Arn M J M van den Maagdenberg

Arn M J M van den Maagdenberg

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Arn M J M van den Maagdenberg

Arn M J M van den Maagdenberg

Publications by authors named "Arn M J M van den Maagdenberg"

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Relief Following Chronic Stress Augments Spreading Depolarization Susceptibility in Familial Hemiplegic Migraine Mice.

Neuroscience 2019 Jul 9;415:1-9. Epub 2019 Jul 9.

Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA; Stroke Service and Neuroscience Intensive Care Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2019.07.006DOI Listing
July 2019

TREX1 Mutation Causing Autosomal Dominant Thrombotic Microangiopathy and CKD Is in Fact a Case of RVCL-S Presenting With Renal Features.

Am J Kidney Dis 2019 Jun 4;73(6):893. Epub 2019 Mar 4.

Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1053/j.ajkd.2018.12.041DOI Listing
June 2019

A miniaturized push-pull-perfusion probe for few-second sampling of neurotransmitters in the mouse brain.

Lab Chip 2019 04;19(8):1332-1343

BIOS - Microdevices for Chemical Analysis group, MESA+ Institute for Nanotechnology, Techmed Centre, University of Twente, Hallenweg 15, 7522 NH Enschede, The Netherlands.

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http://dx.doi.org/10.1039/c8lc01137kDOI Listing
April 2019

Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine.

Neurology 2019 Apr 3;92(16):e1899-e1911. Epub 2019 Apr 3.

From the Departments of Neurology (G.L.J.O., J.A.P., D.A.K., R.Z., I.d.B., M.D.F., G.M.T., A.M.J.M.v.d.M.), Human Genetics (A.D., L.S.V., P.A.C.'tH., A.M.J.M.v.d.M.), Molecular Epidemiology (M.B., P.E.S.), Radiology (D.A.K.), and Medical Statistics (J.J.G.), Leiden University Medical Centre; Department of Biological Psychology (L.L., R.P., D.I.B.), Vrije Universiteit Amsterdam; Amsterdam Public Health Institute (L.L.); Amsterdam Neuroscience and Amsterdam Public Health (M.B., C.S.T., Y.M., D.I.B., B.W.P.); Department of Psychiatry (M.B., C.S.T., Y.M., B.W.P.), VU University Medical Centre/GGZ inGeest, Amsterdam; Departments of Epidemiology (A.D., J.L., K.-x.W., N.A., M.A.I., C.M.v.D.) and Neurology (M.A.I.), Erasmus Medical Centre, Rotterdam; Departments of Genetics (J.F., L.F., C.W.) and Pediatrics (J.F.), University Medical Centre Groningen; Department of Internal Medicine (C.J.H.v.d.K., F.H.M.V., M.M.J.v.G., M.T.S., C.D.A.S.) and Heart and Vascular Center (M.T.S.), Maastricht University Medical Centre; CARIM School for Cardiovascular Diseases (C.J.H.v.d.K., M.M.J.v.G., I.C.W.A., M.T.S., P.C.D., C.D.A.S.), Department of Epidemiology (I.C.W.A.), MaCSBio Maastricht Centre for Systems Biology (I.C.W.A.), and Department of Epidemiology (P.C.D.), Maastricht University; Department of Radiology (M.A.I.), Erasmus MC University Medical Centre, Rotterdam; Leiden Academic Centre in Drug Research, Faculty Science (C.M.v.D.), Leiden University; and Centre for Molecular and Biomolecular Informatics (P.A.C.'tH.), Radboud University Medical Centre Nijmegen, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000007313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550500PMC
April 2019

Novel hypotheses emerging from GWAS in migraine?

J Headache Pain 2019 Jan 11;20(1). Epub 2019 Jan 11.

Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1186/s10194-018-0956-xDOI Listing
January 2019

RVCL-S and CADASIL display distinct impaired vascular function.

Neurology 2018 09 3;91(10):e956-e963. Epub 2018 Aug 3.

From the Departments of Neurology (I.d.B., A.H.S., R.Z., I.v.d.S., A.M.J.M.v.d.M., M.D.F., G.M.T.), Human Genetics (A.M.J.M.v.d.M.), and Internal Medicine (E.J.P.d.K.), Leiden University Medical Center, Leiden, the Netherlands; and Center for Clinical Pharmacology (L.B., J.N.d.H.), University Hospitals Leuven and Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium.

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http://dx.doi.org/10.1212/WNL.0000000000006119DOI Listing
September 2018

Analysis of shared heritability in common disorders of the brain.

