Antony W Burgess

Antony W Burgess

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Antony W Burgess

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Epidermal growth factor receptor: Structure-function informing the design of anticancer therapeutics.

Authors:
Ruth A Mitchell Rodney B Luwor Antony W Burgess

Exp Cell Res 2018 Oct 9;371(1):1-19. Epub 2018 Aug 9.

Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3052, Australia; Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2018.08.009DOI Listing
October 2018

Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity.

Authors:
Jing Wang Dmitri Mouradov Xiaojing Wang Robert N Jorissen Matthew C Chambers Lisa J Zimmerman Suhas Vasaikar Christopher G Love Shan Li Kym Lowes Karl-Johan Leuchowius Helene Jousset Janet Weinstock Christopher Yau John Mariadason Zhiao Shi Yuguang Ban Xi Chen Robert J C Coffey Robbert J C Slebos Antony W Burgess Daniel C Liebler Bing Zhang Oliver M Sieber

Gastroenterology 2017 10 16;153(4):1082-1095. Epub 2017 Jun 16.

Systems Biology and Personalised Medicine Division, The Walter and Eliza Hall Institute of Medial Research, Parkville, VIC, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia; Department of Surgery, The University of Melbourne, Parkville, VIC, Australia; School of Biomedical Sciences, Monash University, Clayton, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623120PMC
October 2017

Evolution of anti-HER2 therapies for cancer treatment.

Authors:
Sagun Parakh Hui K Gan Adam C Parslow Ingrid J G Burvenich Antony W Burgess Andrew M Scott

Cancer Treat Rev 2017 Sep 6;59:1-21. Epub 2017 Jul 6.

Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Australia; School of Cancer Medicine, La Trobe University, Melbourne, Australia; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2017.06.005DOI Listing
September 2017

TGF-β and IL-6 family signalling crosstalk: an integrated model.

Authors:
Shabnam Khatibi Jeff Babon John Wagner Jonathan H Manton Chin Wee Tan Hong-Jian Zhu Sam Wormald Antony W Burgess

Growth Factors 2017 06;35(2-3):100-124

b Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research (WEHI) , Parkville , VIC , Australia.

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https://www.tandfonline.com/doi/full/10.1080/08977194.2017.1
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http://dx.doi.org/10.1080/08977194.2017.1363746DOI Listing
June 2017

Bispecific protein targets prostate cancer.

Authors:
Antony W Burgess

Oncotarget 2017 May;8(22):35484-35485

Walter and Eliza Hall Institute, Parkville, Australia.

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http://dx.doi.org/10.18632/oncotarget.17372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482589PMC
May 2017

Pillars Article: Molecular Cloning of cDNA Encoding a Murine Haematopoietic Growth Regulator, Granulocyte-Macrophage Colony Stimulating Factor. . 1984. 309: 763-767.

Authors:
Nicholas M Gough Jill Gough Donald Metcalf Anne Kelso Dianne Grail Nicos A Nicola Antony W Burgess Ashley R Dunn

J Immunol 2017 04;198(7):2522-2526

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April 2017

Mathematical model of TGF-βsignalling: feedback coupling is consistent with signal switching.

Authors:
Shabnam Khatibi Hong-Jian Zhu John Wagner Chin Wee Tan Jonathan H Manton Antony W Burgess

BMC Syst Biol 2017 04 13;11(1):48. Epub 2017 Apr 13.

Department of Surgery (RMH), The University of Melbourne, Parkville, Victoria, 3050, Australia.

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http://bmcsystbiol.biomedcentral.com/articles/10.1186/s12918
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http://dx.doi.org/10.1186/s12918-017-0421-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390422PMC
April 2017

Synthesis of an inositol hexakisphosphate (IP6) affinity probe to study the interactome from a colon cancer cell line.

Authors:
Meng-Xin Yin Bruno Catimel Mark Gregory Melanie Condron Eugene Kapp Andrew B Holmes Antony W Burgess

Integr Biol (Camb) 2016 Mar;8(3):309-18

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia. and Department of Medical Biology, University of Melbourne, Parkville, Victoria 3052, Australia and Department of Surgery, RMH, University of Melbourne, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1039/c5ib00264hDOI Listing
March 2016

Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells.

Authors:
Lauren E King Christopher G Love Oliver M Sieber Maree C Faux Antony W Burgess

Genom Data 2016 Mar 3;7:293-6. Epub 2016 Feb 3.

Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia; Tumour Biology Branch, Ludwig Institute for Cancer Research, Parkville, Victoria, Australia; Department Surgery, RMH, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1016/j.gdata.2016.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778681PMC
March 2016

Discrete Element Framework for Modelling Extracellular Matrix, Deformable Cells and Subcellular Components.

Authors:
Bruce S Gardiner Kelvin K L Wong Grand R Joldes Addison J Rich Chin Wee Tan Antony W Burgess David W Smith

PLoS Comput Biol 2015 Oct 9;11(10):e1004544. Epub 2015 Oct 9.

Engineering Computational Biology, School of Computer Science and Software Engineering, The University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1371/journal.pcbi.1004544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599884PMC
October 2015

Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer.

Authors:
Robert N Jorissen Michael Christie Dmitri Mouradov Anuratha Sakthianandeswaren Shan Li Christopher Love Zheng-Zhou Xu Peter L Molloy Ian T Jones Stephen McLaughlin Robyn L Ward Nicholas J Hawkins Andrew R Ruszkiewicz James Moore Antony W Burgess Dana Busam Qi Zhao Robert L Strausberg Lara Lipton Jayesh Desai Peter Gibbs Oliver M Sieber

Br J Cancer 2015 Sep 25;113(6):979-88. Epub 2015 Aug 25.

Systems Biology and Personalised Medicine Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.

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http://dx.doi.org/10.1038/bjc.2015.296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578087PMC
September 2015

FunRich: An open access standalone functional enrichment and interaction network analysis tool.

Authors:
Mohashin Pathan Shivakumar Keerthikumar Ching-Seng Ang Lahiru Gangoda Camelia Y J Quek Nicholas A Williamson Dmitri Mouradov Oliver M Sieber Richard J Simpson Agus Salim Antony Bacic Andrew F Hill David A Stroud Michael T Ryan Johnson I Agbinya John M Mariadason Antony W Burgess Suresh Mathivanan

Proteomics 2015 Aug 17;15(15):2597-601. Epub 2015 Jun 17.

Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.

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http://dx.doi.org/10.1002/pmic.201400515DOI Listing
August 2015

Glycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease.

Authors:
Benjamin B Williams Niall C Tebbutt Michael Buchert Tracy L Putoczki Karen Doggett Shisan Bao Cameron N Johnstone Frederick Masson Frederic Hollande Antony W Burgess Andrew M Scott Matthias Ernst Joan K Heath

Dis Model Mech 2015 Aug 8;8(8):805-15. Epub 2015 May 8.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, Victoria 3052, Australia Ludwig Institute for Cancer Research, Melbourne-Parkville Branch, Parkville, Victoria 3050, Australia

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http://dx.doi.org/10.1242/dmm.019935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527289PMC
August 2015

Analysis of Wnt signalling dynamics during colon crypt development in 3D culture.

Authors:
Chin Wee Tan Yumiko Hirokawa Antony W Burgess

Sci Rep 2015 Jun 18;5:11036. Epub 2015 Jun 18.

1] Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052 Australia [2] Department of Medical Biology, University of Melbourne, 1G Royal Parade, Parkville, VIC 3052 Australia [3] Department of Surgery, University of Melbourne, Royal Melbourne Hospital, Parkville, VIC 3050, Australia.

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http://dx.doi.org/10.1038/srep11036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471889PMC
June 2015

Notch ligand delta-like1: X-ray crystal structure and binding affinity.

Authors:
Nadia J Kershaw Nicole L Church Michael D W Griffin Cindy S Luo Timothy E Adams Antony W Burgess

Biochem J 2015 May;468(1):159-66

*Department of Structural Biology, Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Parkville, 3052 Australia.

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http://dx.doi.org/10.1042/BJ20150010DOI Listing
May 2015

LRIG1 extracellular domain: structure and function analysis.

Authors:
Yibin Xu Priscilla Soo Francesca Walker Hui Hua Zhang Nicholas Redpath Chin Wee Tan Nicos A Nicola Timothy E Adams Thomas P Garrett Jian-Guo Zhang Antony W Burgess

J Mol Biol 2015 May 9;427(10):1934-48. Epub 2015 Mar 9.

Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Surgery, RMH, University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2015.03.001DOI Listing
May 2015

Colon cryptogenesis: asymmetric budding.

Authors:
Chin Wee Tan Yumiko Hirokawa Bruce S Gardiner David W Smith Antony W Burgess

PLoS One 2013 21;8(10):e78519. Epub 2013 Oct 21.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia ; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia ; Ludwig Institute for Cancer Research, Melbourne-Parkville Branch, Parkville, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078519PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804607PMC
February 2015

Dual role of Src kinase in governing neuronal survival.

Authors:
M Iqbal Hossain Ashfaqul Hoque Guillaume Lessene M Aizuddin Kamaruddin Percy W Y Chu Ivan H W Ng Sevgi Irtegun Dominic C H Ng Marie A Bogoyevitch Antony W Burgess Andrew F Hill Heung-Chin Cheng

Brain Res 2015 Jan 31;1594:1-14. Epub 2014 Oct 31.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville 3010, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2014.10.040DOI Listing
January 2015

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

Authors:
Toby J Phesse Michael Buchert Emma Stuart Dustin J Flanagan Maree Faux Shoukat Afshar-Sterle Francesca Walker Hui-Hua Zhang Cameron J Nowell Robert Jorissen Chin Wee Tan Yumiko Hirokawa Moritz F Eissmann Ashleigh R Poh Jordane Malaterre Helen B Pearson David G Kirsch Paolo Provero Valeria Poli Robert G Ramsay Oliver Sieber Antony W Burgess Dennis Huszar Elizabeth Vincan Matthias Ernst

Sci Signal 2014 Sep 30;7(345):ra92. Epub 2014 Sep 30.

Ludwig Institute for Cancer Research, Melbourne, Victoria 3052, Australia. Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia. Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3052, Australia.

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http://dx.doi.org/10.1126/scisignal.2005411DOI Listing
September 2014

Quantitative intratumoural microdistribution and kinetics of (131)I-huA33 antibody in patients with colorectal carcinoma.

Authors:
Marika Ciprotti Geoffrey Chong Hui K Gan Anthony Chan Carmel Murone Duncan MacGregor Fook-Thean Lee Terrance G Johns Joan K Heath Matthias Ernst Antony W Burgess Andrew M Scott

EJNMMI Res 2014 30;4:22. Epub 2014 May 30.

Ludwig Institute for Cancer Research, Austin Health, Melbourne 3084, Australia ; Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne 3084, Australia.

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http://www.ejnmmires.com/content/4/1/22
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http://dx.doi.org/10.1186/s13550-014-0022-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070025PMC
July 2014

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.

Authors:
Dmitri Mouradov Clare Sloggett Robert N Jorissen Christopher G Love Shan Li Antony W Burgess Diego Arango Robert L Strausberg Daniel Buchanan Samuel Wormald Liam O'Connor Jennifer L Wilding David Bicknell Ian P M Tomlinson Walter F Bodmer John M Mariadason Oliver M Sieber

Cancer Res 2014 Jun 22;74(12):3238-47. Epub 2014 Apr 22.

Authors' Affiliations: Ludwig Institute for Cancer Research; Systems Biology and Personalised Medicine Division; Structural Biology Division; Walter and Eliza Hall Institute of Medical Research; Faculty of Medicine, Dentistry and Health Sciences, Department of Medical Biology, University of Melbourne, Parkville; VLSCI Life Sciences Computation Centre, a collaboration between Melbourne, Monash and LaTrobe Universities, c/o The University of Melbourne, Carlton; Oncogenic Transcription Laboratory, Ludwig Institute for Cancer Research, Austin, VIC, Australia; Cancer and Population Studies Group, Queensland Institute of Medical Research, Herston, QLD, Australia; Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, 08035 Barcelona; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN); Spain; Ludwig Collaborative Laboratory for Cancer Biology and Therapy, Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland; Ludwig Institute for Cancer Research Ltd., New York, New York; Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford; and Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, Oxford, United KingdomAuthors' Affiliations: Ludwig Institute for Cancer Research; Systems Biology and Personalised Medicine Division; Structural Biology Division; Walter and Eliza Hall Institute of Medical Research; Faculty of Medicine, Dentistry and Health Sciences, Department of Medical Biology, University of Melbourne, Parkville; VLSCI Life Sciences Computation Centre, a collaboration between Melbourne, Monash and LaTrobe Universities, c/o The University of Melbourne, Carlton; Oncogenic Transcription Laboratory, Ludwig Institute for Cancer Research, Austin, VIC, Australia; Cancer and Population Studies

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0013DOI Listing
June 2014

Structure and function of LGR5: an enigmatic G-protein coupled receptor marking stem cells.

