Publications by authors named "Antonios Athanasiou"

101 Publications

Is apex beat a reliable diagnostic tool of left atrial enlargement?

J Cardiol 2021 Apr 6. Epub 2021 Apr 6.

Department of Anatomy, National and Kapodistrian University of Athens, Medical School, Athens, Greece.

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http://dx.doi.org/10.1016/j.jjcc.2021.03.011DOI Listing
April 2021

Letter Regarding: The Effects of Platelet-Rich Plasma to Decrease the Risk of Seroma Formation after Mastectomy and Axillary Dissection.

J Surg Res 2021 03 7;259:576-577. Epub 2020 Nov 7.

Department of Anatomy, National and Kapodistrian University of Athens, Athens, Medical School, Athens, Greece.

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http://dx.doi.org/10.1016/j.jss.2020.09.041DOI Listing
March 2021

Comment on "Are We Harming Cancer Patients by Delaying Their Cancer Surgery During the COVID-19 Pandemic?"

Ann Surg 2020 Oct 15. Epub 2020 Oct 15.

St. James' University Hospital, Leeds Teaching Hospitals NHS Trust, Department of Upper GI, Bariatric & Minimally invasive Surgery, Leeds, UK Laboratory of Experimental Surgery and Surgical Research, University of Athens, Medical School, Ag. Thoma 15B, 11527, Athens, Greece Laboratory of Experimental Surgery and Surgical Research, University of Athens, Medical School, Ag. Thoma 15B, 11527, Athens, Greece.

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http://dx.doi.org/10.1097/SLA.0000000000004542DOI Listing
October 2020

Captopril versus atenolol to prevent expansion rate of thoracic aortic aneurysms: rationale and design.

Future Cardiol 2021 Mar 25;17(2):189-195. Epub 2020 Aug 25.

1st Department of Cardiology, Hippokration Hospital, National & Kapodistrian University of Athens, Medical School, Athens, Greece.

Thoracic aortic aneurysms are correlated with significant mortality and morbidity. No therapy, however, is effective at limiting aneurysm expansion and preventing rupture. Angiotensin-converting enzyme inhibitors can reduce the wall shear stress and inflammation, both of which play vital roles in the expansion of the aneurysm. A total of 636 patients will be randomized into one of three parallel arms, receiving captopril, atenolol or placebo. The primary end point will be the rate of change in the absolute diameter of the aortic root and ascending aorta on MRI of the aorta after 36 months. The trial will investigate the efficacy of angiotensin-converting enzyme inhibitors versus beta-blocker therapy in reducing the growth rate of thoracic aortic aneurysms and rupture. NCT04224675.
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http://dx.doi.org/10.2217/fca-2020-0062DOI Listing
March 2021

Bisphenol-A and polycystic ovary syndrome: a review of the literature.

Rev Environ Health 2020 Nov 14;35(4):323-331. Epub 2020 Jul 14.

Department of Metabolism, Digestion and Reproduction and Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age with reproductive, metabolic and endocrine implications. While the exact pathophysiological mechanisms of the syndrome are unknown, its heterogeneity suggests a multifactorial causal background. In the last two decades, numerous environmental chemicals, including Bisphenol-A (BPA) that is used in the synthesis of polycarbonate plastics, have been proposed as potential contributors to the aetiology of PCOS. This review provides a holistic overview of the available data regarding the possible relation of PCOS with BPA exposure. We have included a total number of 24 studies. Eleven human case-control and 13 animal studies provided data regarding this potential relation. Accumulating evidence suggests that a correlation between high levels of BPA and the presence of PCOS may exist. Contradicting results from human and animal studies, however, render it difficult to conclude on the exact role of BPA in the pathogenesis of PCOS. BPA may constitute a consequence of the syndrome rather than a cause, but further research is still needed to clarify this. Continued efforts to study the early origins of PCOS, using prospective-designed studies, are required to identify the exact effect of BPA on women with PCOS.
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http://dx.doi.org/10.1515/reveh-2020-0032DOI Listing
November 2020

Prasugrel in the treatment of acute coronary syndrome.

Future Cardiol 2020 11 11;16(6):559-568. Epub 2020 May 11.

Division of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece.

