Publications by authors named "Armaghan Moravej Aleali"

12 Publications

  • Page 1 of 1

Effects of saffron on homocysteine, and antioxidant and inflammatory biomarkers levels in patients with type 2 diabetes mellitus: a randomized double-blind clinical trial.

Avicenna J Phytomed 2019 Sep-Oct;9(5):436-445

Cellular and molecular research center, Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objective: Type 2 diabetes mellitus (T2DM) is one of the most common health problems worldwide. Studies have shown that saffron and its derivatives may have therapeutic potentials in T2DM through reducing plasma glucose. The present study aimed to evaluate the effects of saffron extract on serum anti-inflammatory and antioxidant variables in T2DM patients.

Materials And Methods: This was a double-blind randomized clinical trial conducted on 64 T2DM patients. Participants received either 15 mg of saffron or placebo capsules (two pills per day) for 3 months. Anthropometric indices, homocysteine, serum anti-inflammatory and antioxidant variables and dietary intake were assessed pre- and post-intervention.

Results: After 3 months of treatment, interleukin-6 (IL-6), and tumor necrosis factor (TNF-α) increased significantly in both group (p<0.05). No significant differences were observed for total antioxidant capacity (TAC), malondialdehyde (MDA), high sensitivity C-reactive protein (hs-CRP) and interleukin 10(IL-10) after the treatment period (p>0.05). Homocysteine decteased significantly in control group (p<0.05).

Conclusion: Our results showed no improvement in homocystein levels, antioxidant status and inflammatory biomarkers in T2DM patients after treatment with saffron.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727435PMC
September 2019

Frequency of type I and II diabetes in newly diagnosed diabetic patients: Measuring C-Peptide level.

Diabetes Metab Syndr 2019 May - Jun;13(3):1833-1835. Epub 2019 Apr 17.

Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Aims: Diabetes mellitus is a metabolic disease that manifested as hyperglycemia due to the defect in secretion or function of insulin. This study aimed was to survey about frequency type I and II diabetes in newly diagnosed diabetic patients base on c-peptide and anti-glutamate acid decarboxylase (GAD) tests.

Materials & Methods: This study was conducted as a prospective study on 70 diabetic patients aged 15-45 years old who referred to diabetes clinics in Ahvaz city during 2012-2014 and their diabetes was diagnosed for the first time, but their type of diabetes was not clinically definitive. Patients with anti-GAD positive and fasting C-peptide level of less than 0.65 were diagnosed as type I diabetes. Patients with anti-GAD negative fasting C-peptide level of greater than or equal to 0.65 were considered as type II diabetes.

Results: Eighty two patients (49 males and 33 females) with a mean age of 21.64 ± 4.36 years (range 15-34) and a mean BMI of 22.05 ± 4.41 kg/m (range 14-18) were studied. Twenty three patients (28.5%) had type I diabetes and 59 patients (71.95%) had type II diabetes. In patients with type I diabetes, the mean BMI was 24.86 ± 2.36 kg/m and the number of patients with family history (56.22%) was higher. In type II diabetic patients, the number of women (62.71%) was higher than that of men.

Conclusion: Anti-GAD test can be used as a predictive test for early diagnosis of disease and screening of people with a diagnosis of diabetes based on the type of diabetes.
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http://dx.doi.org/10.1016/j.dsx.2019.04.018DOI Listing
December 2019

The effect of hydroalcoholic Saffron (Crocus sativus L.) extract on fasting plasma glucose, HbA1c, lipid profile, liver, and renal function tests in patients with type 2 diabetes mellitus: A randomized double-blind clinical trial.

Phytother Res 2019 Jun 3;33(6):1648-1657. Epub 2019 Apr 3.

Department of Epidemiology & Biostatistics, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Diabetes mellitus is a metabolic disease that manifested as hyperglycemia due to the defect in secretion or function of insulin. Studies have shown that saffron and its derivatives cause a significant reduction in plasma glucose levels in experimental models. The purpose of this study was to investigate the effect of the saffron extract on fasting plasma glucose (FPG), glycated hemoglobin level (HbA1c), lipid profile, liver enzymes, and renal function tests in type 2 diabetic patients. In this double-blind randomized clinical trial, 64 type 2 diabetic patients who were on oral anti-diabetic drugs were examined. Participants received either 15 mg of saffron or placebo capsules (two pills per day) for 3 months. Anthropometric indices, dietary intake, FPG, HbA1c, lipid profiles, liver enzymes (ALT, AST, ALP), and renal function (BUN, Cr.) tests were measured pre and post intervention after 3 months. Independent t test and paired t test were used for data analysis. After 3-months intervention, mean difference of FPG, Cholesterol, LDL-c, and LDL/HDL ratio between two groups showed significant reduction(p < 0.0001), but HbA1c, HDL-C, API, TG showed no significant differences (p > 0.05). In saffron group, FPG, HbA1c, cholesterol, LDL-c, and LDL/HDL ratio decreased significantly after 3-months intervention compare with baseline (p < 0.0001).
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http://dx.doi.org/10.1002/ptr.6351DOI Listing
June 2019

Vitamin D level in non-diabetic adult people with metabolic syndrome.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):236-238. Epub 2018 Aug 2.

Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khuzestan, Iran. Electronic address:

Aims: The aim of this study is comparison the level of Vitamin D deficiency in non-diabetic adult people with metabolic syndrome in Ahvaz.

Material & Methods: This descriptive study investigation carried out on a population of individuals with metabolic syndrome. ATPIII criteria were used for metabolic syndrome. Serum concentration of 25 (OH Vit D) of below 5 ng/ml was considered as severe deficiency, 5-10 ng/ml as average deficiency, 10-20 ng/ml as slight deficiency, and above 20 ng/ml as normal.

Results: The results showed mean level of vitamin D was not significant in individuals with and without HTN and in different genders (P > 0.5). No significant difference was found between case and control groups in terms of the distribution level of vitamin D (P > 0.5). In both groups, the difference between blood pressure (systole and diastole) was not significant in cases of severe and average deficiencies. But it was significant different in the group with slight deficiency (P = 0.03). In the case group, 58% of the participants had FBS>100.

Conclusion: The group with metabolic syndrome had a higher intensity of vitamin D deficiency compared to the control group.
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http://dx.doi.org/10.1016/j.dsx.2018.08.003DOI Listing
May 2019

Incidence of obesity, overweight and hypertension in children and adolescents in Ahvaz southwest of IRAN: Five-years study.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):201-205. Epub 2018 May 22.

Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Objective: The purpose of this study was to investigate the incidence of obesity, overweight and hypertension in children and adolescents aged 10-15 in Ahvaz.

Methods: This is a epidemiologic study performed on 176 people aged 10-15 in Ahvaz. In 2009, 300 people underwent weight, height and blood pressure measurements. Five years later, the same people were reassessed for obesity, overweight and hypertension, of whom a total of 176 people agreed to repeat the procedure.

Results: The study included 100 (57%) males and 76 (43%) females. Mean BMI was 22.1 ± 4.3 kg / m2 in year 2014, without any significant difference between the two sexes (P = 0.518). In the same year, the prevalence of obesity and overweight was 26 (14.8%) and 13 (7.4%), respectively. After 5years, BMI increased significantly (P < 0.001). Of the 150 norma participants with normal BMI in 2009, 15 (10%) and 6 (4%) became overweight and obese in 2014 respectively. The mean systolic and diastolic blood pressures increased significantly over 5 years P = 0.042 and P < 0.001.

Conclusions: This study shows an increase in mean BMI and mean systolic and diastolic blood pressures after 5 years among people aged 10-15 in Ahvaz.
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http://dx.doi.org/10.1016/j.dsx.2018.05.021DOI Listing
May 2019

Evaluation of psychological resistance to insulin treatment in type II diabetic patients.

Diabetes Metab Syndr 2018 Nov 19;12(6):929-932. Epub 2018 May 19.

Department of Psychiatry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Aims: Various studies have demonstrated that the majority of the factors affecting the reluctance of individuals to insulin injections are rooted in psychological factors. Present study aimed to determine relationships between main causes of refusal to insulin injection in diabetic patients and factors such as age, gender, and educational degree of patients.

Material & Methods: This was a descriptive study which was conducted on diabetic patients (n = 505) who need insulin therapy. The data were collected with a questionnaire in following steps. First, the most important causes of patients' reluctance, in the patients' opinion, to insulin therapy were determined using the data of the previous studies. In the second step, the patients were asked to express their opinion on each of these factors and the recorded responses were analyzed.

Results: The results of the study showed that fear of ampoules, fear of pain caused by insulin and the embarrassment of patients from injections in public significantly depended on the gender of the patients, so that these factors were much lower in men than women. In addition, these factors in the patients with higher degrees of education led to lower level of refusal to insulin injections. Another factor influencing the reluctance to insulin injections was the forming of a sense of addiction due to daily insulin injections, which was significantly lower among the patients with higher education, but did not have a significant relationship with sex of the patients. In this regard, another factor was fear of hypoglycemia and insulin side effects, which did not have a significant relationship with gender and educational degree. In addition, there was no significant relationship between the patient's age and any of the factors effective in patients' reluctance to insulin injections.

