Arantxa Gonzalez

Arantxa Gonzalez

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Arantxa Gonzalez

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Circulating Long Noncoding RNA LIPCAR Predicts Heart Failure Outcomes in Patients Without Chronic Kidney Disease.

Hypertension 2019 Apr;73(4):820-828

Program of Cardiovascular Diseases, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain (B.L., S.R., M.U.M., A.G., J.D.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12261DOI Listing
April 2019

Combination of Circulating Type I Collagen-Related Biomarkers Is Associated With Atrial Fibrillation.

J Am Coll Cardiol 2019 Apr;73(12):1398-1410

Program of Cardiovascular Diseases, CIMA, University of Navarra, and IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; CIBERCV, Carlos III Institute of Health, Madrid, Spain; Department of Cardiology and Cardiac Surgery, University of Navarra Clinic, Pamplona, Spain; Department of Nephrology, University of Navarra Clinic, Pamplona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.12.074DOI Listing
April 2019

Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload.

J Am Coll Cardiol 2019 Apr;73(14):1795-1806

School of Cardiovascular Medicine & Sciences, King's College London British Heart Foundation Centre, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.12.087DOI Listing
April 2019

The renal immune-inflammatory component of arterial hypertension: emerging therapeutic strategies.

Cardiovasc Res 2019 Mar;115(4):696-698

Department of Nephrology, University of Navarra Clinic, University of Navarra, Pamplona, Spain.

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https://academic.oup.com/cardiovascres/advance-article/doi/1
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http://dx.doi.org/10.1093/cvr/cvy280DOI Listing
March 2019

CT-1 (Cardiotrophin-1)-Gal-3 (Galectin-3) Axis in Cardiac Fibrosis and Inflammation.

Hypertension 2019 Mar;73(3):602-611

From the Cardiovascular Translational Research, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona. Spain (E.M.-M., J.I., A.F.-C., N.L.-A.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11874DOI Listing
March 2019

Increased Fibroblast Growth Factor 23 in Heart Failure: Biomarker, Mechanism, or Both?

Am J Hypertens 2019 Jan;32(1):15-17

Department of Nephrology, University of Navarra Clinic, University of Navarra, Pamplon, Spain.

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http://dx.doi.org/10.1093/ajh/hpy153DOI Listing
January 2019

Circulating Biomarkers Predicting Longitudinal Changes in Left Ventricular Structure and Function in a General Population.

J Am Heart Assoc 2019 Jan;8(2):e010430

1 Research Unit Hypertension and Cardiovascular Epidemiology KU Leuven Department of Cardiovascular Sciences University of Leuven Belgium.

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http://dx.doi.org/10.1161/JAHA.118.010430DOI Listing
January 2019

ST2 in Heart Failure.

Circ Heart Fail 2018 Dec;11(12):e005582

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005582DOI Listing
December 2018

Biomarker-based phenotyping of myocardial fibrosis identifies patients with heart failure with preserved ejection fraction resistant to the beneficial effects of spironolactone: results from the Aldo-DHF trial.

Eur J Heart Fail 2018 09 30;20(9):1290-1299. Epub 2018 Apr 30.

Institute for Internal Medicine and Cardiology, Charité Universitätsmedizin Berlin, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.

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http://dx.doi.org/10.1002/ejhf.1194DOI Listing
September 2018

Myocardial Remodeling in Hypertension.

Hypertension 2018 09;72(3):549-558

From the Program of Cardiovascular Diseases, Center for Applied Medical Research, University of Navarra, Pamplona, Spain (A.G., S.R., B.L., M.U.M., J.B., G.S.J., J.D.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11125DOI Listing
September 2018

Unraveling New Mechanisms of Renal Fibrosis With Potential Therapeutic Implications.

Hypertension 2018 08 18;72(2):277-278. Epub 2018 Jun 18.

Department of Nephrology (N.G.-F., J.D.)

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11043DOI Listing
August 2018

Myocardial Interstitial Fibrosis in Heart Failure: Biological and Translational Perspectives.

J Am Coll Cardiol 2018 Apr;71(15):1696-1706

Department of Medicine, University of Mississippi, Jackson Mississippi. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.02.021DOI Listing
April 2018

Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation.

Matrix Biol 2018 03 25;66:110-124. Epub 2017 Sep 25.