Dual antiplatelet therapy is the mainstay therapy in patients with acute coronary syndrome. The combination of aspirin and a P2Y12 inhibitor in patients who receive a coronary stent reduces the rate of stent thrombosis and the rates of major adverse cardiovascular events. The newer P2Y12 inhibitors (prasugrel and ticagrelor) have better efficacy than clopidogrel. Prasugrel provides greater inhibition of platelet aggregation and has a rapid onset of action. Current acute coronary syndrome guidelines recommend the use of both newer P2Y12 inhibitors. However, emerging data have shown that prasugrel is more efficient than ticagrelor in reducing the incidence of nonfatal myocardial infarction, stroke or cardiovascular death, without increased risk of major bleeding.
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http://dx.doi.org/10.2217/fca-2020-0018DOI Listing
November 2020

Cervical Pathology Following HPV Vaccination in Greece: A 10-year HeCPA Observational Cohort Study.

In Vivo 2020 May-Jun;34(3):1445-1449

Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, U.K.

Background: In Greece the population-level impact of HPV vaccination is unknown due to lack of official registries. This study presents in a pragmatic frame the comparison of cervical pathology data between HPV-vaccinated and unvaccinated women referred for colposcopy.

Patients And Methods: This is an observational prospective cohort study performed in 7 academic Obstetrics and Gynaecology Departments across Greece between 2009-2019. Cases were women that had completed HPV vaccination before coitarche and were referred for colposcopy due to abnormal cytology. For each vaccinated woman an unvaccinated matched control was selected.

Results: A total of 849 women who had been vaccinated before coitarche and 849 unvaccinated controls were recruited. The combination of cytological, colposcopic and molecular findings necessitated treatment in only a single case among vaccinated (0.1%) and in 8.4% among unvaccinated.

Conclusion: HPV vaccination at a proper age can markedly reduce development of severe cervical precancers and consequently the need for treatment, as well as their long-term related obstetrical morbidity.
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http://dx.doi.org/10.21873/invivo.11927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279786PMC
February 2021

Is the clinical benefit of implantable cardioverter-defibrillators in heart failure patients declining?

J Cardiol 2020 05 27;75(5):583-584. Epub 2020 Feb 27.

1st Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.

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http://dx.doi.org/10.1016/j.jjcc.2020.02.002DOI Listing
May 2020

Diaphragmatic hernia following esophagectomy for esophageal cancer: A systematic review.

J BUON 2019 Sep-Oct;24(5):1793-1800

Department of Surgery, Mercy University Hospital, Cork, Ireland.

Purpose: Diaphragmatic hernia following an esophagectomy for esophageal cancer (EC) can be both an early and late complication. The esophageal hiatus within the diaphragm is disrupted during the operation. However, the incidence of Post-Esophagectomy Diaphragmatic Hernia (PEDH) is unknown. PEDH can be life-threatening and surgical treatment is challenging. However, all PEDH do not require surgery. The rate of EC diagnosis is rising. Therefore, esophageal surgery, particularly esophagectomy, is gradually increasing. Undoubtedly, the numbers of PEDH increase as well.

Methods: This review describes the presentation and diagnosis of PEDH after surgery for esophageal malignancy, as well as the management options for PEDH.

Results: Fifteen papers regarding PEDH have been published. There are many different surgical approaches to complete an esophagectomy, while there are different approaches to repair PEDH.

Conclusion: Upper GI surgeons need to have an index of suspicion for PEDH. They must investigate and operate these patients if this complication develops, since an immediate surgery has a high mortality and poor outcome.
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April 2020

Comparative fertility and pregnancy outcomes after local treatment for cervical intraepithelial neoplasia and stage 1a1 cervical cancer: protocol for a systematic review and network meta-analysis from the CIRCLE group.

BMJ Open 2019 10 21;9(10):e028009. Epub 2019 Oct 21.

Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Institute of Reproductive and Developmental Biology, London, UK

Introduction: There are several local treatment methods for cervical intraepithelial neoplasia that remove or ablate a cone-shaped part of the uterine cervix. There is evidence to suggest that these increase the risk of preterm birth (PTB) and that this is higher for techniques that remove larger parts of the cervix, although the data are conflicting. We present a protocol for a systematic review and network meta-analysis (NMA) that will update the evidence and compare all treatments in terms of fertility and pregnancy complications.