Authors:
Kaavya Krishna Kumar Antony W Burgess Jacqueline M Gulbis

Protein Sci 2014 May 19;23(5):551-65. Epub 2014 Mar 19.

Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria, 3052, Australia.

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http://dx.doi.org/10.1002/pro.2446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005707PMC
May 2014

Cell organisation in the colonic crypt: a theoretical comparison of the pedigree and niche concepts.

Authors:
Richard C van der Wath Bruce S Gardiner Antony W Burgess David W Smith

PLoS One 2013 12;8(9):e73204. Epub 2013 Sep 12.

School of Computer Science and Software Engineering, University of Western Australia, Perth, Western Australia, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073204PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771985PMC
April 2014

Colonic myofibroblast cell line stimulates colonoid formation.

Authors:
Yumiko Hirokawa Kelvin Hon Yan Yip Chin Wee Tan Antony W Burgess

Am J Physiol Gastrointest Liver Physiol 2014 Apr 30;306(7):G547-56. Epub 2014 Jan 30.

The Walter and Eliza Hall Institute of Medical Research, Melbourne;

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http://dx.doi.org/10.1152/ajpgi.00267.2013DOI Listing
April 2014

EGF receptor family: twisting targets for improved cancer therapies.

Authors:
Antony W Burgess Yoav I Henis Nancy E Hynes Thomas Jovin Alexander Levitzki Ronit Pinkas-Kramarski Yosef Yarden

Growth Factors 2014 Apr 18;32(2):74-81. Epub 2014 Mar 18.

The Walter & Eliza Hall Institute of Medical Research, Burgess Lab Structural Biology , Parkville , Australia .

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http://dx.doi.org/10.3109/08977194.2014.896355DOI Listing
April 2014

Recruitment of the adaptor protein Grb2 to EGFR tetramers.

Authors:
Noga Kozer Dipak Barua Christine Henderson Edouard C Nice Antony W Burgess William S Hlavacek Andrew H A Clayton

Biochemistry 2014 Apr 21;53(16):2594-604. Epub 2014 Apr 21.

Centre for Micro-Photonics, Faculty of Engineering and Industrial Sciences, Swinburne University of Technology , Hawthorn, Victoria 3122, Australia.

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http://dx.doi.org/10.1021/bi500182xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010257PMC
April 2014

Analysis of Wnt signaling β-catenin spatial dynamics in HEK293T cells.

Authors:
Chin Wee Tan Bruce S Gardiner Yumiko Hirokawa David W Smith Antony W Burgess

BMC Syst Biol 2014 Apr 8;8:44. Epub 2014 Apr 8.

Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

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http://dx.doi.org/10.1186/1752-0509-8-44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108056PMC
April 2014

Chain-specific antibodies for laminin-511.

Authors:
Laura Zamurs Normand Pouliot Nicole Kusuma Edouard C Nice Antony W Burgess

Growth Factors 2013 Dec;31(6):209-19

The Ludwig Institute for Cancer Research, Melbourne Branch , Parkville, Victoria , Australia .

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http://dx.doi.org/10.3109/08977194.2013.859684DOI Listing
December 2013

Immunopurification of adenomatous polyposis coli (APC) proteins.

Authors:
Kerryn L Elliott Bruno Catimel Nicole L Church Janine L Coates Antony W Burgess Meredith J Layton Maree C Faux

BMC Res Notes 2013 Oct 25;6:429. Epub 2013 Oct 25.

Ludwig Institute for Cancer Research-Parkville branch, Parkville, VIC 3050, Australia.

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http://dx.doi.org/10.1186/1756-0500-6-429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015550PMC
October 2013

Exploring higher-order EGFR oligomerisation and phosphorylation--a combined experimental and theoretical approach.

Authors:
Noga Kozer Dipak Barua Suzanne Orchard Eduoard C Nice Antony W Burgess William S Hlavacek Andrew H A Clayton

Mol Biosyst 2013 Jul 30;9(7):1849-63. Epub 2013 Apr 30.

Centre for Micro-Photonics, Faculty of Engineering and Industrial Sciences, Cell Biophysics Laboratory, Swinburne University of Technology, PO Box 218, Hawthorn, Victoria 3122, Australia.

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http://dx.doi.org/10.1039/c3mb70073aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698845PMC
July 2013

The PI(3)P interactome from a colon cancer cell.

Authors:
Bruno Catimel Eugene Kapp Meng-Xin Yin Mark Gregory Leon S-M Wong Melanie Condron Nicole Church Nadia Kershaw Andrew B Holmes Antony W Burgess

J Proteomics 2013 Apr 15;82:35-51. Epub 2013 Feb 15.

Ludwig Institute for Cancer Research, Melbourne-Parkville Branch, Post Office Box 2008 Royal Melbourne Hospital, Victoria 3050, Australia.

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http://dx.doi.org/10.1016/j.jprot.2013.01.031DOI Listing
April 2013

SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer.

Authors:
Nicholas I Fleming Robert N Jorissen Dmitri Mouradov Michael Christie Anuratha Sakthianandeswaren Michelle Palmieri Fiona Day Shan Li Cary Tsui Lara Lipton Jayesh Desai Ian T Jones Stephen McLaughlin Robyn L Ward Nicholas J Hawkins Andrew R Ruszkiewicz James Moore Hong-Jian Zhu John M Mariadason Antony W Burgess Dana Busam Qi Zhao Robert L Strausberg Peter Gibbs Oliver M Sieber

Cancer Res 2013 Jan 8;73(2):725-35. Epub 2012 Nov 8.