Center for Heart Failure Research, Cardiovascular Research Institute Maastricht, The Netherlands; Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Belgium; ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.matbio.2017.09.002DOI Listing
March 2018

Rationale of the FIBROTARGETS study designed to identify novel biomarkers of myocardial fibrosis.

ESC Heart Fail 2018 02 7;5(1):139-148. Epub 2017 Oct 7.

Centre d'Investigation Clinique 1433 Module Plurithématique, INSERM U1116, Université de Lorraine, CHRU de Nancy, F-CRIN INI-CRCT, Hopitaux de Brabois, Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu, 4 rue du Morvan, 54500, Vandœuvre-lès-Nancy, France.

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http://dx.doi.org/10.1002/ehf2.12218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793978PMC
February 2018

MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure.

Hypertension 2018 02 18;71(2):280-288. Epub 2017 Dec 18.

From the Department of Cardiology (R.V., T.P., R.v.L., W.V., M.H., L.J.d.W., S.H., B.S.), Department of Physiology (C.M., F.A.v.N., M.v.B.), and Department of Internal Medicine (M.B.), CARIM School for Cardiovascular Diseases, Maastricht University, The Netherlands; Program of Cardiovascular Diseases, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain (F.J.B., J.D., A.G.); Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain (F.J.B., J.D., A.G.); CIBERCV, Carlos III Institute of Health, Madrid, Spain (F.J.B., J.D., A.G.); Department of Molecular Cell Biology, Leiden University Medical Biology Center, The Netherlands (T.v.H., M.J.G.); Department of Cardiology and Cardiac Surgery, University of Navarra Clinic, Pamplona, Spain (J.D.); Netherlands Heart Institute (ICIN), Utrecht; and Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology (CMVB), KU Leuven, Belgium (S.H.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10094DOI Listing
February 2018

Reverse Myocardial Remodeling Following Valve Replacement in Patients With Aortic Stenosis.

J Am Coll Cardiol 2018 Feb;71(8):860-871

Barts Heart Centre, St. Bartholomew's Hospital, London, United Kingdom; Institute for Cardiovascular Sciences, University College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.12.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821681PMC
February 2018

Cartilage intermediate layer protein 1 (CILP1): A novel mediator of cardiac extracellular matrix remodelling.

Sci Rep 2017 Nov 22;7(1):16042. Epub 2017 Nov 22.

Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-16201-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700204PMC
November 2017

Role of Myocardial Collagen in Severe Aortic Stenosis With Preserved Ejection Fraction and Symptoms of Heart Failure.

Rev Esp Cardiol (Engl Ed) 2017 Oct 16;70(10):832-840. Epub 2017 Feb 16.

Servicio de Cardiología, Hospital Universitario Donostia, Universidad del País Vasco, San Sebastián, Guipúzcoa, Spain; Área de Enfermedades Sistémicas, Instituto de Investigación Biodonostia, San Sebastián, Guipúzcoa, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.rec.2016.12.038DOI Listing
October 2017

Impact of acute hypertension transients on diastolic function in patients with heart failure with preserved ejection fraction.

Cardiovasc Res 2017 Jul;113(8):906-914

Department of Cardiology, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Gregorio Marañón, and CIBERCV, Dr. Esquerdo 46, 28007 Madrid, Spain.

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http://dx.doi.org/10.1093/cvr/cvx047DOI Listing
July 2017

Phenotyping of myocardial fibrosis in hypertensive patients with heart failure. Influence on clinical outcome.

J Hypertens 2017 04;35(4):853-861

aProgram of Cardiovascular Diseases, Centre for Applied Medical Research, University of NavarrabIdiSNA, Navarra Institute for Health Research, PamplonacDivision of Cardiology, Donostia University Hospital, University of the Basque Country, and Biodonostia Research Institute, San SebastiandDepartment of Cardiology and Cardiac Surgery, University of Navarra Clinic, Pamplona, Spain.

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http://dx.doi.org/10.1097/HJH.0000000000001258DOI Listing
April 2017

Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites.

Sci Rep 2017 02 3;7:41865. Epub 2017 Feb 3.

Program of Cardiovascular Diseases, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1038/srep41865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291109PMC
February 2017

The Hypertensive Myocardium: From Microscopic Lesions to Clinical Complications and Outcomes.