Methods And Analysis: We will search electronic databases (CENTRAL, MEDLINE, EMBASE) from inception till October 2019, in order to identify randomised controlled trials (RCTs) and cohort studies comparing the fertility and pregnancy outcomes among different excisional and ablative treatment techniques and/or to untreated controls. The primary outcome will be PTB (<37 weeks). Secondary outcomes will include severe or extreme PTB, prelabour rupture of membranes, low birth weight (<2500 g), neonatal intensive care unit admission, perinatal mortality, total pregnancy rates, first and second trimester miscarriage. We will search for published and unpublished studies in electronic databases, trial registries and we will hand-search references of published papers. We will assess the risk of bias in RCTs and cohort studies using tools developed by the Cochrane collaboration. Two investigators will independently assess the eligibility, abstract the data and assess the risk of bias of the identified studies. For each outcome, we will perform a meta-analysis for each treatment comparison and an NMA once the transitivity assumption holds, using the OR for dichotomous data. We will use CINeMA (Confidence in Network meta-analysis) to assess the quality of the evidence for the primary outcome.

Ethics And Dissemination: Ethical approval is not required. Results will be disseminated to academic beneficiaries, medical practitioners, patients and the public.

Prospero Registration Number: CRD42018115495.
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http://dx.doi.org/10.1136/bmjopen-2018-028009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803140PMC
October 2019

Endothelium in Aortic Aneurysm Disease: New Insights.

Curr Med Chem 2020 ;27(7):1081-1088

Laboratory of Experimental Surgery and Surgical Research, University of Athens, Medical School, Athens, Greece.

Inflammation is recognized as a fundamental element in the development and growth of aortic aneurysms. Aortic aneurysm is correlated with aortic wall deformities and injury, as a result of inflammation, matrix metalloproteinases activation, oxidative stress, and apoptosis of vascular smooth muscle cells. The endothelial wall has a critical part in the inflammation of the aorta and endothelial heterogeneity has proven to be significant for modeling aneurysm formation. Endothelial shear stress and blood flow affect the aortic wall through hindrance of cytokines and adhesion molecules excreted by endothelial cells, causing reduction of the inflammation process in the media and adventitia. This pathophysiological process results in the disruption of elastic fibers, degradation of collagen fibers, and destruction of vascular smooth muscle cells. Consequently, the aortic wall is impaired due to reduced thickness, decreased mechanical function, and cannot tolerate the impact of blood flow leading to aortic expansion. Surgery is still considered the mainstay therapy for large aortic aneurysms. The prevention of aortic dilation, though, is based on the hinderance of endothelial dysregulation with drugs, the reduction of reactive oxygen and nitrogen species, and also the reduction of pro-inflammatory molecules and metalloproteinases. Further investigations are required to enlighten the emerging role of endothelial cells in aortic disease.
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http://dx.doi.org/10.2174/0929867326666190923151959DOI Listing
April 2020

The Role of the Endothelium in Premature Atherosclerosis: Molecular Mechanisms.

Curr Med Chem 2020 ;27(7):1041-1051

Division of Cardiology, Onassis Cardiac Surgery Center, 17674 Athens, Greece.

Atherosclerotic disease is still one of the leading causes of mortality. Atherosclerosis is a complex progressive and systematic artery disease that involves the intima of the large and middle artery vessels. The inflammation has a key role in the pathophysiological process of the disease and the infiltration of the intima from monocytes, macrophages and T-lymphocytes combined with endothelial dysfunction and accumulated oxidized low-density lipoprotein (LDL) are the main findings of atherogenesis. The development of atherosclerosis involves multiple genetic and environmental factors. Although a large number of genes, genetic polymorphisms, and susceptible loci have been identified in chromosomal regions associated with atherosclerosis, it is the epigenetic process that regulates the chromosomal organization and genetic expression that plays a critical role in the pathogenesis of atherosclerosis. Despite the positive progress made in understanding the pathogenesis of atherosclerosis, the knowledge about the disease remains scarce.
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http://dx.doi.org/10.2174/0929867326666190911141951DOI Listing
April 2020

Erratum to "Proportion of cervical excision for cervical intraepithelial neoplasia as a predictor of pregnancy outcomes"[Int J Gynecol Obstet 128(2015) 141-147].

Int J Gynaecol Obstet 2019 Sep 19;146(3):392. Epub 2019 Jul 19.

Department of Obstetrics and Gynecology-Gynecological Oncology, University Hospital of Ioannina, Ioannina, Greece.

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http://dx.doi.org/10.1002/ijgo.12905DOI Listing
September 2019

Comparative efficacy and complication rates after local treatment for cervical intraepithelial neoplasia and stage 1a1 cervical cancer: protocol for a systematic review and network meta-analysis from the CIRCLE Group.

