Arjan A van de Loosdrecht

Arjan A van de Loosdrecht

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Arjan A van de Loosdrecht

Arjan A van de Loosdrecht

Publications by authors named "Arjan A van de Loosdrecht"

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Computational analysis of flow cytometry data in hematological malignancies: future clinical practice?

Curr Opin Oncol 2020 Mar;32(2):162-169

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Hematology, Cancer Center Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/CCO.0000000000000607DOI Listing
March 2020

Glycan-Modified Apoptotic Melanoma-Derived Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination

Cancers (Basel) 2019 08 28;11(9). Epub 2019 Aug 28.

Department of Molecular Cell Biology and Immunology, Amsterdam Infection and Immunity Institute, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.3390/cancers11091266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769957PMC
August 2019

A novel allogeneic off-the-shelf dendritic cell vaccine for post-remission treatment of elderly patients with acute myeloid leukemia.

Cancer Immunol Immunother 2018 Oct 23;67(10):1505-1518. Epub 2018 Jul 23.

Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00262-018-2198-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182404PMC
October 2018

Diagnostic algorithm for lower-risk myelodysplastic syndromes.

Leukemia 2018 08 26;32(8):1679-1696. Epub 2018 Jun 26.

Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41375-018-0173-2DOI Listing
August 2018

Validation of and proposals for refinements of the WHO 2016 classification for myelodysplastic syndromes.

Am J Hematol 2017 Nov 24;92(11):E631-E634. Epub 2017 Aug 24.

Department of Haematology, VU University Medical Center, Cancer Center Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/ajh.24867DOI Listing
November 2017

Transcriptional profiling reveals functional dichotomy between human slan non-classical monocytes and myeloid dendritic cells.

J Leukoc Biol 2017 10 18;102(4):1055-1068. Epub 2017 Jul 18.

Department of Hematology, Cancer Center Amsterdam, Vrije Universiteit Amsterdam University Medical Center, Amsterdam, The Netherlands;

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http://dx.doi.org/10.1189/jlb.3MA0117-037RDOI Listing
October 2017

MDS classification is improving in an era of the WHO 2016 criteria of MDS: A population-based analysis among 9159 MDS patients diagnosed in the Netherlands.

Cancer Epidemiol 2017 10 11;50(Pt A):137-140. Epub 2017 Sep 11.

Department of Hematology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.canep.2017.08.016DOI Listing
October 2017

Application of flow cytometry for myelodysplastic syndromes: Pitfalls and technical considerations.

Cytometry B Clin Cytom 2016 07 14;90(4):358-67. Epub 2015 Dec 14.

Department of Hematology, Cancer Center Amsterdam (CCA), VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/cyto.b.21333DOI Listing
July 2016

Apoptotic vesicles as tumor vaccine.

Immunotherapy 2016 7;8(1):5-8. Epub 2015 Dec 7.

Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.2217/imt.15.96DOI Listing
June 2016

Prognostic relevance of morphological classification models for myelodysplastic syndromes in an era of the revised International Prognostic Scoring System.

Eur J Cancer 2016 Mar 19;56:10-20. Epub 2016 Jan 19.

Department of Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2015.12.004DOI Listing
March 2016

Multiparameter flow cytometry is instrumental to distinguish myelodysplastic syndromes from non-neoplastic cytopenias.

Eur J Cancer 2016 Feb 22;54:49-56. Epub 2015 Dec 22.

Department of Hematology, VU University Medical Center, Cancer Center Amsterdam (VUmc CCA), De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2015.11.013DOI Listing
February 2016

Trends in incidence, primary treatment and survival in chronic myelomonocytic leukaemia: a population-based study of 1359 patients diagnosed in the Netherlands from 1989 to 2012.

Br J Haematol 2015 Nov 8;171(3):436-9. Epub 2015 Apr 8.

Department of Hematology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.

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http://doi.wiley.com/10.1111/bjh.13414
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http://dx.doi.org/10.1111/bjh.13414DOI Listing
November 2015

Differential capacity of human interleukin-4 and interferon-α monocyte-derived dendritic cells for cross-presentation of free versus cell-associated antigen.

Cancer Immunol Immunother 2015 Nov 28;64(11):1419-27. Epub 2015 Jul 28.

Department of Hematology, Cancer Center Amsterdam, VU University Medical Center, De Boelelaan 1117, 1081HV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00262-015-1741-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612333PMC
November 2015

Immunophenotyping for diagnosis and prognosis in MDS: ready for general application?

Best Pract Res Clin Haematol 2015 Mar 11;28(1):14-21. Epub 2014 Nov 11.

Department of Hematology, VU University Medical Center, Cancer Center Amsterdam (VUmc CCA), Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2014.11.003DOI Listing
March 2015

Class II-associated invariant chain peptide as predictive immune marker in minimal residual disease in acute myeloid leukemia.

Oncoimmunology 2014 Dec 7;3(12):e941737. Epub 2015 Jan 7.

Department of Hematology; Cancer Center Amsterdam; VU Institute for Cancer and Immunology; VU University Medical Center ; Amsterdam, The Netherlands.

