Arie O Verkerk

Arie O Verkerk

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Arie O Verkerk

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Cryopreservation of human pluripotent stem cell-derived cardiomyocytes is not detrimental to their molecular and functional properties.

Stem Cell Res 2020 Jan 7;43:101698. Epub 2020 Jan 7.

Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2019.101698DOI Listing
January 2020

'Mature' resting membrane potentials in human-induced pluripotent stem cell-derived cardiomyocytes: fact or artefact?

Europace 2019 Oct 3. Epub 2019 Oct 3.

Department of Medical Biology, Amsterdam UMC, Location Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/europace/euz243DOI Listing
October 2019

Differential effects on out-of-hospital cardiac arrest of dihydropyridines: real-world data from population-based cohorts across two European countries.

Eur Heart J Cardiovasc Pharmacother 2019 Aug 10. Epub 2019 Aug 10.

Department of Cardiology, Heart Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/ehjcvp/pvz038DOI Listing
August 2019

Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program.

Development 2019 04 25;146(8). Epub 2019 Apr 25.

Department of Medical Biology, University of Amsterdam, Amsterdam University Medical Centers, Amsterdam 1105 AZ, The Netherlands

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http://dx.doi.org/10.1242/dev.173161DOI Listing
April 2019

Aquaporin Channels in the Heart-Physiology and Pathophysiology.

Int J Mol Sci 2019 Apr 25;20(8). Epub 2019 Apr 25.

Department of Medical Biology, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.3390/ijms20082039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514906PMC
April 2019

Down the rabbit hole: deciphering the short QT syndrome.

Eur Heart J 2019 Mar;40(10):854-856

Department of Clinical and Experimental Cardiology, Heart Center, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/eurheartj/ehy906DOI Listing
March 2019

Disease Modifiers of Inherited Channelopathy.

Front Cardiovasc Med 2018 1;5:137. Epub 2018 Oct 1.

Department of Clinical and Experimental Cardiology, Heart Centre, Academic Medical Center, Amsterdam, Netherlands.

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https://www.frontiersin.org/article/10.3389/fcvm.2018.00137/
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http://dx.doi.org/10.3389/fcvm.2018.00137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174200PMC
October 2018

RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling.

Circulation 2018 09;138(13):1330-1342

Department of Experimental Cardiology (M.M.G.v.d.H., A.B., A.S.A., I.v.d.M., S.A., M.A.F.K., C.A.S., J.A.J., C.A.R., A.o.V., A.B., Y.M.P., E.E.C.), Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.031947DOI Listing
September 2018

Embryonic Tbx3 cardiomyocytes form the mature cardiac conduction system by progressive fate restriction.

Development 2018 09 3;145(17). Epub 2018 Sep 3.

Department of Medical Biology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands

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http://dx.doi.org/10.1242/dev.167361DOI Listing
September 2018

Long QT Syndrome and Sinus Bradycardia-A Mini Review.

Front Cardiovasc Med 2018 3;5:106. Epub 2018 Aug 3.

Department of Medical Biology, Amsterdam University Medical Centers, Amsterdam, Netherlands.

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https://www.frontiersin.org/article/10.3389/fcvm.2018.00106/
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http://dx.doi.org/10.3389/fcvm.2018.00106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085426PMC
August 2018

Enhanced late sodium current underlies pro-arrhythmic intracellular sodium and calcium dysregulation in murine sodium channelopathy.

Int J Cardiol 2018 07;263:54-62

Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, Meibergdreef 15, 1105AZ Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.03.044DOI Listing
July 2018

Pharmacodynamics and Pharmacokinetics of Lidocaine in a Rodent Model of Diabetic Neuropathy.

Anesthesiology 2018 03;128(3):609-619

From the Department of Anesthesiology and Laboratory of Experimental Anesthesiology and Intensive Care (LEICA) (W.t.H., M.W.H., J.H., S.P., P.L.); Department of Nuclear Medicine (K.d.B., H.J.V.), Cardiology (A.O.V., H.L.T.), Anatomy, Embryology and Physiology (A.O.V.), and Neurology (C.V.), Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands; Department of Anesthesiology and Intensive Care Medicine, Trauma Hospital, Graz, Austria (M.R.); Department of Anesthesiology, University of Heidelberg, Heidelberg, Germany (S.P.) and Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (P.L.).