BMJ Open 2019 08 2;9(8):e028008. Epub 2019 Aug 2.

Department of Surgery and Cancer, Faculty of Medicine, Institute of Reproductive and Developmental Biology, Imperial College London, London, UK

Introduction: Local treatments for cervical intraepithelial neoplasia (CIN) and microinvasive disease remove or ablate a cone-shaped part of the uterine cervix containing the abnormal cells. A trend toward less radical techniques has raised concerns that this may adversely impact the rates of precancerous and cancerous recurrence. However, there has been no strong evidence to support such claims. We hereby describe a protocol of a systematic review and network meta-analysis that will update the evidence and compare all relevant treatments in terms of efficacy and complications.

Methods And Analysis: Literature searches in electronic databases (CENTRAL, MEDLINE, EMBASE) or trial registries will identify published and unpublished randomised controlled trials (RCTs) and cohort studies comparing the efficacy and complications among different excisional and ablative techniques. The excisional techniques include cold knife, laser or Fischer cone, large loop or needle excision of the transformation zone and the ablative radical point diathermy, cryotherapy, cold coagulation or laser ablation. The primary outcome will be residual/recurrent disease defined as abnormal histology or cytology of any grade, while secondary outcomes will include treatment failure rates defined as high-grade histology or cytology, histologically confirmed CIN1+ or histologically confirmed CIN2+, human papillomavirus positivity rates, involved margins rates, bleeding and cervical stenosis rates. We will assess the risk of bias in RCTs and observational studies using tools developed by the Cochrane Collaboration. Two authors will independently assess study eligibility, abstract the data and assess the risk of bias. Random-effects meta-analyses and network meta-analyses will be conducted using the OR for dichotomous outcomes and the mean difference for continuous outcomes. The quality of the evidence for the primary outcome will be assessed using the CINeMA (Confidence In Network Meta-Analysis) tool.

Ethics And Dissemination: Ethical approval is not required. We will disseminate findings to clinicians, policy-makers, patients and the public.

Prospero Registration Number: CRD42018115508.
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http://dx.doi.org/10.1136/bmjopen-2018-028008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687014PMC
August 2019

Prognostic Value of Subcarinal Lymph Nodes in Minimally Invasive Esophagectomy for Cancer.

Anticancer Res 2019 Aug;39(8):4291-4295

Regional Esophahagogastric Centre, Department of Upper Gastrointestinal Surgery, Broomfield Hospital, Mid Essex Hospital Services NHS Trust, Chelmsford, U.K.

Background/aim: Surgical resection for esophageal cancer has remained the gold-standard therapy provided worldwide. Subcarinal lymph-nodes are classified as peri-esophageal nodes and their dissection may be performed during a 2- or 3-stage esophagectomy. The necessity and prognostic value of subcarinal lymphadenectomy is still debatable. The purpose of this study was to investigate the rate of invaded subcarinal lymph-nodes out of the total lymph-nodes resected. Detection of invaded nodes was correlated with clinical staging and tumor differentiation.

Patients And Methods: This is a retrospective analysis of consecutive esophagectomies for cancer, performed in a UK tertiary center. The study was conducted over a 3-year period.

Results: The rate of subcarinal lymph-node invasion was extremely low according to the results of our analysis.

Conclusion: Lymphadenectomy is not devoid of clinical impact on patients and therefore, the decision should actually be the outcome of a dynamic balance between complications and survival benefit.
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http://dx.doi.org/10.21873/anticanres.13594DOI Listing
August 2019

Post-thyroidectomy Hypocalcemia in Patients With History of Bariatric Operations: Current Evidence and Management Options.

In Vivo 2019 Jul-Aug;33(4):1373-1379

Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, National and Kapodistrian University of Athens, Medical School, Athens, Greece.

Background/aim: Both bariatric and thyroid surgeries promote calcium and vitamin D deficiency. The correlation, however, of hypocalcemia after thyroidectomy in patients with previous bariatric surgery has been poorly described. This review aimed to investigate the relationship between history of bariatric operations and post-thyroidectomy hypocalcemia, as well as suggested management options.

Materials And Methods: MEDLINE and Cochrane databases were searched for relevant publications regarding post-thyroidectomy hypocalcemia in patients with previous bariatric surgery.