Conclusion: Psychological factors seem to be effective in the emergence of the sense of reluctance to insulin injections. Therefore, not only patients but also the entire society need to receive training and appropriate services to improve their attitude to this issue with a psychological approach and help to solve this problem.
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http://dx.doi.org/10.1016/j.dsx.2018.05.017DOI Listing
November 2018

Prevalence of hypertension and prehypertension in adolescence in Ahvaz, Iran.

Diabetes Metab Syndr 2017 Dec 7;11 Suppl 2:S547-S550. Epub 2017 Apr 7.

Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 61357-15794, Iran.

Background: High blood pressure is a risk factor for some disease like stroke, coronary heart disease, and renal failure. High blood pressure in children is an increasing health problem.

Objectives: The aim of this study was to determine prevalence of hypertension and pre-hypertension age between 10 to 17 years old.

Patients And Methods: This descriptive analytic study was conducted using multiphase sampling method in Ahvaz (Southwest of Iran). A questionnaire include: height, weight, and body mass index, systolic and diastolic blood pressures filled for each participant. Blood pressure was measured twice for each person. For the diagnosis of hypertension, the fourth report of the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents of the National Health Institute of United States was used.

Results: Total participants of the study were 1707children and adolescents including 922 boys (54%) and 785 girls (46%). The prevalence of high blood pressure was 1.7% (2.5% in boys and 0.8%). The prevalence of pre-hypertension was 9%(7.6% in boys, 10.6% in girls). The mean systolic and diastolic blood pressures increased with increasing body mass index.

Conclusions: The prevalence of high blood pressure was found to be lower than other studies in our country. The prevalence of the high blood pressure in boys was significantly higher than girls. This study, like other studies showed high correlation between being overweight and an increase in systolic and diastolic blood pressure.
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http://dx.doi.org/10.1016/j.dsx.2017.04.002DOI Listing
December 2017

A study of the prevalence of dyslipidemia among the adult population of Ahvaz, Iran.

Diabetes Metab Syndr 2016 Oct - Dec;10(4):190-193. Epub 2016 Jun 8.

Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Hypercholesterolemia is one of the main causes of the disease burden in developed and developing countries. The present study is planned to access the prevalence of dyslipidemia and its risk factors among the general population of Ahvaz over 20 years of age.

Method: In this descriptive-analytic study, using multi-stage cluster method, out of the 25 existing health centers in the city of Ahvaz (four health centers in the Eastern Ahvaz and two centers in the west were chosen based on the population they covered). The blood samples of the participants were taken after 12h of fasting for measure FBS, TG, Chol, HDLand LDL level their heights, and weights were measured using the standard methods. Interviewing the participants, the research questionnaires were filled by the trained health workers.

Results: Out of 2505 participants, 1155 samples (%46.1) were male with mean age of 42.9±14.5years and 1350 samples (%53.9) were women with the mean age of 39.9±12.6 years. The prevalence of dyslipidemia among the individuals over 20 years of age in Ahvaz was %80.9 (%75.9 in male and %85.1 in female). Age and BMI were positively correlated with increase in the risk of dyslipidemia. Women had a higher risk of dyslipidemia CONCLUSION: This study showed that more than %80 over 20 years old Ahvazian population had dyslipidemia(female more than male). Age and BMI are positively correlated with increasing dyslipidemia in my population.
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http://dx.doi.org/10.1016/j.dsx.2016.06.003DOI Listing
March 2017

Prevalence of metabolic syndrome and its correlated factors among children and adolescents of Ahvaz aged 10 - 19.

J Diabetes Metab Disord 2014 28;13:53. Epub 2014 Apr 28.

Health research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357-15794, Iran.

Background: Population-based studies for prevalence of metabolic syndrome (M.S) in children and adolescents are relatively rare. The aim of this study was to assess the Prevalence of M.S and correlated factors among children and adolescents aged 10 to 19 years in Ahvaz.

Methods: In this descriptive-analytical population- based study, 2246 children and adolescents, 10-19 years old (1113 male and 1133 female) in Ahvaz, were evaluated. Anthropometry, biochemical measurement and blood pressure (BP) were assessed. Modified ATP III criteria 2005 were used for M.S. definition. Center for disease and Control preventions (CDC) percentile were applied to define cut off points of waist circumference and BP.