Authors:
Verneri Anttila Brendan Bulik-Sullivan Hilary K Finucane Raymond K Walters Jose Bras Laramie Duncan Valentina Escott-Price Guido J Falcone Padhraig Gormley Rainer Malik Nikolaos A Patsopoulos Stephan Ripke Zhi Wei Dongmei Yu Phil H Lee Patrick Turley Benjamin Grenier-Boley Vincent Chouraki Yoichiro Kamatani Claudine Berr Luc Letenneur Didier Hannequin Philippe Amouyel Anne Boland Jean-François Deleuze Emmanuelle Duron Badri N Vardarajan Christiane Reitz Alison M Goate Matthew J Huentelman M Ilyas Kamboh Eric B Larson Ekaterina Rogaeva Peter St George-Hyslop Hakon Hakonarson Walter A Kukull Lindsay A Farrer Lisa L Barnes Thomas G Beach F Yesim Demirci Elizabeth Head Christine M Hulette Gregory A Jicha John S K Kauwe Jeffrey A Kaye James B Leverenz Allan I Levey Andrew P Lieberman Vernon S Pankratz Wayne W Poon Joseph F Quinn Andrew J Saykin Lon S Schneider Amanda G Smith Joshua A Sonnen Robert A Stern Vivianna M Van Deerlin Linda J Van Eldik Denise Harold Giancarlo Russo David C Rubinsztein Anthony Bayer Magda Tsolaki Petra Proitsi Nick C Fox Harald Hampel Michael J Owen Simon Mead Peter Passmore Kevin Morgan Markus M Nöthen Martin Rossor Michelle K Lupton Per Hoffmann Johannes Kornhuber Brian Lawlor Andrew McQuillin Ammar Al-Chalabi Joshua C Bis Agustin Ruiz Mercè Boada Sudha Seshadri Alexa Beiser Kenneth Rice Sven J van der Lee Philip L De Jager Daniel H Geschwind Matthias Riemenschneider Steffi Riedel-Heller Jerome I Rotter Gerhard Ransmayr Bradley T Hyman Carlos Cruchaga Montserrat Alegret Bendik Winsvold Priit Palta Kai-How Farh Ester Cuenca-Leon Nicholas Furlotte Tobias Kurth Lannie Ligthart Gisela M Terwindt Tobias Freilinger Caroline Ran Scott D Gordon Guntram Borck Hieab H H Adams Terho Lehtimäki Juho Wedenoja Julie E Buring Markus Schürks Maria Hrafnsdottir Jouke-Jan Hottenga Brenda Penninx Ville Artto Mari Kaunisto Salli Vepsäläinen Nicholas G Martin Grant W Montgomery Mitja I Kurki Eija Hämäläinen Hailiang Huang Jie Huang Cynthia Sandor Caleb Webber Bertram Muller-Myhsok Stefan Schreiber Veikko Salomaa Elizabeth Loehrer Hartmut Göbel Alfons Macaya Patricia Pozo-Rosich Thomas Hansen Thomas Werge Jaakko Kaprio Andres Metspalu Christian Kubisch Michel D Ferrari Andrea C Belin Arn M J M van den Maagdenberg John-Anker Zwart Dorret Boomsma Nicholas Eriksson Jes Olesen Daniel I Chasman Dale R Nyholt Andreja Avbersek Larry Baum Samuel Berkovic Jonathan Bradfield Russell J Buono Claudia B Catarino Patrick Cossette Peter De Jonghe Chantal Depondt Dennis Dlugos Thomas N Ferraro Jacqueline French Helle Hjalgrim Jennifer Jamnadas-Khoda Reetta Kälviäinen Wolfram S Kunz Holger Lerche Costin Leu Dick Lindhout Warren Lo Daniel Lowenstein Mark McCormack Rikke S Møller Anne Molloy Ping-Wing Ng Karen Oliver Michael Privitera Rodney Radtke Ann-Kathrin Ruppert Thomas Sander Steven Schachter Christoph Schankin Ingrid Scheffer Susanne Schoch Sanjay M Sisodiya Philip Smith Michael Sperling Pasquale Striano Rainer Surges G Neil Thomas Frank Visscher Christopher D Whelan Federico Zara Erin L Heinzen Anthony Marson Felicitas Becker Hans Stroink Fritz Zimprich Thomas Gasser Raphael Gibbs Peter Heutink Maria Martinez Huw R Morris Manu Sharma Mina Ryten Kin Y Mok Sara Pulit Steve Bevan Elizabeth Holliday John Attia Thomas Battey Giorgio Boncoraglio Vincent Thijs Wei-Min Chen Braxton Mitchell Peter Rothwell Pankaj Sharma Cathie Sudlow Astrid Vicente Hugh Markus Christina Kourkoulis Joana Pera Miriam Raffeld Scott Silliman Vesna Boraska Perica Laura M Thornton Laura M Huckins N William Rayner Cathryn M Lewis Monica Gratacos Filip Rybakowski Anna Keski-Rahkonen Anu Raevuori James I Hudson Ted Reichborn-Kjennerud Palmiero Monteleone Andreas Karwautz Katrin Mannik Jessica H Baker Julie K O'Toole Sara E Trace Oliver S P Davis Sietske G Helder Stefan Ehrlich Beate Herpertz-Dahlmann Unna N Danner Annemarie A van Elburg Maurizio Clementi Monica Forzan Elisa Docampo Jolanta Lissowska Joanna Hauser Alfonso Tortorella Mario Maj Fragiskos Gonidakis Konstantinos Tziouvas Hana Papezova Zeynep Yilmaz Gudrun Wagner Sarah Cohen-Woods Stefan Herms Antonio Julià Raquel Rabionet Danielle M Dick Samuli Ripatti Ole A Andreassen Thomas Espeseth Astri J Lundervold Vidar M Steen Dalila Pinto Stephen W Scherer Harald Aschauer Alexandra Schosser Lars Alfredsson Leonid Padyukov Katherine A Halmi James Mitchell Michael Strober Andrew W Bergen Walter Kaye Jin Peng Szatkiewicz Bru Cormand Josep Antoni Ramos-Quiroga Cristina Sánchez-Mora Marta Ribasés Miguel Casas Amaia Hervas Maria Jesús Arranz Jan