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http://Insights.ovid.com/crossref?an=00000542-201803000-0002
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http://dx.doi.org/10.1097/ALN.0000000000002035DOI Listing
March 2018

K4.3 Expression Modulates Na1.5 Sodium Current.

Front Physiol 2018 12;9:178. Epub 2018 Mar 12.

Department of Experimental Cardiology, Academic Medical Center, Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fphys.2018.00178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857579PMC
March 2018

Revised roles of ISL1 in a hES cell-based model of human heart chamber specification.

Elife 2018 01 16;7. Epub 2018 Jan 16.

Human Stem Cell Pluripotency Laboratory, Max Planck Institute for Molecular Biomedicine, Münster, Germany.

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http://dx.doi.org/10.7554/eLife.31706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770158PMC
January 2018

A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes.

Stem Cell Reports 2017 12 22;9(6):1765-1779. Epub 2017 Nov 22.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands; Department of Applied Stem Cell Technologies, MIRA Institute, University of Twente, Twente, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22136711173047
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http://dx.doi.org/10.1016/j.stemcr.2017.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785710PMC
December 2017

The Brugada Syndrome Susceptibility Gene Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity.

Circ Res 2017 Aug 21;121(5):537-548. Epub 2017 Jun 21.

From the Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center, Amsterdam, The Netherlands (C.C.V., S.P., R.T., E.M.L., I.M., L.B., A.A.M.W., R.C., A.O.V., C.A.R., C.R.B.); Department of Medicine, Cardiovascular Genetics Center, Montreal Heart Institute, Canada (R.T.); Université de Montréal, Canada (R.T.); Department of Medical Biology, Academic Medical Center, Amsterdam, The Netherlands (B.d.J., R.W., B.J.B., A.O.V.); INSERM, CNRS, Université de Nantes, L'institut du Thorax, Nantes, France (J.B.); Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, Jeddah, Saudi Arabia (A.A.M.W.); and Electrophysiology and Heart Modeling Institute LIRYC, Université de Bordeaux, France (R.C.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.117.31095
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http://dx.doi.org/10.1161/CIRCRESAHA.117.310959DOI Listing
August 2017

Patch-Clamp Recording from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Improving Action Potential Characteristics through Dynamic Clamp.

Int J Mol Sci 2017 Aug 30;18(9). Epub 2017 Aug 30.

Department of Medical Biology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.3390/ijms18091873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618522PMC
August 2017

Cardiac Subtype-Specific Modeling of K1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells.

Front Physiol 2017 6;8:469. Epub 2017 Jul 6.

Human Stem Cell Pluripotency Laboratory, Max Planck Institute for Molecular BiomedicineMünster, Germany.

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http://dx.doi.org/10.3389/fphys.2017.00469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498524PMC
July 2017

Gain-of-function mutation in SCN5A causes ventricular arrhythmias and early onset atrial fibrillation.

Int J Cardiol 2017 Jun 29;236:187-193. Epub 2017 Jan 29.

Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2017.01.113DOI Listing
June 2017

Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes.

Cardiovasc Res 2017 Jun;113(7):829-838

Department of Clinical and Experimental Cardiology/Heart Centre, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22660, 1100 DD Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvx077DOI Listing
June 2017

Human iPSC-Derived Cardiomyocytes for Investigation of Disease Mechanisms and Therapeutic Strategies in Inherited Arrhythmia Syndromes: Strengths and Limitations.

Cardiovasc Drugs Ther 2017 Jun;31(3):325-344

Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center, University of Amsterdam, Room K2-104-2, Meibergdreef 15, PO Box 22700, 1100 DE, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10557-017-6735-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550530PMC
June 2017

Pacing Discovery: G-Protein β Subunit Mutations in Sinus Node Dysfunction.