Ludwig Colon Cancer Initiative Laboratory, Ludwig Institute for Cancer Research, Department of Surgery, University of Melbourne, Parkville, Victoria, Australia.

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http://cancerres.aacrjournals.org/content/early/2013/01/10/0
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http://cancerres.aacrjournals.org/content/early/2012/11/08/0
Web Search
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-12-2706DOI Listing
January 2013

Ligand binding induces a conformational change in epidermal growth factor receptor dimers.

Authors:
Francesca Walker Julie Rothacker Christine Henderson Edouard C Nice Bruno Catimel Hui-Hua Zhang Andrew M Scott Michael F Bailey Suzanne G Orchard Timothy E Adams Zhanqi Liu Thomas P J Garrett Andrew H A Clayton Antony W Burgess

Growth Factors 2012 Dec 20;30(6):394-409. Epub 2012 Nov 20.

Ludwig Institute for Cancer Research Melbourne - Parkville Branch, Australia.

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http://dx.doi.org/10.3109/08977194.2012.739619DOI Listing
December 2012

A high-affinity ErbB4Fc fusion protein is a potent antagonist of heregulin-mediated receptor activation.

Authors:
Eva J Koziolek Jacqueline F Donoghue John D Bentley George Lovrecz Olan Dolezal Colin W Ward Julie Rothacker Edouard C Nice Antony W Burgess M Hafner Terrance G Johns Timothy E Adams

Growth Factors 2012 Oct 2;30(5):310-9. Epub 2012 Aug 2.

CSIRO Division of Materials Science and Engineering, 343 Royal Parade, Parkville, VIC 3052, Australia.

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http://dx.doi.org/10.3109/08977194.2012.709516DOI Listing
October 2012

Identification of a Wnt-induced protein complex by affinity proteomics using an antibody that recognizes a sub-population of β-catenin.

Authors:
Meredith J Layton Maree C Faux Nicole L Church Bruno Catimel Nadia J Kershaw Eugene A Kapp Cameron Nowell Janine L Coates Antony W Burgess Richard J Simpson

Biochim Biophys Acta 2012 Jul 24;1824(7):925-37. Epub 2012 Mar 24.

The Ludwig Institute for Cancer Research, Melbourne Hospital, Parkville, Australia.

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http://dx.doi.org/10.1016/j.bbapap.2012.03.006DOI Listing
July 2012

Solubilisation of the armadillo-repeat protein β-catenin using a zwitterionic detergent allows resolution of phosphorylated forms by 2DE.

Authors:
Meredith J Layton Nicole L Church Maree C Faux Hong Ji Robert J A Goode Eugene A Kapp Antony W Burgess Richard J Simpson

Electrophoresis 2012 Jul;33(12):1804-13

The Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Australia.

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http://dx.doi.org/10.1002/elps.201100671DOI Listing
July 2012

Restoration of full-length APC protein in SW480 colon cancer cells induces exosome-mediated secretion of DKK-4.

Authors:
Justin W E Lim Rommel A Mathias Eugene A Kapp Meredith J Layton Maree C Faux Antony W Burgess Hong Ji Richard J Simpson

Electrophoresis 2012 Jul;33(12):1873-80

Joint Proteomics Research Laboratory, Ludwig Institute for Cancer Research and The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1002/elps.201100687DOI Listing
July 2012

Wnt signalling pathway parameters for mammalian cells.

Authors:
Chin Wee Tan Bruce S Gardiner Yumiko Hirokawa Meredith J Layton David W Smith Antony W Burgess

PLoS One 2012 21;7(2):e31882. Epub 2012 Feb 21.

Ludwig Institute for Cancer Research, Melbourne-Parkville Branch, Parkville, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031882PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283727PMC
June 2012

Targeting of a conformationally exposed, tumor-specific epitope of EGFR as a strategy for cancer therapy.

Authors:
Hui K Gan Antony W Burgess Andrew H A Clayton Andrew M Scott

Cancer Res 2012 Jun 1;72(12):2924-30. Epub 2012 Jun 1.

Joint Austin-Ludwig Medical Oncology Unit, Austin Hospital, Australia.

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http://cancerres.aacrjournals.org/content/early/2012/06/01/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-11-3898DOI Listing
June 2012

LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines.

Authors:
Francesca Walker Hui-Hua Zhang Annalisa Odorizzi Antony W Burgess

PLoS One 2011 28;6(7):e22733. Epub 2011 Jul 28.

Epithelial Biochemistry Laboratory, Ludwig Institute for Cancer Research, Parkville, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022733PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145754PMC
December 2011

Evidence for extended YFP-EGFR dimers in the absence of ligand on the surface of living cells.

Authors:
Noga Kozer Christine Henderson Jacob T Jackson Edouard C Nice Antony W Burgess Andrew H A Clayton

Phys Biol 2011 Dec 26;8(6):066002. Epub 2011 Sep 26.

Centre for Microphotonics, Swinburne University of Technology, Victoria, Australia.

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http://stacks.iop.org/1478-3975/8/i=6/a=066002?key=crossref.
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http://dx.doi.org/10.1088/1478-3975/8/6/066002DOI Listing
December 2011

Wnt signaling and colon tumorigenesis--a view from the periphery.

Authors:
Antony W Burgess Maree C Faux Meredith J Layton Robert G Ramsay

Exp Cell Res 2011 Nov 22;317(19):2748-58. Epub 2011 Aug 22.

Parkville Branch, Ludwig Institute for Cancer Research, Melbourne, 3050, Australia.

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http://dx.doi.org/10.1016/j.yexcr.2011.08.010DOI Listing
November 2011

Use of multiple reaction monitoring for multiplex analysis of colorectal cancer-associated proteins in human feces.

Authors:
Ching-Seng Ang Julie Rothacker Heather Patsiouras Peter Gibbs Antony W Burgess Edouard C Nice

Electrophoresis 2011 Aug 3;32(15):1926-38. Epub 2011 May 3.

Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Melbourne, Victoria, Australia.

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http://doi.wiley.com/10.1002/elps.201000502
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August 2011

Conformational dynamics in a truncated epidermal growth factor receptor ectodomain.

Authors:
Noga Kozer Julie Rothacker Antony W Burgess Edouard C Nice Andrew H A Clayton

Biochemistry 2011 Jun 18;50(23):5130-9. Epub 2011 May 18.