Haavik Tetyana Zayats Stefan Johansson Nigel Williams Astrid Dempfle Aribert Rothenberger Jonna Kuntsi Robert D Oades Tobias Banaschewski Barbara Franke Jan K Buitelaar Alejandro Arias Vasquez Alysa E Doyle Andreas Reif Klaus-Peter Lesch Christine Freitag Olga Rivero Haukur Palmason Marcel Romanos Kate Langley Marcella Rietschel Stephanie H Witt Soeren Dalsgaard Anders D Børglum Irwin Waldman Beth Wilmot Nikolas Molly Claiton H D Bau Jennifer Crosbie Russell Schachar Sandra K Loo James J McGough Eugenio H Grevet Sarah E Medland Elise Robinson Lauren A Weiss Elena Bacchelli Anthony Bailey Vanessa Bal Agatino Battaglia Catalina Betancur Patrick Bolton Rita Cantor Patrícia Celestino-Soper Geraldine Dawson Silvia De Rubeis Frederico Duque Andrew Green Sabine M Klauck Marion Leboyer Pat Levitt Elena Maestrini Shrikant Mane Daniel Moreno- De-Luca Jeremy Parr Regina Regan Abraham Reichenberg Sven Sandin Jacob Vorstman Thomas Wassink Ellen Wijsman Edwin Cook Susan Santangelo Richard Delorme Bernadette Rogé Tiago Magalhaes Dan Arking Thomas G Schulze Robert C Thompson Jana Strohmaier Keith Matthews Ingrid Melle Derek Morris Douglas Blackwood Andrew McIntosh Sarah E Bergen Martin Schalling Stéphane Jamain Anna Maaser Sascha B Fischer Céline S Reinbold Janice M Fullerton José Guzman-Parra Fermin Mayoral Peter R Schofield Sven Cichon Thomas W Mühleisen Franziska Degenhardt Johannes Schumacher Michael Bauer Philip B Mitchell Elliot S Gershon John Rice James B Potash Peter P Zandi Nick Craddock I Nicol Ferrier Martin Alda Guy A Rouleau Gustavo Turecki Roel Ophoff Carlos Pato Adebayo Anjorin Eli Stahl Markus Leber Piotr M Czerski Cristiana Cruceanu Ian R Jones Danielle Posthuma Till F M Andlauer Andreas J Forstner Fabian Streit Bernhard T Baune Tracy Air Grant Sinnamon Naomi R Wray Donald J MacIntyre David Porteous Georg Homuth Margarita Rivera Jakob Grove Christel M Middeldorp Ian Hickie Michele Pergadia Divya Mehta Johannes H Smit Rick Jansen Eco de Geus Erin Dunn Qingqin S Li Matthias Nauck Robert A Schoevers Aartjan Tf Beekman James A Knowles Alexander Viktorin Paul Arnold Cathy L Barr Gabriel Bedoya-Berrio O Joseph Bienvenu Helena Brentani Christie Burton Beatriz Camarena Carolina Cappi Danielle Cath Maria Cavallini Daniele Cusi Sabrina Darrow Damiaan Denys Eske M Derks Andrea Dietrich Thomas Fernandez Martijn Figee Nelson Freimer Gloria Gerber Marco Grados Erica Greenberg Gregory L Hanna Andreas Hartmann Matthew E Hirschtritt Pieter J Hoekstra Alden Huang Chaim Huyser Cornelia Illmann Michael Jenike Samuel Kuperman Bennett Leventhal Christine Lochner Gholson J Lyon Fabio Macciardi Marcos Madruga-Garrido Irene A Malaty Athanasios Maras Lauren McGrath Eurípedes C Miguel Pablo Mir Gerald Nestadt Humberto Nicolini Michael S Okun Andrew Pakstis Peristera Paschou John Piacentini Christopher Pittenger Kerstin Plessen Vasily Ramensky Eliana M Ramos Victor Reus Margaret A Richter Mark A Riddle Mary M Robertson Veit Roessner Maria Rosário Jack F Samuels Paul Sandor Dan J Stein Fotis Tsetsos Filip Van Nieuwerburgh Sarah Weatherall Jens R Wendland Tomasz Wolanczyk Yulia Worbe Gwyneth Zai Fernando S Goes Nicole McLaughlin Paul S Nestadt Hans-Jorgen Grabe Christel Depienne Anuar Konkashbaev Nuria Lanzagorta Ana Valencia-Duarte Elvira Bramon Nancy Buccola Wiepke Cahn Murray Cairns Siow A Chong David Cohen Benedicto Crespo-Facorro James Crowley Michael Davidson Lynn DeLisi Timothy Dinan Gary Donohoe Elodie Drapeau Jubao Duan Lieuwe Haan David Hougaard Sena Karachanak-Yankova Andrey Khrunin Janis Klovins Vaidutis Kučinskas Jimmy Lee Chee Keong Svetlana Limborska Carmel Loughland Jouko Lönnqvist Brion Maher Manuel Mattheisen Colm McDonald Kieran C Murphy Igor Nenadic Jim van Os Christos Pantelis Michele Pato Tracey Petryshen Digby Quested Panos Roussos Alan R Sanders Ulrich Schall Sibylle G Schwab Kang Sim Hon-Cheong So Elisabeth Stögmann Mythily Subramaniam Draga Toncheva John Waddington James Walters Mark Weiser Wei Cheng Robert Cloninger David Curtis Pablo V Gejman Frans Henskens Morten Mattingsdal Sang-Yun Oh Rodney Scott Bradley Webb Gerome Breen Claire Churchhouse Cynthia M Bulik Mark Daly Martin Dichgans Stephen V Faraone Rita Guerreiro Peter Holmans Kenneth S Kendler Bobby Koeleman Carol A Mathews Alkes Price Jeremiah Scharf Pamela Sklar Julie Williams Nicholas W Wood Chris Cotsapas Aarno Palotie Jordan W Smoller Patrick Sullivan Jonathan Rosand Aiden Corvin Benjamin M Neale Jonathan M Schott Richard Anney Josephine Elia Maria Grigoroiu-Serbanescu Howard J Edenberg Robin Murray

