Armando Rossello

Armando Rossello

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Armando Rossello

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Metalloprotease inhibitor profiles of human ADAM8 in vitro and in cell-based assays.

Biol Chem 2019 May;400(6):801-810

Department of Neurosurgery, University of Marburg, Baldingerstrasse, D-35033 Marburg, Germany.

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http://www.degruyter.com/view/j/bchm.ahead-of-print/hsz-2018
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http://dx.doi.org/10.1515/hsz-2018-0396DOI Listing
May 2019

Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP).

Bioorg Med Chem 2019 Jan 29;27(1):196-207. Epub 2018 Nov 29.

Department of Pharmacy, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2018.11.041DOI Listing
January 2019

Age-related macular degeneration: current knowledge of zinc metalloproteinases involvement.

Curr Drug Targets 2019 Jan 21. Epub 2019 Jan 21.

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa. Italy.

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http://dx.doi.org/10.2174/1389450120666190122114857DOI Listing
January 2019

Matrix metalloproteinase inhibitors prevent the release and proteolytic activity of monocyte/macrophage-derived microparticles.

Pharmacol Rep 2019 Jan 31;71(3):485-490. Epub 2019 Jan 31.

Department of Pharmacy, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1016/j.pharep.2019.01.013DOI Listing
January 2019

Synthesis and in vitro Evaluation of ADAM10 and ADAM17 Highly Selective Bioimaging Probes.

ChemMedChem 2018 Oct 12;13(19):2119-2131. Epub 2018 Sep 12.

Department of Pharmacy, University of Pisa, via Bonanno 6, 56126, Pisa, Italy.

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http://doi.wiley.com/10.1002/cmdc.201800482
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http://dx.doi.org/10.1002/cmdc.201800482DOI Listing
October 2018

ADAM metalloproteinases as potential drug targets.

Curr Med Chem 2018 Mar 26. Epub 2018 Mar 26.

Department of Pharmacy, University of Pisa, Via Bonanno 6, Pisa. Italy.

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http://dx.doi.org/10.2174/0929867325666180326164104DOI Listing
March 2018

Synthesis and antiangiogenic activity study of new hop chalcone Xanthohumol analogues.

Eur J Med Chem 2017 Sep 17;138:890-899. Epub 2017 Jul 17.

Dipartimento di Farmacia, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy; Centro Interdipartimentale di Ricerca "Nutraceutica e Alimentazione per la Salute", Università di Pisa, Via Del Borghetto 80, 56124 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.07.024DOI Listing
September 2017

Targeting ADAM17 Sheddase Activity in Cancer.

Curr Drug Targets 2016 ;17(16):1908-1927

IRCCS AOU San Martino- IST, Department of Integrated Oncological Therapies, Genoa, Italy.

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August 2017

Hepatitis C virus-induced NK cell activation causes metzincin-mediated CD16 cleavage and impaired antibody-dependent cytotoxicity.

J Hepatol 2017 06 10;66(6):1130-1137. Epub 2017 Feb 10.

Division of Infectious Diseases and Immunology, Department of Medical Sciences and Infectious Diseases, Fondazione IRCCS Policlinico San Matteo, Italy; Department of Internal Medicine and Therapeutics, University of Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.01.032DOI Listing
June 2017

N-(Aroyl)-N-(arylmethyloxy)-α-alanines: Selective inhibitors of aldose reductase.

Bioorg Med Chem 2017 06 28;25(12):3068-3076. Epub 2017 Mar 28.

Dipartimento di Farmacia, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy; Dipartimento di Scienze della Terra, Università di Pisa, Via S. Maria 53, 56126 Pisa, Italy.

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http://dx.doi.org/10.1016/j.bmc.2017.03.056DOI Listing
June 2017

Synthesis and structural analysis of halogen substituted fibril formation inhibitors of Human Transthyretin (TTR).

J Enzyme Inhib Med Chem 2016 11;31(sup1):40-51. Epub 2016 Apr 11.

a Dipartimento di Farmacia , Università di Pisa , Pisa , Italy and.