Swinburne University of Technology , Victoria 3122, Australia.

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http://dx.doi.org/10.1021/bi200095wDOI Listing
June 2011

Optimizing targeted therapeutic development: analysis of a colorectal cancer patient population with the BRAF(V600E) mutation.

Authors:
Jeanne Tie Peter Gibbs Lara Lipton Michael Christie Robert N Jorissen Antony W Burgess Matthew Croxford Ian Jones Rachel Langland Suzanne Kosmider Daniel McKay Gideon Bollag Keith Nolop Oliver M Sieber Jayesh Desai

Int J Cancer 2011 May;128(9):2075-84

Ludwig Colon Cancer Initiative Laboratory, Ludwig Institute for Cancer Research, Melbourne, Australia.

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http://doi.wiley.com/10.1002/ijc.25555
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May 2011

Differential and synergistic effects of epidermal growth factor receptor antibodies on unliganded ErbB dimers and oligomers.

Authors:
Noga Kozer Marcus P Kelly Suzanne Orchard Antony W Burgess Andrew M Scott Andrew H A Clayton

Biochemistry 2011 May 15;50(18):3581-90. Epub 2011 Apr 15.

Ludwig Institute for Cancer Research, Melbourne-Parkville Branch, Royal Melbourne Hospital, Victoria 3050, Australia.

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http://dx.doi.org/10.1021/bi101785hDOI Listing
May 2011

Nonsense mediated decay resistant mutations are a source of expressed mutant proteins in colon cancer cell lines with microsatellite instability.

Authors:
David S Williams Matthew J Bird Robert N Jorissen Yen Lin Yu Francesca Walker Franscesa Walker Hui Hua Zhang Edouard C Nice Antony W Burgess

PLoS One 2010 Dec 31;5(12):e16012. Epub 2010 Dec 31.

Epithelial Biochemistry Laboratory, Ludwig Institute for Cancer Research, Melbourne Branch, Parkville, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016012PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013145PMC
December 2010

Analysis of cellular phosphatidylinositol (3,4,5)-trisphosphate levels and distribution using confocal fluorescent microscopy.

Authors:
Michelle Palmieri Cameron J Nowell Melanie Condron James Gardiner Andrew B Holmes Jayesh Desai Antony W Burgess Bruno Catimel

Anal Biochem 2010 Nov 25;406(1):41-50. Epub 2010 Jun 25.

Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victsoria, Australia.

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http://dx.doi.org/10.1016/j.ab.2010.06.033DOI Listing
November 2010

Independent interactions of phosphorylated β-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions.

Authors:
Maree C Faux Janine L Coates Nadia J Kershaw Meredith J Layton Antony W Burgess

PLoS One 2010 Nov 30;5(11):e14127. Epub 2010 Nov 30.

Ludwig Institute for Cancer Research, Melbourne, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014127PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994709PMC
November 2010

Murine fecal proteomics: a model system for the detection of potential biomarkers for colorectal cancer.

Authors:
Ching-Seng Ang Julie Rothacker Heather Patsiouras Antony W Burgess Edouard C Nice

J Chromatogr A 2010 May 8;1217(19):3330-40. Epub 2009 Oct 8.

Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, PO Box 2008, Royal Melbourne Hospital, Australia.

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http://dx.doi.org/10.1016/j.chroma.2009.10.007DOI Listing
May 2010

Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes.

Authors:
Stuart J Conway James Gardiner Simon J A Grove Melloney K Johns Ze-Yi Lim Gavin F Painter Diane E J E Robinson Christine Schieber Jan W Thuring Leon S-M Wong Meng-Xin Yin Antony W Burgess Bruno Catimel Phillip T Hawkins Nicholas T Ktistakis Leonard R Stephens Andrew B Holmes

Org Biomol Chem 2010 Jan 9;8(1):66-76. Epub 2009 Nov 9.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

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http://dx.doi.org/10.1039/b913399bDOI Listing
January 2010

Incentives: encouraging adventurous ideas.

Authors:
Joseph A Trapani Antony W Burgess David J Hill

Science 2010 Jan;327(5962):145

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http://dx.doi.org/10.1126/science.327.5962.145-aDOI Listing
January 2010

Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf.

Authors:
Hui-Hua Zhang Francesca Walker Sara Kiflemariam Robert H Whitehead David Williams Wayne A Phillips Thomas Mikeska Alexander Dobrovic Antony W Burgess

Int J Cancer 2009 Jul;125(2):297-307

Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Centre for Medical Research, Victoria, Australia.

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http://dx.doi.org/10.1002/ijc.24289DOI Listing
July 2009

PI(3,4,5)P3 Interactome.

Authors:
Bruno Catimel Meng-Xin Yin Christine Schieber Melanie Condron Heather Patsiouras Jenny Catimel Diane E J E Robinson Leon S-M Wong Edouard C Nice Andrew B Holmes Antony W Burgess

J Proteome Res 2009 Jul;8(7):3712-26

Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, and School of Chemistry, Bio21 Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1021/pr900320aDOI Listing
July 2009

A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo.

Authors:
Timothy E Adams Eva J Koziolek Peter H Hoyne John D Bentley Louis Lu George Lovrecz Colin W Ward F T Lee Andrew M Scott Andrew D Nash Julie Rothacker Edouard C Nice Antony W Burgess Terrance G Johns

Growth Factors 2009 Jun;27(3):141-54

CSIRO Division of Molecular and Health Technologies, Parkville, VIC, Australia.

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http://dx.doi.org/10.1080/08977190902843565DOI Listing
June 2009

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR.

Authors:
Thomas P J Garrett Antony W Burgess Hui K Gan Rod B Luwor Glenn Cartwright Francesca Walker Suzanne G Orchard Andrew H A Clayton Edouard C Nice Julie Rothacker Bruno Catimel Webster K Cavenee Lloyd J Old Elisabeth Stockert Gerd Ritter Timothy E Adams Peter A Hoyne Dane Wittrup Ginger Chao Jennifer R Cochran Cindy Luo Mezhen Lou Trevor Huyton Yibin Xu W Douglas Fairlie Shenggen Yao Andrew M Scott Terrance G Johns

Proc Natl Acad Sci U S A 2009 Mar 16;106(13):5082-7. Epub 2009 Mar 16.

Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Australia.

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http://dx.doi.org/10.1073/pnas.0811559106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656555PMC
March 2009

Predominance of activated EGFR higher-order oligomers on the cell surface.

Authors:
Andrew H A Clayton Suzanne G Orchard Edouard C Nice Richard G Posner Antony W Burgess

Growth Factors 2008 Dec;26(6):316-24

Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1080/08977190802442187DOI Listing
December 2008

The PI(3,5)P2 and PI(4,5)P2 interactomes.

Authors:
Bruno Catimel Christine Schieber Melanie Condron Heather Patsiouras Lisa Connolly Jenny Catimel Edouard C Nice Antony W Burgess Andrew B Holmes

J Proteome Res 2008 Dec;7(12):5295-313

Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Parkville Victoria 3052, Australia.

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December 2008

EGFR family: structure physiology signalling and therapeutic targets.

Authors:
Antony W Burgess

Growth Factors 2008 Oct;26(5):263-74

Ludwig Institute for cancer Research, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1080/08977190802312844DOI Listing
October 2008

IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice.

Authors:
Francesca Walker Hui-Hua Zhang Vance Matthews Janet Weinstock Edouard C Nice Matthias Ernst Stefan Rose-John Antony W Burgess

Blood 2008 Apr 21;111(8):3978-85. Epub 2007 Dec 21.

Ludwig Institute for Cancer Research, Melbourne Tumor Biology Branch, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1182/blood-2007-10-119636DOI Listing
April 2008

Macrophage-colony stimulating factor is required for the production of neutrophil-promoting activity by mouse embryo fibroblasts deficient in G-CSF and GM-CSF.

Authors:
Hui Hua Zhang Sunanda Basu Fenqiang Wu C Glenn Begley Christiaan J M Saris Ashley R Dunn Antony W Burgess Francesca Walker

J Leukoc Biol 2007 Oct 25;82(4):915-25. Epub 2007 Jul 25.

Ludwig Institute for Cancer Research, Melbourne Tumor Biology Branch, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1189/jlb.0107023DOI Listing
October 2007

De novo design of beta-helical polypeptides.

Authors:
Gideon Kowadlo Nathan E Hall Antony W Burgess

Growth Factors 2007 Jun;25(3):168-90

Ludwig Institute for Cancer Research, Tumor Biology Branch, Melbourne, Australia.

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http://dx.doi.org/10.1080/08977190701679772DOI Listing
June 2007

Mice lacking three myeloid colony-stimulating factors (G-CSF, GM-CSF, and M-CSF) still produce macrophages and granulocytes and mount an inflammatory response in a sterile model of peritonitis.

Authors:
Margaret L Hibbs Cathy Quilici Nicole Kountouri John F Seymour Jane E Armes Antony W Burgess Ashley R Dunn

J Immunol 2007 May;178(10):6435-43

Signal Transduction Laboratory, Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Victoria, and Department of Medicine, University of Melbourne, Parkville, Australia.

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May 2007

A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors.

Authors:
Andrew M Scott Fook-Thean Lee Niall Tebbutt Rebecca Herbertson Sanjeev S Gill Zhanqi Liu Effie Skrinos Carmel Murone Timothy H Saunder Bridget Chappell Anthony T Papenfuss Aurora M T Poon Wendie Hopkins Fiona E Smyth Duncan MacGregor Lawrence M Cher Achim A Jungbluth Gerd Ritter Martin W Brechbiel Roger Murphy Antony W Burgess Eric W Hoffman Terrance G Johns Lloyd J Old

Proc Natl Acad Sci U S A 2007 Mar 28;104(10):4071-6. Epub 2007 Feb 28.

Ludwig Institute for Cancer Research, 143-165 Studley Road, Heidelberg, Melbourne, Victoria 3084, Australia.

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http://dx.doi.org/10.1073/pnas.0611693104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805701PMC
March 2007

The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor AG1478 increases the formation of inactive untethered EGFR dimers. Implications for combination therapy with monoclonal antibody 806.

Authors:
Hui K Gan Francesca Walker Antony W Burgess Angela Rigopoulos Andrew M Scott Terrance G Johns

J Biol Chem 2007 Feb 8;282(5):2840-50. Epub 2006 Nov 8.

Oncogenic Signalling Laboratory, Ludwig Institute of Cancer Research, Austin Hospital, Level 6, Harold Stokes Building, Studley Road, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1074/jbc.M605136200DOI Listing
February 2007

Identification of a novel EGF-sensitive cell cycle checkpoint.

Authors:
Francesca Walker Hui-Hua Zhang Antony W Burgess

Exp Cell Res 2007 Feb 10;313(3):511-26. Epub 2006 Nov 10.

Ludwig Institute for Cancer Research, P.O Royal Melbourne Hospital, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1016/j.yexcr.2006.10.026DOI Listing
February 2007

In situ phosphorylation of immobilized receptors on biosensor surfaces: application to E-cadherin/beta-catenin interactions.

Authors:
Bruno Catimel Meredith Layton Nicole Church Janine Ross Melanie Condron Maree Faux Richard J Simpson Antony W Burgess Edouard C Nice

Anal Biochem 2006 Oct 11;357(2):277-88. Epub 2006 Aug 11.

Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Vic. 3052, Australia.

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http://dx.doi.org/10.1016/j.ab.2006.07.034DOI Listing
October 2006

Designing amino acid residues with single-conformations.

Authors:
Tran T Tran Herbert Treutlein Antony W Burgess

Protein Eng Des Sel 2006 Sep 24;19(9):401-8. Epub 2006 Jun 24.

Ludwig Institute for Cancer Research and Cooperative Research Centre for Cellular and Growth Factors, Melbourne, Victoria 3050, Australia.

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http://dx.doi.org/10.1093/protein/gzl024DOI Listing
September 2006

Purification and characterization of a high specificity polyclonal antibody to the adenomatous polyposis coli tumour suppressor protein.

Authors:
Bruno Catimel Edouard C Nice Maria Kärrlander Janine Ross Jenny Catimel Antony W Burgess Maree Faux

Biomed Chromatogr 2006 Jun-Jul;20(6-7):569-75

Ludwig Institute for Cancer Research, PO Royal Melbourne Hospital, Parkville, Victoria, Australia.