Science 2018 06;360(6395)

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1126/science.aap8757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097237PMC
June 2018

Differential neuromodulatory role of endocannabinoids in the rodent trigeminal sensory ganglion and cerebral cortex relevant to pain processing.

Neuropharmacology 2018 03 7;131:39-50. Epub 2017 Dec 7.

Neuroscience Department, International School for Advanced Studies (SISSA), Trieste, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2017.12.013DOI Listing
March 2018

Clinical spectrum of hemiplegic migraine and chances of finding a pathogenic mutation.

Neurology 2018 02 17;90(7):e575-e582. Epub 2018 Jan 17.

From the Departments of Neurology (N.P., J.H., A.H.S., A.S., M.D.F., A.M.J.M.v.d.M., G.M.T.) and Human Genetics (L.S.V., S.C.K., B.d.V., A.M.J.M.v.d.M.), Leiden University Medical Centre; and Department of Neurology (J.H.), Alrijne Hospital, Leiderdorp, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000004966DOI Listing
February 2018

Calcitonin gene-related peptide (receptor) antibodies: an exciting avenue for migraine treatment.

Genome Med 2018 02 22;10(1):10. Epub 2018 Feb 22.

Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/s13073-018-0524-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824555PMC
February 2018

In situ imaging reveals properties of purinergic signalling in trigeminal sensory ganglia in vitro.

Purinergic Signal 2017 Dec 18;13(4):511-520. Epub 2017 Aug 18.

Center for Biomedical Sciences and Engineering, University of Nova Gorica, Vipavska 13, 5000, Nova Gorica, Slovenia.

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http://dx.doi.org/10.1007/s11302-017-9576-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714839PMC
December 2017

Circulating Endothelial Markers in Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations.

Stroke 2017 12 7;48(12):3301-3307. Epub 2017 Nov 7.

From the Department of Neurology (N.P., M.D.F., A.M.J.M.v.d.M., G.M.T.), Department of Internal Medicine (Nephrology) (R.B., M.E.J.R., A.J.v.Z.), Einthoven Laboratory for Vascular and Regenerative Medicine (R.B., A.J.v.Z., J.E.), Department of Human Genetics (A.M.J.M.v.d.M.), and Department of Internal Medicine, Section Thrombosis and Hemostasis (J.E.), Leiden University Medical Center, the Netherlands.

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http://dx.doi.org/10.1161/STROKEAHA.117.018556DOI Listing
December 2017

δ-Catenin () missense mutation in familial cortical myoclonic tremor and epilepsy.

Neurology 2017 Dec 10;89(23):2341-2350. Epub 2017 Nov 10.

From the Departments of Neurology and Clinical Neurophysiology (A.-F.v.R., A.B., M.A.J.T.), Academic Medical Centre, Amsterdam Neuroscience, University of Amsterdam; Departments of Functional Genomics and Clinical Genetics (A.J.G.), CNCR, Neuroscience Campus Amsterdam, VU University and VU Medical Centre; Departments of Human Genetics (B.d.V., S.K., L.S.V., A.M.J.M.v.d.M.), Clinical Genetics (G.W.E.S.), and Neurology (A.M.J.M.v.d.M.), Leiden University Medical Centre; and Department of Neurology (P.M.C.C., M.A.J.T.), University Medical Centre Groningen, University of Groningen, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000004709DOI Listing
December 2017

Inhibition of the P2X7-PANX1 complex suppresses spreading depolarization and neuroinflammation.

Brain 2017 Jun;140(6):1643-1656

Neurovascular Research Lab, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

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https://academic.oup.com/brain/article/140/6/1643/3744970
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http://dx.doi.org/10.1093/brain/awx085DOI Listing
June 2017

Hyperpolarization-activated current I in mouse trigeminal sensory neurons in a transgenic mouse model of familial hemiplegic migraine type-1.

Neuroscience 2017 05 29;351:47-64. Epub 2017 Mar 29.

Neuroscience Department, International School for Advanced Studies (SISSA), Trieste, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03064522173019
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http://dx.doi.org/10.1016/j.neuroscience.2017.03.033DOI Listing
May 2017

Valproate Reduces Delayed Brain Injury in a Rat Model of Subarachnoid Hemorrhage.

Stroke 2017 02 27;48(2):452-458. Epub 2016 Dec 27.

From the Departments of Neurology (A.M.H., H.J.A.v.O., M.D.F., A.M.J.M.v.d.M., M.J.H.W.), Human Genetics (A.M.J.M.v.d.M.), Medical Statistics (E.v.Z.), Leiden University Medical Center, Leiden, The Netherlands; Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands (A.M.H., A.v.d.T., U.S.R., R.M.D.); and Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Centre, Dallas (L.M., K.P., A.M.S.).

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http://dx.doi.org/10.1161/STROKEAHA.116.014738DOI Listing
February 2017

Identifying a gene expression signature of cluster headache in blood.

Sci Rep 2017 01 11;7:40218. Epub 2017 Jan 11.

Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/srep40218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225606PMC
January 2017

Automated Ischemic Lesion Segmentation in MRI Mouse Brain Data after Transient Middle Cerebral Artery Occlusion.

Front Neuroinform 2017 31;11. Epub 2017 Jan 31.

Department of Neurology, Leiden University Medical CenterLeiden, Netherlands; Department of Human Genetics, Leiden University Medical CenterLeiden, Netherlands.

