Publications by authors named "Arkaitz Carracedo"

100Publications

Phosphoinositide 3-Kinase-Regulated Pericyte Maturation Governs Vascular Remodeling.

Circulation 2020 Aug 29;142(7):688-704. Epub 2020 May 29.

Vascular Biology and Signalling Group, ProCURE, Oncobell Program, Institut d´Investigació Biomèdica de Bellvitge (IDIBELL), Gran Via de l'Hospitalet 199, 08908 L´Hospitalet de Llobregat, Barcelona, Spain (A.M.F., P.V., P.K., A.M.-R., A.A.-U., M.G.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.042354DOI Listing
August 2020

rMTA: robust metabolic transformation analysis.

Bioinformatics 2019 11;35(21):4350-4355

Tecnun, University of Navarra, San Sebastián 20018, Spain.

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http://dx.doi.org/10.1093/bioinformatics/btz231DOI Listing
November 2019

Rewiring urea cycle metabolism in cancer to support anabolism.

Nat Rev Cancer 2018 10;18(10):634-645

Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1038/s41568-018-0054-zDOI Listing
October 2018

Re-evaluating statin activity in cancer.

Aging (Albany NY) 2018 Jul;10(7):1538-1539

CIC bioGUNE, Bizkaia Technology Park, Derio, Spain.

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http://dx.doi.org/10.18632/aging.101504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075430PMC
July 2018

CK1α promotes tumour suppressive autophagy.

Nat Cell Biol 2018 04;20(4):369-371

Centre for Cooperative Research in Biosciences, CIC bioGUNE, Bizkaia, Spain.

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http://dx.doi.org/10.1038/s41556-018-0079-2DOI Listing
April 2018

Oil for the cancer engine: The cross-talk between oncogenic signaling and polyamine metabolism.

Sci Adv 2018 01 24;4(1):eaar2606. Epub 2018 Jan 24.

CIC bioGUNE, Bizkaia Technology Park, 801A Building, 48160 Derio, Bizkaia, Spain.

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http://dx.doi.org/10.1126/sciadv.aar2606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783676PMC
January 2018

Metabolism and Transcription in Cancer: Merging Two Classic Tales.

Front Cell Dev Biol 2017 5;5:119. Epub 2018 Jan 5.

CIC bioGUNE, Bizkaia Technology Park, Derio, Spain.

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http://dx.doi.org/10.3389/fcell.2017.00119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760552PMC
January 2018

Mitochondrial Metabolism: Yin and Yang for Tumor Progression.

Trends Endocrinol Metab 2017 10;28(10):748-757

CIC bioGUNE, Bizkaia Technology Park, Building 801a, 48160 Derio, Bizkaia, Spain; CIBERONC, Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5, Pabellón 11, Planta 0, 28029 Madrid, Spain; Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), P. O. Box 644, E-48080 Bilbao, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2017.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047739PMC
October 2017

Quiescence-like Metabolism to Push Cancer Out of the Race.

Cell Metab 2017 May;25(5):997-999

CIC bioGUNE, 801A Bizkaia Technology Park, 48160 Derio, Spain; CIBERONC; IKERBASQUE, Basque foundation for science, 48011 Bilbao, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Barrio Sarriena 48940 Leioa, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.04.027DOI Listing
May 2017

Promyelocytic Leukemia Protein, a Protein at the Crossroad of Oxidative Stress and Metabolism.

Antioxid Redox Signal 2017 03 12;26(9):432-444. Epub 2016 Dec 12.

1 Collège de France , Paris, France .

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http://dx.doi.org/10.1089/ars.2016.6898DOI Listing
March 2017

New insights on prostate cancer progression.

Cell Cycle 2017 01 20;16(1):13-14. Epub 2016 Sep 20.

a CIC bioGUNE, Bizkaia Technology Park , Derio , Bizkaia , Spain.

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https://www.tandfonline.com/doi/full/10.1080/15384101.2016.1
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http://dx.doi.org/10.1080/15384101.2016.1235845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270526PMC
January 2017

Vesicle-MaNiA: extracellular vesicles in liquid biopsy and cancer.

Curr Opin Pharmacol 2016 08 28;29:47-53. Epub 2016 Jun 28.

