Antonio Simeone

Antonio Simeone

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Antonio Simeone

Antonio Simeone

Publications by authors named "Antonio Simeone"

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OTX2 restricts entry to the mouse germline.

Nature 2018 10 3;562(7728):595-599. Epub 2018 Oct 3.

MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, Scotland.

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http://www.nature.com/articles/s41586-018-0581-5
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http://dx.doi.org/10.1038/s41586-018-0581-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485399PMC
October 2018

Functional Antagonism between OTX2 and NANOG Specifies a Spectrum of Heterogeneous Identities in Embryonic Stem Cells.

Stem Cell Reports 2017 11 19;9(5):1642-1659. Epub 2017 Oct 19.

Institute of Genetics and Biophysics "Adriano Buzzati-Traverso", CNR, Via P. Castellino,111, 80131 Naples, Italy; IRCCS Neuromed, 86077 Pozzilli, IS, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22136711173042
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http://dx.doi.org/10.1016/j.stemcr.2017.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935799PMC
November 2017

Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast.

Cell Rep 2016 06 9;15(12):2651-64. Epub 2016 Jun 9.

Institute of Genetics and Biophysics "Adriano Buzzati-Traverso," CNR, Via P. Castellino 111, 80131 Naples, Italy; IRCCS Neuromed, 86077 Pozzilli (IS), Italy. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.05.041DOI Listing
June 2016

FGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellum.

PLoS One 2014 1;9(7):e101124. Epub 2014 Jul 1.

Institute of Developmental Genetics, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Neuherberg, Germany; Technische Universität München-Weihenstephan, Lehrstuhl für Entwicklungsgenetik c/o Helmholtz Zentrum München, Neuherberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101124PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077754PMC
December 2015

Mitochondrial Protection by Exogenous Otx2 in Mouse Retinal Neurons.

Cell Rep 2015 Nov 22;13(5):990-1002. Epub 2015 Oct 22.

Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.09.075DOI Listing
November 2015

A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice.

Neurobiol Dis 2015 Oct 3;82:32-45. Epub 2015 Jun 3.

Institute of Developmental Genetics, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany; Technische Universität München-Weihenstephan, Lehrstuhl für Entwicklungsgenetik c/o Helmholtz Zentrum München, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09699961150018
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http://dx.doi.org/10.1016/j.nbd.2015.05.015DOI Listing
October 2015

Sox6 and Otx2 control the specification of substantia nigra and ventral tegmental area dopamine neurons.

Cell Rep 2014 Aug 7;8(4):1018-25. Epub 2014 Aug 7.

Ludwig Institute for Cancer Research, 17177 Stockholm, Sweden; Department of Cell and Molecular Biology, Karolinska Institutet, 17177 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.07.016DOI Listing
August 2014

Reorganization of enhancer patterns in transition from naive to primed pluripotency.

Cell Stem Cell 2014 Jun;14(6):838-53

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491504PMC
June 2014

Graded Otx2 activities demonstrate dose-sensitive eye and retina phenotypes.

Hum Mol Genet 2014 Apr 13;23(7):1742-53. Epub 2013 Nov 13.

Collège de France, Center for Interdisciplinary Research in Biology, UMR CNRS 7241/INSERM U1050, 11 place Marcelin Berthelot, Paris 75005, France.

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http://dx.doi.org/10.1093/hmg/ddt562DOI Listing
April 2014

Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity.

Development 2014 Jan 11;141(2):377-88. Epub 2013 Dec 11.

Institute of Genetics and Biophysics "Adriano Buzzati-Traverso", CNR, Via P. Castellino 111, 80131 Naples, Italy.

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http://dx.doi.org/10.1242/dev.102954DOI Listing
January 2014

The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord.

PeerJ 2013 29;1:e142. Epub 2013 Aug 29.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université de Strasbourg, Illkirch Cedex, France.

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http://dx.doi.org/10.7717/peerj.142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757465PMC
September 2013

Embryonic defects and growth alteration in mice with homozygous disruption of the Patz1 gene.