Med Clin North Am 2017 Jan 27;101(1):43-52. Epub 2016 Oct 27.

Program of Cardiovascular Diseases, Center of Applied Medical Research, University of Navarra, Edificio CIMA, Av. Pío XII, 55, Pamplona 31008, Spain; Department of Cardiology and Cardiac Surgery, University Clinic, University of Navarra, Av. Pío XII, 36, Pamplona 31008, Spain; IdiSNA, Navarra Institute for Health Resarch, Pamplona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.mcna.2016.08.002DOI Listing
January 2017

Potential role of microRNA-10b down-regulation in cardiomyocyte apoptosis in aortic stenosis patients.

Clin Sci (Lond) 2016 12 13;130(23):2139-2149. Epub 2016 Sep 13.

Program of Cardiovascular Diseases, Centre for Applied Medical Research, University of Navarra, Pamplona 31008, Spain

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http://dx.doi.org/10.1042/CS20160462DOI Listing
December 2016

Understanding the Role of CCN Matricellular Proteins in Myocardial Fibrosis.

J Am Coll Cardiol 2016 04;67(13):1569-1571

Program of Cardiovascular Diseases, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1016/j.jacc.2016.01.029DOI Listing
April 2016

Association of cystatin C with heart failure with preserved ejection fraction in elderly hypertensive patients: potential role of altered collagen metabolism.

J Hypertens 2016 Jan;34(1):130-8

aDepartment of Internal Medicine, University of Navarra Clinic bProgram of Cardiovascular Diseases, Center for Applied Medical Research, University of Navarra cIdiSNA, Navarra Institute for Health Research, Pamplona dDivision of Cardiology, Donostia University Hospital, University of the Basque Country, San Sebastián eDivision of Internal Medicine, Donostia University Hospital, University of the Basque Country, San Sebastián fDepartment of Cardiology and Cardiac Surgery, University of Navarra Clinic, Pamplona, Spain *Javier Díez and Arantxa González contributed equally to the study.

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http://pdfs.journals.lww.com/jhypertension/2016/01000/Associ
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http://dx.doi.org/10.1097/HJH.0000000000000757DOI Listing
January 2016

Myocardial Collagen Cross-Linking Is Associated With Heart Failure Hospitalization in Patients With Hypertensive Heart Failure.

J Am Coll Cardiol 2016 Jan;67(3):251-60

Program of Cardiovascular Diseases, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; Department of Cardiology and Cardiac Surgery, University of Navarra Clinic, Pamplona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2015.10.063DOI Listing
January 2016

Searching for new mechanisms of myocardial fibrosis with diagnostic and/or therapeutic potential.

Eur J Heart Fail 2015 Aug 30;17(8):764-71. Epub 2015 Jun 30.

Program of Cardiovascular Diseases, Center for Applied Medical Research-FIMA, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1002/ejhf.312DOI Listing
August 2015

p-SMAD2/3 and DICER promote pre-miR-21 processing during pressure overload-associated myocardial remodeling.

Biochim Biophys Acta 2015 Jul 15;1852(7):1520-30. Epub 2015 Apr 15.

Departamento de Fisiología y Farmacología, Facultad de Medicina, Universidad de Cantabria, Santander, Spain; Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander, Spain.

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http://dx.doi.org/10.1016/j.bbadis.2015.04.006DOI Listing
July 2015

Circulating Biomarkers of Myocardial Fibrosis: The Need for a Reappraisal.

J Am Coll Cardiol 2015 Jun;65(22):2449-56

Program of Cardiovascular Diseases, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; Department of Cardiology and Cardiac Surgery, University of Navarra Clinic, University of Navarra, Pamplona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2015.04.026DOI Listing
June 2015

Association of low GLP-1 with oxidative stress is related to cardiac disease and outcome in patients with type 2 diabetes mellitus: a pilot study.

Free Radic Biol Med 2015 Apr 13;81:1-12. Epub 2015 Jan 13.

Program of Cardiovascular Diseases, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain; Department of Cardiology and Cardiac Surgery, University of Navarra Clinic, University of Navarra. Pamplona, Spain.

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http://dx.doi.org/10.1016/j.freeradbiomed.2015.01.002DOI Listing
April 2015

Galectin-3 and histological, molecular and biochemical aspects of myocardial fibrosis in heart failure of hypertensive origin.

