Publications by authors named "Arghya Chattopadhyay"

47 Publications

Lupus Mastitis.

Reumatol Clin (Engl Ed) 2021 Sep 6. Epub 2021 Sep 6.

Department of Clinical Immunology and Rheumatology, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India.

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http://dx.doi.org/10.1016/j.reuma.2021.05.004DOI Listing
September 2021

Complex Regional Pain Syndrome.

Mediterr J Rheumatol 2021 Jun 30;32(2):174-175. Epub 2021 Jun 30.

Clinical Immunology and Rheumatology Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.31138/mjr.32.2.174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369268PMC
June 2021

Methotrexate and theaflavin-3, 3'-digallate synergistically restore the balance between apoptosis and autophagy in synovial fibroblast of RA: an ex vivo approach with cultured human RA FLS.

Inflammopharmacology 2021 Oct 5;29(5):1427-1442. Epub 2021 Aug 5.

Department of Clinical Immunology and Rheumatology, Institute of Postgraduate Medical Education and Research, SSKM Hospital, 244 B, Acharya J C Bose Road, Kolkata, 700020, India.

Background: Imbalance between apoptosis and autophagy in fibroblast-like synoviocytes (FLS) is one of the pathogenic mechanisms responsible for their abnormal proliferation in rheumatoid arthritis (RA). Methotrexate (MTX) demonstrated limited efficacy in amending this imbalance in fluid-derived (fd)-FLS. The active compound of black tea Theaflavin 3,3'-digallate (TF3) may be effective in restoring apoptosis-autophagy imbalance in (fd)-FLS. The combined effect of MTX + TF3 upon the same is yet to be elucidated.

Objective: To evaluate the effect of MTX + TF3 on fd-FLS to induce apoptosis and inhibit autophagy through Endoplasmic Reticulum (ER) stress-mediated pathways.

Methods: FLS from synovial fluid of 11 RA and 10 osteoarthritis patients were cultured after treatment with MTX/TF3 or a combination of MTX (125 nM) and TF3(10 µM) and the following parameters were evaluated. C-reactive protein, cytokines (TNF-α, IL-6), angiogenic markers were quantified by ELISA. fd-FLS viability was determined by MTT assay and apoptosis by flow cytometry. ER stress markers were estimated by RT-PCR (IRE1A, spliced-XBP-1) and immunoblotting (Grp78, Hsp70, CHOP, HIF-1α). Immunoblot studies were done to evaluate apoptotic (Bcl-2, Bax, Caspases) and autophagic (Beclin1, LC3b, p62) proteins.

Results: MTX (IC) and TF3 (IC) both in single doses could down-regulate the levels of pro-inflammatory and angiogenic markers. Combinatorial treatment modulated autophagosomal proteins in fd-FLS and induced apoptosis by regulating ER stress response.

Conclusion: Disruption in homeostasis between apoptosis and autophagy in fd-FLS might be an underlying phenomenon in the progression of pathophysiology in RA. Co-administration of MTX + TF3 successfully restored the homeostasis by inducing apoptosis.
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http://dx.doi.org/10.1007/s10787-021-00857-0DOI Listing
October 2021

Correspondence on 'Onset of rheumatoid arthritis after COVID-19: coincidence or connected?'

Ann Rheum Dis 2021 Apr 27. Epub 2021 Apr 27.

Department of Clinical Immunology and Rheumatology, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India.

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http://dx.doi.org/10.1136/annrheumdis-2021-220479DOI Listing
April 2021

Prospective Comparison of Angiogenesis-Specific 68Ga-RGD2 PET/CT Imaging Parameters and DAS28-ESR in Rheumatoid Arthritis.

Clin Nucl Med 2021 Jul;46(7):556-561

From the Departments of Nuclear Medicine.

Objective: The aim of this study was to compare the performance of angiogenesis-specific 68Ga-RGD2 PET/CT with Disease Activity Score 28-erythrocyte sedimentation rate (DAS28-ESR) in assessing disease activity and treatment response in rheumatoid arthritis (RA).

Methods: This was a prospective study comparing the performance of 68Ga-RGD2 PET/CT and DAS28-ESR in 30 RA patients. All of them underwent 68Ga-RGD2 PET/CT scan from head to toe and clinical examination at the baseline. A repeat scan and clinical examination were done in 27 patients after 3 months of treatment with disease-modifying antirheumatic drugs ± steroids. Three PET parameters, that is, PJC (PET-positive joint count), aSUVmax (average SUVmax), and hSUVmax (highest SUVmax), of positive joints were compared with the DAS28-ESR for disease activity assessment and response evaluation.

Results: Among the 3 PET parameters, PJC showed a significant correlation with the DAS28-ESR (0.64, P < 0.01). A significant change was observed with treatment in the DAS28-ESR and PET parameters of 27 patients at follow-up. There was significant correlation between percentage changes in DAS28-ESR and scan parameters such as PJC (0.689, P < 0.001), aSUVmax (0.712, P < 0.001), and hSUVmax (0.555, P = 0.003) values. The absolute change in aSUVmax value could accurately discriminate (area under the curve, 0.98; P = 0.001) European League Against Rheumatism responders from nonresponders.