Results: Prevalence of M.S. was 9% (95% CI: 8-10%) with prevalence in male 11% (95% CI: 10-12%) and female 7% (95% CI 6-8%). Among individuals with M.S, triglyceride (TG) and decreased high density lipoprotein (HDL) cholesterol levels were the most common components (33.5% and 24.1%, respectively). Prevalence of M.S was higher in overweight persons comparing to participants with at risk and normal weight group (in male: 24.1%, 14.3% and 9.9% respectively P = 0.0001), (in female: 22.6%, 18.3% and 4.5% respectively P = 0.0001). Among the correlated factors of M.S age (P = 0.0006), sex and BMI (P = 0.0001) had significant differences between subjects with and without M.S. whereas there was no significant difference between two groups in ethnicity, history of breast fed, birth weight neonatal ICU admission, maternal history(GDM, gestational HTN, Parity) and family history of HTN, obesity and DM (P > 0.05).

Conclusion: This study shows high prevalence of M.S in Children and Adolescents in south west of Iran (Ahvaz) especially in overweight persons.
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http://dx.doi.org/10.1186/2251-6581-13-53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031928PMC
May 2014

Albuminuria and its correlates in type 2 diabetic patients.

Iran J Kidney Dis 2013 Jul;7(4):268-76

Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Introduction: The aim of this study was to determine the prevalence of albuminuria and its correlates and investigate disease management for patients with type 2 diabetes mellitus in Ahvaz.

Materials And Methods: This was a cross-sectional study on the 350 patients with type 2 diabetes mellitus attending the Diabetes Clinic at Golestan Hospital, from October 2010 to September 2011. Demographic characteristics were recorded and height, weight, and blood pressure were measured. Blood urea nitrogen and serum levels of creatinine, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, and glycosylated hemoglobin A were measured in fasting blood samples. Spot urine and 24-hour urine collection were tested for albumin and kidney ultrasonography was done.

Results: A total of 72 of 350 patients (20.6%) had microalbuminuria and 18 (5.1%) had macroalbuminuria. Elevated serum creatinine was seen in 6.9% and azotemia in 6.0%. In multivariable analysis, blood urea nitrogen level, glycosylated hemoglobin A, and duration of diabetes mellitus were associated with urinary albumin excretion (P = .04). A small proportion of the participants achieved optimal treatment goals for modifiable risk factors.

Conclusions: Abnormal urinary albumin excretion is seen in one-quarter of type 2 diabetic patients and a small but important number of them have azotemia. Albuminuria was found to be associated with long-term duration of diabetes mellitus, poor glucose control (revealed by high glycosylated hemoglobin A levels), and high blood urea nitrogen. Poor glycemic control may have a significant role in the progression of diabetic nephropathy in these patients.
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July 2013

Metabolic syndrome and its correlated factors in an urban population in South West of Iran.

J Diabetes Metab Disord 2013 Feb 8;12(1):11. Epub 2013 Feb 8.

Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 61157-15794, Iran.

Background: This study was designed to assess the prevalence of metabolic syndrome and its correlated factors in an urban population in Ahvaz.

Methods: This descriptive analytical study performed with random cluster sampling method in 6 health centers in Ahvaz. In each selected center, 55 households were randomly selected. A questionnaire included: age, sex, marital status, ethnicity, education level, family history of diabetes (DM), Hypertension (HTN) and obesity, smoking and parity and previous history of gestational diabetes Mellitus in women were filled for each person.Blood pressure, weight, height, body mass index (BMI), abdominal and waist circumference were measured in each participant. Fasting blood glucose (FBS), serum total cholesterol, triglyceride and high density lipoprotein (HDL) level were measured in fasting blood sample.

Results: The mean age of all participants was 42.27 ± 14 years (44.2 ± 14.26 years in men and 40.5 ± 13.5 in women). From total 912 participant, 434(47.2%) were men and 478(52.8%) women. Prevalence of metabolic syndrome based on ATPIII criteria (update2005) was 22.8% (15.9% in men and 29.1% in women) that showed significant difference (P = 0.0001). Prevalence of each component of MS in studied population was: 29.4% for abdominal obesity, 40.7% for high TG level, 40.2% for low HDL, 15.4% for hypertension and 37.8% for abnormal FBS. Among these factor, age of patients, BMI, sex had significant differences between persons with or without Ms (P = 0.0001). Ethnicity (Arab or Persian), cigarette smoking and family history of diabetes mellitus, hypertension and obesity, marital statues, education level, parity and previous history of GDM in women showed no significant differences between persons with MS and without MS.

Conclusion: Metabolic syndrome has high prevalence in our population and its prevalence increases with increasing age and BMI. Women are at higher risk for metabolic syndrome than men.
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http://dx.doi.org/10.1186/2251-6581-12-11DOI Listing
February 2013

Familial mirror movements over five generations.

Neurol India 2008 Oct-Dec;56(4):482-3

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http://dx.doi.org/10.4103/0028-3886.44813DOI Listing
March 2009