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http://journal.frontiersin.org/article/10.3389/fninf.2017.00
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http://dx.doi.org/10.3389/fninf.2017.00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5281583PMC
January 2017

Familial Hemiplegic Migraine and Recurrent Episodes of Psychosis: A Case Report.

Headache 2015 Jul-Aug;55(7):1004-7. Epub 2015 Jun 18.

Danish Headache Center, Department of Neurology Glostrup, Copenhagen University Hospital, Glostrup, Denmark.

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http://doi.wiley.com/10.1111/head.12595
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http://dx.doi.org/10.1111/head.12595DOI Listing
November 2016

Metabolomic changes in CSF of migraine patients measured with H-NMR spectroscopy.

Mol Biosyst 2016 11;12(12):3674-3682

Department of Neurology, Leiden University Medical Center, P.O. 9600, 2300 WB, Leiden, The Netherlands.

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http://dx.doi.org/10.1039/c6mb00424eDOI Listing
November 2016

Loss of inhibition by brain natriuretic peptide over P2X3 receptors contributes to enhanced spike firing of trigeminal ganglion neurons in a mouse model of familial hemiplegic migraine type-1.

Neuroscience 2016 09 23;331:197-205. Epub 2016 Jun 23.

Neuroscience Department, International School for Advanced Studies (SISSA), Via Bonomea 265, 34136 Trieste, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03064522163026
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http://dx.doi.org/10.1016/j.neuroscience.2016.06.034DOI Listing
September 2016

Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.

Authors:
Padhraig Gormley Verneri Anttila Bendik S Winsvold Priit Palta Tonu Esko Tune H Pers Kai-How Farh Ester Cuenca-Leon Mikko Muona Nicholas A Furlotte Tobias Kurth Andres Ingason George McMahon Lannie Ligthart Gisela M Terwindt Mikko Kallela Tobias M Freilinger Caroline Ran Scott G Gordon Anine H Stam Stacy Steinberg Guntram Borck Markku Koiranen Lydia Quaye Hieab H H Adams Terho Lehtimäki Antti-Pekka Sarin Juho Wedenoja David A Hinds Julie E Buring Markus Schürks Paul M Ridker Maria Gudlaug Hrafnsdottir Hreinn Stefansson Susan M Ring Jouke-Jan Hottenga Brenda W J H Penninx Markus Färkkilä Ville Artto Mari Kaunisto Salli Vepsäläinen Rainer Malik Andrew C Heath Pamela A F Madden Nicholas G Martin Grant W Montgomery Mitja I Kurki Mart Kals Reedik Mägi Kalle Pärn Eija Hämäläinen Hailiang Huang Andrea E Byrnes Lude Franke Jie Huang Evie Stergiakouli Phil H Lee Cynthia Sandor Caleb Webber Zameel Cader Bertram Muller-Myhsok Stefan Schreiber Thomas Meitinger Johan G Eriksson Veikko Salomaa Kauko Heikkilä Elizabeth Loehrer Andre G Uitterlinden Albert Hofman Cornelia M van Duijn Lynn Cherkas Linda M Pedersen Audun Stubhaug Christopher S Nielsen Minna Männikkö Evelin Mihailov Lili Milani Hartmut Göbel Ann-Louise Esserlind Anne Francke Christensen Thomas Folkmann Hansen Thomas Werge Jaakko Kaprio Arpo J Aromaa Olli Raitakari M Arfan Ikram Tim Spector Marjo-Riitta Järvelin Andres Metspalu Christian Kubisch David P Strachan Michel D Ferrari Andrea C Belin Martin Dichgans Maija Wessman Arn M J M van den Maagdenberg John-Anker Zwart Dorret I Boomsma George Davey Smith Kari Stefansson Nicholas Eriksson Mark J Daly Benjamin M Neale Jes Olesen Daniel I Chasman Dale R Nyholt Aarno Palotie

Nat Genet 2016 09;48(10):1296

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http://dx.doi.org/10.1038/ng1016-1296cDOI Listing
September 2016

Activity-dependent calcium, oxygen, and vascular responses in a mouse model of familial hemiplegic migraine type 1.

Ann Neurol 2016 08 26;80(2):219-32. Epub 2016 Jul 26.

Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/ana.24707DOI Listing
August 2016

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.

Authors:
Padhraig Gormley Verneri Anttila Bendik S Winsvold Priit Palta Tonu Esko Tune H Pers Kai-How Farh Ester Cuenca-Leon Mikko Muona Nicholas A Furlotte Tobias Kurth Andres Ingason George McMahon Lannie Ligthart Gisela M Terwindt Mikko Kallela Tobias M Freilinger Caroline Ran Scott G Gordon Anine H Stam Stacy Steinberg Guntram Borck Markku Koiranen Lydia Quaye Hieab H H Adams Terho Lehtimäki Antti-Pekka Sarin Juho Wedenoja David A Hinds Julie E Buring Markus Schürks Paul M Ridker Maria Gudlaug Hrafnsdottir Hreinn Stefansson Susan M Ring Jouke-Jan Hottenga Brenda W J H Penninx Markus Färkkilä Ville Artto Mari Kaunisto Salli Vepsäläinen Rainer Malik Andrew C Heath Pamela A F Madden Nicholas G Martin Grant W Montgomery Mitja I Kurki Mart Kals Reedik Mägi Kalle Pärn Eija Hämäläinen Hailiang Huang Andrea E Byrnes Lude Franke Jie Huang Evie Stergiakouli Phil H Lee Cynthia Sandor Caleb Webber Zameel Cader Bertram Muller-Myhsok Stefan Schreiber Thomas Meitinger Johan G Eriksson Veikko Salomaa Kauko Heikkilä Elizabeth Loehrer Andre G Uitterlinden Albert Hofman Cornelia M van Duijn Lynn Cherkas Linda M Pedersen Audun Stubhaug Christopher S Nielsen Minna Männikkö Evelin Mihailov Lili Milani Hartmut Göbel Ann-Louise Esserlind Anne Francke Christensen Thomas Folkmann Hansen Thomas Werge Jaakko Kaprio Arpo J Aromaa Olli Raitakari M Arfan Ikram Tim Spector Marjo-Riitta Järvelin Andres Metspalu Christian Kubisch David P Strachan Michel D Ferrari Andrea C Belin Martin Dichgans Maija Wessman Arn M J M van den Maagdenberg John-Anker Zwart Dorret I Boomsma George Davey Smith Kari Stefansson Nicholas Eriksson Mark J Daly Benjamin M Neale Jes Olesen Daniel I Chasman Dale R Nyholt Aarno Palotie

