Ariel E Feldstein

Ariel E Feldstein

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Ariel E Feldstein

Publications by authors named "Ariel E Feldstein"

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MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury.

Mol Ther 2020 Feb 13;28(2):653-663. Epub 2019 Sep 13.

Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Rady Children's Hospital San Diego, 3020 Children's Way, MC 5030, San Diego, CA 92103-8450, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000998PMC
February 2020

Designing Clinical Trials in Pediatric Nonalcoholic Steatohepatitis: Tips for Patient Selection and Appropriate Endpoints.

Hepatol Commun 2019 Dec 8;3(12):1563-1570. Epub 2019 Nov 8.

Department of Pediatric Gastroenterology University of California San Diego La Jolla CA.

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http://dx.doi.org/10.1002/hep4.1449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887671PMC
December 2019

Complex Network of NKT Cell Subsets Controls Immune Homeostasis in Liver and Gut.

Front Immunol 2018 11;9:2082. Epub 2018 Sep 11.

Laboratory of Immune Regulation, University of California, San Diego, La Jolla, CA, United States.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02082
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http://dx.doi.org/10.3389/fimmu.2018.02082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141878PMC
September 2019

NAFLD in children: new genes, new diagnostic modalities and new drugs.

Nat Rev Gastroenterol Hepatol 2019 09 5;16(9):517-530. Epub 2019 Jul 5.

Texas Liver Institute, UT Health San Antonio, San Antonio, TX, USA.

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http://dx.doi.org/10.1038/s41575-019-0169-zDOI Listing
September 2019

Novel Drivers of the Inflammatory Response in Liver Injury and Fibrosis.

Semin Liver Dis 2019 07 17;39(3):275-282. Epub 2019 May 17.

Department of Pediatric Gastroenterology, University of California, San Diego (UCSD), San Diego, California and Rady Children's Hospital, San Diego, California.

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http://dx.doi.org/10.1055/s-0039-1685515DOI Listing
July 2019

Extracellular vesicles, the liquid biopsy of the future.

J Hepatol 2019 Jun 12;70(6):1292-1294. Epub 2019 Apr 12.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01688278193007
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http://dx.doi.org/10.1016/j.jhep.2019.01.030DOI Listing
June 2019

Non-alcoholic fatty liver disease in pediatric type 2 diabetes: Metabolic and histologic characteristics in 38 subjects.

Pediatr Diabetes 2019 02 9;20(1):41-47. Epub 2018 Dec 9.

Pediatric Gastroenterology, University of California San Diego and Rady Children's Hospital San Diego, San Diego, California.

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http://dx.doi.org/10.1111/pedi.12798DOI Listing
February 2019

Extracellular Vesicles in Liver Diseases: Meeting Report from the International Liver Congress 2018.

Hepatol Commun 2019 Feb 2;3(2):305-315. Epub 2019 Jan 2.

Department of Oncology, Hematology and Rheumatology University Hospital Bonn Bonn Germany.

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http://dx.doi.org/10.1002/hep4.1300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357829PMC
February 2019

Liquid biopsy for liver diseases.

Gut 2018 12 3;67(12):2204-2212. Epub 2018 Sep 3.

Department of Pediatrics, University of California, San Diego, California, USA.

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2017-315846
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http://dx.doi.org/10.1136/gutjnl-2017-315846DOI Listing
December 2018

Emricasan, a pan-caspase inhibitor, improves survival and portal hypertension in a murine model of common bile-duct ligation.

J Mol Med (Berl) 2018 06 5;96(6):575-583. Epub 2018 May 5.

Department of Pediatrics, University of California - San Diego, 9500 Gilman Drive, MC 0715, 9500 Gilman Drive, La Jolla, CA, USA.

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http://dx.doi.org/10.1007/s00109-018-1642-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347405PMC
June 2018

Triggering and resolution of inflammation in NASH.

Nat Rev Gastroenterol Hepatol 2018 06;15(6):349-364

Department of Pediatrics, University of California, San Diego, CA, USA.

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http://dx.doi.org/10.1038/s41575-018-0009-6DOI Listing
June 2018

Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress.

Biomolecules 2018 03 26;8(2). Epub 2018 Mar 26.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY 40202, USA.

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http://dx.doi.org/10.3390/biom8020016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022870PMC
March 2018

Extracellular vesicles in non-alcoholic and alcoholic fatty liver diseases.

Liver Res 2018 Mar 28;2(1):30-34. Epub 2018 Feb 28.

