016

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study.

Eur J Cancer 2016 09 29;65:91-101. Epub 2016 Jul 29.

Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg, 69120, Germany; German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2016.06.009DOI Listing
September 2016

Selective downregulation of HLA-C and HLA-E in childhood acute lymphoblastic leukaemia.

Br J Haematol 2016 08 3;174(3):477-80. Epub 2015 Nov 3.

Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.13777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854806PMC
August 2016

Homozygous HOXB1 loss-of-function mutation in a large family with hereditary congenital facial paresis.

Am J Med Genet A 2016 07 4;170(7):1813-9. Epub 2016 May 4.

Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.a.37682DOI Listing
July 2016

Hodgkin lymphoma as a novel presentation of familial DICER1 syndrome.

Eur J Pediatr 2016 Apr 3;175(4):593-7. Epub 2015 Nov 3.

Pediatric Hematology and Oncology, Children's Hospital Medical Centre, University of Bonn, Bonn, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00431-015-2660-zDOI Listing
April 2016

Experiences in palliative home care of infants with life-limiting conditions.

Eur J Pediatr 2016 Mar 28;175(3):321-7. Epub 2015 Sep 28.

Department of Paediatric Oncology, Haematology and Clinical Immunology, Medical Faculty, Centre for Child and Adolescent Health, University of Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00431-015-2637-yDOI Listing
March 2016

GEMMs addressing Pax5 loss-of-function in childhood pB-ALL.

Eur J Med Genet 2016 Mar 26;59(3):166-72. Epub 2015 Nov 26.

Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine University Dusseldorf, Medical Faculty, Dusseldorf, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmg.2015.11.009DOI Listing
March 2016

Symptoms and management of pediatric patients with incurable brain tumors in palliative home care.

Eur J Paediatr Neurol 2016 Mar 22;20(2):261-269. Epub 2015 Dec 22.

University of Dusseldorf, Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Moorenstr. 5, 40225 Dusseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejpn.2015.12.004DOI Listing
March 2016

De novo PIK3R1 gain-of-function with recurrent sinopulmonary infections, long-lasting chronic CMV-lymphadenitis and microcephaly.

Clin Immunol 2016 Jan 31;162:27-30. Epub 2015 Oct 31.

University of Duesseldorf, Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Duesseldorf, Germany. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15216616153005
Publisher Site
http://dx.doi.org/10.1016/j.clim.2015.10.008DOI Listing
January 2016

Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients.

Leuk Res 2015 Sep 14;39(9):990-1001. Epub 2015 Jun 14.

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.leukres.2015.06.005DOI Listing
September 2015

Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.

Nat Genet 2015 Sep 27;47(9):1020-1029. Epub 2015 Jul 27.

Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603357PMC
September 2015

Visceral Leishmaniasis as a Possible Reason for Pancytopenia.

Front Pediatr 2015 29;3:59. Epub 2015 Jun 29.

Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine University Düsseldorf , Düsseldorf , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fped.2015.00059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483513PMC
July 2015

Identification of TEL-AML1 (ETV6-RUNX1) associated DNA and its impact on mRNA and protein output using ChIP, mRNA expression arrays and SILAC.

Genom Data 2014 Dec 27;2:85-8. Epub 2014 May 27.

Heinrich-Heine-University Düsseldorf, Medical Faculty, Clinic for Pediatric Oncology, Hematology and Clinical Immunology, Duesseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gdata.2014.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536161PMC
December 2014