Ari M Melnick

Ari M Melnick

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Ari M Melnick

Ari M Melnick

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The therapeutic landscape for cells engineered with chimeric antigen receptors.

Authors:
Matthew MacKay Ebrahim Afshinnekoo Jonathan Rub Ciaran Hassan Mihir Khunte Nithyashri Baskaran Bryan Owens Lauren Liu Gail J Roboz Monica L Guzman Ari M Melnick Shixiu Wu Christopher E Mason

Nat Biotechnol 2020 Jan 6. Epub 2020 Jan 6.

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.

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http://dx.doi.org/10.1038/s41587-019-0329-2DOI Listing
January 2020

Selective inhibition of HDAC3 targets synthetic vulnerabilities and activates immune surveillance in lymphoma.

Authors:
Patrizia Mondello Saber Tadros Matt Teater Lorena Fontan Aaron Y Chang Neeraj Jain Haopeng Yang Shailbala Singh Hsia-Yuan Ying Chi-Shuen Chu Man Chun John Ma Eneda Toska Stefan Alig Matthew Durant Elisa de Stanchina Sreejoyee Ghosh Anja Mottok Loretta Nastoupil Sattva S Neelapu Oliver Weigert Giorgio Inghirami Jose Baselga Anas Younes Cassian Yee Ahmet Dogan David A Scheinberg Robert G Roeder Ari M Melnick Michael R Green

Cancer Discov 2020 Jan 8. Epub 2020 Jan 8.

Lymphoma/Myeloma, University of Texas MD Anderson Cancer Center

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http://dx.doi.org/10.1158/2159-8290.CD-19-0116DOI Listing
January 2020

Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization.

Authors:
Ana P Gomes Didem Ilter Vivien Low Adam Rosenzweig Zih-Jie Shen Tanya Schild Martin A Rivas Ekrem E Er Dylan R McNally Anders P Mutvei Julie Han Yi-Hung Ou Paola Cavaliere Edouard Mullarky Michal Nagiec Sejeong Shin Sang-Oh Yoon Noah Dephoure Joan Massagué Ari M Melnick Lewis C Cantley Jessica K Tyler John Blenis

Cancer Cell 2019 Oct 26;36(4):402-417.e13. Epub 2019 Sep 26.

Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA; Department of Pharmacology, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801101PMC
October 2019

An "EZ" Epigenetic Road to Leukemia Stem Cell Metabolic Reprogramming?

Authors:
Meng Li Ari M Melnick

Cancer Discov 2019 Sep;9(9):1158-1160

Department of Medicine, Division of Hematology & Medical Oncology, Weill Cornell Medicine, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-19-0737DOI Listing
September 2019

Role of chromosomal architecture in germinal center B cells and lymphomagenesis.

Authors:
Martin A Rivas Ari M Melnick

Curr Opin Hematol 2019 Jul;26(4):294-302

Division of Hematology and Medical Oncology, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Sandra and Edward Meyer Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000505DOI Listing
July 2019

Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML.

Authors:
Cihangir Duy Matt Teater Francine E Garrett-Bakelman Tak C Lee Cem Meydan Jacob L Glass Meng Li Johannes C Hellmuth Helai P Mohammad Kimberly N Smitheman Alan H Shih Omar Abdel-Wahab Martin S Tallman Monica L Guzman David Muench H Leighton Grimes Gail J Roboz Ryan G Kruger Caretha L Creasy Elisabeth M Paietta Ross L Levine Martin Carroll Ari M Melnick

Cancer Discov 2019 Jul 10;9(7):872-889. Epub 2019 May 10.

Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, New York.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-19-0106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606333PMC
July 2019

MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition.

Authors:
Xiangdong Lu Chi-Shuen Chu Terry Fang Violeta Rayon-Estrada Fang Fang Alina Patke Ye Qian Stephen H Clarke Ari M Melnick Yi Zhang F Nina Papavasiliou Robert G Roeder

Cell Rep 2019 Jul;28(2):472-485.e5

The Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.06.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690613PMC
July 2019

BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection.

Authors:
Bibo Zhu Ruixuan Zhang Chaofan Li Li Jiang Min Xiang Zhenqing Ye Hirohito Kita Ari M Melnick Alexander L Dent Jie Sun

Proc Natl Acad Sci U S A 2019 Jun 28;116(24):11888-11893. Epub 2019 May 28.

Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN 55905;

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http://dx.doi.org/10.1073/pnas.1902310116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6575592PMC
June 2019

Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis.

Authors:
Meng Li Ying-Ling Chiang Costas A Lyssiotis Matthew R Teater Jun Young Hong Hao Shen Ling Wang Jing Hu Hui Jing Zhengming Chen Neeraj Jain Cihangir Duy Sucharita J Mistry Leandro Cerchietti Justin R Cross Lewis C Cantley Michael R Green Hening Lin Ari M Melnick

Cancer Cell 2019 Jun;35(6):916-931.e9

Department of Medicine, Division of Hematology & Medical Oncology, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.05.002DOI Listing
June 2019

BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress.