Nat Genet 2016 08 20;48(8):856-66. Epub 2016 Jun 20.

Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331903PMC
August 2016

Spreading depolarizations increase delayed brain injury in a rat model of subarachnoid hemorrhage.

J Cereb Blood Flow Metab 2016 07 30;36(7):1224-31. Epub 2015 Nov 30.

Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Centre Utrecht, Utrecht, The Netherlands

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http://dx.doi.org/10.1177/0271678X15619189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929702PMC
July 2016

Funnel-freezing versus heat-stabilization for the visualization of metabolites by mass spectrometry imaging in a mouse stroke model.

Proteomics 2016 06 9;16(11-12):1652-9. Epub 2016 May 9.

Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/pmic.201500402DOI Listing
June 2016

Genome-wide association studies in migraine: current state and route to follow.

Curr Opin Neurol 2016 06;29(3):302-8

aStatistical and Genomic Epidemiology Laboratory, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia bDepartments of Human Genetics and Neurology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1097/WCO.0000000000000316DOI Listing
June 2016

Spatial Autocorrelation in Mass Spectrometry Imaging.

Anal Chem 2016 06 24;88(11):5871-8. Epub 2016 May 24.

Maastricht MultiModal Molecular Imaging Institute (M4I), Maastricht University , Universiteitssingel 50, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1021/acs.analchem.6b00672DOI Listing
June 2016

Expression and function of calcitonin gene-related peptide (CGRP) receptors in trigeminal ganglia of R192Q Cacna1a knock-in mice.

Neurosci Lett 2016 05 25;620:104-10. Epub 2016 Mar 25.

Neuroscience Department, International School for Advanced Studies (SISSA), Trieste, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2016.03.046DOI Listing
May 2016

Mass spectrometry imaging of amino neurotransmitters: a comparison of derivatization methods and application in mouse brain tissue.

Metabolomics 2016;12:30. Epub 2016 Jan 8.

Center for Proteomics and Metabolomics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands ; Fondazione Pisana per la Scienza ONLUS, Pisa, Italy.

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http://dx.doi.org/10.1007/s11306-015-0926-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705126PMC
January 2016

Brain Region-Specific Dynamics of On-Tissue Protein Digestion Using MALDI Mass Spectrometry Imaging.

J Proteome Res 2015 Dec 13;14(12):5348-54. Epub 2015 Nov 13.

Center for Proteomics and Metabolomics, Leiden University Medical Center , Leiden 2333 ZA, The Netherlands.

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http://dx.doi.org/10.1021/acs.jproteome.5b00849DOI Listing
December 2015

Ethanol contamination of cerebrospinal fluid during standardized sampling and its effect on (1)H-NMR metabolomics.

Anal Bioanal Chem 2015 Jun 3;407(16):4835-9. Epub 2015 May 3.

Center for Proteomics and Metabolomics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00216-015-8663-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446525PMC
June 2015

In silico phenotyping via co-training for improved phenotype prediction from genotype.

Bioinformatics 2015 Jun;31(12):i303-10

Machine Learning and Computational Biology Lab, Department of Biosystems Science and Engineering, ETH Zurich, Switzerland, Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Program in Medical and Population Genetics and Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA, Department of Neurology and Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/bioinformatics/btv254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765855PMC
June 2015

Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies.

Cephalalgia 2015 May 1;35(6):489-99. Epub 2014 Sep 1.

Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, USA Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, USA Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, USA Department of Neurology, Massachusetts General Hospital, USA.

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http://dx.doi.org/10.1177/0333102414547784DOI Listing
May 2015

From migraine genes to mechanisms.

Pain 2015 Apr;156 Suppl 1:S64-74

Departments of aNeurology and bHuman Genetics, Leiden University Medical Centre, Leiden, the Netherlands.

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http://dx.doi.org/10.1097/01.j.pain.0000460346.00213.16DOI Listing
April 2015

Abnormal cortical synaptic transmission in CaV2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans.

Front Cell Neurosci 2015 17;9. Epub 2015 Feb 17.

Department of Biomedical Sciences, University of Padova, and Consiglio Nazionale delle Ricerche (CNR) Institute of Neuroscience Padova, Italy.

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http://journal.frontiersin.org/Article/10.3389/fncel.2015.00
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http://dx.doi.org/10.3389/fncel.2015.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330891PMC
March 2015

Comprehensive analysis of the mouse brain proteome sampled in mass spectrometry imaging.

Anal Chem 2015 Feb 13;87(3):1867-75. Epub 2015 Jan 13.