Conclusions: 68Ga-RGD2 PET/CT is a promising tool for objective assessment of disease activity and treatment response in patients with RA.
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http://dx.doi.org/10.1097/RLU.0000000000003586DOI Listing
July 2021

Effect of Phosphorus Application on Arsenic Species Accumulation and Co-Deposition of Polyphenols in Rice Grain: Phyto and Food Safety Evaluation.

Plants (Basel) 2021 Feb 2;10(2). Epub 2021 Feb 2.

Centre of Excellence in Rice Value Addition (CERVA), International Rice Research Institute (IRRI)-South Asia Regional Centre (ISARC), Varanasi 221106, India.

The present study was aimed at exploring the effect of soil application of different concentrations of orthophosphate (P) (0, 10, 20, 30, and 40 mg kg) on rice agronomic and yield parameters, arsenic (As) species accumulation, and polyphenol levels in the grain of rice grown under As spiked soil (10 mg kg). The contents of As species (As(V), As (III), MMA and DMA) and polyphenols in rice grain samples were estimated using LC-ICP-MS and LC-MS/MS, respectively. P treatments significantly reduced the toxic effects of As on agronomic parameters such as root weight and length, shoot and spike length, straw, and grain yield. Among the treatments studied, only the treatment of 30 mg kg P helps to decrease the elevated levels of As (V), As (III), and DMA in rice grains due to As application. The study revealed that 30 mg kg was the optimal P application amount to minimize AS accumulation in rice grains and As-linked toxicity on agronomic parameters and chlorophyll biosynthesis. Furthermore, the levels of trans-ferulic acid, chlorogenic acid, caffeic acid, and apigenin-7-glucoside increased in response to accumulation of As in the rice grain. In conclusion, the precise use of phosphorus may help to mitigate arsenic linked phytotoxicity and enhance the food safety aspect of rice grain.
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http://dx.doi.org/10.3390/plants10020281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912781PMC
February 2021

Long-Term Rituximab Use to Maintain Remission of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

Ann Intern Med 2020 12;173(11):947

Postgraduate Institute of Medical Education and Research, Chandigarh, India (S.J., A.C., A.S.).

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http://dx.doi.org/10.7326/L20-1197DOI Listing
December 2020

Spontaneous Subdural Hemorrhage in a Patient With Systemic Sclerosis: A Rare Association.

J Clin Rheumatol 2020 Nov 24. Epub 2020 Nov 24.

From the Clinical Immunology and Rheumatology Unit, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India.

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http://dx.doi.org/10.1097/RHU.0000000000001649DOI Listing
November 2020

Pseudotumour cerebri in lupus.

Clin Rheumatol 2021 Apr 10;40(4):1661-1662. Epub 2020 Nov 10.

Department of Clinical Immunology and Rheumatology, Institute of Postgraduate Medical Education and Research, 244, A.J.C. Bose Road, Kolkata, 700020, India.

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http://dx.doi.org/10.1007/s10067-020-05503-8DOI Listing
April 2021

Headache in lupus: look for dense clot and empty delta signs.

Rheumatology (Oxford) 2021 03;60(3):1572

Clinical Immunology and Rheumatology Unit, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1093/rheumatology/keaa482DOI Listing
March 2021

Comment on: EUREKA algorithm predicts obstetric risk and response to treatment in women with different subsets of anti-phospholipid antibodies.

Rheumatology (Oxford) 2021 03;60(3):e109

Department of Internal Medicine, Clinical Immunology and Rheumatology Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India.

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http://dx.doi.org/10.1093/rheumatology/keaa533DOI Listing
March 2021

Looking at the lobule-importance of ears and years in rheumatology.

Rheumatology (Oxford) 2021 01;60(1):477-478

Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1093/rheumatology/keaa426DOI Listing
January 2021

Lupus with abdominal pain.

Rheumatology (Oxford) 2021 01;60(1):475

Division of Rheumatology, Department of Internal Medicine.

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http://dx.doi.org/10.1093/rheumatology/keaa384DOI Listing
January 2021

COVID-19, hydroxychloroquine and the eighth alternative.

Clin Med (Lond) 2020 07;20(4):e132-e133

University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.

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http://dx.doi.org/10.7861/clinmed.Let.20.4.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385788PMC
July 2020

Young female with limb pain and proteinuria.

Nephrology (Carlton) 2020 09 12;25(9):731-732. Epub 2020 Jul 12.

Department of Internal Medicine, Clinical Immunology and Rheumatology services, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1111/nep.13746DOI Listing
September 2020

'Halo Score': missing large-vessel giant cell arteritis- do we need a 'modified Halo Score'?

Ann Rheum Dis 2020 Jul 10. Epub 2020 Jul 10.