Authors:
Tharu M Fernando Rossella Marullo Benet Pera Gresely Jude M Phillip Shao Ning Yang Geoffrey Lundell-Smith Ingrid Torregroza Haelee Ahn Todd Evans Balázs Győrffy Gilbert G Privé Masayuki Hirano Ari M Melnick Leandro Cerchietti

Cancer Discov 2019 May 18;9(5):662-679. Epub 2019 Feb 18.

Division of Hematology and Oncology, Department of Medicine, Weill Cornell Medicine, New York, New York.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-17-1444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497559PMC
May 2019

Ex vivo synthetic immune tissues with T cell signals for differentiating antigen-specific, high affinity germinal center B cells.

Authors:
Alberto Purwada Shivem B Shah Wendy Béguelin Avery August Ari M Melnick Ankur Singh

Biomaterials 2019 Apr 26;198:27-36. Epub 2018 Jun 26.

Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA; Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, 14853, USA; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2018.06.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355359PMC
April 2019

Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition.

Authors:
Daisuke Ennishi Katsuyoshi Takata Wendy Béguelin Gerben Duns Anja Mottok Pedro Farinha Ali Bashashati Saeed Saberi Merrill Boyle Barbara Meissner Susana Ben-Neriah Bruce W Woolcock Adèle Telenius Daniel Lai Matt Teater Robert Kridel Kerry J Savage Laurie H Sehn Ryan D Morin Marco A Marra Sohrab P Shah Joseph M Connors Randy D Gascoyne David W Scott Ari M Melnick Christian Steidl

Cancer Discov 2019 04 31;9(4):546-563. Epub 2019 Jan 31.

Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/2159-8290.CD-18-1090DOI Listing
April 2019

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight.

Authors:
Francine E Garrett-Bakelman Manjula Darshi Stefan J Green Ruben C Gur Ling Lin Brandon R Macias Miles J McKenna Cem Meydan Tejaswini Mishra Jad Nasrini Brian D Piening Lindsay F Rizzardi Kumar Sharma Jamila H Siamwala Lynn Taylor Martha Hotz Vitaterna Maryam Afkarian Ebrahim Afshinnekoo Sara Ahadi Aditya Ambati Maneesh Arya Daniela Bezdan Colin M Callahan Songjie Chen Augustine M K Choi George E Chlipala Kévin Contrepois Marisa Covington Brian E Crucian Immaculata De Vivo David F Dinges Douglas J Ebert Jason I Feinberg Jorge A Gandara Kerry A George John Goutsias George S Grills Alan R Hargens Martina Heer Ryan P Hillary Andrew N Hoofnagle Vivian Y H Hook Garrett Jenkinson Peng Jiang Ali Keshavarzian Steven S Laurie Brittany Lee-McMullen Sarah B Lumpkins Matthew MacKay Mark G Maienschein-Cline Ari M Melnick Tyler M Moore Kiichi Nakahira Hemal H Patel Robert Pietrzyk Varsha Rao Rintaro Saito Denis N Salins Jan M Schilling Dorothy D Sears Caroline K Sheridan Michael B Stenger Rakel Tryggvadottir Alexander E Urban Tomas Vaisar Benjamin Van Espen Jing Zhang Michael G Ziegler Sara R Zwart John B Charles Craig E Kundrot Graham B I Scott Susan M Bailey Mathias Basner Andrew P Feinberg Stuart M C Lee Christopher E Mason Emmanuel Mignot Brinda K Rana Scott M Smith Michael P Snyder Fred W Turek

Science 2019 04;364(6436)

Northwestern University, Evanston, IL, USA.

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http://dx.doi.org/10.1126/science.aau8650DOI Listing
April 2019

Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL.

Authors:
Alessandro Pastore Federico Gaiti Sydney X Lu Ryan M Brand Scott Kulm Ronan Chaligne Hongcang Gu Kevin Y Huang Elena K Stamenova Wendy Béguelin Yanwen Jiang Rafael C Schulman Kyu-Tae Kim Alicia Alonso John N Allan Richard R Furman Andreas Gnirke Catherine J Wu Ari M Melnick Alexander Meissner Bradley E Bernstein Omar Abdel-Wahab Dan A Landau

Nat Commun 2019 04 23;10(1):1874. Epub 2019 Apr 23.

New York Genome Center, New York, 10013, NY, USA.

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http://dx.doi.org/10.1038/s41467-019-09645-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478836PMC
April 2019

The Impact of Heterogeneity on Single-Cell Sequencing.

Authors:
Samantha L Goldman Matthew MacKay Ebrahim Afshinnekoo Ari M Melnick Shuxiu Wu Christopher E Mason

Front Genet 2019 1;10. Epub 2019 Mar 1.

Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, United States.

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http://dx.doi.org/10.3389/fgene.2019.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405636PMC
March 2019

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease.

Authors:
Katelyn Paz Ryan Flynn Jing Du Jun Qi Leo Luznik Ivan Maillard Kelli P MacDonald Geoffrey R Hill Jonathan S Serody William J Murphy Peter T Sage Arlene H Sharpe David Miklos Corey S Cutler John Koreth Joseph H Antin Robert J Soiffer Jerome Ritz James E Bradner Ari M Melnick Bruce R Blazar

Blood 2019 01 2;133(1):94-99. Epub 2018 Oct 2.

Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN.

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http://dx.doi.org/10.1182/blood-2018-03-839993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318432PMC
January 2019

Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis.

Authors:
Katerina Hatzi Huimin Geng Ashley S Doane Cem Meydan Reed LaRiviere Mariano Cardenas Cihangir Duy Hao Shen Maria Nieves Calvo Vidal Timour Baslan Helai P Mohammad Ryan G Kruger Rita Shaknovich Ann M Haberman Giorgio Inghirami Scott W Lowe Ari M Melnick

Nat Immunol 2019 01 10;20(1):86-96. Epub 2018 Dec 10.

Department of Medicine, Division of Hematology & Medical Oncology, Weill Cornell Medicine, New York, NY, USA.

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http://dx.doi.org/10.1038/s41590-018-0273-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294324PMC
January 2019

TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.

Authors:
Pilar M Dominguez Hussein Ghamlouch Wojciech Rosikiewicz Parveen Kumar Wendy Béguelin Lorena Fontán Martín A Rivas Patrycja Pawlikowska Marine Armand Enguerran Mouly Miguel Torres-Martin Ashley S Doane María T Calvo Fernandez Matt Durant Veronique Della-Valle Matt Teater Luisa Cimmino Nathalie Droin Saber Tadros Samaneh Motanagh Alan H Shih Mark A Rubin Wayne Tam Iannis Aifantis Ross L Levine Olivier Elemento Giorgio Inghirami Michael R Green Maria E Figueroa Olivier A Bernard Said Aoufouchi Sheng Li Rita Shaknovich Ari M Melnick

Cancer Discov 2018 12 1;8(12):1632-1653. Epub 2018 Oct 1.

Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, New York.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-18-0657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279514PMC
December 2018

PRMT5 interacts with the BCL6 oncoprotein and is required for germinal center formation and lymphoma cell survival.

Authors:
Xiaoqing Lu Tharu M Fernando Chen Lossos Nevin Yusufova Fan Liu Lorena Fontán Matthew Durant Huimin Geng Jacob Melnick Yuan Luo Francisco Vega Vincent Moy Giorgio Inghirami Stephen Nimer Ari M Melnick Izidore S Lossos

Blood 2018 11 6;132(19):2026-2039. Epub 2018 Aug 6.

Division of Hematology, Department of Medicine, University of Miami, Miami, FL.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-02
Publisher Site
http://dx.doi.org/10.1182/blood-2018-02-831438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236466PMC
November 2018

How Biophysical Forces Regulate Human B Cell Lymphomas.

Authors:
F Apoorva Alexander M Loiben Shivem B Shah Alberto Purwada Lorena Fontan Rebecca Goldstein Brian J Kirby Ari M Melnick Benjamin D Cosgrove Ankur Singh

Cell Rep 2018 Apr;23(2):499-511

Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.03.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965297PMC
April 2018

Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs.

Authors:
Kyung-Min Noh Haibo Wang Hyunjae R Kim Wendy Wenderski Fang Fang Charles H Li Scott Dewell Stephen H Hughes Ari M Melnick Dinshaw J Patel Haitao Li C David Allis

Mol Cell 2018 02;69(3):533

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http://dx.doi.org/10.1016/j.molcel.2018.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813493PMC
February 2018

EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop.

Authors:
Wendy Béguelin Martín A Rivas María T Calvo Fernández Matt Teater Alberto Purwada David Redmond Hao Shen Matt F Challman Olivier Elemento Ankur Singh Ari M Melnick

Nat Commun 2017 10 12;8(1):877. Epub 2017 Oct 12.

Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, 10021, USA.

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http://dx.doi.org/10.1038/s41467-017-01029-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638898PMC
October 2017

Genetic and epigenetic inactivation of controls mTORC1 and response to EZH2 inhibition in follicular lymphoma.

Authors:
Elisa Oricchio Natalya Katanayeva Maria Christine Donaldson Stephanie Sungalee Joyce P Pasion Wendy Béguelin Elena Battistello Viraj R Sanghvi Man Jiang Yanwen Jiang Matt Teater Anita Parmigiani Andrei V Budanov Fong Chun Chan Sohrab P Shah Robert Kridel Ari M Melnick Giovanni Ciriello Hans-Guido Wendel

Sci Transl Med 2017 06;9(396)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/scitranslmed.aak9969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559734PMC
June 2017

The Expanding Role of the BCL6 Oncoprotein as a Cancer Therapeutic Target.

Authors:
Mariano G Cardenas Erin Oswald Wenbo Yu Fengtian Xue Alexander D MacKerell Ari M Melnick

Clin Cancer Res 2017 Feb 23;23(4):885-893. Epub 2016 Nov 23.

Department of Hematology/Oncology, Weill Cornell Medicine, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-2071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315622PMC
February 2017

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.