Eur J Heart Fail 2015 Apr 11;17(4):385-92. Epub 2015 Feb 11.

Program of Cardiovascular Diseases, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1002/ejhf.246DOI Listing
April 2015

Atrial fibrillation and biomarkers of myocardial fibrosis in heart failure.

Scand Cardiovasc J 2014 Oct 6;48(5):299-303. Epub 2014 Aug 6.

Division of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet , Stockholm , Sweden.

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http://dx.doi.org/10.3109/14017431.2014.940063DOI Listing
October 2014

Biomarkers of collagen type I metabolism are related to B-type natriuretic peptide, left ventricular size, and diastolic function in heart failure.

J Cardiovasc Med (Hagerstown) 2014 Jun;15(6):463-9

aDivision of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet bDepartment of Cardiology, Danderyd University Hospital, Stockholm, Sweden cDivision of Cardiovascular Sciences, Centre of Applied Medical Research dDepartment of Cardiology and Cardiac Surgery, School of Medicine, University of Navarra, Pamplona, Spain eErsta Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.2459/01.JCM.0000435617.86180.0bDOI Listing
June 2014

microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-β1 up-regulation.

Clin Sci (Lond) 2014 Apr;126(7):497-506

*Division of Cardiovascular Sciences, Centre for Applied Medical Research, University of Navarra, 31008 Pamplona, Spain.

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http://dx.doi.org/10.1042/CS20130538DOI Listing
April 2014

Association of cardiotrophin-1 with myocardial fibrosis in hypertensive patients with heart failure.

Hypertension 2014 Mar 23;63(3):483-9. Epub 2013 Dec 23.

Área de Ciencias Cardiovasculares, CIMA, Avenida Pío XII 55, 31008 Pamplona, Spain.

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.113.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.02654DOI Listing
March 2014

The activity of circulating dipeptidyl peptidase-4 is associated with subclinical left ventricular dysfunction in patients with type 2 diabetes mellitus.

Cardiovasc Diabetol 2013 Oct 7;12:143. Epub 2013 Oct 7.

Division of Cardiovascular Sciences, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1186/1475-2840-12-143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852480PMC
October 2013

Decreased Nox4 levels in the myocardium of patients with aortic valve stenosis.

Clin Sci (Lond) 2013 Sep;125(6):291-300

Division of Cardiovascular Sciences, Centre for Applied Medical Research, University of Navarra, Avda. Pío XII 55, 31008 Pamplona, Spain.

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http://www.clinsci.org/content/ppclinsci/125/6/291.full.pdf
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http://clinsci.org/lookup/doi/10.1042/CS20120612
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http://dx.doi.org/10.1042/CS20120612DOI Listing
September 2013

Association of cardiotrophin-1 with left ventricular systolic properties in asymptomatic hypertensive patients.

J Hypertens 2013 Mar;31(3):587-94

Division of Cardiovascular Sciences, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1097/HJH.0b013e32835ca903DOI Listing
March 2013

Blockade of TGF-β 1 signalling inhibits cardiac NADPH oxidase overactivity in hypertensive rats.

Oxid Med Cell Longev 2012 3;2012:726940. Epub 2012 Jun 3.

Division of Cardiovascular Sciences, Centre for Applied Medical Research, University of Navarra, 31008 Pamplona, Spain.

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http://dx.doi.org/10.1155/2012/726940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372069PMC
October 2012

Collagen cross-linking but not collagen amount associates with elevated filling pressures in hypertensive patients with stage C heart failure: potential role of lysyl oxidase.

Hypertension 2012 Sep 23;60(3):677-83. Epub 2012 Jul 23.

Division of Cardiovascular Sciences, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.112.196113DOI Listing
September 2012

Cardiotrophin-1 in hypertensive heart disease.

Endocrine 2012 Aug 15;42(1):9-17. Epub 2012 Mar 15.

Área de Ciencias Cardiovasculares, Centro de Investigación Médica Aplicada, Universidad de Navarra, Av. Pío XII 55, 31008, Pamplona, Spain.

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http://link.springer.com/content/pdf/10.1007/s12020-012-9649
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http://link.springer.com/10.1007/s12020-012-9649-4
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http://dx.doi.org/10.1007/s12020-012-9649-4DOI Listing
August 2012

New targets to treat the structural remodeling of the myocardium.