J Cell Physiol 2013 Mar;228(3):646-53

Istituto di Endocrinologia ed Oncologia Sperimentale del CNR and Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Naples, Italy.

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http://dx.doi.org/10.1002/jcp.24174DOI Listing
March 2013

The transcription factor Otx2 regulates choroid plexus development and function.

Development 2013 Mar 30;140(5):1055-66. Epub 2013 Jan 30.

Helmholtz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research, Neuherberg, 85764 Munich, Germany.

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http://dx.doi.org/10.1242/dev.090860DOI Listing
March 2013

Otx2 selectively controls the neurogenesis of specific neuronal subtypes of the ventral tegmental area and compensates En1-dependent neuronal loss and MPTP vulnerability.

Dev Biol 2013 Jan 29;373(1):176-83. Epub 2012 Oct 29.

CEINGE Biotecnologie Avanzate and SEMM European School of Molecular Medicine-Naples site, Via Gaetano Salvatore 486, 80145 Naples, Italy.

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http://dx.doi.org/10.1016/j.ydbio.2012.10.022DOI Listing
January 2013

Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition.

Development 2013 Jan 15;140(1):43-55. Epub 2012 Nov 15.

CEINGE Biotecnologie Avanzate, Via G. Salvatore 486, 80145 Naples, Italy.

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http://dx.doi.org/10.1242/dev.085290DOI Listing
January 2013

Otx genes in neurogenesis of mesencephalic dopaminergic neurons.

Dev Neurobiol 2011 Aug;71(8):665-79

CEINGE Biotecnologie Avanzate, SEMM European School of Molecular Medicine, via Gaetano Salvatore 486, 80145 Naples, Italy.

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http://dx.doi.org/10.1002/dneu.20877DOI Listing
August 2011

The role of otx2 in adult mesencephalic-diencephalic dopaminergic neurons.

Mol Neurobiol 2011 Apr 18;43(2):107-13. Epub 2010 Nov 18.

CEINGE Biotecnologie Avanzate, and SEMM European School of Molecular Medicine, Via Comunale Margherita 482, 80145, Naples, Italy.

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http://link.springer.com/content/pdf/10.1007/s12035-010-8148
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http://link.springer.com/10.1007/s12035-010-8148-y
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http://dx.doi.org/10.1007/s12035-010-8148-yDOI Listing
April 2011

Fgf15-mediated control of neurogenic and proneural gene expression regulates dorsal midbrain neurogenesis.

Dev Biol 2011 Feb 21;350(2):496-510. Epub 2010 Dec 21.

Institute of Developmental Genetics, Helmholtz Centre Munich, Technical University Munich, Neuherberg, Germany.

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http://dx.doi.org/10.1016/j.ydbio.2010.12.017DOI Listing
February 2011

Bmp5/7 in concert with the mid-hindbrain organizer control development of noradrenergic locus coeruleus neurons.

Mol Cell Neurosci 2010 Sep 21;45(1):1-11. Epub 2010 May 21.

Zlotowski Center for Neuroscience, Department of Morphology, Division of Basic Sciences, Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er Sheva, Israel.

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http://dx.doi.org/10.1016/j.mcn.2010.05.003DOI Listing
September 2010

Otx2 expression is restricted to dopaminergic neurons of the ventral tegmental area in the adult brain.

Int J Dev Biol 2010 ;54(5):939-45

CEINGE Biotecnologie Avanzate, A Buzzati-Traverso, CNR, Naples, Italy.

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http://dx.doi.org/10.1387/ijdb.092974msDOI Listing
August 2010

The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons.

Brain 2010 Jul 23;133(Pt 7):2022-31. Epub 2010 Jun 23.

Neuroregeneration Laboratories, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1093/brain/awq142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892944PMC
July 2010

A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei.

Nat Neurosci 2010 Jun 23;13(6):680-9. Epub 2010 May 23.

Instituto Cajal (Consejo Superior de Investigaciones Científicas), Laboratory of Telencephalic Development, Molecular, Cellular and Developmental Neurobiology Department, Madrid, Spain.

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http://dx.doi.org/10.1038/nn.2556DOI Listing
June 2010

Foxg1 is required for proper separation and formation of sensory cristae during inner ear development.