Authors:
Yanwen Jiang Ana Ortega-Molina Huimin Geng Hsia-Yuan Ying Katerina Hatzi Sara Parsa Dylan McNally Ling Wang Ashley S Doane Xabier Agirre Matt Teater Cem Meydan Zhuoning Li David Poloway Shenqiu Wang Daisuke Ennishi David W Scott Kristy R Stengel Janice E Kranz Edward Holson Sneh Sharma James W Young Chi-Shuen Chu Robert G Roeder Rita Shaknovich Scott W Hiebert Randy D Gascoyne Wayne Tam Olivier Elemento Hans-Guido Wendel Ari M Melnick

Cancer Discov 2017 01 12;7(1):38-53. Epub 2016 Oct 12.

Department of Medicine and Weill Cornell Cancer Center, Weill Cornell Medicine, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300005PMC
January 2017

CD99 is a therapeutic target on disease stem cells in myeloid malignancies.

Authors:
Stephen S Chung William S Eng Wenhuo Hu Mona Khalaj Francine E Garrett-Bakelman Montreh Tavakkoli Ross L Levine Martin Carroll Virginia M Klimek Ari M Melnick Christopher Y Park

Sci Transl Med 2017 01;9(374)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaj2025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624309PMC
January 2017

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling.

Authors:
Olga A Guryanova Kaitlyn Shank Barbara Spitzer Luisa Luciani Richard P Koche Francine E Garrett-Bakelman Chezi Ganzel Benjamin H Durham Abhinita Mohanty Gregor Hoermann Sharon A Rivera Alan G Chramiec Elodie Pronier Lennart Bastian Matthew D Keller Daniel Tovbin Evangelia Loizou Abby R Weinstein Adriana Rodriguez Gonzalez Yen K Lieu Jacob M Rowe Friederike Pastore Anna Sophia McKenney Andrei V Krivtsov Wolfgang R Sperr Justin R Cross Christopher E Mason Martin S Tallman Maria E Arcila Omar Abdel-Wahab Scott A Armstrong Stefan Kubicek Philipp B Staber Mithat Gönen Elisabeth M Paietta Ari M Melnick Stephen D Nimer Siddhartha Mukherjee Ross L Levine

Nat Med 2016 12 14;22(12):1488-1495. Epub 2016 Nov 14.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nm.4210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359771PMC
December 2016

Roles for small noncoding RNAs in silencing of retrotransposons in the mammalian brain.

Authors:
Sayan Nandi Dhruva Chandramohan Luana Fioriti Ari M Melnick Jean M Hébert Christopher E Mason Priyamvada Rajasethupathy Eric R Kandel

Proc Natl Acad Sci U S A 2016 Nov 24;113(45):12697-12702. Epub 2016 Oct 24.

Department of Neuroscience, Columbia University, New York, NY 10032;

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http://dx.doi.org/10.1073/pnas.1609287113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111663PMC
November 2016

Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma.

Authors:
Mariano G Cardenas Wenbo Yu Wendy Beguelin Matthew R Teater Huimin Geng Rebecca L Goldstein Erin Oswald Katerina Hatzi Shao-Ning Yang Joanna Cohen Rita Shaknovich Kenno Vanommeslaeghe Huimin Cheng Dongdong Liang Hyo Je Cho Joshua Abbott Wayne Tam Wei Du John P Leonard Olivier Elemento Leandro Cerchietti Tomasz Cierpicki Fengtian Xue Alexander D MacKerell Ari M Melnick

J Clin Invest 2016 09 2;126(9):3351-62. Epub 2016 Aug 2.

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http://dx.doi.org/10.1172/JCI85795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004937PMC
September 2016

SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents.

Authors:
Warren Fiskus Veena Coothankandaswamy Jianguang Chen Hongwei Ma Kyungsoo Ha Dyana T Saenz Stephanie S Krieger Christopher P Mill Baohua Sun Peng Huang Jeffrey S Mumm Ari M Melnick Kapil N Bhalla

Cancer Res 2016 09 8;76(18):5467-78. Epub 2016 Aug 8.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345574PMC
September 2016

Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region.

Authors:
Karen L Bunting T David Soong Rajat Singh Yanwen Jiang Wendy Béguelin David W Poloway Brandon L Swed Katerina Hatzi William Reisacher Matt Teater Olivier Elemento Ari M Melnick

Immunity 2016 09 13;45(3):497-512. Epub 2016 Sep 13.

Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA; Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033726PMC
September 2016

A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.

Authors:
Dali Han Xingyu Lu Alan H Shih Ji Nie Qiancheng You Meng Michelle Xu Ari M Melnick Ross L Levine Chuan He

Mol Cell 2016 08 28;63(4):711-719. Epub 2016 Jul 28.

Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.06.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992443PMC
August 2016

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.

Authors:
Wendy Béguelin Matt Teater Micah D Gearhart María Teresa Calvo Fernández Rebecca L Goldstein Mariano G Cárdenas Katerina Hatzi Monica Rosen Hao Shen Connie M Corcoran Michelle Y Hamline Randy D Gascoyne Ross L Levine Omar Abdel-Wahab Jonathan D Licht Rita Shaknovich Olivier Elemento Vivian J Bardwell Ari M Melnick

Cancer Cell 2016 08;30(2):197-213

Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medical College, Cornell University, 413 E 69(th) Street, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000552PMC
August 2016

The many layers of epigenetic dysfunction in B-cell lymphomas.