Circ Res 2017 05;120(10):1524-1526

From the Heart Center, Department of Clinical and Experimental Cardiology (E.M.L., A.O.V., C.R.B.) and Department of Medical Biology (A.O.V.), Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1161/CIRCRESAHA.117.310953DOI Listing
May 2017

Readthrough-Promoting Drugs Gentamicin and PTC124 Fail to Rescue Nav1.5 Function of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Carrying Nonsense Mutations in the Sodium Channel Gene SCN5A.

Circ Arrhythm Electrophysiol 2016 11;9(11)

From the Department of Anatomy and Embryology, Leiden University Medical Center, Leiden (G.K., S.C., S.v.d.P., M.B., C.L.M.); and Heart Center, Department of Experimental and Clinical Cardiology (C.C.V., A.A.M.W., C.R.B.) and Department of Anatomy and Embryology, Academic Medical Center (A.O.V.), Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCEP.116.004227DOI Listing
November 2016

hiPSC-derived cardiomyocytes from Brugada Syndrome patients without identified mutations do not exhibit clear cellular electrophysiological abnormalities.

Sci Rep 2016 08 3;6:30967. Epub 2016 Aug 3.

Heart Centre, Department of Experimental and Clinical Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/srep30967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971529PMC
August 2016

Chemokine ligand 9 modulates cardiac repolarization via Cxcr3 receptor binding.

Int J Cardiol 2015 Dec 31;201:49-52. Epub 2015 Jul 31.

Department of Anatomy, Embryology and Physiology, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2015.07.096DOI Listing
December 2015

Dyscholesterolemia Protects Against Ischemia-Induced Ventricular Arrhythmias.

Circ Arrhythm Electrophysiol 2015 Dec 1;8(6):1481-90. Epub 2015 Oct 1.

Departments of Clinical and Experimental Cardiology (A.B., C.A.S., V.W., M.W.V., R.J.v.O., I.E., R.C.), Anatomy Embryology and Physiology (A.O.V.), and Medical Biochemistry (R.O., C.v.R., H.A.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; and IHU Institut de Rythmologie et Modélisation Cardiaque, Fondation Bordeaux Université, Bordeaux, France (R.C.).

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http://dx.doi.org/10.1161/CIRCEP.115.002751DOI Listing
December 2015

Immaturity of human stem-cell-derived cardiomyocytes in culture: fatal flaw or soluble problem?

Stem Cells Dev 2015 May 25;24(9):1035-52. Epub 2015 Feb 25.

1 Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam , Amsterdam, the Netherlands .

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http://dx.doi.org/10.1089/scd.2014.0533DOI Listing
May 2015

Reply to Christ et al.: LQT1 and JLNS phenotypes in hiPSC-derived cardiomyocytes are due to KCNQ1 mutations.

Proc Natl Acad Sci U S A 2015 Apr 20;112(16):E1969. Epub 2015 Mar 20.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands

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http://dx.doi.org/10.1073/pnas.1503762112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413298PMC
April 2015

Dynamic clamp as a tool to study the functional effects of individual membrane currents.

Methods Mol Biol 2014 ;1183:309-26

Health Innovations Research Institute, RMIT University, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/978-1-4939-1096-0_20DOI Listing
February 2015

Ion channelopathies in human induced pluripotent stem cell derived cardiomyocytes: a dynamic clamp study with virtual IK1.

Front Physiol 2015 3;6. Epub 2015 Feb 3.

Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fphys.2015.00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315032PMC
February 2015

Ca(2+) cycling properties are conserved despite bradycardic effects of heart failure in sinoatrial node cells.

Front Physiol 2015 2;6:18. Epub 2015 Feb 2.

Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fphys.2015.00018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313601PMC
February 2015

Pacemaker activity of the human sinoatrial node: an update on the effects of mutations in HCN4 on the hyperpolarization-activated current.

Int J Mol Sci 2015 Jan 29;16(2):3071-94. Epub 2015 Jan 29.

Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

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http://www.mdpi.com/1422-0067/16/2/3071
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http://dx.doi.org/10.3390/ijms16023071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346881PMC
January 2015

PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function.

Circulation 2014 Jul 3;130(2):147-60. Epub 2014 Jun 3.

From the Department of Clinical Research, University of Bern, Bern, Switzerland (D.S., L.G., J.O., M.A., J.-S.R., M.C.E., N.S., H.A.); Department of Anatomy, Embryology and Physiology (A.O.V.) and Department of Clinical and Experimental Cardiology (R.W., J.B., R.F.M., C.R.B., C.A.R.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; ICIN-Netherlands Heart Institute, Utrecht, The Netherlands (J.B.); Center for Human and Clinical Genetics, Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands (A.M.v.M.); Institute of Pathology, University of Lausanne, Lausanne, Switzerland (S.R.); Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche 1087, L'Institut du Thorax, Nantes, France (R.R.); Centre National de la Recherche Scientifique Unité Mixte de Recherche 6291, Nantes, France (R.R.); Université de Nantes, Nantes, France (R.R.); and Centre Hospitalier Universitaire Nantes, L'Institut du Thorax, Service de Cardiologie, Nantes, France (R.R.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.007852DOI Listing
July 2014

Hyperpolarization-activated current, If, in mathematical models of rabbit sinoatrial node pacemaker cells.

Biomed Res Int 2013 8;2013:872454. Epub 2013 Jul 8.

Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1155/2013/872454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722861PMC
March 2014

Pacemaker activity of the human sinoatrial node: effects of HCN4 mutations on the hyperpolarization-activated current.

Europace 2014 Mar;16(3):384-95

Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands.

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http://europace.oxfordjournals.org/content/europace/16/3/384
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http://europace.oxfordjournals.org/cgi/doi/10.1093/europace/
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http://dx.doi.org/10.1093/europace/eut348DOI Listing
March 2014

Electrophysiological changes in heart failure and their implications for arrhythmogenesis.

Biochim Biophys Acta 2013 Dec 8;1832(12):2432-41. Epub 2013 Apr 8.

Department of Experimental Cardiology, Heart Center, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2013.04.002DOI Listing
December 2013

Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome.

Circ Arrhythm Electrophysiol 2013 Oct 31;6(5):1002-9. Epub 2013 Aug 31.

Heart Center, and Departments of Anatomy, Embryology, and Physiology, Cardiology, Hospital Pharmacy, Academic Medical Center, University of Amsterdam, the Netherlands; and Department of Hospital Pharmacy, Reinier de Graaf Group Hospitals, Delft, the Netherlands.

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http://dx.doi.org/10.1161/CIRCEP.113.000239DOI Listing
October 2013

Calcium transient and sodium-calcium exchange current in human versus rabbit sinoatrial node pacemaker cells.

ScientificWorldJournal 2013 24;2013:507872. Epub 2013 Feb 24.

Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1155/2013/507872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621208PMC
September 2013

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.

Nat Genet 2013 Sep 21;45(9):1044-9. Epub 2013 Jul 21.

Department of Clinical and Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/ng.2712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869788PMC
September 2013

Intracardiac origin of heart rate variability, pacemaker funny current and their possible association with critical illness.

Curr Cardiol Rev 2013 Feb;9(1):82-96

Democritus University of Thrace, Alexandroupolis University Hospital, Intensive Care Unit, Alexandroupolis Medical School, Dragana 68100, Greece.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584310PMC
http://dx.doi.org/10.2174/157340313805076359DOI Listing
February 2013

Sodium current inhibition by nanosecond pulsed electric field (nsPEF)--fact or artifact?

Bioelectromagnetics 2013 Feb 7;34(2):162-4. Epub 2012 Sep 7.

Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/bem.21754DOI Listing
February 2013

Early repolarization in mice causes overestimation of ventricular activation time by the QRS duration.

Cardiovasc Res 2013 Jan 20;97(1):182-91. Epub 2012 Sep 20.

