Publications by authors named "Arash Ghoorchian"

7 Publications

  • Page 1 of 1

Wearable Potentiometric Sensor Based on NaMnO for Non-invasive Monitoring of Sodium Ions in Sweat.

Anal Chem 2022 02 20;94(4):2263-2270. Epub 2022 Jan 20.

Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran.

Here, we present a wearable potentiometric ion sensor for real-time monitoring of sodium ions (Na) in human sweat samples using NaMnO as the sensing material. NaMnO is an attractive material for developing wearable electrochemical sensors due to its good Na incorporation ability, electrical conductivity, stability, and low fabrication cost. In the first step, the analytical performance of the electrode prepared using NaMnO is presented. Then, a miniaturized potentiometric cell integrated into a wearable substrate is developed, which reveals a Nernstian response (58 mV dec). We achieved the detection of Na in the linear ranges of 0.21-24.54 mmol L, which is well within the physiological range of Na. Finally, for on-body sweat analysis, the potentiometric sensor is fully integrated into a headband textile. This platform can be employed for non-invasive analysis of Na in human sweat for healthcare and disease diagnosis.
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http://dx.doi.org/10.1021/acs.analchem.1c04960DOI Listing
February 2022

Controlled Transdermal Iontophoresis of Insulin from Water-Soluble Polypyrrole Nanoparticles: An In Vitro Study.

Int J Mol Sci 2021 Nov 19;22(22). Epub 2021 Nov 19.

Research Institute of Oncology and Hematology, Cancer Care Manitoba, University of Manitoba, Winnipeg, MB R3E 3P4, Canada.

The iontophoresis delivery of insulin (INS) remains a serious challenge due to the low permeability of the drug through the skin. This work aims to investigate the potential of water-soluble polypyrrole nanoparticles (WS-PPyNPs) as a drug donor matrix for controlled transdermal iontophoresis of INS. WS-PPyNPs have been prepared via a simple chemical polymerization in the presence of sodium dodecyl sulfate (SDS) as both dopant and the stabilizing agent. The synthesis of the soluble polymer was characterized using field emission scanning electron microscopy (FESEM), dynamic light scattering (DLS), fluorescence spectroscopy, and Fourier transform infrared (FT-IR) spectroscopy. The loading mechanism of INS onto the WS-PPyNPs is based on the fact that the drug molecules can be replaced with doped dodecyl sulfate. A two-compartment Franz-type diffusion cell was employed to study the effect of current density, formulation pH, INS concentration, and sodium chloride concentration on anodal iontophoresis (AIP) and cathodal iontophoresis (CIP) of INS across the rat skin. Both AIP and CIP delivery of INS using WS-PPyNPs were significantly increased compared to passive delivery. Furthermore, while the AIP experiment (60 min at 0.13 mA cm) show low cumulative drug permeation for INS (about 20.48 µg cm); the CIP stimulation exhibited a cumulative drug permeation of 68.29 µg cm. This improvement is due to the separation of positively charged WS-PPyNPs and negatively charged INS that has occurred in the presence of cathodal stimulation. The obtained results confirm the potential applicability of WS-PPyNPs as an effective approach in the development of controlled transdermal iontophoresis of INS.
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http://dx.doi.org/10.3390/ijms222212479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621898PMC
November 2021

Crystal violet-modified HKUST-1 framework with improved hydrostability as an efficient adsorbent for direct solid-phase microextraction.

Mikrochim Acta 2021 Aug 26;188(9):305. Epub 2021 Aug 26.

Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.

Metal-organic frameworks (MOFs) have received extensive attention in adsorption applications owing to their high surface area. However, some MOFs do not perform well as the extraction medium when used under aqueous conditions. The low hydrostability of MOFs limits the practical application of these materials in solid-phase microextraction (SPME). Here, the fabrication of a water resistance SPME fiber coating is introduced based on the crystal violet (CV)-modified HKUST-1 framework on copper ([email protected]@CV). The HKUST-1 was prepared by the in situ growth method, followed by post-synthetic modification of HKUST-1 with the CV layer. The preparation of the modified HKUST-1 was characterized by FESEM, XRD, FTIR, and DFT approaches. The prepared SPME coating was successfully employed for the quantification of anthracene (AN), as a model analyte, in water samples. The limit of detection was 0.8 ng mL. The developed method will open up a new door towards searching for promising materials in SPME applications.
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http://dx.doi.org/10.1007/s00604-021-04966-zDOI Listing
August 2021

Application of magnetic nanomaterials in electroanalytical methods: A review.

Talanta 2021 Apr 9;225:121974. Epub 2020 Dec 9.

Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran. Electronic address:

Magnetic nanomaterials (MNMs) have gained high attention in different fields of studies due to their ferromagnetic/superparamagnetic properties and their low toxicity and high biocompatibility. MNMs contain magnetic elements such as iron and nickel in metallic, bimetallic, metal oxide, and mixed metal oxide. In electroanalytical methods, MNMs have been applied as sorbents for sample preparation before the electrochemical detection (sorbent role), as the electrode modifier (catalytic role), and the integration of the above two roles (as both sorbent and catalytic agent). In this paper, the application of MNMs in electroanalytical methods have been classified based on the main role of the nanomaterial and discussed separately. Furthermore, catalytic activities of MNMs in electroanalytical methods such as redox electrocatalytic, nanozymes catalytic (peroxidase, catalase activity, oxidase activity, superoxide dismutase activity), catalyst gate, and nanocontainer have been discussed.
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http://dx.doi.org/10.1016/j.talanta.2020.121974DOI Listing
April 2021

In Situ Growth of Metal-Organic Framework HKUST-1 on Graphene Oxide Nanoribbons with High Electrochemical Sensing Performance in Imatinib Determination.

