Publications by authors named "Apurva Sakarde"

8 Publications

  • Page 1 of 1

COVID-19 and lung pathologies.

Horm Mol Biol Clin Investig 2021 Jul 30. Epub 2021 Jul 30.

Department of Biochemistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.

COVID-19 is a global emergency with over 10 million cases and over 500, 000 deaths worldwide. The SARS CoV-2 is a RNA virus belonging to the family coronaviridae. It has high infectivity. The manifestations of the disease range from asymptomatic or mild symptoms to severe pneumonia and ARDS. The CT scan of lung shows consolidation and "Ground Glass Opacities". The persons with other comorbidities are considered to be at a higher rate of acquiring the infection. Asthma and other allergies have not been identified as major risk factors for COVID-19 as the number of asthmatic patients having COVID-19 is not high enough for it to be considered so. The occurrence of COVID-19 in COPD patients can be related with smoking. The ACE-2 expression in such patients was considerably high. The relation between COVID-19 and Tuberculosis can also be reflected in terms of the stigma associated with diagnosis and treatment of such diseases in some communities, eventually increasing the chances of people's reluctance to seek medical help. Cancer patients are usually more susceptible to infections. Lung cancer is no different. Additionally, lung cancer also has strong association with smoking further increasing the risk. The risk of getting infection and its severity is high for autoimmune disorders as well as fungal infections. Currently there is no definite treatment of COVID-19. However, some of the currently used modalities are hydroxychloroquine and antiviral drugs.
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http://dx.doi.org/10.1515/hmbci-2020-0096DOI Listing
July 2021

COVID-19 transmission: a positive perspective.

Horm Mol Biol Clin Investig 2021 Jul 30. Epub 2021 Jul 30.

Department of Community Medicine, AIIMS Nagpur, Nagpur, Maharashtra, India.

Objectives: To understand the dynamics of infectivity of COVID-19 and allay the fear and anxiety associated with it in healthcare workers and the society.

Case Presentation: Three individuals accompanied their pediatric patients in the COVID ward but did not develop infection. Information about their knowledge and perspective about the disease and the protective measures undertaken by them during their stay in the hospital was gathered by administering a questionnaire 14 days after discharge.

Conclusions: It was observed that use of proper precautionary measures like wearing a mask and regular hand sanitization helped in prevention from COVID-19 infection even after having close contact with confirmed cases. Such facts/observation will help in sensitizing the public about COVID-19 and eliminate panic in the society.
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http://dx.doi.org/10.1515/hmbci-2021-0006DOI Listing
July 2021

Kerala model for combating COVID-19 pandemic.

Horm Mol Biol Clin Investig 2021 Feb 12;42(1):1-2. Epub 2021 Feb 12.

Department of Biochemistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.

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http://dx.doi.org/10.1515/hmbci-2021-0004DOI Listing
February 2021

COVID-19 and nutritional deficiency: a review of existing knowledge.

Horm Mol Biol Clin Investig 2021 Feb 4;42(1):77-85. Epub 2021 Feb 4.

Department of Biochemistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.

COVID-19 has resulted in an ongoing global pandemic, which spread largely among people who have had close contact with the infected person. The immunopathology of the SARS-CoV-2 virus includes the production of an excess amount of pro-inflammatory cytokines "a cytokine-storm". The respiratory system (main), cardiovascular system and the gastrointestinal tract are the most affected body systems during viral infection. It has been found that most of the patients who require admission to hospital are elderly or have chronic underlying diseases. Higher cases of malnutrition and co-morbidities like diabetes mellitus and cardiovascular diseases are reported in elderly patients due to which, the immune system weakens and hence, the response to the virus is diminished in magnitude. A deficiency of micronutrients results in impaired immune responses leading to improper secretion of cytokines, alterations in secretory antibody response and antibody affinity which increases susceptibility to viral infection. The deficiency of various micronutrients in COVID-19 patient can be treated by appropriate nutritional supplements, prescribed after evaluating the patients' nutritional status. Here we aim to highlight the role of a few particular nutrients namely Vitamin D, Vitamin C, Omega-3 fatty acids, Zinc and Magnesium along with the synergistic roles they play in enhancing immunity and thus, maintaining homeostasis.
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http://dx.doi.org/10.1515/hmbci-2020-0074DOI Listing
February 2021

COVID-19 and cardiovascular disease: a review of current knowledge.