Dev Dyn 2009 Nov;238(11):2725-34

Lab of Molecular Biology, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA.

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http://doi.wiley.com/10.1002/dvdy.22111
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http://dx.doi.org/10.1002/dvdy.22111DOI Listing
November 2009

The role of Otx genes in progenitor domains of ventral midbrain.

Adv Exp Med Biol 2009 ;651:36-46

CEINGE Biotecnologie Avanzate and SEMM European School of Molecular Medicine, via Comunale Margherita 482, 80145 Naples, Italy.

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http://dx.doi.org/10.1007/978-1-4419-0322-8_3DOI Listing
October 2009

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain.

Development 2009 Aug;136(15):2545-55

Helmholtz Centre Munich, German Research Centre for Environmental Health (GmbH) and Technical University Munich, Institute of Developmental Genetics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich/Neuherberg, Germany.

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http://dx.doi.org/10.1242/dev.031781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729334PMC
August 2009

Serotonin hyperinnervation abolishes seizure susceptibility in Otx2 conditional mutant mice.

J Neurosci 2008 Sep;28(37):9271-6

Istituto di Neuroscienze del Consiglio Nazionale delle Ricerche, Laboratorio di Neurobiologia della Scuola Normale Superiore, 56100 Pisa, Italy.

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http://dx.doi.org/10.1523/JNEUROSCI.2208-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670936PMC
September 2008

Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development.

Curr Biol 2007 May 3;17(10):873-80. Epub 2007 May 3.

Department of Developmental Biology, Institute Biology 1, University of Freiburg, Hauptstrasse 1, D-79104 Freiburg, Germany.

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http://dx.doi.org/10.1016/j.cub.2007.04.003DOI Listing
May 2007

Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors.

Mol Cell Biol 2007 Jan 23;27(1):340-51. Epub 2006 Oct 23.

Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Veterinärplatz 1, A-1210 Vienna, Austria.

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http://mcb.asm.org/content/27/1/340.full.pdf
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http://mcb.asm.org/cgi/doi/10.1128/MCB.00811-06
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http://dx.doi.org/10.1128/MCB.00811-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800652PMC
January 2007

Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border.

Development 2006 May 29;133(9):1779-87. Epub 2006 Mar 29.

Max-Planck Institute for Biophysical Chemistry, Dept of Molecular Cell Biology, am Fassberg, 37077 Göttingen, Germany.

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http://dx.doi.org/10.1242/dev.02326DOI Listing
May 2006

Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants.

Development 2006 May 12;133(10):1891-900. Epub 2006 Apr 12.

MRC Centre for Developmental Neurobiology, New Hunt's House, King's College London, London SE1 9RT, UK.

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http://dx.doi.org/10.1242/dev.02352DOI Listing
May 2006

Altered dopaminergic innervation and amphetamine response in adult Otx2 conditional mutant mice.

Mol Cell Neurosci 2006 Feb 26;31(2):293-302. Epub 2005 Oct 26.

Department of Neuroscience, Karolinska Institutet, Retzius väg 8, S-17177 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.mcn.2005.09.018DOI Listing
February 2006

A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo.

Development 2006 Jan;133(1):89-98

GSF-National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, Ingolstaedter Landstrasse 1, 85764 Munich/Neuherberg, Germany.

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http://dev.biologists.org/content/develop/133/1/89.full.pdf
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http://dev.biologists.org/cgi/doi/10.1242/dev.02181
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http://dx.doi.org/10.1242/dev.02181DOI Listing
January 2006

Otx genes in the evolution of the vertebrate brain.

Brain Res Bull 2005 Sep 24;66(4-6):410-20. Epub 2005 Feb 24.

MRC Centre for Developmental Neurobiology, New Hunt's House, 4th Floor, King's College London, UK.

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http://dx.doi.org/10.1016/j.brainresbull.2005.02.005DOI Listing
September 2005

Otx2 regulates subtype specification and neurogenesis in the midbrain.