Authors:
Yanwen Jiang Pilar M Dominguez Ari M Melnick

Curr Opin Hematol 2016 07;23(4):377-84

aWeill Cornell Cancer Center bDepartment of Physiology and Biophysics cDepartment of Medicine, Weill Cornell Medicine, New York City, New York, USA.

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http://pdfs.journals.lww.com/co-hematology/2016/07000/The_ma
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http://dx.doi.org/10.1097/MOH.0000000000000249DOI Listing
July 2016

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia.

Authors:
Sheng Li Francine E Garrett-Bakelman Stephen S Chung Mathijs A Sanders Todd Hricik Franck Rapaport Jay Patel Richard Dillon Priyanka Vijay Anna L Brown Alexander E Perl Joy Cannon Lars Bullinger Selina Luger Michael Becker Ian D Lewis Luen Bik To Ruud Delwel Bob Löwenberg Hartmut Döhner Konstanze Döhner Monica L Guzman Duane C Hassane Gail J Roboz David Grimwade Peter J M Valk Richard J D'Andrea Martin Carroll Christopher Y Park Donna Neuberg Ross Levine Ari M Melnick Christopher E Mason

Nat Med 2016 07 20;22(7):792-9. Epub 2016 Jun 20.

Department of Physiology and Biophysics and the HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938719PMC
July 2016

Mutant IDH: a targetable driver of leukemic phenotypes linking metabolism, epigenetics and transcriptional regulation.

Authors:
Francine E Garrett-Bakelman Ari M Melnick

Epigenomics 2016 07 19;8(7):945-57. Epub 2016 Jul 19.

Division of Hematology/Medical Oncology, Department of Medicine, Weill Cornell Medicine, 413 East 69th Street, BRB 14th floor, New York, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066133PMC
July 2016

Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics.

Authors:
Eloy F Robles Maria Mena-Varas Laura Barrio Sara V Merino-Cortes Péter Balogh Ming-Qing Du Takashi Akasaka Anton Parker Sergio Roa Carlos Panizo Idoia Martin-Guerrero Reiner Siebert Victor Segura Xabier Agirre Laura Macri-Pellizeri Beatriz Aldaz Amaia Vilas-Zornoza Shaowei Zhang Sarah Moody Maria Jose Calasanz Thomas Tousseyn Cyril Broccardo Pierre Brousset Elena Campos-Sanchez Cesar Cobaleda Isidro Sanchez-Garcia Jose Luis Fernandez-Luna Ricardo Garcia-Muñoz Esther Pena Beatriz Bellosillo Antonio Salar Maria Joao Baptista Jesús Maria Hernandez-Rivas Marcos Gonzalez Maria Jose Terol Joan Climent Antonio Ferrandez Xavier Sagaert Ari M Melnick Felipe Prosper David G Oscier Yolanda R Carrasco Martin J S Dyer Jose A Martinez-Climent

Nat Commun 2016 06 14;7:11889. Epub 2016 Jun 14.

Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona 31008, Spain.

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June 2016

A clinical measure of DNA methylation predicts outcome in de novo acute myeloid leukemia.

Authors:
Marlise R Luskin Phyllis A Gimotty Catherine Smith Alison W Loren Maria E Figueroa Jenna Harrison Zhuoxin Sun Martin S Tallman Elisabeth M Paietta Mark R Litzow Ari M Melnick Ross L Levine Hugo F Fernandez Selina M Luger Martin Carroll Stephen R Master Gerald B W Wertheim

JCI Insight 2016 Jun;1(9)

Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/jci.insight.87323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951094PMC
June 2016

Integrin-specific hydrogels as adaptable tumor organoids for malignant B and T cells.

Authors:
Ye F Tian Haelee Ahn Rebecca S Schneider Shao Ning Yang Lidia Roman-Gonzalez Ari M Melnick Leandro Cerchietti Ankur Singh

Biomaterials 2015 Dec 11;73:110-9. Epub 2015 Sep 11.

Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2015.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623826PMC
December 2015

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma.

Authors:
Yanwen Jiang Kui Nie David Redmond Ari M Melnick Wayne Tam Olivier Elemento

J Vis Exp 2015 Dec 28(106):e53215. Epub 2015 Dec 28.

Institute for Computational Biomedicine, Weill Cornell Medical College;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780861PMC
December 2015

The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.

Authors:
Ana Ortega-Molina Isaac W Boss Andres Canela Heng Pan Yanwen Jiang Chunying Zhao Man Jiang Deqing Hu Xabier Agirre Itamar Niesvizky Ji-Eun Lee Hua-Tang Chen Daisuke Ennishi David W Scott Anja Mottok Christoffer Hother Shichong Liu Xing-Jun Cao Wayne Tam Rita Shaknovich Benjamin A Garcia Randy D Gascoyne Kai Ge Ali Shilatifard Olivier Elemento Andre Nussenzweig Ari M Melnick Hans-Guido Wendel

Nat Med 2015 Oct 14;21(10):1199-208. Epub 2015 Sep 14.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, New York, USA.