Horm Mol Biol Clin Investig 2021 Feb 4;42(1):99-104. Epub 2021 Feb 4.

Department of Physiology, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.

The uncontrolled spread of the COVID-19 pandemic which originated in China created a global turmoil. While the world is still busy figuring out a cure for the deadly disease, scientists worked out on many theories and conducted several studies to establish a relationship between the infection and other known diseases. Cardiovascular diseases (CVD) are one of the major complications of this infection after the respiratory manifestations. Individuals with cardiovascular complication are said to be more susceptible to acquiring the infection because the novel coronavirus uses the ACE2 receptor for its entry inside the cell and there is a high level of ACE2 expression in individuals with cardiovascular complications because of the enzyme's anti-hypertrophic, anti-fibrotic and anti-hypertensive effects on the heart. Individuals who belong to the older age group are also more susceptible. Knowing the above information, it might seem that using ACE2 inhibitors would help to slow or prevent the entry of the novel coronavirus but it would also at the same time prove to have deleterious effects on the cardiovascular system as the protective functions of ACE2 would be lost. While the search for a cure still continues it has been stated many a times that the conditions might worsen with time and the only way to keep ourselves and our family safe would be to follow the appropriate social distancing methods and get a COVID test if we experience any of the major symptoms.
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http://dx.doi.org/10.1515/hmbci-2020-0052DOI Listing
February 2021

COVID-19 and geriatric population: from pathophysiology to clinical perspectives.

Horm Mol Biol Clin Investig 2021 Feb 4;42(1):87-98. Epub 2021 Feb 4.

Department of Physiology, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.

The COVID-19 pandemic has not only led to a worldwide socio-economic depression, but has also had the highest health impact on the geriatric population. Elderly population, due to various reasons such as low immunity, pre-existing co-morbidities such as hypertension, cardiovascular diseases or diabetes, are obviously predisposed to develop severe infections and exhibit a high mortality rate. This is because of many reasons which include the atypical presentation in the geriatric population which might have led to diagnostic delay. As per the WHO guidelines to perform RT-PCR only on the symptomatic individuals, a very small portion of individuals were tested, leaving a fraction of population undiagnosed. Therefore, there remained a chance that many asymptomatic individuals such caregivers, healthcare professionals, family members were undiagnosed and might have carried this virus to the geriatric patients. Also, many countries were not prepared to handle the burden on their healthcare system which included sudden increased demand of ICU beds, mechanical ventilation etc. As a result, they had to make decision on who to be admitted. Atypical presentation in geriatric population may include afebrile or low-grade fever, absence of cough, malaise, muscle pains, dyspnoea etc. Geriatric population shows a more severe type of pneumonia, significantly higher number of neutrophils and C-reactive protein, less lymphocytes and a higher proportion of multiple lobe involvement. Extreme social suppression during COVID-19 pandemic has increased the risk of mental and physical adverse effects that has made older adults more vulnerable to depression and anxiety.
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http://dx.doi.org/10.1515/hmbci-2020-0053DOI Listing
February 2021

COVID -19 outbreak - Diabetes aspect and perspective.

Curr Med Res Pract 2020 May-Jun;10(3):134. Epub 2020 May 19.

Department of Ophthalmology, Indira Gandhi ESI Hospital, Jhilmi, New Delhi, 110095, India.

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http://dx.doi.org/10.1016/j.cmrp.2020.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236676PMC
May 2020

COVID 19 Outbreak: Potential of Biochemistry Speciality.

Indian J Clin Biochem 2020 Apr 18:1-2. Epub 2020 Apr 18.

Department of Biochemistry, Rajiv Gandhi Super Specialist Hospital, New Delhi, 110093 India.

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http://dx.doi.org/10.1007/s12291-020-00885-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166093PMC
April 2020
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