Center for Proteomics and Metabolomics, Leiden University Medical Center , Leiden, 2333ZA The Netherlands.

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http://dx.doi.org/10.1021/ac503952qDOI Listing
February 2015

Migraine mutations impair hippocampal learning despite enhanced long-term potentiation.

J Neurosci 2015 Feb;35(8):3397-402

Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, Stroke Service and Neuroscience Intensive Care Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114

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http://dx.doi.org/10.1523/JNEUROSCI.2630-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339352PMC
February 2015

Migraine prophylaxis, ischemic depolarizations, and stroke outcomes in mice.

Stroke 2015 Jan 25;46(1):229-36. Epub 2014 Nov 25.

From the Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown (K.E.-H., J.H.L., N.Y., E.S.Y., A.D., Y.W., Y.Z., A.C., B.S., C.A.); Department of Neurology (M.D.F., A.M.J.M.v.d.M), and Department of Human Genetics, Leiden University Medical Centre, The Netherlands (A.M.J.M.v.d.M); and Stroke Service and Neuroscience Intensive Care Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (C.A.).

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http://stroke.ahajournals.org/cgi/doi/10.1161/STROKEAHA.114.
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http://dx.doi.org/10.1161/STROKEAHA.114.006982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276468PMC
January 2015

Familial hemiplegic migraine type-1 mutated cav2.1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice.

Hear Res 2015 Jan 4;319:56-68. Epub 2014 Dec 4.

Instituto de Fisiología, Biología molecular y Neurociencias, CONICET, Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.

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http://dx.doi.org/10.1016/j.heares.2014.11.006DOI Listing
January 2015

Migraine pathophysiology: lessons from mouse models and human genetics.

Lancet Neurol 2015 Jan;14(1):65-80

Department of Neurology, Leiden University Medical Centre, Leiden, Netherlands; Department of Human Genetics, Leiden University Medical Centre, Leiden, Netherlands.

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January 2015

Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses.

PLoS Genet 2015 Jan 8;11(1):e1004835. Epub 2015 Jan 8.

Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands; Department of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1371/journal.pgen.1004835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287344PMC
January 2015

Two novel SCN1A mutations identified in families with familial hemiplegic migraine.

Cephalalgia 2014 Nov 4;34(13):1062-9. Epub 2014 Apr 4.

Department of Human Genetics, Leiden University Medical Center, the Netherlands Department of Neurology, Leiden University Medical Center, the Netherlands.

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http://dx.doi.org/10.1177/0333102414529195DOI Listing
November 2014

The first knockin mouse model of episodic ataxia type 2.

Exp Neurol 2014 Nov 8;261:553-62. Epub 2014 Aug 8.

Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2014.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194266PMC
November 2014

Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with enhanced excitatory transmission in CaV2.1 knockin migraine mice.

Neurobiol Dis 2014 Sep 5;69:225-34. Epub 2014 Jun 5.

Department of Biomedical Sciences, University of Padova and CNR Institute of Neuroscience, 35121 Padova, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.05.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107271PMC
September 2014

Automatic generic registration of mass spectrometry imaging data to histology using nonlinear stochastic embedding.

Anal Chem 2014 Sep 26;86(18):9204-11. Epub 2014 Aug 26.

Division of Image Processing, Department of Radiology, ‡Center for Proteomics and Metabolomics, §Department of Human Genetics, ∥Department of Neurology, and ⊥Department of Pathology, Leiden University Medical Center , 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.1021/ac502170fDOI Listing
September 2014

PRRT2 and hemiplegic migraine: a complex association.

Neurology 2014 Jul 13;83(3):288-90. Epub 2014 Jun 13.

From Leiden University Medical Center (N.P., B.d.V., J.T.K., L.S.V., M.D.F., J.H., A.M.J.M.v.d.M., G.M.T.); and Rijnland Hospital (J.H.), Leiderdorp, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000000590DOI Listing
July 2014

Synaptic gain-of-function effects of mutant Cav2.1 channels in a mouse model of familial hemiplegic migraine are due to increased basal [Ca2+]i.

J Neurosci 2014 May;34(21):7047-58

Institute of Physiology, Molecular Biology and Neuroscience (IFIBYNE, UBA-CONICET), Department of Physiology, Molecular, and Cell Biology, University of Buenos Aires, Buenos Aires C1428EHA, Argentina,

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http://dx.doi.org/10.1523/JNEUROSCI.2526-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028489PMC
May 2014

Differential trigeminovascular nociceptive responses in the thalamus in the familial hemiplegic migraine 1 knock-in mouse: a Fos protein study.

Neurobiol Dis 2014 Apr 17;64:1-7. Epub 2013 Dec 17.

Headache Group-Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; NIHR-Wellcome Trust Clinical Research Facility, King's College London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2013.12.004DOI Listing
April 2014

Automatic registration of mass spectrometry imaging data sets to the Allen brain atlas.

Anal Chem 2014 Apr 2;86(8):3947-54. Epub 2014 Apr 2.

Division of Image Processing, Department of Radiology, ‡Center for Proteomics and Metabolomics, §Department of Human Genetics, and ∥Department of Neurology, Leiden University Medical Center , 2333 ZA Leiden, the Netherlands.

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http://dx.doi.org/10.1021/ac500148aDOI Listing
April 2014

RNA expression profiling in brains of familial hemiplegic migraine type 1 knock-in mice.

Cephalalgia 2014 Mar 28;34(3):174-82. Epub 2013 Aug 28.

Department of Human Genetics, Leiden University Medical Centre, The Netherlands.