J Neurosci 2005 May;25(19):4856-67

Institut de Génétique et de Biologie Moléculaire et Cellulaire/Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale, Université Louis Pasteur, 67404 Illkirch cedex, Strasbourg, France.

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http://dx.doi.org/10.1523/JNEUROSCI.5158-04.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724764PMC
May 2005

Genetic control of dopaminergic neuron differentiation.

Authors:
Antonio Simeone

Trends Neurosci 2005 Feb;28(2):62-5; discussion 65-6

MRC Centre for Developmental Neurobiology, 4th Floor, New Hunt's House, Guy's Campus, King's College London, London Bridge, London SE1 1UL, UK.

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http://www.cell.com/trends/neurosciences/pdf/S0166-2236(04)0
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http://linkinghub.elsevier.com/retrieve/pii/S016622360400363
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http://dx.doi.org/10.1016/j.tins.2004.11.007DOI Listing
February 2005

Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain.

Development 2004 May;131(9):2037-48

MRC Centre for Developmental Neurobiology, New Hunt's House, 4th Floor, King's College London, Guy's Campus, London Bridge, London SE1 1UL, UK.

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http://dx.doi.org/10.1242/dev.01107DOI Listing
May 2004

Isolation and expression of the homeobox gene Gbx1 during mouse development.

Dev Dyn 2004 Feb;229(2):334-9

Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany.

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http://dx.doi.org/10.1002/dvdy.10435DOI Listing
February 2004

OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm.

Gene Expr Patterns 2003 Aug;3(4):497-501

MRC Centre for Developmental Neurobiology, New Hunt's House, 4th Floor, King's College London, Guy's Campus, London Bridge, London SE1 1UL, UK.

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http://dx.doi.org/10.1016/s1567-133x(03)00056-5DOI Listing
August 2003

Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain.

Nat Neurosci 2003 May;6(5):453-60

MRC Centre for Developmental Neurobiology, New Hunt's House, 4th Floor, King's College London, Guy's Campus, London Bridge, London SE1 1UL, UK.

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http://dx.doi.org/10.1038/nn1037DOI Listing
May 2003

Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer.

J Neurosci 2003 May;23(10):4199-207

Max-Planck-Institute of Psychiatry, 80804 Munich, Germany, and GSF-National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, 85758 Oberschleissheim, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741088PMC
May 2003

The Otx family.

Curr Opin Genet Dev 2002 Aug;12(4):409-15

MRC Centre for Developmental Neurobiology, New Hunt's House, 4th Floor, King's College London, Guy's campus, London Bridge, UK.

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http://dx.doi.org/10.1016/s0959-437x(02)00318-0DOI Listing
August 2002

Evolutionary conservation of otd/Otx2 transcription factor action: a genome-wide microarray analysis in Drosophila.

Genome Biol 2002 14;3(4):RESEARCH0015. Epub 2002 Mar 14.

Institute of Zoology, Biozentrum/Pharmazentrum, Klingelbergstrasse 50, University of Basel, CH-4056 Basel, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC115189PMC
http://dx.doi.org/10.1186/gb-2002-3-4-research0015DOI Listing
June 2002

The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum.

Mech Dev 2002 Jun;114(1-2):213-7

MRC Centre for Developmental Neurobiology, 4th Floor, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, UK.

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http://dx.doi.org/10.1016/s0925-4773(02)00067-9DOI Listing
June 2002

Towards the comprehension of genetic mechanisms controlling brain morphogenesis.

Authors:
Antonio Simeone

Trends Neurosci 2002 Mar;25(3):119-21

MRC Centre for Developmental Neurobiology, New Hunt's House, 4th Floor, King's College London, Guy's Campus, London Bridge, London, UK.

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http://dx.doi.org/10.1016/s0166-2236(00)02095-6DOI Listing
March 2002

Folic acid prevents exencephaly in Cited2 deficient mice.

Hum Mol Genet 2002 Feb;11(3):283-93

MRC Centre for Developmental Neurobiology, 4th floor New Hunt's House, King's College London, Guy's Campus, London Bridge, London SE1 1UL, UK.

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http://dx.doi.org/10.1093/hmg/11.3.283DOI Listing
February 2002