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Rady's Children Hospital, University of California San Diego, San Diego, CA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S25425684180000
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http://dx.doi.org/10.1016/j.livres.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190912PMC
March 2018

Transmembrane BAX Inhibitor motif-containing 1, a novel anti-inflammatory approach for nonalcoholic steatohepatitis treatment.

Hepatology 2018 01;67(1):438-441

Department of Pediatric Gastroenterology, University of California San Diego (UCSD), and Rady Children's Hospital, San Diego, CA.

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http://dx.doi.org/10.1002/hep.29495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770148PMC
January 2018

Dietary Linoleic Acid and Its Oxidized Metabolites Exacerbate Liver Injury Caused by Ethanol via Induction of Hepatic Proinflammatory Response in Mice.

Am J Pathol 2017 Oct;187(10):2232-2245

Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky; Hepatobiology and Toxicology Program, University of Louisville School of Medicine, Louisville, Kentucky; University of Louisville Alcohol Research Center, University of Louisville School of Medicine, Louisville, Kentucky. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808136PMC
October 2017

NASH: Novel therapeutic strategies targeting ASK1 in NASH.

Nat Rev Gastroenterol Hepatol 2017 06 5;14(6):329-330. Epub 2017 Apr 5.

Department of Pediatrics, University of California, San Diego, Biomedical Research Building II, 9500 Gilman Drive, MC0602, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nrgastro.2017.42DOI Listing
June 2017

Inflammasomes in Liver Fibrosis.

Semin Liver Dis 2017 05 31;37(2):119-127. Epub 2017 May 31.

Department of Pediatric Gastroenterology, University of California San Diego (UCSD), and Rady Children's Hospital, San Diego, California.

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http://dx.doi.org/10.1055/s-0037-1601350DOI Listing
May 2017

Treating nonalcoholic steatohepatitis in children: Not a cinch task.

Hepatology 2017 04;65(4):1407-1409

Department of Pediatrics, University of California San Diego, San Diego, CA.

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http://dx.doi.org/10.1002/hep.29043DOI Listing
April 2017

NASH-RELATED CIRRHOSIS: AN OCCULT LIVER DISEASE BURDEN.

Hepatol Commun 2017 Apr 6;1(2):84-86. Epub 2017 Apr 6.

Department of Pediatrics, University of California San Diego (UCSD), CA, 92123, United States.

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http://dx.doi.org/10.1002/hep4.1033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721433PMC
April 2017

Update on lipid species and paediatric nonalcoholic fatty liver disease.

Curr Opin Clin Nutr Metab Care 2017 03;20(2):110-116

aDepartment of Paediatrics, University of Cambridge, Cambridge, UK bDepartment of Pediatric Gastroenterology, University of California San Diego (UCSD) cRady Children's Hospital, San Diego, California, USA dHepatometabolic Unit eLiver Research Unit, Bambino Gesu Hospital, IRCCS, Rome, Italy.

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http://dx.doi.org/10.1097/MCO.0000000000000346DOI Listing
March 2017

Fatty liver in adolescents: Mechanisms, clinical features and therapy.

J Hepatol 2016 12 11;65(6):1258-1260. Epub 2016 Oct 11.

Department of Pediatric Gastroenterology, Hepatology and Nutrition, Rady Children's Hospital, University of California San Diego (UCSD), San Diego, CA, USA.

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http://dx.doi.org/10.1016/j.jhep.2016.07.036DOI Listing
December 2016

Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress.

J Mol Med (Berl) 2016 11 9;94(11):1241-1253. Epub 2016 Jul 9.

Department of Pediatrics, University of California San Diego (UCSD), La Jolla, CA, 92093, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071132PMC
http://dx.doi.org/10.1007/s00109-016-1446-8DOI Listing
November 2016

Similarities and differences between pediatric and adult nonalcoholic fatty liver disease.

Metabolism 2016 Aug 20;65(8):1161-71. Epub 2016 Jan 20.

Department of Pediatric Gastroenterology, Cleveland Clinic Children's, Cleveland, OH, USA; Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2016.01.008DOI Listing
August 2016

Noninvasive diagnosis of nonalcoholic fatty liver disease: Are we there yet?

Metabolism 2016 Aug 2;65(8):1087-95. Epub 2016 Feb 2.

Department of Pediatrics, University of California San Diego (UCSD), CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2016.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931968PMC
August 2016

Hepatocyte mitochondrial DNA released in microparticles and toll-like receptor 9 activation: A link between lipotoxicity and inflammation during nonalcoholic steatohepatitis.

Hepatology 2016 08 24;64(2):669-71. Epub 2016 Jun 24.

Department of Pediatric Gastroenterology, University of California San Diego (UCSD) and Rady Children's Hospital, San Diego, CA.