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http://dx.doi.org/10.3109/14756366.2016.1167048DOI Listing
February 2017

X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors.

J Enzyme Inhib Med Chem 2016 Oct 3;31(5):824-33. Epub 2015 Aug 3.

b Dipartimento di Farmacia , Università di Pisa , Pisa , Italy.

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http://dx.doi.org/10.3109/14756366.2015.1070265DOI Listing
October 2016

Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II.

Hypertension 2016 10 1;68(4):949-955. Epub 2016 Aug 1.

Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia PA (T.T., S.J.F., T.K., T.O., T.T., Y.F., K.J.E., R.S., V.R., S.E.), Department of Pharmacy, University of Pisa, Pisa, Italy (E.N., A.R.), and Faculty of Health Sciences, University of Macau, Macau, China (HF.K.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.07620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016240PMC
October 2016

Targeting Different Transthyretin Binding Sites with Unusual Natural Compounds.

ChemMedChem 2016 08 9;11(16):1865-74. Epub 2016 May 9.

Dipartimento di Farmacia, Università di Pisa, V. Bonanno 6, 56126, Pisa, Italy.

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http://dx.doi.org/10.1002/cmdc.201600092DOI Listing
August 2016

Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors.

Eur J Med Chem 2016 Jan 28;108:141-153. Epub 2015 Nov 28.

Department of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of Norway, NO-9037 Tromsø, Norway.

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http://dx.doi.org/10.1016/j.ejmech.2015.11.019DOI Listing
January 2016

Kinetic characterization of 4,4'-biphenylsulfonamides as selective non-zinc binding MMP inhibitors.

J Enzyme Inhib Med Chem 2015 Dec 19;30(6):947-54. Epub 2015 Feb 19.

a Dipartimento di Farmacia , Università di Pisa , Pisa , Italy .

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http://dx.doi.org/10.3109/14756366.2014.1000889DOI Listing
December 2015

Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors.

J Med Chem 2015 Nov 4;58(21):8564-72. Epub 2015 Nov 4.

Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma , Piazzale Aldo Moro 5, I-00185 Roma, Italy.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01144DOI Listing
November 2015

Multicomponent mixtures for cryoprotection and ligand solubilization.

Biotechnol Rep (Amst) 2015 Sep 23;7:120-127. Epub 2015 Jun 23.

CEA, iBiTec-S, Service d'Ingénierie Moléculaire des Protéines, Laboratoire de Toxinologie Moléculaire et Biotechnologies, Gif-sur-Yvette, F-91191, France.

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http://dx.doi.org/10.1016/j.btre.2015.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466044PMC
September 2015

Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors.

Eur J Med Chem 2015 Jan 18;89:340-8. Epub 2014 Oct 18.

Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, NO-9037 Tromsø, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.10.009DOI Listing
January 2015

ADAM10 correlates with uveal melanoma metastasis and promotes in vitro invasion.

Pigment Cell Melanoma Res 2014 Nov 11;27(6):1138-48. Epub 2014 Sep 11.

IRCCS A.O.U. San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.

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http://dx.doi.org/10.1111/pcmr.12306DOI Listing
November 2014

Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.

J Med Chem 2014 Nov 17;57(21):9152-67. Epub 2014 Oct 17.

Laboratorio di Chimica Bioinorganica, Polo Scientifico, Università degli Studi di Firenze , Rm. 188, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.

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http://pubs.acs.org/doi/10.1021/jm501314c
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http://dx.doi.org/10.1021/jm501314cDOI Listing
November 2014

Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.

Bioorg Med Chem 2014 Jan 18;22(1):334-40. Epub 2013 Nov 18.

Università degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, 50019 Sesto Fiorentino (Florence), Italy; Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2013.11.016DOI Listing
January 2014

New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy.

J Inorg Biochem 2013 Oct 16;127:188-202. Epub 2013 Mar 16.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal.

