Ari M Melnick

Ari M Melnick

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Ari M Melnick

Ari M Melnick

Publications by authors named "Ari M Melnick"

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An "EZ" Epigenetic Road to Leukemia Stem Cell Metabolic Reprogramming?

Cancer Discov 2019 Sep;9(9):1158-1160

Department of Medicine, Division of Hematology & Medical Oncology, Weill Cornell Medicine, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-19-0737DOI Listing
September 2019

Role of chromosomal architecture in germinal center B cells and lymphomagenesis.

Curr Opin Hematol 2019 Jul;26(4):294-302

Division of Hematology and Medical Oncology, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Sandra and Edward Meyer Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000505DOI Listing
July 2019

BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection.

Proc Natl Acad Sci U S A 2019 Jun 28;116(24):11888-11893. Epub 2019 May 28.

Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN 55905;

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http://dx.doi.org/10.1073/pnas.1902310116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6575592PMC
June 2019

Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis.

Cancer Cell 2019 Jun;35(6):916-931.e9

Department of Medicine, Division of Hematology & Medical Oncology, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.05.002DOI Listing
June 2019

Ex vivo synthetic immune tissues with T cell signals for differentiating antigen-specific, high affinity germinal center B cells.

Biomaterials 2019 Apr 26;198:27-36. Epub 2018 Jun 26.

Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA; Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, 14853, USA; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2018.06.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355359PMC
April 2019

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight.

Science 2019 04;364(6436)

Northwestern University, Evanston, IL, USA.

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http://dx.doi.org/10.1126/science.aau8650DOI Listing
April 2019

The Impact of Heterogeneity on Single-Cell Sequencing.

Front Genet 2019 1;10. Epub 2019 Mar 1.

Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, United States.

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http://dx.doi.org/10.3389/fgene.2019.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405636PMC
March 2019

How Biophysical Forces Regulate Human B Cell Lymphomas.

Cell Rep 2018 Apr;23(2):499-511

Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.03.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965297PMC
April 2018

EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop.

Nat Commun 2017 10 12;8(1):877. Epub 2017 Oct 12.

Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, 10021, USA.

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http://dx.doi.org/10.1038/s41467-017-01029-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638898PMC
October 2017

The Expanding Role of the BCL6 Oncoprotein as a Cancer Therapeutic Target.

Clin Cancer Res 2017 Feb 23;23(4):885-893. Epub 2016 Nov 23.

Department of Hematology/Oncology, Weill Cornell Medicine, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-2071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315622PMC
February 2017

Roles for small noncoding RNAs in silencing of retrotransposons in the mammalian brain.

Proc Natl Acad Sci U S A 2016 Nov 24;113(45):12697-12702. Epub 2016 Oct 24.

Department of Neuroscience, Columbia University, New York, NY 10032;

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http://dx.doi.org/10.1073/pnas.1609287113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111663PMC
November 2016

Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region.

Immunity 2016 09 13;45(3):497-512. Epub 2016 Sep 13.

Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA; Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033726PMC
September 2016

A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.

Mol Cell 2016 08 28;63(4):711-719. Epub 2016 Jul 28.

Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.06.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992443PMC
August 2016

The many layers of epigenetic dysfunction in B-cell lymphomas.

Curr Opin Hematol 2016 07;23(4):377-84

aWeill Cornell Cancer Center bDepartment of Physiology and Biophysics cDepartment of Medicine, Weill Cornell Medicine, New York City, New York, USA.

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http://pdfs.journals.lww.com/co-hematology/2016/07000/The_ma
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http://dx.doi.org/10.1097/MOH.0000000000000249DOI Listing
July 2016

Mutant IDH: a targetable driver of leukemic phenotypes linking metabolism, epigenetics and transcriptional regulation.

Epigenomics 2016 07 19;8(7):945-57. Epub 2016 Jul 19.

Division of Hematology/Medical Oncology, Department of Medicine, Weill Cornell Medicine, 413 East 69th Street, BRB 14th floor, New York, NY, USA.