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http://dx.doi.org/10.1002/hep.28666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956555PMC
August 2016

Etiology, outcome and prognostic factors of childhood acute liver failure in a German Single Center.

Ann Hepatol 2015 Sep-Oct;14(5):722-8

Department of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen, Essen, Germany.

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May 2016

Innate Immunity and Inflammation in NAFLD/NASH.

Dig Dis Sci 2016 May 3;61(5):1294-303. Epub 2016 Feb 3.

Department of Pediatrics, University of California San Diego (UCSD), San Diego, CA, USA.

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http://dx.doi.org/10.1007/s10620-016-4049-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948286PMC
May 2016

Microparticles release by adipocytes act as "find-me" signals to promote macrophage migration.

PLoS One 2015 7;10(4):e0123110. Epub 2015 Apr 7.

Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California, United States of America; Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123110PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388837PMC
April 2016

Soluble IgM links apoptosis to complement activation in early alcoholic liver disease in mice.

Mol Immunol 2016 Apr 27;72:9-18. Epub 2016 Feb 27.

Center for Liver Disease Research, Department of Pathobiology, Cleveland Clinic, United States; Department of Gastroenterology, Cleveland Clinic, United States; Department of Molecular Medicine, Case Western Reserve University, Cleveland, OH, United States. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2016.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828291PMC
April 2016

Liver Bid suppression for treatment of fibrosis associated with non-alcoholic steatohepatitis.

J Hepatol 2016 Mar 7;64(3):699-707. Epub 2015 Nov 7.

Department of Pediatrics, University of California - San Diego, 9500 Gilman Drive, La Jolla, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761314PMC
March 2016

Targeting Cell Death and Sterile Inflammation Loop for the Treatment of Nonalcoholic Steatohepatitis.

Semin Liver Dis 2016 Feb 12;36(1):27-36. Epub 2016 Feb 12.

Department of Pediatrics, University of California San Diego (UCSD), and Rady Children's Hospital, San Diego, California.

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https://www.thieme-connect.com/products/ejournals/pdf/10.105
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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0035-1571272
Publisher Site
http://dx.doi.org/10.1055/s-0035-1571272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955833PMC
February 2016

Novel Molecular Mechanisms in the Development of Non-Alcoholic Steatohepatitis.

Diabetes Metab J 2016 Feb;40(1):1-11

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Rady's Children Hospital, University of California San Diego, San Diego, CA, USA.

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http://dx.doi.org/10.4093/dmj.2016.40.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768045PMC
February 2016

Serum cytokeratin-18 fragment levels predict development of type 2 diabetes mellitus in adult patients with NAFLD.

Liver Int 2015 Dec 21;35(12):2621. Epub 2015 May 21.

Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1111/liv.12862DOI Listing
December 2015

Circulating Soluble Fas and Fas Ligand Levels Are Elevated in Children with Nonalcoholic Steatohepatitis.

Dig Dis Sci 2015 Aug 13;60(8):2353-9. Epub 2015 Mar 13.

Department of Pediatric Gastroenterology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA,

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http://dx.doi.org/10.1007/s10620-015-3614-zDOI Listing
August 2015

Burden of nonalcoholic fatty liver disease and advanced fibrosis in a Texas Hispanic community cohort.

World J Hepatol 2015 Jun;7(11):1586-94

Jen-Jung Pan, Chaoru Chen, Michael B Fallon, Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, the University of Texas Health Science Center at Houston, Houston, TX 77030, United States.

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http://dx.doi.org/10.4254/wjh.v7.i11.1586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462697PMC
June 2015

The evaluation of hepatic fibrosis scores in children with nonalcoholic fatty liver disease.

Dig Dis Sci 2015 May 25;60(5):1440-7. Epub 2014 Dec 25.

Department of Pediatric Gastroenterology and Hepatology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.

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http://dx.doi.org/10.1007/s10620-014-3494-7DOI Listing
May 2015

Endoscopic treatment of pediatric post-transplant biliary complications is safe and effective.

Dig Endosc 2015 May 4;27(4):505-11. Epub 2015 Feb 4.

Department of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1111/den.12420DOI Listing
May 2015

Adipocyte cell death, fatty liver disease and associated metabolic disorders.

Dig Dis 2014 14;32(5):579-85. Epub 2014 Jul 14.

Department of Pediatrics, University of California San Diego, San Diego, Calif., USA.

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http://dx.doi.org/10.1159/000360509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512744PMC
March 2015

Leptin deficiency recapitulates the histological features of pulmonary arterial hypertension in mice.