J Am Coll Cardiol 2011 Oct;58(18):1833-43

Division of Cardiovascular Sciences, Centre of Applied Medical Research, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1016/j.jacc.2011.06.058DOI Listing
October 2011

Cardiotrophin-1 plasma levels are associated with the severity of hypertrophy in hypertrophic cardiomyopathy.

Eur Heart J 2011 Jan 8;32(2):177-83. Epub 2010 Nov 8.

Insituto de Investigación Biomédica de A Coruña, Complejo Hospitalario Universitario A Coruña, As Xubias 84, A Coruña, Spain.

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http://dx.doi.org/10.1093/eurheartj/ehq400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021387PMC
January 2011

Association between left ventricular mass and telomere length in a population study.

Am J Epidemiol 2010 Aug 26;172(4):440-50. Epub 2010 Jul 26.

Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Biomedical Sciences Group, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1093/aje/kwq142DOI Listing
August 2010

Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects.

Am J Physiol Heart Circ Physiol 2010 Jul 14;299(1):H1-9. Epub 2010 May 14.

Area de Ciencias Cardiovasculares, Centre for Applied Medical Research, University of Navarra, Avenida Pío XII 55, Pamplona, Spain.

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http://ajpheart.physiology.org/content/ajpheart/299/1/H1.ful
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http://ajpheart.physiology.org/cgi/doi/10.1152/ajpheart.0033
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http://dx.doi.org/10.1152/ajpheart.00335.2010DOI Listing
July 2010

Filling pressures and collagen metabolism in hypertensive patients with heart failure and normal ejection fraction.

Hypertension 2010 Jun 19;55(6):1418-24. Epub 2010 Apr 19.

Division of Cardiovascular Sciences, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.149112DOI Listing
June 2010

Circulating biomarkers of collagen metabolism in cardiac diseases.

Circulation 2010 Apr;121(14):1645-54

Division of Cardiovascular Sciences, Centre for Applied Medical Research, University Clinic, University of Navarra, School of Medicine, Pamplona, Spain.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.109.912774DOI Listing
April 2010

Cardiovascular translational medicine (III). Genomics and proteomics in heart failure research.

Rev Esp Cardiol 2009 Mar;62(3):305-13

Area de Ciencias Cardiovasculares, Centro de Investigación Médica, Universidad de Navarra, 31008 Pamplona, Navarra, Spain.

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March 2009

Prevalence of left ventricular diastolic dysfunction in a general population.

Circ Heart Fail 2009 Mar 10;2(2):105-12. Epub 2009 Feb 10.

Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.108.822627DOI Listing
March 2009

Biochemical markers of myocardial remodelling in hypertensive heart disease.

Cardiovasc Res 2009 Feb 1;81(3):509-18. Epub 2008 Sep 1.

Division of Cardiovascular Sciences, Centre of Applied Medical Research, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1093/cvr/cvn235DOI Listing
February 2009

A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats.

Cardiovasc Res 2009 Feb 19;81(3):601-9. Epub 2008 Nov 19.

Division of Cardiovascular Sciences, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1093/cvr/cvn315DOI Listing
February 2009

Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure.

Hypertension 2009 Feb 15;53(2):236-42. Epub 2008 Dec 15.

Division of Cardiovascular Sciences, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain.

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http://hyper.ahajournals.org/content/53/2/236.full.pdf
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http://hyper.ahajournals.org/cgi/doi/10.1161/HYPERTENSIONAHA
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.108.125278DOI Listing
February 2009

Myocardial fibrosis in chronic kidney disease: potential benefits of torasemide.

Kidney Int Suppl 2008 Dec(111):S19-23

Division of Cardiovascular Sciences, Center of Applied Medical Research, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1038/ki.2008.512DOI Listing
December 2008

Upregulation of myocardial Annexin A5 in hypertensive heart disease: association with systolic dysfunction.

Eur Heart J 2007 Nov 31;28(22):2785-91. Epub 2007 Aug 31.

Division of Cardiovascular Sciences, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1093/eurheartj/ehm370DOI Listing
November 2007

Association of increased plasma cardiotrophin-1 with inappropriate left ventricular mass in essential hypertension.

Hypertension 2007 Nov 10;50(5):977-83. Epub 2007 Sep 10.