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http://dx.doi.org/10.4161/21624011.2014.941737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353169PMC
December 2014

High flow cytometric scores identify adverse prognostic subgroups within the revised international prognostic scoring system for myelodysplastic syndromes.

Br J Haematol 2014 Oct 30;167(1):100-9. Epub 2014 Jun 30.

Department of Haematology, Cancer Centre Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/bjh.12994DOI Listing
October 2014

ZAP70 in B-CLL cells related to the expression in NK cells is a surrogate marker for mutational status.

Cytometry B Clin Cytom 2014 Jul 8;86(4):280-7. Epub 2013 Oct 8.

Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/cyto.b.21132DOI Listing
July 2014

loading of skin dendritic cells with apoptotic bleb-derived antigens for the induction of tumor-directed immunity.

Oncoimmunology 2014;3(7):e946360. Epub 2014 Jul 3.

Department of Medical Oncology; VU University Medical Center; Cancer Center Amsterdam ; Amsterdam, The Netherlands.

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http://dx.doi.org/10.4161/21624011.2014.946360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292219PMC
July 2014

Absence of aberrant myeloid progenitors by flow cytometry is associated with favorable response to azacitidine in higher risk myelodysplastic syndromes.

Cytometry B Clin Cytom 2014 May 28;86(3):207-15. Epub 2014 Jan 28.

Department of Hematology, VU Institute of Cancer and Immunology (V-ICI), Cancer Center Amsterdam (CCA), VU University Medical Center, Amsterdam, Netherlands.

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http://dx.doi.org/10.1002/cyto.b.21160DOI Listing
May 2014

Apoptotic blebs from leukemic cells as a preferred source of tumor-associated antigen for dendritic cell-based vaccines.

Cancer Immunol Immunother 2014 Apr 3;63(4):335-45. Epub 2014 Jan 3.

Department of Hematology, Cancer Center Amsterdam, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00262-013-1515-6DOI Listing
April 2014

Trends in incidence, initial treatment and survival of myelodysplastic syndromes: a population-based study of 5144 patients diagnosed in the Netherlands from 2001 to 2010.

Eur J Cancer 2014 Mar 31;50(5):1004-12. Epub 2013 Dec 31.

Department of Hematology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2013.12.002DOI Listing
March 2014

Absence of aberrant myeloid progenitors by flow cytometry is associated with favorable response to azacitidine in higher risk myelodysplastic syndromes.

Cytometry B Clin Cytom 2014 Jan 15. Epub 2014 Jan 15.

Department of Hematology, VU Institute of Cancer and Immunology (V-ICI), Cancer Center Amsterdam (CCA), VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/cytob.21160DOI Listing
January 2014

ZAP70 in B-CLL cells related to the expression in NK cells is a surrogate marker for mutational status.

Cytometry B Clin Cytom 2013 Oct 1. Epub 2013 Oct 1.

Department of Hematology, VU University medical center, Cancer Center Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1002/cytob.21132DOI Listing
October 2013

Targeting the acute myeloid leukemic stem cell compartment by enhancing tumor cell-based vaccines.

Immunotherapy 2013 Aug;5(8):859-68

Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.2217/imt.13.76DOI Listing
August 2013

Cutting edge: flow cytometry in myelodysplastic syndromes.

J Natl Compr Canc Netw 2013 Jul;11(7):892-902

Department of Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.6004/jnccn.2013.0106DOI Listing
July 2013

Dendritic cells in myelodysplastic syndromes: from pathogenesis to immunotherapy.

Immunotherapy 2013 Jun;5(6):621-37

Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.2217/imt.13.51DOI Listing
June 2013

MicroRNA profiling can classify acute leukemias of ambiguous lineage as either acute myeloid leukemia or acute lymphoid leukemia.

Clin Cancer Res 2013 Apr 26;19(8):2187-96. Epub 2013 Feb 26.

Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3657DOI Listing
April 2013

A threshold of 10% for myeloperoxidase by flow cytometry is valid to classify acute leukemia of ambiguous and myeloid origin.

Cytometry B Clin Cytom 2013 Mar 16;84(2):114-8. Epub 2013 Jan 16.

Department of Hematology, Cancer Centre Amsterdam, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/cyto.b.21072DOI Listing
March 2013

Azacitidine differentially affects CD4(pos) T-cell polarization in vitro and in vivo in high risk myelodysplastic syndromes.

Leuk Res 2012 Jul 14;36(7):921-30. Epub 2012 Apr 14.

Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.leukres.2012.03.026DOI Listing
July 2012

Tumor immune escape in acute myeloid leukemia: Class II-associated invariant chain peptide expression as result of deficient antigen presentation.

Oncoimmunology 2012 Mar;1(2):211-213

Department of Hematology; Cancer Center Amsterdam; VU Institute for Cancer and Immunology; VU University Medical Center; Amsterdam, The Netherlands ; Department of Immunopathology; Sanquin Research and Landsteiner Laboratory; Academic Medical Center; University of Amsterdam; Amsterdam, The Netherlands.

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http://dx.doi.org/10.4161/onci.1.2.18100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376995PMC
March 2012

Class II-associated invariant chain peptide expression represents a novel parameter for flow cytometric detection of acute promyelocytic leukemia.