Results: A total of 17 publications reporting on 126 patients met the inclusion criteria. These included 13 publications about Roux-en-Y gastric bypass (RYGB), 2 regarding biliopancreatic diversion (BPD), 1 about sleeve gastrectomy (SG) and 1 compared three bariatric procedures: SG, RYGB, laparoscopic adjustable gastric band (LAGB). Post-thyroidectomy hypocalcemia was found to be more prevalent in patients with previous RYGB and BPD, but not in previous LAGB and SG.

Conclusion: Patients with previous bariatric surgery are at high risk of post-thyroidectomy hypocalcemia that sometimes leads to higher length of hospital stay and demands more invasive solutions. There is a need, however, for additional studies and further investigation in order to reach more conclusive results.
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http://dx.doi.org/10.21873/invivo.11614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689337PMC
December 2019

Efficacy of cryoablation for paroxysmal and persistent atrial fibrillation in patients with structural heart disease.

J Cardiol 2019 12 27;74(6):543. Epub 2019 Jun 27.

1(st) Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.

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http://dx.doi.org/10.1016/j.jjcc.2019.05.016DOI Listing
December 2019

Minimally invasive surgical management of spontaneous esophageal perforation (Boerhaave's syndrome).

Surg Endosc 2019 10 29;33(10):3494-3502. Epub 2019 May 29.

Department of Surgery, Mercy University Hospital, Cork, Ireland.

Background: Spontaneous esophageal perforation (Boerhaave's syndrome) is a highly morbid condition traditionally associated with poor outcomes. The Pittsburgh perforation severity score (PSS) accurately predicts risk of morbidity, length of stay (LOS) and mortality. Operative management is indicated among patients with medium (3-5) or high (> 5) PSS; however, the role of minimally invasive surgery remains uncertain.

Methods: Consecutive patients presenting with Boerhaave's syndrome with intermediate or high PSS managed via a thoracoscopic and laparoscopic approach from 2012 to 2018 were reviewed. Demographics, clinical presentation, management, and outcomes were analyzed.

Results: Ten patients (80% male) with a mean age of 61.3 years (range 37-81) were included. Two patients had intermediate and eight had high PSS (7.9 ± 2.8, range 4-12). The mean time from onset of symptoms to diagnosis was 27 ± 12 h and APACHE II score was 13.6 ± 4.9. Thoracoscopic debridement and primary repair was performed in eight cases, with two perforations repaired primarily over a T-tube. Laparoscopic feeding jejunostomy was performed in all patients. Critical care LOS was 8.7 ± 6.8 days (range 3-26), while inpatient LOS was 23.1 ± 12.5 days (range 14-46). Mean comprehensive complications index was 42.1 ± 26.2, with grade IIIa and IV morbidity in 60% and 10%, respectively. One patient developed dehiscence at the primary repair, which was managed non-operatively. In-hospital and 90-day mortality was 10%.

Conclusion: Minimally invasive surgical management of spontaneous esophageal perforation with medium to high perforation severity scores is feasible and safe, with outcomes which compare favorably to the published literature.
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http://dx.doi.org/10.1007/s00464-019-06863-2DOI Listing
October 2019

Prehabilitation for Patients With Esophageal Cancer During Neoadjuvant Treatment and Surgery.

J Surg Res 2019 10 3;242:1-2. Epub 2019 May 3.

Department of Upper GI, Bariatric & Minimally invasive Surgery, St. James' University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2019.04.022DOI Listing
October 2019

Conduit necrosis following esophagectomy: An up-to-date literature review.

World J Gastrointest Surg 2019 Mar;11(3):155-168

Department of Upper Gastrointestinal Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, United Kingdom.

Esophageal conduit ischaemia and necrosis is an uncommon but devastating complication of esophagectomy and remains one of the most challenging issues in surgical practice. The incidence, time interval to develop symptoms, and clinical presentation are highly variable with no predictable pattern. Evidence comes from case reports and case series rather than randomized controlled trials. We describe the issues surrounding conduit necrosis affecting the stomach, jejunum and colon as an esophageal replacement and the advantages, disadvantages and challenges of each type of reconstruction. Diagnosis is challenging for the most experienced surgeon. Upper gastrointestinal endoscopy and computed tomography thorax with both oral and intravenous contrast is the gold standard. Management, either conservative or interventional is also a difficult decision. Management options include conservative treatment and more aggressive treatments such as stent insertion, surgical debridement and repair of the esophagus using jejunum, colon or a musculocutaneous flap. In spite of recent advances in surgical techniques, there is no reliable strategy to manage esophageal conduit necrosis. Our review covers the pathophysiology and clinical significance of esophageal necrosis while highlighting current techniques of prevention, diagnosis and treatment of this life-threatening condition.
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http://dx.doi.org/10.4240/wjgs.v11.i3.155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478597PMC
March 2019

Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer.