CIC bioGUNE, Bizkaia Technology Park, 801ª bld., 48160 Derio, Bizkaia, Spain; Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), P.O. Box 644, E-48080 Bilbao, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2016.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992611PMC
August 2016

Oncosuppressive functions of tribbles pseudokinase 3.

Biochem Soc Trans 2015 Oct;43(5):1122-6

Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain Instituto de Investigaciones Sanitarias San Carlos (IdISSC), 28040 Madrid, Spain

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http://biochemsoctrans.org/cgi/doi/10.1042/BST20150124
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http://dx.doi.org/10.1042/BST20150124DOI Listing
October 2015

The promyelocytic leukemia protein is upregulated in conditions of obesity and liver steatosis.

Int J Biol Sci 2015 11;11(6):629-32. Epub 2015 Apr 11.

1. Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.7150/ijbs.11615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440252PMC
April 2016

RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation.

EMBO Mol Med 2014 Jul;6(7):865-81

Oncology Program, Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

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http://dx.doi.org/10.15252/emmm.201303675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119352PMC
July 2014

PML: Not all about Tumor Suppression.

Front Oncol 2013 5;3:200. Epub 2013 Aug 5.

CIC bioGUNE, Bizkaia Technology Park Derio, Spain.

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http://dx.doi.org/10.3389/fonc.2013.00200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732998PMC
August 2013

Cancer metabolism: fatty acid oxidation in the limelight.

Nat Rev Cancer 2013 04 28;13(4):227-32. Epub 2013 Feb 28.

CIC bioGUNE, Bizkaia Technology Park, Derio, Spain.

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http://dx.doi.org/10.1038/nrc3483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766957PMC
April 2013

A metabolic prosurvival role for PML in breast cancer.

J Clin Invest 2012 Sep 13;122(9):3088-100. Epub 2012 Aug 13.

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Harvard Medical School, and Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA.

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http://dx.doi.org/10.1172/JCI62129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433768PMC
September 2012

Is the bench getting closer to the bedside in the war on cancer? A quick look at prostate cancer.

Front Endocrinol (Lausanne) 2012 12;3:53. Epub 2012 Apr 12.

CIC bioGUNE, Technology Park of Bizkaia Derio, Spain.

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http://dx.doi.org/10.3389/fendo.2012.00053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356079PMC
August 2012

The nuclear bodies inside out: PML conquers the cytoplasm.

Curr Opin Cell Biol 2011 Jun 16;23(3):360-6. Epub 2011 Apr 16.

CIC bioGUNE, Technology Park of Bizkaia, 48160 Derio, Bizkaia, Spain.

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http://dx.doi.org/10.1016/j.ceb.2011.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109131PMC
June 2011

Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.

Sci Signal 2011 Mar 8;4(163):ra13. Epub 2011 Mar 8.

1Division of Signal Transduction, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scisignal.2001518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437993PMC
March 2011

PTEN level in tumor suppression: how much is too little?

Cancer Res 2011 Feb 25;71(3):629-33. Epub 2011 Jan 25.

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249925PMC
February 2011

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.

Cell 2011 Jan;144(2):187-99

Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.cell.2010.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249980PMC
January 2011

Faithfull modeling of PTEN loss driven diseases in the mouse.

Curr Top Microbiol Immunol 2010 ;347:135-68

Department of Medicine and Pathology, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1007/82_2010_62DOI Listing
January 2011

Subtle variations in Pten dose determine cancer susceptibility.

Nat Genet 2010 May 18;42(5):454-8. Epub 2010 Apr 18.

Cancer Genetics Program, Department of Medicine, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://www.nature.com/articles/ng.556
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http://dx.doi.org/10.1038/ng.556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118559PMC
May 2010

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.

J Clin Invest 2010 Mar 8;120(3):681-93. Epub 2010 Feb 8.

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1172/JCI40535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827955PMC
March 2010

Differential p53-independent outcomes of p19(Arf) loss in oncogenesis.

Sci Signal 2009 Aug 18;2(84):ra44. Epub 2009 Aug 18.

Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scisignal.2000053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928478PMC
August 2009

TRB3 links ER stress to autophagy in cannabinoid anti-tumoral action.

Autophagy 2009 Oct 14;5(7):1048-9. Epub 2009 Oct 14.

Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain.