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http://dx.doi.org/10.2217/epi-2016-0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066133PMC
July 2016

A clinical measure of DNA methylation predicts outcome in de novo acute myeloid leukemia.

JCI Insight 2016 Jun;1(9)

Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/jci.insight.87323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951094PMC
June 2016

Integrin-specific hydrogels as adaptable tumor organoids for malignant B and T cells.

Biomaterials 2015 Dec 11;73:110-9. Epub 2015 Sep 11.

Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2015.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623826PMC
December 2015

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma.

J Vis Exp 2015 Dec 28(106):e53215. Epub 2015 Dec 28.

Institute for Computational Biomedicine, Weill Cornell Medical College;

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http://dx.doi.org/10.3791/53215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780861PMC
December 2015

VII. Are lymphomas driven by epigenetic lesions?

Hematol Oncol 2015 Jun;33 Suppl 1:42-5

Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA.

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http://dx.doi.org/10.1002/hon.2215DOI Listing
June 2015

Epigenomic evolution in diffuse large B-cell lymphomas.

Nat Commun 2015 Apr 20;6:6921. Epub 2015 Apr 20.

1] Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10021, USA [2] Institute for Precision Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/ncomms7921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411286PMC
April 2015

A roadmap for discovery and translation in lymphoma.

Blood 2015 Mar;125(13):2175-7

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1182/blood-2015-01-623777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375113PMC
March 2015

Differentiation therapy for IDH1/2 mutant malignancies.

Cell Res 2013 Aug 4;23(8):975-7. Epub 2013 Jun 4.

Department of Medicine, Division of Hematology/Oncology, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA.

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http://dx.doi.org/10.1038/cr.2013.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731561PMC
August 2013

New effector functions and regulatory mechanisms of BCL6 in normal and malignant lymphocytes.

Curr Opin Immunol 2013 Jun 30;25(3):339-46. Epub 2013 May 30.

Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.coi.2013.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075446PMC
June 2013

BCL6 breaks occur at different AID sequence motifs in Ig-BCL6 and non-Ig-BCL6 rearrangements.

Blood 2013 May 8;121(22):4551-4. Epub 2013 Mar 8.

Norris Comprehensive Cancer Center, Department of Pathology, Biochemistry, and Molecular Biology, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1182/blood-2012-10-464958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668488PMC
May 2013

Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphoma.

PLoS One 2012 12;7(7):e40332. Epub 2012 Jul 12.

HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine and Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040332PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395700PMC
March 2013

Oncogene-mediated alterations in chromatin conformation.

Proc Natl Acad Sci U S A 2012 Jun 21;109(23):9083-8. Epub 2012 May 21.

Department of Pathology and Laboratory Medicine, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1073/pnas.1112570109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384175PMC
June 2012

SYK inhibition and response prediction in diffuse large B-cell lymphoma.

Blood 2011 Dec 24;118(24):6342-52. Epub 2011 Oct 24.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-02-33
Publisher Site
http://dx.doi.org/10.1182/blood-2011-02-333773DOI Listing
December 2011

Epigenetics in AML.

Authors:
Ari M Melnick

Best Pract Res Clin Haematol 2010 Dec 1;23(4):463-8. Epub 2010 Nov 1.

Weill Cornell Medical College, New York, NY 10065, United States.

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http://dx.doi.org/10.1016/j.beha.2010.09.017DOI Listing
December 2010

The theoretical basis of transcriptional therapy of cancer: can it be put into practice?

J Clin Oncol 2005 Jun 2;23(17):3957-70. Epub 2005 May 2.

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.

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http://dx.doi.org/10.1200/JCO.2005.14.498DOI Listing
June 2005

The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT.

Blood 2004 Jun 24;103(12):4650-8. Epub 2004 Feb 24.

Division of Hematology/Oncology, Department of Medicine, Mount Sinai School of Medicine, Box 1079, One Gustave Levy Place, New York, NY 10029, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2003-08-27
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http://dx.doi.org/10.1182/blood-2003-08-2759DOI Listing
June 2004