Publications by authors named "Ari J Firestone"

20Publications

Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers.

Cell Rep 2019 10;29(1):118-134.e8

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, MA. Electronic address:

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October 2019

A three-drug combination to treat BRAF-mutant cancers.

Nat Med 2017 08;23(8):913-914

Calico Life Sciences, South San Francisco, California, USA.

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August 2017

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.

Cell 2017 02 16;168(5):817-829.e15. Epub 2017 Feb 16.

Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address:

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February 2017

KRAS insertion mutations are oncogenic and exhibit distinct functional properties.

Nat Commun 2016 Feb 8;7:10647. Epub 2016 Feb 8.

Department of Pediatrics, University of California, 1450 3rd St, San Francisco, California 94158, USA.

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February 2016

Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice.

PLoS Genet 2015 May 22;11(5):e1005235. Epub 2015 May 22.

Department of Radiation Oncology, University of California, San Francisco, San Francisco, California, United States of America.

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May 2015

Preclinical efficacy of MEK inhibition in Nras-mutant AML.

Blood 2014 Dec 31;124(26):3947-55. Epub 2014 Oct 31.

Department of Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI;

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December 2014

Arhgap36-dependent activation of Gli transcription factors.

Proc Natl Acad Sci U S A 2014 Jul 14;111(30):11061-6. Epub 2014 Jul 14.

Departments of Chemical and Systems Biology,Developmental Biology, and

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July 2014

Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation.

Cancer Discov 2013 Sep 3;3(9):993-1001. Epub 2013 Jun 3.

1Department of Pediatrics and 2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California; 3Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, 4Department of Biology, David H. Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts; 5Department of Pathology, Institute for Genomics and Systems Biology, 6Ben May Department for Cancer Research, 7Section of Hematology/Oncology and Comprehensive Cancer Center, University of Chicago, Chicago, Illinois; 8Department of Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan; and 9Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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September 2013

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.

Nature 2012 Mar 18;484(7392):125-9. Epub 2012 Mar 18.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA.

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March 2012

Controlling destiny through chemistry: small-molecule regulators of cell fate.

ACS Chem Biol 2010 Jan;5(1):15-34

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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January 2010

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.

Proc Natl Acad Sci U S A 2009 Aug 5;106(33):14132-7. Epub 2009 Aug 5.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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August 2009

Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent.

Dev Biol 2009 Apr 4;328(2):342-54. Epub 2009 Feb 4.

Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.

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April 2009

The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling.

Angew Chem Int Ed Engl 2009 ;48(13):2321-4

Department of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305-5174, USA.

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April 2009

Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis.

J Biol Chem 2006 Jul 17;281(29):20632-42. Epub 2006 May 17.

Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA.

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July 2006

Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch.

J Cell Biol 2003 Dec;163(6):1339-49

Department of Pharmacology, Program in Molecular and Cellular Pharmacology, University of Wisconsin Medical School, Madison, WI 53706, USA.

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December 2003

Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling.

J Biol Chem 2003 Jun 6;278(25):23036-45. Epub 2003 Apr 6.

Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA.

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June 2003

Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions.

Nature 2002 Nov;420(6911):89-93

Department of Pharmacology, Program in Molecular and Cellular Pharmacology, University of Wisconsin-Madison, 1300 University Avenue, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA.

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November 2002