Department of Anatomy, Embryology, and Physiology, Academic Medical Center Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1093/cvr/cvs299DOI Listing
January 2013

Dietary Omega-3 Polyunsaturated Fatty Acids Suppress NHE-1 Upregulation in a Rabbit Model of Volume- and Pressure-Overload.

Front Physiol 2012 2;3:76. Epub 2012 Apr 2.

Heart Failure Research Center, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fphys.2012.00076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317268PMC
October 2012

Effects of acetylcholine and noradrenalin on action potentials of isolated rabbit sinoatrial and atrial myocytes.

Front Physiol 2012 31;3:174. Epub 2012 May 31.

Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.

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http://journal.frontiersin.org/article/10.3389/fphys.2012.00
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http://dx.doi.org/10.3389/fphys.2012.00174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385584PMC
October 2012

Zebrafish: a novel research tool for cardiac (patho)electrophysiology and ion channel disorders.

Front Physiol 2012 10;3:255. Epub 2012 Jul 10.

Department of Anatomy, Embryology, and Physiology, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fphys.2012.00255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429032PMC
October 2012

Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias.

Front Physiol 2012 31;3:346. Epub 2012 Aug 31.

Department of Clinical and Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fphys.2012.00346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449331PMC
October 2012

Functional Nav1.8 channels in intracardiac neurons: the link between SCN10A and cardiac electrophysiology.

Circ Res 2012 Jul 20;111(3):333-43. Epub 2012 Jun 20.

Department of Anatomy, Embryology, and Physiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCRESAHA.112.274035DOI Listing
July 2012

T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.

Cardiovasc Res 2012 Jun 14;94(3):439-49. Epub 2012 Mar 14.

Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Room L2-108, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvs120DOI Listing
June 2012

A diet rich in unsaturated fatty acids prevents progression toward heart failure in a rabbit model of pressure and volume overload.

Circ Heart Fail 2012 May 2;5(3):376-84. Epub 2012 Apr 2.

Experimental Cardiology Group of the Heart Center, Institute for Health Care Research, VU University Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.111.963116DOI Listing
May 2012

The chemical compound PTC124 does not affect cellular electrophysiology of cardiac ventricular myocytes.

Cardiovasc Drugs Ther 2012 Feb;26(1):41-5

Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands.

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http://link.springer.com/10.1007/s10557-011-6352-2
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http://dx.doi.org/10.1007/s10557-011-6352-2DOI Listing
February 2012

Activated human platelet products induce proarrhythmic effects in ventricular myocytes.

J Mol Cell Cardiol 2011 Sep 30;51(3):347-56. Epub 2011 May 30.

Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.yjmcc.2011.05.016DOI Listing
September 2011

Reconstituted high-density lipoprotein shortens cardiac repolarization.

J Am Coll Cardiol 2011 Jun;58(1):40-4

Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2010.11.072DOI Listing
June 2011

Incorporated fish oil fatty acids prevent action potential shortening induced by circulating fish oil fatty acids.

Front Physiol 2010 22;1:149. Epub 2010 Nov 22.

Department of Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fphys.2010.00149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059945PMC
May 2011

Etiology-dependency of ionic remodeling in cardiomyopathic rabbits.

Int J Cardiol 2011 Apr 17;148(2):154-60. Epub 2009 Nov 17.

Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ijcard.2009.10.047DOI Listing
April 2011

Sex-deparities in cardiac electrophysiology: L-type Ca2+ current and the Na+-Ca2+ exchanger go hand in hand.

J Physiol 2011 Mar;589(Pt 6):1247-8

Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1113/jphysiol.2011.206425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082086PMC
March 2011

Re-evaluation of the action potential upstroke velocity as a measure of the Na+ current in cardiac myocytes at physiological conditions.

PLoS One 2010 Dec 31;5(12):e15772. Epub 2010 Dec 31.

Department of Anatomy, Embryology, and Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015772PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013114PMC
December 2010

Role of the R1135H KCNH2 mutation in Brugada syndrome.

