Publications by authors named "Antonio Ponzetto"

90 Publications

The Role of Neuroinflammation in Glaucoma: An Update on Molecular Mechanisms and New Therapeutic Options.

Front Neurol 2020 4;11:612422. Epub 2021 Feb 4.

Eye Clinic, Department of Surgical Sciences, University of Torino, Torino, Italy.

Glaucoma is a multifactorial optic neuropathy characterized by the continuous loss of retinal ganglion cells, leading to progressive and irreversible visual impairment. In this minireview, we report the results of the most recent experimental studies concerning cells, molecular mechanisms, genes, and microbiome involved in neuroinflammation processes correlated to glaucoma neurodegeneration. The identification of cellular mechanisms and molecular pathways related to retinal ganglion cell death is the first step toward the discovery of new therapeutic strategies. Recent experimental studies identified the following possible targets: adenosine A receptor, sterile alpha and TIR motif containing 1 (neurofilament light chain), toll-like receptors (TLRs) 2 and 4, phosphodiesterase type 4 (PDE4), and FasL-Fas signaling (in particular ONL1204, a small peptide antagonist of Fas receptors), and therapies directed against them. The continuous progress in knowledge provides interesting data, although the total lack of human studies remains an important limitation. Further research is required to better define the role of neuroinflammation in the neurodegeneration processes that occur in glaucomatous disease and to discover neuroprotective treatments amenable to clinical trials. The hereinafter reviewed studies are reported and evaluated according to their translational relevance.
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http://dx.doi.org/10.3389/fneur.2020.612422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890114PMC
February 2021

Intestinal Ischemic Manifestations of COVID-19.

Gastroenterology 2020 Dec 29. Epub 2020 Dec 29.

Department of Medical Sciences, University of Turin, Torino, Italy.

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http://dx.doi.org/10.1053/j.gastro.2020.10.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771904PMC
December 2020

COVID-19, coagulopathy and venous thromboembolism: more questions than answers-comment.

Intern Emerg Med 2021 03 17;16(2):525-526. Epub 2020 Sep 17.

Department of Biotechnology Chemistry and Pharmacy, University of Siena, Via A. Moro, 53100, Siena, Italy.

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http://dx.doi.org/10.1007/s11739-020-02503-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497853PMC
March 2021

Thermomagnetic resonance affects cancer growth and motility.

R Soc Open Sci 2020 Jul 15;7(7):200299. Epub 2020 Jul 15.

Department of Oncology, University of Torino, Via Santena 5 bis, 10126 Torino, Italy.

The fight against a multifaceted incurable disease such as cancer requires a multidisciplinary approach to overcome the multitude of molecular defects at its origin. Here, a new thermophysical biochemical approach has been suggested and associated with the use of electromagnetic fields to control the growth of cancer cells. In particular, thermodynamic analysis of the heat transfer is developed in correlation with cellular parameters such as the volume/area ratio. We propose that the electromagnetic wave, at the specific frequency calculated as the characteristic response time of any cell type to the external thermal perturbation, can affect resonant intracellular molecular oscillations. The biochemical model hypothesizes that microtubules are stabilized, and the impact is predicted on cell growth, migration and mitochondrial activity. Experimental validation of the theoretical results shows that the thermodynamic analysis allows the application of the specific electromagnetic field able to decrease cancer cell invasion and proliferation.
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http://dx.doi.org/10.1098/rsos.200299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428280PMC
July 2020

Impact of Cirrhosis on 90-Day Outcomes After Percutaneous Coronary Intervention.

Am J Cardiol 2020 06 19;125(11):1754. Epub 2020 Mar 19.

Department of Medical Sciences, University of Turin, Torino, Italy.

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http://dx.doi.org/10.1016/j.amjcard.2020.03.008DOI Listing
June 2020

Risk Factors for Open-angle Glaucoma in Persons of Latin American Descent.

J Glaucoma 2020 05;29(5):e36-e37

Medical Sciences, University of Turin Torino, Italy.

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http://dx.doi.org/10.1097/IJG.0000000000001482DOI Listing
May 2020

Infection and Autoimmune Thyroid Diseases: The Role of Virulent Strains.