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http://dx.doi.org/10.1177/0333102413502736DOI Listing
March 2014

Familial hemiplegic migraine mutations affect Na,K-ATPase domain interactions.

Biochim Biophys Acta 2013 Dec 15;1832(12):2173-9. Epub 2013 Aug 15.

Department of Pharmacology and Toxicology 149, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address:

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December 2013

CaV 2.1 ablation in cortical interneurons selectively impairs fast-spiking basket cells and causes generalized seizures.

Ann Neurol 2013 Aug 1;74(2):209-22. Epub 2013 Jul 1.

NYU Neuroscience Institute, New York University School of Medicine, New York, NY; Pediatric Neurology Department of Neuroscience, Saint Justine University Hospital Center, University of Montreal, Montreal, Quebec, Canada.

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http://doi.wiley.com/10.1002/ana.23913
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849346PMC
August 2013

Genome-wide meta-analysis identifies new susceptibility loci for migraine.

Authors:
Verneri Anttila Bendik S Winsvold Padhraig Gormley Tobias Kurth Francesco Bettella George McMahon Mikko Kallela Rainer Malik Boukje de Vries Gisela Terwindt Sarah E Medland Unda Todt Wendy L McArdle Lydia Quaye Markku Koiranen M Arfan Ikram Terho Lehtimäki Anine H Stam Lannie Ligthart Juho Wedenoja Ian Dunham Benjamin M Neale Priit Palta Eija Hamalainen Markus Schürks Lynda M Rose Julie E Buring Paul M Ridker Stacy Steinberg Hreinn Stefansson Finnbogi Jakobsson Debbie A Lawlor David M Evans Susan M Ring Markus Färkkilä Ville Artto Mari A Kaunisto Tobias Freilinger Jean Schoenen Rune R Frants Nadine Pelzer Claudia M Weller Ronald Zielman Andrew C Heath Pamela A F Madden Grant W Montgomery Nicholas G Martin Guntram Borck Hartmut Göbel Axel Heinze Katja Heinze-Kuhn Frances M K Williams Anna-Liisa Hartikainen Anneli Pouta Joyce van den Ende Andre G Uitterlinden Albert Hofman Najaf Amin Jouke-Jan Hottenga Jacqueline M Vink Kauko Heikkilä Michael Alexander Bertram Muller-Myhsok Stefan Schreiber Thomas Meitinger Heinz Erich Wichmann Arpo Aromaa Johan G Eriksson Bryan Traynor Daniah Trabzuni Elizabeth Rossin Kasper Lage Suzanne B R Jacobs J Raphael Gibbs Ewan Birney Jaakko Kaprio Brenda W Penninx Dorret I Boomsma Cornelia van Duijn Olli Raitakari Marjo-Riitta Jarvelin John-Anker Zwart Lynn Cherkas David P Strachan Christian Kubisch Michel D Ferrari Arn M J M van den Maagdenberg Martin Dichgans Maija Wessman George Davey Smith Kari Stefansson Mark J Daly Dale R Nyholt Daniel Chasman Aarno Palotie

Nat Genet 2013 Aug 23;45(8):912-917. Epub 2013 Jun 23.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.2676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041123PMC
August 2013

Pearls and pitfalls in genetic studies of migraine.

Cephalalgia 2013 Jun;33(8):614-25

Department of Human Genetics, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1177/0333102413484988DOI Listing
June 2013

Epigenetic mechanisms in migraine: a promising avenue?

BMC Med 2013 Feb 4;11:26. Epub 2013 Feb 4.

Department of Human Genetics, Leiden University Medical Centre, Einthovenweg 20, Leiden 2333 ZC, The Netherlands.

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http://dx.doi.org/10.1186/1741-7015-11-26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584973PMC
February 2013

Limited regional cerebellar dysfunction induces focal dystonia in mice.

Neurobiol Dis 2013 Jan 28;49:200-10. Epub 2012 Jul 28.

Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2012.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567246PMC
January 2013

Reduced sleep and low adenosinergic sensitivity in cacna1a R192Q mutant mice.

Sleep 2013 Jan 1;36(1):127-36. Epub 2013 Jan 1.

Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.5665/sleep.2316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524534PMC
January 2013

Presynaptic CaV2.1 calcium channels carrying familial hemiplegic migraine mutation R192Q allow faster recovery from synaptic depression in mouse calyx of Held.

J Neurophysiol 2012 Dec 5;108(11):2967-76. Epub 2012 Sep 5.

Instituto de Fisiología, Biología molecular y Neurociencias, CONICET, Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.

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http://dx.doi.org/10.1152/jn.01183.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544873PMC
December 2012

Metabolic profiling of mouse cerebrospinal fluid by sheathless CE-MS.

Anal Bioanal Chem 2012 Dec 7;404(10):2895-900. Epub 2012 Oct 7.

Biomolecular Mass Spectrometry Unit, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00216-012-6431-7DOI Listing
December 2012

PRRT2 mutation causes benign familial infantile convulsions.

Neurology 2012 Nov 17;79(21):2154-5. Epub 2012 Oct 17.

Department of Human Genetics, Leiden University Medical Centre, Leiden, the Netherlands.

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http://www.neurology.org/cgi/doi/10.1212/WNL.0b013e3182752c3
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http://dx.doi.org/10.1212/WNL.0b013e3182752c30DOI Listing
November 2012

Imaging mass spectrometry to visualize biomolecule distributions in mouse brain tissue following hemispheric cortical spreading depression.

J Proteomics 2012 Aug 6;75(16):5027-5035. Epub 2012 Jul 6.

Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2012.06.025DOI Listing
August 2012