Publications


Tracking digital ulcers in systemic sclerosis: a feasibility study assessing lesion area in patient-recorded smartphone photographs.
Ann Rheum Dis 2018 Feb 3. Epub 2018 Feb 3.
Division of Musculoskeletal and Dermatological Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

The assessment of nailfold capillaries: comparison of dermoscopy and nailfold videocapillaroscopy.
Rheumatology (Oxford) 2018 Feb 13. Epub 2018 Feb 13.
Division of Musculoskeletal & Dermatological Sciences, University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester.




Evidence-based management of Raynaud's phenomenon.
Ther Adv Musculoskelet Dis 2017 Dec 20;9(12):317-329. Epub 2017 Nov 20.
Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester UK, M13 9PT and NIHR Manchester Biomedical Research Centre, Central Manchester NHS Foundation Trust, Manchester, UK.

An international SUrvey on non-iNvaSive tecHniques to assess the mIcrocirculation in patients with RayNaud's phEnomenon (SUNSHINE survey).
Rheumatol Int 2017 Nov 11;37(11):1879-1890. Epub 2017 Sep 11.
Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.


Quantitative outcome measures for systemic sclerosis-related Microangiopathy - Reliability of image acquisition in Nailfold Capillaroscopy.
Microvasc Res 2017 Sep 8;113:56-59. Epub 2017 May 8.
Division of Musculoskeletal & Dermatological Sciences, University of Manchester, Salford Royal Hospital NHS Foundation Trust, Salford Royal Hospital, Stott Lane, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

Pilot study assessing pathophysiology and healing of digital ulcers in patients with systemic sclerosis using laser Doppler imaging and thermography.
Clin Exp Rheumatol 2016 Sep-Oct;34 Suppl 100(5):100-105. Epub 2016 Oct 14.
Inst.of Inflammation and Repair, University of Manchester, Salford Royal NHS Foundation Trust, Salford; and NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, UK.


A pilot study using high-frequency ultrasound to measure digital ulcers: a possible outcome measure in systemic sclerosis clinical trials?
Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 106(4):218-219. Epub 2017 Jun 7.
Centre for Musculoskeletal Research, The University of Manchester, Manchester Academic Health Science Centre; and Photon Science Institute, The University of Manchester, UK.

Quartz Crystal Microbalance Assay of Clinical Calcinosis Samples and Their Synthetic Models Differentiates the Efficacy of Chelation-Based Treatments.
ACS Appl Mater Interfaces 2017 Aug 15;9(33):27544-27552. Epub 2017 Aug 15.
Manchester Institute of Biotechnology, University of Manchester , 131 Princess Street, Manchester, M1 7DN, U.K.



Recent advances in the pathogenesis and management of Raynaud's phenomenon and digital ulcers.
Curr Opin Rheumatol 2016 Nov;28(6):577-85
aCentre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester bNIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, UK.

Non-invasive Imaging of Localised Scleroderma for Assessment of Skin Blood Flow and Structure.
Acta Derm Venereol 2016 Jun;96(5):641-4
Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, M6 8HD Salford, United Kingdom.


Consensus best practice pathway of the UK Scleroderma Study Group: digital vasculopathy in systemic sclerosis.
Rheumatology (Oxford) 2015 Nov 26;54(11):2015-24. Epub 2015 Jun 26.
Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, University of Manchester, Manchester Academic Health Science Centre, Manchester.

Long-term outcome of patients with systemic sclerosis requiring home parenteral nutrition.
Clin Nutr 2015 Oct 8;34(5):991-6. Epub 2014 Nov 8.
Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Salford Royal NHS Foundation Trust, Salford, United Kingdom; Intestinal Failure Unit, Salford Royal NHS Foundation Trust, Salford, United Kingdom.

A study comparing videocapillaroscopy and dermoscopy in the assessment of nailfold capillaries in patients with systemic sclerosis-spectrum disorders.
Rheumatology (Oxford) 2015 Aug 6;54(8):1435-42. Epub 2015 Mar 6.
Centre for Musculoskeletal Research, The University of Manchester, Manchester Academic Health Science Centre and.

Whole finger iontophoresis of sodium nitroprusside to increase blood flow in patients with systemic sclerosis: Influence of concentration.
Int J Pharm 2015 Jul 22;490(1-2):446-9. Epub 2015 May 22.
Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

Leri's pleonosteosis, a congenital rheumatic disease, results from microduplication at 8q22.1 encompassing GDF6 and SDC2 and provides insight into systemic sclerosis pathogenesis.
Ann Rheum Dis 2015 Jun 17;74(6):1249-56. Epub 2014 Jan 17.
Faculty of Medical and Human Sciences, Manchester Centre for Genomic Medicine, Institute of Human Development, University of Manchester, Manchester Academic Health Science Centre (MAHSC), Manchester, UK Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, MAHSC, Manchester, UK.