Int J Cardiol 2010 Sep 27;144(1):149-51. Epub 2009 Jan 27.

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http://dx.doi.org/10.1016/j.ijcard.2008.12.177DOI Listing
September 2010

Relative importance of funny current in human versus rabbit sinoatrial node.

J Mol Cell Cardiol 2010 Apr 11;48(4):799-801; author reply 802-3. Epub 2010 Jan 11.

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http://linkinghub.elsevier.com/retrieve/pii/S002228280900548
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http://dx.doi.org/10.1016/j.yjmcc.2009.09.020DOI Listing
April 2010

Dietary fish oil reduces pacemaker current and heart rate in rabbit.

Heart Rhythm 2009 Oct 16;6(10):1485-92. Epub 2009 Jul 16.

Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.hrthm.2009.07.024DOI Listing
October 2009

Dynamic action potential clamp as a powerful tool in the development of a gene-based bio-pacemaker.

Conf Proc IEEE Eng Med Biol Soc 2008 ;2008:133-6

Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1109/IEMBS.2008.4649108DOI Listing
May 2009

Pacemaker activity of the human sinoatrial node: role of the hyperpolarization-activated current, I(f).

Int J Cardiol 2009 Mar 31;132(3):318-36. Epub 2009 Jan 31.

Department of Physiology, Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S016752730801541
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http://dx.doi.org/10.1016/j.ijcard.2008.12.196DOI Listing
March 2009

Is sodium current present in human sinoatrial node cells?

Int J Biol Sci 2009 13;5(2):201-4. Epub 2009 Feb 13.

Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646265PMC
http://dx.doi.org/10.7150/ijbs.5.201DOI Listing
March 2009

Intracellular calcium modulation of voltage-gated sodium channels in ventricular myocytes.

Cardiovasc Res 2009 Jan 1;81(1):72-81. Epub 2008 Oct 1.

Department of Clinical and Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, AZ 1105 Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvn274DOI Listing
January 2009

Engineering physiologically controlled pacemaker cells with lentiviral HCN4 gene transfer.

J Gene Med 2008 May;10(5):487-97

Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/jgm.1172DOI Listing
May 2008

Computational model of rabbit SA node pacemaker activity probed with action potential and calcium transient clamp.

Conf Proc IEEE Eng Med Biol Soc 2007 ;2007:156-9

Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1109/IEMBS.2007.4352246DOI Listing
March 2008

Single cells isolated from human sinoatrial node: action potentials and numerical reconstruction of pacemaker current.

Conf Proc IEEE Eng Med Biol Soc 2007 ;2007:904-7

Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.1109/IEMBS.2007.4352437DOI Listing
March 2008

Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure.

Circulation 2008 Jan 14;117(4):536-44. Epub 2008 Jan 14.

Department of Experimental Cardiology, Center for Heart Failure Research, Academic Medical Center, Room K2-113, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.107.733329DOI Listing
January 2008

Dietary fish oil reduces the incidence of triggered arrhythmias in pig ventricular myocytes.

Heart Rhythm 2007 Nov 17;4(11):1452-60. Epub 2007 Jul 17.

Experimental Cardiology Group (ECG), Center for Heart Failure Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.hrthm.2007.07.015DOI Listing
November 2007

Pacemaker current (I(f)) in the human sinoatrial node.

Eur Heart J 2007 Oct 6;28(20):2472-8. Epub 2007 Sep 6.

Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/eurheartj/ehm339DOI Listing
October 2007

Effects of heart failure on brain-type Na+ channels in rabbit ventricular myocytes.

Europace 2007 Aug 19;9(8):571-7. Epub 2007 Jun 19.

Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/europace/eum121DOI Listing
August 2007

Dietary fish oil reduces the occurrence of early afterdepolarizations in pig ventricular myocytes.

J Mol Cell Cardiol 2006 Nov 11;41(5):914-7. Epub 2006 Sep 11.

Department of Clinical and Experimental Cardiology, Experimental and Molecular Cardiology Groups, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.yjmcc.2006.08.001DOI Listing
November 2006