N Engl J Med 2019 04;380(17):e28

University of Athens Medical School, Athens, Greece.

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http://dx.doi.org/10.1056/NEJMc1901650DOI Listing
April 2019

Management of oesophageal perforation based on the Pittsburgh Perforation Severity Score: still a matter of debate.

Eur J Cardiothorac Surg 2020 01;57(1):198

Department of Upper Gastrointestinal Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

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http://dx.doi.org/10.1093/ejcts/ezz061DOI Listing
January 2020

Obesity Paradox in Esophageal Cancer: Fashion or Reality?

Ann Thorac Surg 2019 02 27;107(2):686-687. Epub 2018 Sep 27.

Upper Gastrointestinal Unit, Department of Surgery, Broomfield Hospital, Chelmsford, United Kingdom.

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http://dx.doi.org/10.1016/j.athoracsur.2018.07.071DOI Listing
February 2019

Platelets-to-lymphocyte ratio and esophageal cancer.

J Thorac Dis 2018 Aug;10(8):E650-E651

Laboratory of Experimental Surgery and Surgical Research, University of Athens, Medical School, Athens, Greece.

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http://dx.doi.org/10.21037/jtd.2018.07.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129936PMC
August 2018

Transperitoneal Extraperitoneal Laparoscopic Lymphadenectomy for Gynecological Malignancies: A Systematic Review and Meta-analysis.

Anticancer Res 2018 Aug;38(8):4677-4681

Laboratory of Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Background/aim: Para-aortic lymphadenectomy is established as a standard procedure for disease staging and management of patients with advanced cervical, ovarian and high-risk endometrial cancer. Our meta-analysis accumulated the current evidence on the impact of transperitoneal (TLL) and extraperitoneal (ELL) laparoscopic lymphadenectomy for the management of patients with gynecological malignancies.

Materials And Methods: A systematic search of the literature was undertaken for articles published up to April 2018. Statistical meta-analysis was performed using the RevMan 5.3 software.

Results: Seven studies were eligible for meta-analysis and comprised a total of 608 women. ELL was associated with significantly shorter operative times for lymphadenectomy, whereas total operative times were not different between the two groups. Significantly increased intraoperative complications were found in the TLL group.

Conclusion: ELL is safe and efficient with outcomes comparable to TLL in terms of lymph node yield and improved operative outcomes with regard to lymphadenectomy times and intraoperative complications.
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http://dx.doi.org/10.21873/anticanres.12773DOI Listing
August 2018

Prognostic value of platelet-to-lymphocyte ratio in oncologic outcomes of esophageal cancer: what should we expect from a meta-analysis?

Int J Biol Markers 2018 Nov 9;33(4):551-552. Epub 2018 Jul 9.

Laboratory of Experimental Surgery and Surgical Research, University of Athens, Medical School, Athens, Greece.

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http://dx.doi.org/10.1177/1724600818785128DOI Listing
November 2018

Comment on "Establishing a Porcine Model of Small for Size Syndrome following Liver Resection".

Can J Gastroenterol Hepatol 2018 22;2018:4915817. Epub 2018 May 22.

First Surgery Department, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

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http://dx.doi.org/10.1155/2018/4915817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987303PMC
October 2018

Safety concerns regarding ablative radiotherapy for ventricular tachycardia.

Radiother Oncol 2018 08 21;128(2):387. Epub 2018 Jun 21.

Laboratory of Experimental Surgery and Surgical Research, University of Athens Medical School, Greece.

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http://dx.doi.org/10.1016/j.radonc.2018.06.009DOI Listing
August 2018

The role of multidetector CT angiography and 3D postprocessing imaging in the diagnosis and investigation of bronchopulmonary sequestration.

Clin Case Rep 2018 03 31;6(3):545-546. Epub 2018 Jan 31.

Department of Thoracic Surgery "Attikon" Hospital Athens Medical School Athens Greece.

Congenital bronchopulmonary malformations are usually asymptomatic. Precise multimodality imaging plays an essential role in the identification of rare cardiothoracic entities, offering excellent imaging quality and the decisive diagnosis.
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http://dx.doi.org/10.1002/ccr3.1394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838274PMC
March 2018