Rheumatology & Clinical Immunology, Institute of Post Graduate Medial Education and Research, Kolkata, West Bengal, India

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http://dx.doi.org/10.1136/annrheumdis-2020-218224DOI Listing
July 2020

Neck pain in rheumatoid arthritis: a look beyond cervical spine involvement.

Rheumatology (Oxford) 2021 01;60(1):471

Department of Internal Medicine, Clinical Immunology and Rheumatology Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1093/rheumatology/keaa308DOI Listing
January 2021

Protrusio Acetabuli.

J Clin Rheumatol 2020 Jun 23. Epub 2020 Jun 23.

From the Clinical Immunology and Rheumatology Unit, Department of Internal Medicine, Nehru Hospital, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1097/RHU.0000000000001468DOI Listing
June 2020

An unusual cause of granulomatous colitis: Behcet's disease.

JGH Open 2020 Apr 15;4(2):303-305. Epub 2019 Aug 15.

Department of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India.

Intestinal involvement in Behcet's disease (BD) is uncommon. Differentiating it from close mimics like Crohn's Disease is difficult. Further, in asymptomatic cases, diagnostic challenges posed is still greater. A 17-year-old boy had history of recurrent oro-genital ulcers, papulo-pustular skin eruptions, ocular lesions and had presented with recent onset perianal abscess. Fecal calprotectin was elevated, and ileo-colonoscopy showed ileocolonic ulcers of inflammatory nature. Clinical diagnosis of intestinal BD was made. Patients with BD having mucosal lesions may harbor asymptomatic intestinal lesions. Screening them with fecal calprotectin levels and if positive, with subsequent imaging and endoscopic biopsy with timely initiation of appropriate treatment in such asymptomatic cases help to control overall disease activity.
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http://dx.doi.org/10.1002/jgh3.12215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144775PMC
April 2020

Jaccoud's arthropathy.

Rheumatology (Oxford) 2020 Apr 7. Epub 2020 Apr 7.

Department of Clinical Immunology and Rheumatology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.

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http://dx.doi.org/10.1093/rheumatology/keaa128DOI Listing
April 2020

Lupus hand.

Rheumatology (Oxford) 2020 Mar 12. Epub 2020 Mar 12.

Clinical Immunology and Rheumatology Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India.

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http://dx.doi.org/10.1093/rheumatology/keaa099DOI Listing
March 2020

Rhupus With Pyoderma Gangrenosum Treated With Immunosuppression and Skin Grafting.

J Clin Rheumatol 2021 Aug;27(5):e192

From the Division of Rheumatology, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1097/RHU.0000000000001341DOI Listing
August 2021

Spatial variability of arsenic in Indo-Gangetic basin of Varanasi and its cancer risk assessment.

Chemosphere 2020 Jan 19;238:124623. Epub 2019 Aug 19.

Division of Agricultural Physics, Indian Agricultural Research Institute, New Delhi, 110012, India.

The Indo-Gangetic alluvium is prime region for intensive agricultural. In some areas of this region, groundwater is now becoming progressively polluted by contamination with poisonous substances like arsenic. Intensive irrigation with arsenic contaminated ground water in dry spell results in the formation of As(III) which is more toxic. Thus groundwater quality assessment of Gangetic basin has become essential for its safer use. Therefore we under took study on the spatial variability of arsenic by collecting georeferred groundwater samples on grid basis from various water sources like dug well, bore and hand pumps covering the river bank region of Ganga basin. Water quality was investigated through determination pH, EC, TDS, salinity, Na, K, Ca, Mg, SAR, SSP, CO, HCO, RSC, Cl, As, Fe, Zn, Mn and Cu, etc. Results pointed severe As contamination in ground water of three sites of the study area. ARC GIS software is now able to process maps along with tabular data and compare them well, to provide the spatial visualization of information and using this tool, the Geographical Information System (GIS) of arsenic was developed. It was noticed from spatial maps that concentration of arsenic was more near the meandering points of Ganga.
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http://dx.doi.org/10.1016/j.chemosphere.2019.124623DOI Listing
January 2020

'DESIRABLE' or not?

Ann Rheum Dis 2019 Sep 6. Epub 2019 Sep 6.

Internal Medicine (Rheumatology Unit), Postgraduate Institute of Medical Education & Research, Chandigarh, India

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http://dx.doi.org/10.1136/annrheumdis-2019-216236DOI Listing
September 2019

Nodal Eosinophilic Granulomatosis With Polyangiitis (EGPA).

J Clin Rheumatol 2020 Oct;26(7):e259-e260

Clinical Immunology and Rheumatology Services, Department of Internal Medicine, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1097/RHU.0000000000001110DOI Listing
October 2020

Craniofacial Fibrous Dysplasia.

J Clin Rheumatol 2020 Oct;26(7):e214

From the Clinical Immunology and Rheumatology Services, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1097/RHU.0000000000001082DOI Listing
October 2020

Calcinosis Cutis at an Unusual Location.

J Clin Rheumatol 2020 Sep;26(6):e200

From the Clinical Immunology and Rheumatology Services, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1097/RHU.0000000000001069DOI Listing
September 2020
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