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http://dx.doi.org/10.1038/nm.3943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676270PMC
October 2015

Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs.

Authors:
Kyung-Min Noh Haibo Wang Hyunjae R Kim Wendy Wenderski Fang Fang Charles H Li Scott Dewell Stephen H Hughes Ari M Melnick Dinshaw J Patel Haitao Li C David Allis

Mol Cell 2015 Jul 11;59(1):89-103. Epub 2015 Jun 11.

Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.molcel.2015.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491196PMC
July 2015

VII. Are lymphomas driven by epigenetic lesions?

Authors:
Isaac W Boss Ari M Melnick

Hematol Oncol 2015 Jun;33 Suppl 1:42-5

Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA.

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June 2015

Epigenomic evolution in diffuse large B-cell lymphomas.

Authors:
Heng Pan Yanwen Jiang Michela Boi Fabrizio Tabbò David Redmond Kui Nie Marco Ladetto Annalisa Chiappella Leandro Cerchietti Rita Shaknovich Ari M Melnick Giorgio G Inghirami Wayne Tam Olivier Elemento

Nat Commun 2015 Apr 20;6:6921. Epub 2015 Apr 20.

1] Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10021, USA [2] Institute for Precision Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/ncomms7921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411286PMC
April 2015

A roadmap for discovery and translation in lymphoma.

Authors:
David M Weinstock Riccardo Dalla-Favera Randy D Gascoyne John P Leonard Ronald Levy Izidore S Lossos Ari M Melnick Grzegorz S Nowakowski Oliver W Press Kerry J Savage Margaret A Shipp Louis M Staudt

Blood 2015 Mar;125(13):2175-7

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1182/blood-2015-01-623777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375113PMC
March 2015

Enhanced reduced representation bisulfite sequencing for assessment of DNA methylation at base pair resolution.

Authors:
Francine E Garrett-Bakelman Caroline K Sheridan Thadeous J Kacmarczyk Jennifer Ishii Doron Betel Alicia Alonso Christopher E Mason Maria E Figueroa Ari M Melnick

J Vis Exp 2015 Feb 24(96):e52246. Epub 2015 Feb 24.

Department of Medicine, Weill Cornell Medical College.

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http://dx.doi.org/10.3791/52246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354670PMC
February 2015

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia.

Authors:
Joni Van der Meulen Viraj Sanghvi Konstantinos Mavrakis Kaat Durinck Fang Fang Filip Matthijssens Pieter Rondou Monica Rosen Tim Pieters Peter Vandenberghe Eric Delabesse Tim Lammens Barbara De Moerloose Björn Menten Nadine Van Roy Bruno Verhasselt Bruce Poppe Yves Benoit Tom Taghon Ari M Melnick Frank Speleman Hans-Guido Wendel Pieter Van Vlierberghe

Blood 2015 Jan 15;125(1):13-21. Epub 2014 Oct 15.

Center for Medical Genetics, Ghent University, Ghent, Belgium;

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http://dx.doi.org/10.1182/blood-2014-05-577270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347284PMC
January 2015

Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas.

Authors:
Yanwen Jiang David Redmond Kui Nie Ken W Eng Thomas Clozel Peter Martin Leonard Hc Tan Ari M Melnick Wayne Tam Olivier Elemento

Genome Biol 2014 Aug 15;15(8):432. Epub 2014 Aug 15.

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http://dx.doi.org/10.1186/s13059-014-0432-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158101PMC
August 2014

Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells.

Authors:
Kyungsoo Ha Warren Fiskus Dong Soon Choi Srividya Bhaskara Leandro Cerchietti Santhana G T Devaraj Bhavin Shah Sunil Sharma Jenny C Chang Ari M Melnick Scott Hiebert Kapil N Bhalla

Oncotarget 2014 Jul;5(14):5637-50

Houston Methodist Research Institute, Houston, TX.

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http://dx.doi.org/10.18632/oncotarget.2154DOI Listing
July 2014

Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia.

Authors:
Behzad Kharabi Masouleh Huimin Geng Christian Hurtz Lai N Chan Aaron C Logan Mi Sook Chang Chuanxin Huang Srividya Swaminathan Haibo Sun Elisabeth Paietta Ari M Melnick Phillip Koeffler Markus Müschen

Proc Natl Acad Sci U S A 2014 May 12;111(21):E2219-28. Epub 2014 May 12.

Department of Laboratory Medicine and

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http://www.pnas.org/cgi/doi/10.1073/pnas.1400958111
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040579PMC
May 2014

Hematopoietic stem cell origin of BRAFV600E mutations in hairy cell leukemia.

Authors:
Stephen S Chung Eunhee Kim Jae H Park Young Rock Chung Piro Lito Julie Teruya-Feldstein Wenhuo Hu Wendy Beguelin Sebastien Monette Cihangir Duy Raajit Rampal Leon Telis Minal Patel Min Kyung Kim Kety Huberman Nancy Bouvier Michael F Berger Ari M Melnick Neal Rosen Martin S Tallman Christopher Y Park Omar Abdel-Wahab

Sci Transl Med 2014 May;6(238):238ra71

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/scitranslmed.3008004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501573PMC
May 2014

Differentiation therapy for IDH1/2 mutant malignancies.