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http://dx.doi.org/10.4161/auto.5.7.9508DOI Listing
October 2009

The CB(2) cannabinoid receptor regulates human sperm cell motility.

Fertil Steril 2010 Mar 27;93(5):1378-87. Epub 2009 Mar 27.

Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Leioa, P.O. Box 699, E-48080, Bilbao, Biscay, Spain.

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http://dx.doi.org/10.1016/j.fertnstert.2009.01.153DOI Listing
March 2010

Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis.

Glia 2009 Oct;57(13):1374-85

Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain.

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http://dx.doi.org/10.1002/glia.20856DOI Listing
October 2009

Differential requirement of mTOR in postmitotic tissues and tumorigenesis.

Sci Signal 2009 Jan 27;2(55):ra2. Epub 2009 Jan 27.

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scisignal.2000189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906144PMC
January 2009

Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors.

Cell Cycle 2008 Dec 22;7(24):3805-9. Epub 2008 Dec 22.

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130531PMC
http://dx.doi.org/10.4161/cc.7.24.7244DOI Listing
December 2008

The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network.

Nature 2008 Oct 20;455(7214):813-7. Epub 2008 Aug 20.

Cancer Genetics Program, Beth Israel Deaconess Cancer Center and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nature07290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398484PMC
October 2008

Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.

Genes Dev 2008 Aug;22(16):2172-7

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1101/gad.1699608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518820PMC
August 2008

Tenets of PTEN tumor suppression.

Cell 2008 May;133(3):403-14

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, New Research Building, 330 Brookline Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2008.04.013DOI Listing
May 2008

Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression.

Cancer Res 2008 Mar;68(6):1945-52

Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-5176DOI Listing
March 2008

Cannabinoids and gliomas.

Mol Neurobiol 2007 Aug 28;36(1):60-7. Epub 2007 Jun 28.

Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain.

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http://dx.doi.org/10.1007/s12035-007-0002-5DOI Listing
August 2007

Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity?

Neuropharmacology 2008 Jan 1;54(1):235-43. Epub 2007 Jul 1.

Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain.

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http://dx.doi.org/10.1016/j.neuropharm.2007.06.021DOI Listing
January 2008

Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis.

J Biol Chem 2007 Mar 2;282(9):6854-62. Epub 2007 Jan 2.

Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain.

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http://dx.doi.org/10.1074/jbc.M608900200DOI Listing
March 2007

Cannabinoid receptors as novel targets for the treatment of melanoma.

FASEB J 2006 Dec 25;20(14):2633-5. Epub 2006 Oct 25.

Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain.

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http://dx.doi.org/10.1096/fj.06-6638fjeDOI Listing
December 2006

Expression and localization of delta-, kappa-, and mu-opioid receptors in human spermatozoa and implications for sperm motility.

J Clin Endocrinol Metab 2006 Dec 19;91(12):4969-75. Epub 2006 Sep 19.

Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, PO Box 699, Bilbao, 48080 Bizkaia, Spain.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2006-0599DOI Listing
December 2006

Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes.

Cancer Res 2006 Jul;66(13):6748-55

Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, c/José Antonio Novais s/n, 28040 Madrid, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-0169DOI Listing
July 2006

The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway.

Exp Cell Res 2006 Jul 19;312(11):2121-31. Epub 2006 Apr 19.

Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, c/José Antonio Novais s/n, 28040 Madrid, Spain.

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http://dx.doi.org/10.1016/j.yexcr.2006.03.009DOI Listing
July 2006

p8 Upregulation sensitizes astrocytes to oxidative stress.

FEBS Lett 2006 Mar 9;580(6):1571-5. Epub 2006 Feb 9.

Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, c/José Antonio Novais s/n, 28040 Madrid, Spain.

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http://dx.doi.org/10.1016/j.febslet.2006.01.084DOI Listing
March 2006

p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells.

FEBS Lett 2005 Sep;579(22):5084-8

Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, c/José Antonio Novais s/n, 28040 Madrid, Spain.

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http://dx.doi.org/10.1016/j.febslet.2005.08.021DOI Listing
September 2005

Ceramide sensitizes astrocytes to oxidative stress: protective role of cannabinoids.

Biochem J 2004 Jun;380(Pt 2):435-40

Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain.

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http://dx.doi.org/10.1042/BJ20031714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224177PMC
June 2004