ACS Appl Mater Interfaces 2020 Jan 16;12(4):4859-4869. Epub 2020 Jan 16.

Faculty of Chemistry , Bu-Ali Sina University , Hamedan 6517838695 , Iran.

Metal-organic frameworks (MOFs) have been previously investigated as electrode materials for developing electrochemical sensors. They have usually been reported to suffer from poor conductivity and improvement in the conductivity of MOFs is still a great challenge. Here, we reported the fabrication of an electrochemical sensor based on the in situ growth of framework HKUST-1 on conductive graphene oxide nanoribbons (GONRs)-modified glassy carbon electrode (GCE) (HKUST-1/GONRs/GCE). The as-fabricated modified electrode was characterized using field emission scanning electron microscopy, transmission electron microscopy (TEM), high-resolution TEM, Fourier transform infrared, X-ray diffraction, electrochemical impedance spectroscopy, cyclic voltammetry, and Raman spectroscopy. The voltammetric response of HKUST-1/GONRs/GCE toward Imatinib (IMA), as an anticancer drug, is dramatically higher than HKUST-1/GCE because of the synergic effect of the GONRs and HKUST-1 framework. The calibration curve at the HKUST-1/GONRs/GCE for IMA covered two linear dynamic ranges, 0.04-1.0 and 1.0-80 μmol L, with a detection limit of 0.006 μmol L (6 nmol L). Taking advantage of the conductivity of GONRs and large surface area of HKUST-1, a sensitive modified electrode was developed for the electrochemical determination of IMA. The present method provides an effective strategy to solve the poor conductivity of the MOFs. Finally, the obtained electrochemical performance made this modified electrode promising in the determination of IMA in urine and serum samples.
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http://dx.doi.org/10.1021/acsami.9b18097DOI Listing
January 2020

Hybrid Optoelectrochemical Sensor for Superselective Detection of 2,4,6-Trinitrotoluene Based on Electrochemical Reduced Meisenheimer Complex.

Anal Chem 2018 09 17;90(17):10360-10368. Epub 2018 Aug 17.

Department of Chemistry, Faculty of Basic Sciences , Tarbiat Modares University , Tehran , Iran 14115-175.

2,4,6-Trinitrotoluene (TNT) is known as one of the most used explosives, and its detection is significant in public security, human health, and environmental protection. The fabrication of absorbance based optical sensors for TNT is a serious challenge due to poor selectivity and sensitivity. We reported the design and fabrication of a superselective hybrid optoelectrochemical sensor based on the electrochemical reduction of Meisenheimer complex in a deep eutectic solvent (DES) modified with n-butylamine (nBA) for determination of TNT. The hybrid optoelectrochemical sensor (HOPES) that placed in DES modified with nBA and also an optical sensor (OPS) were fabricated. The electrochemical reduction of Meisenheimer complex occurred at HOPES when the potential was applied and consequently the sensing performance (sensitivity and selectivity) was dramatically enhanced compared to OPS. The both OPS and HOPES responded linearly to TNT with detection limits of 310 and 8 nmol L, respectively. The selectivity observed for the HOPES toward TNT compared to the other interferences was enhanced by a factor of 10-10, thus we can use the term "superselectivity" for HOPES. The mechanism of HOPES response was proved by optoelectrochemical and electrochemical impedance spectroscopy (EIS) techniques. The field emission scanning electron microscope (FESEM) was employed for the characterization of electrodeposited Meisenheimer layer. Finally, we presented a proposed model for the sensing mechanism of OPS and HOPES based on TNT complexation in the absence and presence of electric potential, respectively.
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http://dx.doi.org/10.1021/acs.analchem.8b02183DOI Listing
September 2018

Photophysical Diversity of Water-Soluble Fluorescent Conjugated Polymers Induced by Surfactant Stabilizers for Rapid and Highly Selective Determination of 2,4,6-Trinitrotoluene Traces.

ACS Appl Mater Interfaces 2016 Sep 9;8(37):24901-8. Epub 2016 Sep 9.

Department of Chemistry, Faculty of Basic Sciences, Tarbiat Modares University , 14115-175, Tehran, Iran.

The increasing application of fluorescence spectroscopy in development of reliable sensing platforms has triggered a lot of research interest for the synthesis of advanced fluorescent materials. Herein, we report a simple, low-cost strategy for the synthesis of a series of water-soluble conjugated polymer nanoparticles with diverse emission range using cationic (hexadecyltrimethylammonium bromide, CTAB), anionic (sodium dodecylbenzenesulfonate, SDBS), and nonionic (TX114) surfactants as the stabilizing agents. The role of surfactant type on the photophisical and sensing properties of resultant polymers has been investigated using dynamic light scattering (DLS), FT-IR, UV-vis, fluorescence, and energy dispersive X-ray (EDS) spectroscopies. The results show that the surface polarity, size, and spectroscopic and sensing properties of conjugated polymers could be well controlled by the proper selection of the stabilizer type. The fluorescent conjugated polymers exhibited fluorescence quenching toward nitroaromatic compounds. Further studies on the fluorescence properties of conjugated polymers revealed that the emission of the SDBS stabilized polymer, N-methylpolypyrrole-SDBS (NMPPY-SDBS), is strongly quenched by 2,4,6-trinitrotoluene molecule with a large Stern -Volmer constant of 59 526 M(-1) and an excellent detection limit of 100 nM. UV-vis and cyclic voltammetry measurements unveiled that fluorescence quenching occurs through a charge transfer mechanism between electron rich NMPPY-SDBS and electron deficient 2,4,6-trinitrotoluene molecules. Finally, the as-prepared conjugated polymer and approach were successfully applied to the determination of 2,4,6-trinitrotoluene in real water samples.
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http://dx.doi.org/10.1021/acsami.6b08577DOI Listing
September 2016
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