Division of Cardiovascular Sciences, University Clinic, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.098111DOI Listing
November 2007

Association of depressed cardiac gp130-mediated antiapoptotic pathways with stimulated cardiomyocyte apoptosis in hypertensive patients with heart failure.

J Hypertens 2007 Oct;25(10):2148-57

Division of Cardiovascular Sciences, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1097/HJH.0b013e32828626e2DOI Listing
October 2007

Myocardial fibrosis and diastolic dysfunction in patients with hypertension: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA).

J Hypertens 2007 Sep;25(9):1958-66

Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden, and Department of Cardiology and Cardiovascular Surgery, School of Medicine, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1097/HJH.0b013e3282170adaDOI Listing
September 2007

Identification of a potential cardiac antifibrotic mechanism of torasemide in patients with chronic heart failure.

J Am Coll Cardiol 2007 Aug 13;50(9):859-67. Epub 2007 Aug 13.

Division of Cardiovascular Sciences, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S073510970701822
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http://dx.doi.org/10.1016/j.jacc.2007.04.080DOI Listing
August 2007

Apoptosis in hypertensive heart disease: a clinical approach.

Curr Opin Cardiol 2006 Jul;21(4):288-94

Division of Cardiovascular Sciences, Centre for Applied Medical Research, School of Medicine, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1097/01.hco.0000231397.64362.70DOI Listing
July 2006

Alterations in the pattern of collagen deposition may contribute to the deterioration of systolic function in hypertensive patients with heart failure.

J Am Coll Cardiol 2006 Jul 12;48(1):89-96. Epub 2006 Jun 12.

Division of Cardiovascular Sciences, Centre for Applied Medical Research, School of Medicine, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1016/j.jacc.2006.01.077DOI Listing
July 2006

Myocardial fibrosis, impaired coronary hemodynamics, and biventricular dysfunction in salt-loaded SHR.

Am J Physiol Heart Circ Physiol 2006 Apr 18;290(4):H1503-9. Epub 2005 Nov 18.

Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, LA 70121, USA.

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http://dx.doi.org/10.1152/ajpheart.00970.2005DOI Listing
April 2006

Altered cardiac expression of peroxisome proliferator-activated receptor-isoforms in patients with hypertensive heart disease.

Cardiovasc Res 2006 Mar 20;69(4):899-907. Epub 2005 Dec 20.

Division of Cardiovascular Sciences, Centre for Applied Medical Research, University of Navarra, 31008 Pamplona, Spain.

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http://dx.doi.org/10.1016/j.cardiores.2005.11.016DOI Listing
March 2006

Usefulness of plasma cardiotrophin-1 in assessment of left ventricular hypertrophy regression in hypertensive patients.

J Hypertens 2005 Dec;23(12):2297-304

Division of Cardiovascular Pathophysiology, Centre for Applied Medical Research, School of Medicine, University of Navarra, Pamplona, Spain.

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December 2005

New directions in the assessment and treatment of hypertensive heart disease.

Curr Opin Nephrol Hypertens 2005 Sep;14(5):428-34

Division of Cardiovascular Pathophysiology, Centre for Applied Medical Research, University Clinic, School of Medicine, University of Navarra, C/Pio XII 55, 31008 Pamplona, Spain.

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September 2005

The use of collagen-derived serum peptides for the clinical assessment of hypertensive heart disease.

J Hypertens 2005 Aug;23(8):1445-51

Division of Cardiovascular Pathophysiology, Centre for Applied Medical Research, School of Medicine, University of Navarra, Pamplona, Spain.

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August 2005

Mechanisms of disease: pathologic structural remodeling is more than adaptive hypertrophy in hypertensive heart disease.

Nat Clin Pract Cardiovasc Med 2005 Apr;2(4):209-16

Division of Cardiovascular Pathophysiology, Center for Applied Medical Research, University of Navarra, Pamplona, and Division of Cardiology, Donostia University Hospital, San Sebastián, Spain.

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http://dx.doi.org/10.1038/ncpcardio0158DOI Listing
April 2005

Is plasma cardiotrophin-1 a marker of hypertensive heart disease?

J Hypertens 2005 Mar;23(3):625-32

Area of Cardiovascular Pathophysiology, Centre for Applied Medical Research, School of Medicine, University of Navarra, Navarra, Spain.

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March 2005