Publications by authors named "Aparecida Pietro Pereira"

2 Publications

  • Page 1 of 1

Antibody response from whole-cell pertussis vaccine immunized Brazilian children against different strains of Bordetella pertussis.

Am J Trop Med Hyg 2010 Apr;82(4):678-82

Genetics, Virology, Biochemistry and Immunochemistry Laboratories, Butantan Institute, São Paulo, Brazil.

Bordetella pertussis is a gram-negative bacillus that causes the highly contagious disease known as pertussis or whooping cough. Antibody response in children may vary depending on the vaccination schedule and the product used. In this study, we have analyzed the antibody response of cellular pertussis vaccinated children against B. pertussis strains and their virulence factors, such as pertussis toxin, pertactin, and filamentous hemagglutinin. After the completion of the immunization process, according to the Brazilian vaccination program, children serum samples were collected at different periods of time, and tested for the presence of specific antibodies and antigenic cross-reactivity. Results obtained show that children immunized with three doses of the Brazilian whole-cell pertussis vaccine present high levels of serum antibodies capable of recognizing the majority of the components present in vaccinal and non-vaccinal B. pertussis strains and their virulence factors for at least 2 years after the completion of the immunization procedure.
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http://dx.doi.org/10.4269/ajtmh.2010.09-0486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844572PMC
April 2010

Antigenic cross-reactivity and immunogenicity of Bothrops venoms from snakes of the Amazon region.

Toxicon 2010 Apr 29;55(4):881-7. Epub 2009 Dec 29.

Herpetology Laboratories, Butantan Institute, Av. Prof. Vital Brazil, 1500, CEP 05503-000 São Paulo, Brazil.

Snakebites are still a critical public health problem in developing countries or isolated areas. In Brazil, the North Region has a high distribution coefficient worsened by the significant number of eventually unreported cases, due to difficulties in access to health services, to the natural geographic barriers and the vast territory. In the Rio Negro area, the species Bothrops atrox, Bothrops brazili, Lachesis muta muta and Bothriopsis taeniata are thought to be the major species responsible for snakebites. The aim of this study was to qualitatively and quantitatively determine the antigenic cross-reactivity and expression of toxins and the immunogenicity of Bothrops venom species of the Amazon and to evaluate the general efficacy of the therapeutic sera. The in vivo assays demonstrated that the defibrinating activity of B. taeniata venom was absent but that the lethal and hemorrhagic properties were more intense than in the B. atrox venom. The results evidence venom variability among the two B. atrox populations from two distinct Amazonian regions, which may reveal a subjacent speciation process. The results point to new aspects that may guide the improvement of anti-Bothropic therapeutic serum.
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http://dx.doi.org/10.1016/j.toxicon.2009.12.014DOI Listing
April 2010