Am J Pathol 2011 Nov 9;179(5):2157-61. Epub 2011 Sep 9.

Department of Hematology, Cancer Center Amsterdam, VU Institute for Cancer and Immunology, VU University Medical Center, Amsterdam, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S000294401100748
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http://dx.doi.org/10.1016/j.ajpath.2011.07.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204089PMC
November 2011

Role of immune responses in the pathogenesis of low-risk MDS and high-risk MDS: implications for immunotherapy.

Br J Haematol 2011 Jun 13;153(5):568-81. Epub 2011 Apr 13.

Department of Haematology, VU Institute for Cancer and Immunology, VU University Medical Centre, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1111/j.1365-2141.2011.08683.xDOI Listing
June 2011

Review of the relevance of aberrant antigen expression by flow cytometry in myeloid neoplasms.

Br J Haematol 2011 May 9;153(4):421-36. Epub 2011 Mar 9.

Department of Haematology, VU University Medical Center, De Boelelaan 1117, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1111/j.1365-2141.2011.08595.xDOI Listing
May 2011

Absence of class II-associated invariant chain peptide on leukemic blasts of patients promotes activation of autologous leukemia-reactive CD4+ T cells.

Cancer Res 2011 Apr 10;71(7):2507-17. Epub 2011 Feb 10.

Department of Hematology, Cancer Center Amsterdam and VU Institute for Cancer and Immunology, VU University Medical Center, The Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3689DOI Listing
April 2011

Chronic myeloid leukemia lysate-loaded dendritic cells induce T-cell responses towards leukemia progenitor cells.

Immunotherapy 2011 Apr;3(4):569-76

Department of Hematology, Cancer Center Amsterdam/VUmc Institute for Cancer & Immunology, VU University Medical Center, Amsterdam, The Netherlands.

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https://www.futuremedicine.com/doi/10.2217/imt.11.3
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http://dx.doi.org/10.2217/imt.11.3DOI Listing
April 2011

Targeting Toll-like receptor 7/8 enhances uptake of apoptotic leukemic cells by monocyte-derived dendritic cells but interferes with subsequent cytokine-induced maturation.

Cancer Immunol Immunother 2011 Jan 22;60(1):37-47. Epub 2010 Sep 22.

Department of Hematology, Cancer Center Amsterdam, VU Institute for Cancer and Immunology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00262-010-0917-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029806PMC
January 2011

Monoclonal antibody therapy in haematological malignancies.

Curr Clin Pharmacol 2010 Aug;5(3):148-59

Department of Haematology, VU University Medical Center, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.2174/157488410791498752DOI Listing
August 2010

Efficacy of single-agent lenalidomide in patients with JAK2 (V617F) mutated refractory anemia with ring sideroblasts and thrombocytosis.

Blood 2010 Jul 1;116(2):180-2. Epub 2010 Mar 1.

Department of Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands.

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http://dx.doi.org/10.1182/blood-2010-01-263087DOI Listing
July 2010

Class II-associated invariant chain peptide down-modulation enhances the immunogenicity of myeloid leukemic blasts resulting in increased CD4+ T-cell responses.

Haematologica 2010 Mar 10;95(3):485-93. Epub 2009 Nov 10.

Department of Hematology, VU Institute for Cancer and Immunology, Cancer Center Amsterdam, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.3324/haematol.2009.010595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833080PMC
March 2010

Recent advances in antigen-loaded dendritic cell-based strategies for treatment of minimal residual disease in acute myeloid leukemia.

Immunotherapy 2010 Jan;2(1):69-83

Department of Hematology, VU Institute for Cancer & Immunology, Cancer Center Amsterdam, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.2217/imt.09.85DOI Listing
January 2010

Impaired antigen presentation in neoplasia: basic mechanisms and implications for acute myeloid leukemia.

Immunotherapy 2010 Jan;2(1):85-97

Department of Hematology, VU Institute for Cancer & Immunology, Cancer Center Amsterdam, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.2217/imt.09.84DOI Listing
January 2010

Antibody response to polysaccharide conjugate vaccines after nonmyeloablative allogeneic stem cell transplantation.

Biol Blood Marrow Transplant 2009 Dec 25;15(12):1523-30. Epub 2009 Sep 25.

Department of Internal Medicine, St. Antonius Hospital, Nieuwegein, The Netherlands.

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http://dx.doi.org/10.1016/j.bbmt.2009.07.020DOI Listing
December 2009

Transient neonatal myelosuppression after fetal exposure to maternal chemotherapy. Case report and review of the literature.

Neonatology 2009 12;95(1):80-5. Epub 2008 Sep 12.

Subdivision of Neonatology, Department of Pediatrics, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000151759DOI Listing
June 2009

Human dendritic cell line models for DC differentiation and clinical DC vaccination studies.

J Leukoc Biol 2008 Dec 29;84(6):1364-73. Epub 2008 Jul 29.

Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.1189/jlb.0208092DOI Listing
December 2008

High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome.

Haematologica 2008 Dec;93(12):1894-8

Department of Hematology, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.3324/haematol.13113DOI Listing
December 2008