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http://doi.wiley.com/10.1002/bmc.648
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August 2006

Enhanced efficacy of radioimmunotherapy with 90Y-CHX-A''-DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478.

Authors:
Fook T Lee Angela J Mountain Marcus P Kelly Cathrine Hall Angela Rigopoulos Terrance G Johns Fiona E Smyth Martin W Brechbiel Edouard C Nice Antony W Burgess Andrew M Scott

Clin Cancer Res 2005 Oct;11(19 Pt 2):7080s-7086s

Tumour Targeting Program, Ludwig Institute for Cancer Research, Austin Hospital, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-1004-0019DOI Listing
October 2005

Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical epidermal growth factor receptor-specific antibody generates enhanced antitumor activity.

Authors:
Rushika M Perera Yoshitaka Narita Frank B Furnari Hui K Gan Carmel Murone Marika Ahlkvist Rodney B Luwor Antony W Burgess Elisabeth Stockert Achim A Jungbluth Lloyd J Old Webster K Cavenee Andrew M Scott Terrance G Johns

Clin Cancer Res 2005 Sep;11(17):6390-9

Ludwig Institute for Cancer Research, Melbourne Branch, Tumor Targeting Program, Austin Hospital, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-2653DOI Listing
September 2005

Ligand-induced dimer-tetramer transition during the activation of the cell surface epidermal growth factor receptor-A multidimensional microscopy analysis.

Authors:
Andrew H A Clayton Francesca Walker Suzanne G Orchard Christine Henderson Dominik Fuchs Julie Rothacker Edouard C Nice Antony W Burgess

J Biol Chem 2005 Aug 30;280(34):30392-9. Epub 2005 Jun 30.

Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Victoria 3050, Australia.

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http://dx.doi.org/10.1074/jbc.M504770200DOI Listing
August 2005

Fluorescence and analytical ultracentrifugation analyses of the interaction of the tyrosine kinase inhibitor, tyrphostin AG 1478-mesylate, with albumin.

Authors:
Andrew H A Clayton Matthew A Perugini Janet Weinstock Julie Rothacker Keith G Watson Antony W Burgess Edouard C Nice

Anal Biochem 2005 Jul;342(2):292-9

Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, P.O. Royal Melbourne Hospital, Parkville, Vic. 3050, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S000326970500297
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http://dx.doi.org/10.1016/j.ab.2005.04.002DOI Listing
July 2005

A phase I trial of humanized monoclonal antibody A33 in patients with colorectal carcinoma: biodistribution, pharmacokinetics, and quantitative tumor uptake.

Authors:
Andrew M Scott Fook-Thean Lee Robert Jones Wendie Hopkins Duncan MacGregor Jonathan S Cebon Anthony Hannah Geoffrey Chong Paul U Anthony Papenfuss Angela Rigopoulos Susan Sturrock Roger Murphy Veronika Wirth Carmel Murone Fiona E Smyth Simon Knight Sydney Welt Gerd Ritter Elizabeth Richards Edouard C Nice Antony W Burgess Lloyd J Old

Clin Cancer Res 2005 Jul;11(13):4810-7

Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-2329DOI Listing
July 2005

Phase I trial of 131I-huA33 in patients with advanced colorectal carcinoma.

Authors:
Geoffrey Chong Fook Thean Lee Wendie Hopkins Niall Tebbutt Jonathan S Cebon Angela J Mountain Bridget Chappell Anthony Papenfuss Paul Schleyer Paul U Roger Murphy Veronika Wirth Fiona E Smyth Nicole Potasz Aurora Poon Ian D Davis Tim Saunder Graeme J O'keefe Antony W Burgess Eric W Hoffman Lloyd J Old Andrew M Scott

Clin Cancer Res 2005 Jul;11(13):4818-26

Ludwig Institute for Cancer Research, Melbourne, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-2330DOI Listing
July 2005

The role of disulfide bonds in the structure and function of murine epidermal growth factor (mEGF).

Authors:
Dianne Alewood Kathy Nielsen Paul F Alewood David J Craik Peter Andrews Maureen Nerrie Sara White Teresa Domagala Francesca Walker Julie Rothacker Antony W Burgess Edouard C Nice

Growth Factors 2005 Jun;23(2):97-110

The Institute for Molecular Bioscience, The University of Queensland, Australia.

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http://www.tandfonline.com/doi/full/10.1080/0897719050009606
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http://dx.doi.org/10.1080/08977190500096061DOI Listing
June 2005

The antitumor monoclonal antibody 806 recognizes a high-mannose form of the EGF receptor that reaches the cell surface when cells over-express the receptor.

Authors:
Terrance G Johns Ira Mellman Glenn A Cartwright Gerd Ritter Lloyd J Old Antony W Burgess Andrew M Scott

FASEB J 2005 May 17;19(7):780-2. Epub 2005 Mar 17.

Ludwig Institute for Cancer Research, Tumour Targeting Program, Austin Hospital, Heidelberg, Australia.

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http://dx.doi.org/10.1096/fj.04-1766fjeDOI Listing
May 2005

The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR.

Authors:
Rodney B Luwor Hong-Jian Zhu Francesca Walker Angela A Vitali Rushika M Perera Antony W Burgess Andrew M Scott Terrance G Johns

Oncogene 2004 Aug;23(36):6095-104

Tumour Targeting Program, Ludwig Institute for Cancer Research, Melbourne Branch, Austin Hospital, Heidelberg 3084, Australia.

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http://dx.doi.org/10.1038/sj.onc.1207870DOI Listing
August 2004

Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor.

Authors:
Terrance G Johns Timothy E Adams Jennifer R Cochran Nathan E Hall Peter A Hoyne Mark J Olsen Yong-Sung Kim Julie Rothacker Edouard C Nice Francesca Walker Gerd Ritter Achim A Jungbluth Lloyd J Old Colin W Ward Antony W Burgess K Dane Wittrup Andrew M Scott

J Biol Chem 2004 Jul 9;279(29):30375-84. Epub 2004 Apr 9.

Tumour Targeting Program, Ludwig Institute for Cancer Research, Austin Hospital, Heidelberg 3084, Australia.

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http://www.jbc.org/content/early/2004/04/09/jbc.M401218200.f
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July 2004

CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor.