Int J Clin Exp Pathol 2014 15;7(5):1935-46. Epub 2014 Apr 15.

Department of Pathobiology, Lerner Research Institute, Respiratory Institute Cleveland Clinic Cleveland, Ohio, USA ; Department of Pulmonary and Critical Care Medicine, Respiratory Institute Cleveland Clinic Cleveland, Ohio, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069962PMC
February 2015

Circulating microRNAs: emerging biomarkers of liver disease.

Semin Liver Dis 2015 Feb 29;35(1):43-54. Epub 2015 Jan 29.

Department of Pediatric Gastroenterology, Rady Children's Hospital, University of California San Diego, California.

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http://dx.doi.org/10.1055/s-0034-1397348DOI Listing
February 2015

Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol-induced alcoholic liver disease.

Am J Pathol 2015 Jan 31;185(1):43-54. Epub 2014 Oct 31.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278357PMC
January 2015

Adipocyte cell size, free fatty acids and apolipoproteins are associated with non-alcoholic liver injury progression in severely obese patients.

Metabolism 2014 Dec 6;63(12):1542-52. Epub 2014 Sep 6.

Department of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen, Essen, 45122, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2014.09.001DOI Listing
December 2014

NLRP3 inflammasome activation is required for fibrosis development in NAFLD.

J Mol Med (Berl) 2014 Oct 28;92(10):1069-82. Epub 2014 May 28.

Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, MC 0715, La Jolla, CA, 92037-0715, USA.

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http://dx.doi.org/10.1007/s00109-014-1170-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349416PMC
October 2014

OxNASH score correlates with histologic features and severity of nonalcoholic fatty liver disease.

Dig Dis Sci 2014 Jul 25;59(7):1617-24. Epub 2014 Jan 25.

Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA,

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http://dx.doi.org/10.1007/s10620-014-3031-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279921PMC
July 2014

Differential regulation of inflammation and apoptosis in Fas-resistant hepatocyte-specific Bid-deficient mice.

J Hepatol 2014 Jul 27;61(1):107-15. Epub 2014 Mar 27.

Department of Pediatrics, University of California - San Diego, La Jolla, CA, United States; Department of Cell Biology, Cleveland Clinic, Cleveland, OH, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.03.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712949PMC
July 2014

Lipidomic profiling of bile in distinguishing benign from malignant biliary strictures: a single-blinded pilot study.

Am J Gastroenterol 2014 Jun 8;109(6):895-902. Epub 2014 Apr 8.

Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1038/ajg.2014.60DOI Listing
June 2014

Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet-induced NASH model.

Dig Dis Sci 2014 Jun 3;59(6):1197-206. Epub 2014 May 3.

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1007/s10620-014-3167-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512760PMC
June 2014

Biomarkers of liver cell death.

J Hepatol 2014 May 8;60(5):1063-74. Epub 2014 Jan 8.

Department of Pediatric Gastroenterology, Rady Children's Hospital, University of California San Diego, San Diego, CA 92123, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2013.12.026DOI Listing
May 2014

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice.

Hepatology 2014 Mar 30;59(3):898-910. Epub 2014 Jan 30.

Department of Pediatrics, University of California San Diego, La Jolla, CA; Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany.

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http://dx.doi.org/10.1002/hep.26592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008151PMC
March 2014

Obesity, nutrition, and liver disease in children.

Clin Liver Dis 2014 Feb;18(1):219-31

Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Rady Children's Hospital, 3020 Children's Way, San Diego, CA 92123, USA; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, University of California, San Diego, 9500 Gilman Drive, MC 0984, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cld.2013.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008146PMC
February 2014

Oxidized fatty acids: A potential pathogenic link between fatty liver and type 2 diabetes in obese adolescents?

Antioxid Redox Signal 2014 Jan 3;20(2):383-9. Epub 2013 Aug 3.

1 Department of Pediatrics, Yale University School of Medicine , New Haven, Connecticut.

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http://dx.doi.org/10.1089/ars.2013.5466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887421PMC
January 2014

Limited value of plasma cytokeratin-18 as a biomarker for NASH and fibrosis in patients with non-alcoholic fatty liver disease.

J Hepatol 2014 Jan 20;60(1):167-74. Epub 2013 Aug 20.

Department of Pathology, The University of Texas Health Science Center at San Antonio (UTHSCSA), United States; Audie L. Murphy Veterans Administration Medical Center (VAMC), San Antonio, TX, United States.

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http://dx.doi.org/10.1016/j.jhep.2013.07.042DOI Listing
January 2014

Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial.