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http://dx.doi.org/10.1016/j.jinorgbio.2013.03.003DOI Listing
October 2013

Tafamidis (Vyndaqel): a light for FAP patients.

ChemMedChem 2013 Oct 2;8(10):1617-9. Epub 2013 Sep 2.

Dipartimento di Farmacia, Università di Pisa, Via Bonanno 6, 56126 Pisa (Italy).

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http://dx.doi.org/10.1002/cmdc.201300245DOI Listing
October 2013

Activated leukocyte cell adhesion molecule soluble form: a potential biomarker of epithelial ovarian cancer is increased in type II tumors.

Int J Cancer 2013 Jun 13;132(11):2597-605. Epub 2012 Dec 13.

Department of Integrated Oncological Therapies, IRCCS AOU San Martino-IST, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.

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http://dx.doi.org/10.1002/ijc.27948DOI Listing
June 2013

Crystallization of bi-functional ligand protein complexes.

J Struct Biol 2013 Jun 6;182(3):246-54. Epub 2013 Apr 6.

CEA, iBiTec-S, Service d'Ingénierie Moléculaire des Protéines-SIMOPRO, Gif-sur-Yvette F-91191, France.

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https://linkinghub.elsevier.com/retrieve/pii/S10478477130008
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http://dx.doi.org/10.1016/j.jsb.2013.03.015DOI Listing
June 2013

N-O-isopropyl sulfonamido-based hydroxamates: kinetic characterisation of a series of MMP-12/MMP-13 dual target inhibitors.

Biochem Pharmacol 2012 Sep 4;84(6):813-20. Epub 2012 Jul 4.

Dipartimento di Scienze Farmaceutiche, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy.

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http://dx.doi.org/10.1016/j.bcp.2012.06.026DOI Listing
September 2012

Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases.

J Med Chem 2011 Dec 17;54(24):8289-98. Epub 2011 Nov 17.

Centro de Quı́mica Estrutural, Instituto Superior Técnico, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal.

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https://pubs.acs.org/doi/10.1021/jm200593b
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http://dx.doi.org/10.1021/jm200593bDOI Listing
December 2011

Novel folate-hydroxamate based antimetabolites: synthesis and biological evaluation.

Med Chem 2011 Jul;7(4):265-74

Centro de Química Estrutural, Instituto Superior Técnico, 1049-001 Lisboa, Portugal.

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July 2011

Immobilization of matrix metalloproteinase 8 (MMP-8) for online drug screening.

J Chromatogr B Analyt Technol Biomed Life Sci 2011 Apr 22;879(11-12):756-62. Epub 2011 Feb 22.

Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Pisa, Italy.

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http://dx.doi.org/10.1016/j.jchromb.2011.02.024DOI Listing
April 2011

Synthesis, molecular docking and binding studies of selective serotonin transporter inhibitors.

Eur J Med Chem 2011 Mar 22;46(3):825-34. Epub 2010 Dec 22.

Dipartimento di Scienze Farmaceutiche, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2010.12.018DOI Listing
March 2011

Multitemplate alignment method for the development of a reliable 3D-QSAR model for the analysis of MMP3 inhibitors.

J Chem Inf Model 2009 Jul;49(7):1715-24

Dipartimento di Scienze Farmaceutiche, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy.

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http://dx.doi.org/10.1021/ci900118vDOI Listing
July 2009

Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.

J Med Chem 2008 Dec;51(24):7968-79

Centro de Química Estrutural, Instituto Superior Técnico, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal.

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http://dx.doi.org/10.1021/jm800964fDOI Listing
December 2008

Development of a receptor-based 3D-QSAR study for the analysis of MMP2, MMP3, and MMP9 inhibitors.

Bioorg Med Chem 2008 Aug 8;16(16):7749-58. Epub 2008 Jul 8.

Dipartimento di Scienze Farmaceutiche, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy.