Authors:
Francesca Walker Suzanne G Orchard Robert N Jorissen Nathan E Hall Hui-Hua Zhang Peter A Hoyne Timothy E Adams Terrance G Johns Colin Ward Thomas P J Garrett Hong-Jian Zhu Maureen Nerrie Andrew M Scott Edouard C Nice Antony W Burgess

J Biol Chem 2004 May 11;279(21):22387-98. Epub 2004 Mar 11.

Ludwig Institute for Cancer Research, PO Royal Melbourne Hospital, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1074/jbc.M401244200DOI Listing
May 2004

Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion.

Authors:
Maree C Faux Janine L Ross Clare Meeker Terry Johns Hong Ji Richard J Simpson Meredith J Layton Antony W Burgess

J Cell Sci 2004 Jan 16;117(Pt 3):427-39. Epub 2003 Dec 16.

Ludwig Institute for Cancer Research, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1242/jcs.00862DOI Listing
January 2004

Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478.

Authors:
Terrance G Johns Rodney B Luwor Carmel Murone Francesca Walker Janet Weinstock Angela A Vitali Rushika M Perera Achim A Jungbluth Elisabeth Stockert Lloyd J Old Edouard C Nice Antony W Burgess Andrew M Scott

Proc Natl Acad Sci U S A 2003 Dec 15;100(26):15871-6. Epub 2003 Dec 15.

Ludwig Institute for Cancer Research, Austin Hospital, Studley Road, Heidelberg 3084, Australia.

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http://dx.doi.org/10.1073/pnas.2036503100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC307660PMC
December 2003

An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors.

Authors:
Antony W Burgess Hyun-Soo Cho Charles Eigenbrot Kathryn M Ferguson Thomas P J Garrett Daniel J Leahy Mark A Lemmon Mark X Sliwkowski Colin W Ward Shigeyuki Yokoyama

Mol Cell 2003 Sep;12(3):541-52

Cooperative Research Centre for Cellular Growth Factors, P.O. Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia.

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September 2003

Epidermal growth factor receptor: mechanisms of activation and signalling.

Authors:
Robert N Jorissen Francesca Walker Normand Pouliot Thomas P J Garrett Colin W Ward Antony W Burgess

Exp Cell Res 2003 Mar;284(1):31-53

Ludwig Institute for Cancer Research, Parkville, Victoria, Australia.

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March 2003

Epidermal growth factor receptor: association of extracellular domain negatively regulates intracellular kinase activation in the absence of ligand.

Authors:
Hong-Jian Zhu Josephine Iaria Suzanne Orchard Francesca Walker Antony W Burgess

Growth Factors 2003 Mar;21(1):15-30

Ludwig Institute for Cancer Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia.

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March 2003

The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors.

Authors:
Thomas P J Garrett Neil M McKern Meizhen Lou Thomas C Elleman Timothy E Adams George O Lovrecz Michael Kofler Robert N Jorissen Edouard C Nice Antony W Burgess Colin W Ward

Mol Cell 2003 Feb;11(2):495-505

Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, 3050, Parkville, Victoria, Australia.

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February 2003

The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants.

Authors:
Thao V Nheu Hong He Yumiko Hirokawa Kazuhiko Tamaki Lore Florin M Lienhard Schmitz Ikuko Suzuki-Takahashi Robert N Jorissen Antony W Burgess Susumu Nishimura John Wood Hiroshi Maruta

Cancer J 2002 Jul-Aug;8(4):328-36

Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Australia.

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January 2003

Cytokine enhancement of in vitro antibody-dependent cellular cytotoxicity mediated by chimeric anti-GD3 monoclonal antibody KM871.

Authors:
Zhanqi Liu Fook-Thean Lee Nobuo Hanai Fiona E Smyth Antony W Burgess Lloyd J Old Andrew M Scott

Cancer Immun 2002 Oct 7;2:13. Epub 2002 Oct 7.

Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Austin and Repatriation Medical Centre, Heidelberg, Victoria, 3084, Australia.

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October 2002

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha.

Authors:
Thomas P J Garrett Neil M McKern Meizhen Lou Thomas C Elleman Timothy E Adams George O Lovrecz Hong-Jian Zhu Francesca Walker Morry J Frenkel Peter A Hoyne Robert N Jorissen Edouard C Nice Antony W Burgess Colin W Ward

Cell 2002 Sep;110(6):763-73

Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Parkville, 3050, Victoria, Australia.

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September 2002

Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.

Authors:
Yu Wang Ke-Jun Han Xue-Wen Pang Hilary A Vaughan Wei Qu Xue-Yuan Dong Ji-Run Peng Hai-Tao Zhao Jing-An Rui Xi-Sheng Leng Jonathan Cebon Antony W Burgess Wei-Feng Chen

J Immunol 2002 Jul;169(2):1102-9

Immunology Department, School of Basic Medical Science, Peking University Health Science Center, Beijing, China.

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July 2002

Modeling the epidermal growth factor -- epidermal growth factor receptor l2 domain interaction: implications for the ligand binding process.

Authors:
Robert N Jorissen Herbert R Treutlein V Chandana Epa Antony W Burgess

J Biomol Struct Dyn 2002 Jun;19(6):961-72

The Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia.

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http://www.tandfonline.com/doi/full/10.1080/07391102.2002.10
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http://dx.doi.org/10.1080/07391102.2002.10506800DOI Listing
June 2002

Effects of thioamide substitutions on the conformation and stability of alpha- and 3(10)-helices.

Authors:
Tran Trung Tran Jun Zeng Herbert Treutlein Antony W Burgess

J Am Chem Soc 2002 May;124(18):5222-30

Ludwig Institute for Cancer Research and Cooperative Research Centre for Cellular and Growth Factors, Melbourne, Victoria, 3050, Australia.

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May 2002

Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene.

Authors:
Terrance G Johns Elisabeth Stockert Gerd Ritter Achim A Jungbluth H-J Su Huang Webster K Cavenee Fiona E Smyth Cathrine M Hall Nadine Watson Edouard C Nice William J Gullick Lloyd J Old Antony W Burgess Andrew M Scott

Int J Cancer 2002 Mar;98(3):398-408

Tumour Targeting Program, Ludwig Institute for Cancer Research, Melbourne, Australia.

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March 2002