Cardiac troponin testing in idiopathic inflammatory myopathies and systemic sclerosis-spectrum disorders: biomarkers to distinguish between primary cardiac involvement and low-grade skeletal muscle disease activity.
Ann Rheum Dis 2015 May 2;74(5):795-8. Epub 2015 Mar 2.
Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

Sparing effect of hemiplegia on skin fibrosis and microvascular involvement: reports of two cases of systemic sclerosis and review of the literature.
Semin Arthritis Rheum 2015 Apr 29;44(5):597-601. Epub 2014 Oct 29.
Division of Rheumatology, Department of Clinical Sciences and Community Health, Gaetano Pini Orthopedic Institute, University of Milano, Piazza Cardinal Ferrari 1, Milano 20122, Italy.

Abnormalities of selenium but not of copper homeostasis may drive tissue fibrosis in patients with systemic sclerosis.
Rheumatology (Oxford) 2015 Apr 18;54(4):747-8. Epub 2015 Jan 18.
Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, Research and Development, Rheumatology Directorate and Department of Clinical Biochemistry, Salford Royal NHS Foundation Trust, Salford, UK.


A longitudinal study of ankle brachial pressure indices in a cohort of patients with systemic sclerosis.
Rheumatology (Oxford) 2014 Nov 6;53(11):2009-13. Epub 2014 Jun 6.
Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, Manchester, Centre for Biostatistics, Institute of Population Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, Rheumatology Directorate, Salford Royal NHS Foundation Trust, Salford, UK and Institute of Public Health Epidemiology and Development, University of Bordeaux Segalen, Bordeaux, France.

A comparison of intense pulsed light and laser treatment of telangiectases in patients with systemic sclerosis: a within-subject randomized trial.
Rheumatology (Oxford) 2014 Aug 13;53(8):1422-30. Epub 2014 Mar 13.
Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, Photon Science Institute, University of Manchester, Manchester, Department of Clinical Dermatology, Salford Royal NHS Foundation Trust, Research and Development, Salford Royal NHS Foundation Trust, Salford, UK, Department of Clinical Health Psychology, Mercy University Hospital, Grenville Place, Cork, Ireland and Centre for Dermatology Research, Institute of Inflammation and Repair, Salford Royal NHS Foundation Trust, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.


A multicentre study on the reliability of qualitative and quantitative nail-fold videocapillaroscopy assessment.
Rheumatology (Oxford) 2012 Apr 20;51(4):749-55. Epub 2011 Dec 20.
Department of Internal Medicine, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

Expression of advanced glycation end products and their receptor in skin from patients with systemic sclerosis with and without calcinosis.
Rheumatology (Oxford) 2009 Aug 19;48(8):876-82. Epub 2009 Jun 19.
Tissue Injury and Repair Research Group, Research School of Clinical and Laboratory Sciences, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.




Thermographic Abnormalities are Associated with Future Digital Ulcers and Death in Patients with Systemic Sclerosis.
J Rheumatol 2016 08 15;43(8):1519-22. Epub 2016 Jun 15.
From the Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre; Photon Science Institute, University of Manchester; UK National Institute for Health Research (NIHR) Manchester Musculoskeletal Biomedical Research Unit, Central Manchester National Health Service (NHS) Foundation Trust, Manchester Academic Health Science Centre, Manchester; Research and Development, and Department of Rheumatology, Salford Royal NHS Foundation Trust, Salford, UK.M. Hughes, MSc, MRCP, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre; J. Wilkinson, MSc, Research and Development, Salford Royal NHS Foundation Trust; T. Moore, BSc, Department of Rheumatology, Salford Royal NHS Foundation Trust; J. Manning, BSc, Department of Rheumatology, Salford Royal NHS Foundation Trust; P. New, MPharm, Department of Rheumatology, Salford Royal NHS Foundation Trust; G. Dinsdale, PhD, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre; A. Murray, PhD, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, and Photon Science Institute, University of Manchester; A.L. Herrick, MD, FRCP, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, and NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre.

Differential diagnosis of critical digital ischemia in systemic sclerosis: Report of five cases and review of the literature.
Semin Arthritis Rheum 2016 10 12;46(2):209-16. Epub 2016 May 12.
Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Stott Lane, Manchester, M6 8HD, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, 29 Grafton Street, Manchester, M13 9WU, UK.

Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: A Scleroderma Clinical Trials Consortium study.
Semin Arthritis Rheum 2016 12 2;46(3):344-349. Epub 2016 Jun 2.
Department of Immunology and Rheumatology, Stanford University School of Medicine, 1000 Welch Road, Suite 203 MC 5755, Palo Alto, CA 94304. Electronic address:

Raynaud's phenomenon.
Best Pract Res Clin Rheumatol 2016 02 11;30(1):112-32. Epub 2016 May 11.
Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

Intra-and inter-observer reliability of nailfold videocapillaroscopy - A possible outcome measure for systemic sclerosis-related microangiopathy.
Microvasc Res 2017 07 2;112:1-6. Epub 2017 Feb 2.
Division of Musculoskeletal & Dermatological Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

Efficacy and Safety of Selexipag in Adults With Raynaud's Phenomenon Secondary to Systemic Sclerosis: A Randomized, Placebo-Controlled, Phase II Study.
Arthritis Rheumatol 2017 12;69(12):2370-2379
The University of Manchester, Salford Royal NHS Foundation Trust and NIHR Manchester Musculoskeletal Biomedical Research Centre, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

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