Pain 2013 Nov 22;154(11):2441-51. Epub 2013 Jul 22.

Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA; Department of Physical Medicine and Rehabilitation, Program on Integrative Medicine, University of North Carolina-Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pain.2013.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850757PMC
November 2013

From NAFLD to NASH to cirrhosis-new insights into disease mechanisms.

Nat Rev Gastroenterol Hepatol 2013 Nov 20;10(11):627-36. Epub 2013 Aug 20.

Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037-0715, USA.

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http://dx.doi.org/10.1038/nrgastro.2013.149DOI Listing
November 2013

Health-related quality of life in children with autoimmune liver disease.

J Pediatr Gastroenterol Nutr 2013 Oct;57(4):444-50

*Division of Pediatric Gastroenterology and Nutrition †Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH ‡Division of Pediatric Gastroenterology and Nutrition, UC San Diego, Rady Children's Hospital, San Diego, CA.

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http://dx.doi.org/10.1097/MPG.0b013e31829ef82cDOI Listing
October 2013

Serum cytokeratin-18 fragment levels are useful biomarkers for nonalcoholic steatohepatitis in children.

Am J Gastroenterol 2013 Sep 11;108(9):1526-31. Epub 2013 Jun 11.

Department of Pediatric Gastroenterology, Hepatology and Nutrition, Rady Children's Hosptial, University of California San Diego (UCSD), San Diego, CA, USA.

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http://dx.doi.org/10.1038/ajg.2013.168DOI Listing
September 2013

Oxidized metabolites of linoleic acid as biomarkers of liver injury in nonalcoholic steatohepatitis.

Clin Lipidol 2013 Aug;8(4):411-418

Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.2217/clp.13.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578804PMC
August 2013

Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis.

PLoS One 2013 7;8(2):e56100. Epub 2013 Feb 7.

Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567081PMC
July 2013

Novel therapeutic targets for nonalcoholic fatty liver disease.

Expert Opin Ther Targets 2013 Jul 22;17(7):773-9. Epub 2013 Apr 22.

Rady Children's Hospital, Department of Pediatric Gastroenterology, University of California-San Diego, CA 92123, USA.

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http://dx.doi.org/10.1517/14728222.2013.789502DOI Listing
July 2013

Circulating levels of FGF-21 in obese youth: associations with liver fat content and markers of liver damage.

J Clin Endocrinol Metab 2013 Jul 26;98(7):2993-3000. Epub 2013 Apr 26.

Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1210/jc.2013-1250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701279PMC
July 2013

Lysosomal Cathepsin D contributes to cell death during adipocyte hypertrophy.

Adipocyte 2013 Jul 19;2(3):170-5. Epub 2013 Apr 19.

Department of Pediatrics; University of California, San Diego; San Diego, CA USA.

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http://dx.doi.org/10.4161/adip.24144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756106PMC
July 2013

Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans.

Prostaglandins Leukot Essent Fatty Acids 2012 Oct-Nov;87(4-5):135-41. Epub 2012 Sep 5.

Section on Nutritional Neurosciences, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.plefa.2012.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467319PMC
February 2013

Combined paediatric NAFLD fibrosis index and transient elastography to predict clinically significant fibrosis in children with fatty liver disease.

Liver Int 2013 Jan 12;33(1):79-85. Epub 2012 Nov 12.

Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1111/liv.12024DOI Listing
January 2013

Development and validation of a new histological score for pediatric non-alcoholic fatty liver disease.

J Hepatol 2012 Dec 4;57(6):1312-8. Epub 2012 Aug 4.

Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, United States.

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http://dx.doi.org/10.1016/j.jhep.2012.07.027DOI Listing
December 2012

Adipocyte hypertrophy is associated with lysosomal permeability both in vivo and in vitro: role in adipose tissue inflammation.

Am J Physiol Endocrinol Metab 2012 Sep 26;303(5):E597-606. Epub 2012 Jun 26.

Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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http://www.physiology.org/doi/10.1152/ajpendo.00022.2012
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http://dx.doi.org/10.1152/ajpendo.00022.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468510PMC
September 2012

Leptin levels predict survival in pulmonary arterial hypertension.

Pulm Circ 2012 Apr-Jun;2(2):214-9

Department of Pulmonary, Allergy and Critical Care Medicine, Respiratory Institute, Cleveland, Ohio, USA.

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http://dx.doi.org/10.4103/2045-8932.97607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401875PMC
August 2012

Lipidomic profiling of serum and pancreatic fluid in chronic pancreatitis.

Pancreas 2012 May;41(4):518-22

Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1097/MPA.0b013e31823ca306DOI Listing
May 2012