Authors:
Francine E Garrett-Bakelman Ari M Melnick

Cell Res 2013 Aug 4;23(8):975-7. Epub 2013 Jun 4.

Department of Medicine, Division of Hematology/Oncology, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA.

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http://dx.doi.org/10.1038/cr.2013.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731561PMC
August 2013

New effector functions and regulatory mechanisms of BCL6 in normal and malignant lymphocytes.

Authors:
Karen L Bunting Ari M Melnick

Curr Opin Immunol 2013 Jun 30;25(3):339-46. Epub 2013 May 30.

Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.coi.2013.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075446PMC
June 2013

BCL6 breaks occur at different AID sequence motifs in Ig-BCL6 and non-Ig-BCL6 rearrangements.

Authors:
Zhengfei Lu Albert G Tsai Takashi Akasaka Hitoshi Ohno Yanwen Jiang Ari M Melnick Harvey A Greisman Michael R Lieber

Blood 2013 May 8;121(22):4551-4. Epub 2013 Mar 8.

Norris Comprehensive Cancer Center, Department of Pathology, Biochemistry, and Molecular Biology, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1182/blood-2012-10-464958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668488PMC
May 2013

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.

Authors:
Wendy Béguelin Relja Popovic Matt Teater Yanwen Jiang Karen L Bunting Monica Rosen Hao Shen Shao Ning Yang Ling Wang Teresa Ezponda Eva Martinez-Garcia Haikuo Zhang Yupeng Zheng Sharad K Verma Michael T McCabe Heidi M Ott Glenn S Van Aller Ryan G Kruger Yan Liu Charles F McHugh David W Scott Young Rock Chung Neil Kelleher Rita Shaknovich Caretha L Creasy Randy D Gascoyne Kwok-Kin Wong Leandro Cerchietti Ross L Levine Omar Abdel-Wahab Jonathan D Licht Olivier Elemento Ari M Melnick

Cancer Cell 2013 May;23(5):677-92

Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.ccr.2013.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681809PMC
May 2013

Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphoma.

Authors:
Yanwen Jiang T David Soong Ling Wang Ari M Melnick Olivier Elemento

PLoS One 2012 12;7(7):e40332. Epub 2012 Jul 12.

HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine and Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395700PMC
March 2013

Methylome profiling reveals distinct alterations in phenotypic and mutational subgroups of myeloproliferative neoplasms.

Authors:
Sangeeta Nischal Sanchari Bhattacharyya Maximilian Christopeit Yiting Yu Li Zhou Tushar D Bhagat Davendra Sohal Britta Will Yongkai Mo Masako Suzuki Animesh Pardanani Michael McDevitt Jaroslaw P Maciejewski Ari M Melnick John M Greally Ulrich Steidl Alison Moliterno Amit Verma

Cancer Res 2013 Feb 11;73(3):1076-85. Epub 2012 Oct 11.

Albert Einstein College of Medicine, Bronx, New York; Mayo Clinic, Rochester, MN, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500294PMC
February 2013

Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression.

Authors:
Pei-Chun Lin Ya-Lin Chiu Samprit Banerjee Kyung Park Juan Miguel Mosquera Eugenia Giannopoulou Pedro Alves Ashutosh K Tewari Mark B Gerstein Himisha Beltran Ari M Melnick Olivier Elemento Francesca Demichelis Mark A Rubin

Cancer Res 2013 Feb 11;73(3):1232-44. Epub 2012 Dec 11.

DepartmentS of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563734PMC
February 2013

Notch activation inhibits AML growth and survival: a potential therapeutic approach.

Authors:
Sankaranarayanan Kannan Robert M Sutphin Mandy G Hall Leonard S Golfman Wendy Fang Riitta M Nolo Lauren J Akers Richard A Hammitt John S McMurray Steven M Kornblau Ari M Melnick Maria E Figueroa Patrick A Zweidler-McKay

J Exp Med 2013 Feb 28;210(2):321-37. Epub 2013 Jan 28.

Division of Pediatrics, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1084/jem.20121527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570106PMC
February 2013

Negative regulation of osteoclast precursor differentiation by CD11b and β2 integrin-B-cell lymphoma 6 signaling.

Authors:
Kyung-Hyun Park-Min Eun Young Lee Neal K Moskowitz Elisha Lim Sun-Kyeong Lee Joseph A Lorenzo Chuanxin Huang Ari M Melnick P Edward Purdue Steven R Goldring Lionel B Ivashkiv

J Bone Miner Res 2013 Jan;28(1):135-49

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, USA.

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http://doi.wiley.com/10.1002/jbmr.1739
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522783PMC
January 2013

Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia.