Antibiotics (Basel) 2019 Dec 30;9(1). Epub 2019 Dec 30.

Department of Medical Sciences, University of Torino, 10126 Torino, Italy.

Aim: To verify a possible association between overall and CagA+ infection and autoimmune thyroid diseases (AITDs).

Methods: Consecutive patients with AITDs admitted to one single centre of Endocrinology during one solar year were examined. The diagnoses were Hashimoto thyroiditis (HT) in 76, Graves' Disease (GD) in 39, and aspecific thyroiditis (AT) in 44 patients. Controls were 136 individuals without AITDs. Median values of fT3, fT4, anti-thyreoglobulin (Tg) antibodies, IL-1β, IL-6, and TNF-α in patients were compared with those in controls. infection and CagA status were determined serologically. Structural homology of some thyroid proteins with antigens was investigated.

Results: infection prevalence was significantly increased in GD (66.6%) and HT (64.4%) patients, vs. 29.4% of controls and 34.0% of AT. CagA seropositivity was significantly more frequent in GD (46.1%) and HT (46.9%) infected patients, vs. infected controls (20%). fT3 and fT4 median values were significantly decreased in infected CagA+ GD patients vs. uninfected GD patients. IL-1β median values were increased in patients respect to controls, independently of the clinical form of AITD. Median values of IL-6, TNF-α and anti-Tg autoantibodies in CagA infected patients were significantly higher than those measured in infected CagA- and uninfected patients and in infected CagA+ controls. The examined thyroid proteins shared putative conserved domains with numerous bacterial antigens.

Conclusions: Overall and CagA+ infection were associated with GD and HT, putatively through an increased inflammatory status and molecular mimicry.
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http://dx.doi.org/10.3390/antibiotics9010012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167994PMC
December 2019

Sudden Sensorineural Hearing Loss.

JAMA Otolaryngol Head Neck Surg 2020 02;146(2):211

Department of Biotechnology Chemistry & Pharmacy, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1001/jamaoto.2019.3662DOI Listing
February 2020

Serum magnesium and the prevalence of peripheral artery disease.

Atherosclerosis 2020 01 4;292:230. Epub 2019 Nov 4.

Department of Biotechnology Chemistry & PharmacyVia A. Moro, 53100, Siena, Italy.

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.10.020DOI Listing
January 2020

Addition of Bismuth to the Standard Triple Therapy for Helicobacter Pylori Infection.

Clin Gastroenterol Hepatol 2019 12;17(13):2822

Division of Gastroenterology, Department of Medical Sciences, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1016/j.cgh.2019.05.036DOI Listing
December 2019

Prevalence of ischemic stroke and Helicobacter pylori infection.

Helicobacter 2020 02 27;25(1):e12664. Epub 2019 Oct 27.

Department of Biotechnology Chemistry & Pharmacy, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1111/hel.12664DOI Listing
February 2020

Prepregnancy calcium supplementation and pre-eclampsia.

Lancet 2019 08;394(10198):e6

Department of Medical Sciences, University of Turin, Turin 10126, Italy.

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http://dx.doi.org/10.1016/S0140-6736(19)31265-6DOI Listing
August 2019

Preeclampsia and platelets activation.

Platelets 2020 25;31(1):128. Epub 2019 Jul 25.

Department of Electronics and Telecommunications, Politecnico di Torino, Torino, Italy.

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http://dx.doi.org/10.1080/09537104.2019.1646901DOI Listing
April 2020

The extremely low frequency electromagnetic stimulation selective for cancer cells elicits growth arrest through a metabolic shift.

Biochim Biophys Acta Mol Cell Res 2019 09 31;1866(9):1389-1397. Epub 2019 May 31.

