Publications by authors named "Ari Satia Nugraha"

4 Publications

  • Page 1 of 1

Anti-cancer Evaluation of Depsides Isolated from Indonesian Folious Lichens: , and .

Biomolecules 2020 10 8;10(10). Epub 2020 Oct 8.

School of Chemistry & Molecular Bioscience and Molecular Horizons, University of Wollongong, and Illawarra Health & Medical Research Institute, Wollongong, NSW 2522, Australia.

Cancer is a serious health burden on global societies. The discovery and development of new anti-cancer therapies remains a challenging objective. Although it has been shown that lichen secondary metabolites may be potent sources for new anti-cancer agents, the Indonesian- grown folious lichens, and have not yet been explored. In this study exhaustive preparative high-performance liquid chromatography was employed to isolate the lichen constituents with spectroscopic and spectrometric protocols identifying nine depsides -, including the new methyl 4-formyl-2,3-dihydroxy-6-methylbenzoate . The cytotoxicity of the depsides towards cancer cells was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results indicated lowest toxicity of the depsides towards human A549 lung cancer cells. Importantly, the di-depsides (, and ) showed greatest toxicity, indicating that these structures are biologically more active than the mono-depsides against the HepG2 liver cancer, A549 lung cancer and HL-60 leukemia cell lines.
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http://dx.doi.org/10.3390/biom10101420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600581PMC
October 2020

Anthelmintic and antimicrobial activities of three new depsides and ten known depsides and phenols from Indonesian lichen: Ach.

Nat Prod Res 2021 Dec 6;35(23):5001-5010. Epub 2020 May 6.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle/Saale, Germany.

An extensive phytochemical study of a foliose lichen from Indonesia, , resulted in the successful isolation of 13 phenol and depside derivatives (-) including the previously unreported depsides 3'-hydroxyl-5'-pentylphenyl 2,4-dihydroxyl-6-methylbenzoate (), 3'-hydroxyl-5'-propylphenyl 2,4-dihydroxyl-6-methylbenzoate () and 3'-hydroxyl-5'-methylphenyl 2-hydroxyl-4-methoxyl-6-propylbenzoate (). The anti-infective activity of isolated compounds was evaluated against the gram-negative bacterium and the nematode . 2,4-Dihydroxyl-6-pentylbenzoate () and lecanoric acid () induced growth inhibition of with inhibition values of 49% and 100% at a concentration of 100 µM, respectively. The antibacterial activity might be due to their free carboxyl group. A phenolic group at C4 also contributed to the antimicrobial activity of the depsides as shown for compounds and , which caused 89% and 96% growth inhibition at 100 µM, respectively. Lecanoric acid () in addition possesses significant anthelmintic effects causing 80% mortality of at 100 µg/mL.
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http://dx.doi.org/10.1080/14786419.2020.1761361DOI Listing
December 2021

Vascular Epiphytic Medicinal Plants as Sources of Therapeutic Agents: Their Ethnopharmacological Uses, Chemical Composition, and Biological Activities.

Biomolecules 2020 01 24;10(2). Epub 2020 Jan 24.

School of Chemistry and Molecular Bioscience and Molecular Horizons, University of Wollongong, and Illawarra Health & Medical Research Institute, Wollongong, NSW 2522, Australia.

This is an extensive review on epiphytic plants that have been used traditionally as medicines. It provides information on 185 epiphytes and their traditional medicinal uses, regions where Indigenous people use the plants, parts of the plants used as medicines and their preparation, and their reported phytochemical properties and pharmacological properties aligned with their traditional uses. These epiphytic medicinal plants are able to produce a range of secondary metabolites, including alkaloids, and a total of 842 phytochemicals have been identified to date. As many as 71 epiphytic medicinal plants were studied for their biological activities, showing promising pharmacological activities, including as anti-inflammatory, antimicrobial, and anticancer agents. There are several species that were not investigated for their activities and are worthy of exploration. These epipythes have the potential to furnish drug lead compounds, especially for treating cancers, and thus warrant indepth investigations.
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http://dx.doi.org/10.3390/biom10020181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072150PMC
January 2020

Anti-Infective and Anti-Cancer Properties of the Species: Their Ethnomedicinal Uses, Alkaloid Diversity, and Pharmacological Activities.

Molecules 2019 Dec 3;24(23). Epub 2019 Dec 3.

School of Chemistry & Molecular Bioscience and Molecular Horizons, University of Wollongong, and Illawarra Health & Medical Research Institute, Wollongong, NSW 2533, Australia.

species have been a valuable source of anti-infective and anticancer agents. However, only limited evaluations of their alkaloids have been carried out. This review collates and evaluates the biological data from extracts and purified isolates for their anti-infective and anti-cancer activities. An isoquinoline backbone is a major structural alkaloid moiety of the genus, and more than 83 alkaloids have been isolated from this genus alone. Crude extracts of genus are reported with moderate activities against showing larvicidal activities. However, no pure compounds from the genus were tested against the parasite. The methanol extract of showed apparent antimicrobial activities. The isolated alkaloids from this genus including liriodenine, anonaine, asimilobine showed sensitivity against Other alkaloids such as (+)-Xylopine and isocoreximine indicated significant anti-cancer activity against A549 and K-562 cell lines, respectively. This review revealed that the alkaloids from genus are rich in structural diversity and pharmacological activities. Further exploration of this genus and their alkaloids has potential for developing novel anti-infective and anticancer drugs.
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http://dx.doi.org/10.3390/molecules24234419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930583PMC
December 2019
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