Authors:
Huimin Geng Sarah Brennan Thomas A Milne Wei-Yi Chen Yushan Li Christian Hurtz Soo-Mi Kweon Lynette Zickl Seyedmehdi Shojaee Donna Neuberg Chuanxin Huang Debabrata Biswas Yuan Xin Janis Racevskis Rhett P Ketterling Selina M Luger Hillard Lazarus Martin S Tallman Jacob M Rowe Mark R Litzow Monica L Guzman C David Allis Robert G Roeder Markus Müschen Elisabeth Paietta Olivier Elemento Ari M Melnick

Cancer Discov 2012 Nov 29;2(11):1004-23. Epub 2012 Oct 29.

Department of Medicine/Hematology-Oncology Division, Weill Medical College of Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516186PMC
November 2012

Oncogene-mediated alterations in chromatin conformation.

Authors:
David S Rickman T David Soong Benjamin Moss Juan Miguel Mosquera Jan Dlabal Stéphane Terry Theresa Y MacDonald Joseph Tripodi Karen Bunting Vesna Najfeld Francesca Demichelis Ari M Melnick Olivier Elemento Mark A Rubin

Proc Natl Acad Sci U S A 2012 Jun 21;109(23):9083-8. Epub 2012 May 21.

Department of Pathology and Laboratory Medicine, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1073/pnas.1112570109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384175PMC
June 2012

The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis.

Authors:
Grant D Barish Ruth T Yu Malith S Karunasiri Diana Becerra Jason Kim Tiffany W Tseng Li-Jung Tai Matthias Leblanc Cody Diehl Leandro Cerchietti Yury I Miller Joseph L Witztum Ari M Melnick Alexander L Dent Rajendra K Tangirala Ronald M Evans

Cell Metab 2012 Apr 29;15(4):554-62. Epub 2012 Mar 29.

Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.cmet.2012.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367511PMC
April 2012

SYK inhibition and response prediction in diffuse large B-cell lymphoma.

Authors:
Shuhua Cheng Greg Coffey X Hannah Zhang Rita Shaknovich Zibo Song Pin Lu Anjali Pandey Ari M Melnick Uma Sinha Y Lynn Wang

Blood 2011 Dec 24;118(24):6342-52. Epub 2011 Oct 24.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA.

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December 2011

BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia.

Authors:
Christian Hurtz Katerina Hatzi Leandro Cerchietti Melanie Braig Eugene Park Yong-mi Kim Sebastian Herzog Parham Ramezani-Rad Hassan Jumaa Martin C Müller Wolf-Karsten Hofmann Andreas Hochhaus B Hilda Ye Anupriya Agarwal Brian J Druker Neil P Shah Ari M Melnick Markus Müschen

J Exp Med 2011 Oct 12;208(11):2163-74. Epub 2011 Sep 12.

Department of Laboratory Medicine, University of California-San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1084/jem.20110304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201200PMC
October 2011

EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis.

Authors:
Irina Velichutina Rita Shaknovich Huimin Geng Nathalie A Johnson Randy D Gascoyne Ari M Melnick Olivier Elemento

Blood 2010 Dec 24;116(24):5247-55. Epub 2010 Aug 24.

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012542PMC
December 2010

Epigenetics in AML.

Authors:
Ari M Melnick

Best Pract Res Clin Haematol 2010 Dec 1;23(4):463-8. Epub 2010 Nov 1.

Weill Cornell Medical College, New York, NY 10065, United States.

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December 2010

BCL6 is critical for the development of a diverse primary B cell repertoire.

Authors:
Cihangir Duy J Jessica Yu Rahul Nahar Srividya Swaminathan Soo-Mi Kweon Jose M Polo Ester Valls Lars Klemm Seyedmehdi Shojaee Leandro Cerchietti Wolfgang Schuh Hans-Martin Jäck Christian Hurtz Parham Ramezani-Rad Sebastian Herzog Hassan Jumaa H Phillip Koeffler Ignacio Moreno de Alborán Ari M Melnick B Hilda Ye Markus Müschen

J Exp Med 2010 Jun 24;207(6):1209-21. Epub 2010 May 24.

Childrens Hospital Los Angeles and Leukemia and Lymphoma Program, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90027, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882829PMC
June 2010

Derepression in the desert: the third workshop on clinical translation of epigenetics in cancer therapeutics.

Authors:
Arthur Zelent Kevin Petrie Manuel Boix-Chornet Ari M Melnick Samuel Waxman Steven D Gore

Cancer Res 2008 Jul;68(13):4967-70

Institute of Cancer Research, Sutton, Surrey, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864592PMC
July 2008

The theoretical basis of transcriptional therapy of cancer: can it be put into practice?

Authors:
Ari M Melnick Kerin Adelson Jonathan D Licht

J Clin Oncol 2005 Jun 2;23(17):3957-70. Epub 2005 May 2.

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.

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June 2005

The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT.

Authors:
Shinichiro Takahashi Melanie J McConnell Hideo Harigae Mitsuo Kaku Takeshi Sasaki Ari M Melnick Jonathan D Licht

Blood 2004 Jun 24;103(12):4650-8. Epub 2004 Feb 24.

Division of Hematology/Oncology, Department of Medicine, Mount Sinai School of Medicine, Box 1079, One Gustave Levy Place, New York, NY 10029, USA.

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June 2004