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http://dx.doi.org/10.1016/j.bmc.2008.07.004DOI Listing
August 2008

Peptidyl 3-substituted 1-hydroxyureas as isosteric analogues of succinylhydroxamate MMP inhibitors.

Eur J Med Chem 2008 May 15;43(5):1008-14. Epub 2007 Jul 15.

Dipartimento di Scienze del Farmaco, Università G. d'Annunzio, Via dei Vestini 31, 66013 Chieti, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2007.07.002DOI Listing
May 2008

Homology modeling and receptor-based 3D-QSAR study of carbonic anhydrase IX.

J Chem Inf Model 2007 Nov-Dec;47(6):2253-62. Epub 2007 Oct 20.

Dipartimento di Scienze Farmaceutiche, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy.

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http://pubs.acs.org/doi/abs/10.1021/ci700214j
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http://dx.doi.org/10.1021/ci700214jDOI Listing
February 2008

The ALCAM shedding by the metalloprotease ADAM17/TACE is involved in motility of ovarian carcinoma cells.

Mol Cancer Res 2007 Dec;5(12):1246-53

Department of Translational Oncology, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-0060DOI Listing
December 2007

3-[(Aryl)(4-fluorobenzyloxy)methyl]piperidine derivatives: high-affinity ligands for the serotonin transporter.

J Pharm Pharmacol 2007 Oct;59(10):1439-45

Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy.

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http://dx.doi.org/10.1211/jpp.59.10.0016DOI Listing
October 2007

Matrix metalloproteinase inhibitors: new challenges in the era of post broad-spectrum inhibitors.

Curr Pharm Des 2007 ;13(20):2087-100

Dipartimento di Scienze Farmaceutiche, Università di Pisa, Pisa, Italy.

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August 2007

Analysis of human carbonic anhydrase II: docking reliability and receptor-based 3D-QSAR study.

J Chem Inf Model 2007 Mar-Apr;47(2):515-25. Epub 2007 Feb 13.

Dipartimento di Scienze Farmaceutiche, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy.

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http://dx.doi.org/10.1021/ci600469wDOI Listing
May 2007

Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.

Bioorg Med Chem 2007 Mar 19;15(6):2298-311. Epub 2007 Jan 19.

Dipartimento di Scienze Farmaceutiche, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy.

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http://dx.doi.org/10.1016/j.bmc.2007.01.023DOI Listing
March 2007

Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs.

Bioorg Med Chem 2007 Feb 14;15(3):1266-74. Epub 2006 Nov 14.

Centro de Química Estrutural, Instituto Superior Técnico, 1049-001 Lisboa, Portugal.

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http://dx.doi.org/10.1016/j.bmc.2006.11.017DOI Listing
February 2007

Design, synthesis and molecular modeling study of iminodiacetyl monohydroxamic acid derivatives as MMP inhibitors.

Bioorg Med Chem 2006 Nov 27;14(22):7539-50. Epub 2006 Jul 27.

Centro de Química Estrutural, Instituto Superior Técnico, Rua Rovisco Pais 1, 1049-001 Lisboa, Portugal.

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http://dx.doi.org/10.1016/j.bmc.2006.07.011DOI Listing
November 2006

New NO-releasing pharmacodynamic hybrids of losartan and its active metabolite: design, synthesis, and biopharmacological properties.

J Med Chem 2006 Apr;49(8):2628-39

Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy.

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http://dx.doi.org/10.1021/jm0600186DOI Listing
April 2006

Synthesis and antimicrobial activity of new 7 beta-(benzo[a]dihydrocarbazolyloxyacetyl)-substituted cephalosporins.

Farmaco 2004 Sep;59(9):691-6

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Pisa, via Bonanno, 6, Pisa 56126, Italy.

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http://dx.doi.org/10.1016/j.farmac.2004.05.001DOI Listing
September 2004

Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole.

J Med Chem 2002 Oct;45(22):4903-12

Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia, Università degli Studi di Pisa, Via Bonanno, 6, 56100 Pisa, Italy.

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October 2002