Department of Oncology, University of Torino, Via Santena 5 bis, 10126 Torino, Italy. Electronic address:

The efficacy of the very low frequency electromagnetic field in cancer treatment remains elusive due to a lack of explanatory mechanisms for its effect. We developed a novel thermodynamic model that calculates for every cell type the frequency capable of inhibiting proliferation. When this frequency was applied to two human cancer cell lines, it reduced their growth while not affecting healthy cells. The effect was abolished by the inhibition of calcium fluxes. We found evidences of an enhanced respiratory activity due to the increased expression of the elements of the respiratory chain and oxidative phosphorylation, both at the mRNA and protein level. The respiratory burst potentiated the production of reactive oxygen species but was not associated to increased levels of ATP, leading to the conclusion that the energy was readily spent in the adaptive response to the electromagnetic field. Taken together, our data demonstrate that, regardless of individual molecular defects, it is possible to control cancer cells with a specific irradiation that imposes a mitochondrial metabolic switch, regulating calcium fluxes and deleterious to cancer growth. This approach lays the foundations for a personalized cancer medicine.
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http://dx.doi.org/10.1016/j.bbamcr.2019.05.006DOI Listing
September 2019

Heterogeneity and coexistence of oncogenic mechanisms involved in HCV-associated B-cell lymphomas.

Crit Rev Oncol Hematol 2019 Jun 16;138:156-171. Epub 2019 Apr 16.

Department of Medical Sciences, University of Torino, Corso A.M. Dogliotti 14, 10126 Torino, Italy. Electronic address:

The association of HCV-infection with B-lymphomas is supported by the regression of most indolent/low-grade lymphomas following anti-viral therapy. Studies on direct and indirect oncogenic mechanisms have elucidated the pathogenesis of HCV-associated B-lymphoma subtypes. These include B-lymphocyte proliferation and sustained clonal expansion by HCV-envelope protein stimulation of B-cell receptors, and prolonged HCV-infected B-cell growth by overexpression of an anti-apoptotic BCL-2 oncogene caused by the increased frequency of t(14;18) chromosomal translocations in follicular lymphomas. HCV has been implicated in lymphomagenesis by a "hit-and-run" mechanism, inducing enhanced mutation rate in immunoglobulins and anti-oncogenes favoring immune escape, due to permanent genetic damage by double-strand DNA-breaks. More direct oncogenic mechanisms have been identified in cytokines and chemokines in relation to NS3 and Core expression, particularly in diffuse large B-cell lymphoma. By reviewing genetic alterations and disrupted signaling pathways, we intend to highlight how mutually non-contrasting mechanisms cooperate with environmental factors toward progression of HCV-lymphoma.
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http://dx.doi.org/10.1016/j.critrevonc.2019.04.005DOI Listing
June 2019

Reader's Comments: Subclinical Hypothyroidism and the Risk of Cardiovascular Disease.

Am J Cardiol 2019 07 24;124(2):319. Epub 2019 Apr 24.

Division of Cardiology, Department of Medical Sciences, University of Turin, Torino, Italy.

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http://dx.doi.org/10.1016/j.amjcard.2019.04.034DOI Listing
July 2019

Colon Cancer Risk and VacA Toxin of Helicobacter pylori.

Gastroenterology 2019 06 14;156(8):2356. Epub 2019 Mar 14.

Department of Biotechnology Chemistry & Pharmacy, Siena Italy.

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http://dx.doi.org/10.1053/j.gastro.2018.11.083DOI Listing
June 2019

Gastric cancer in Latin America.

Scand J Gastroenterol 2019 02 8;54(2):219. Epub 2019 Mar 8.

b Department of Biotechnology Chemistry & Pharmacy , University of Siena , Via A. Moro , Siena 53100 , Italy.

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http://dx.doi.org/10.1080/00365521.2019.1577483DOI Listing
February 2019

Mona Lisa and Postpartum Hypothyroidism.

Mayo Clin Proc 2019 03;94(3):544

Public Health England, London, United Kingdom.

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http://dx.doi.org/10.1016/j.mayocp.2018.11.025DOI Listing
March 2019

The management of portal vein thrombosis.

Eur J Gastroenterol Hepatol 2019 04;31(4):547

FRCPath National Mycobacterium Reference Service-South, Public Health England, London UK.

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http://dx.doi.org/10.1097/MEG.0000000000001323DOI Listing
April 2019

Non-alcoholic liver disease and gut bacteria.

Pharmacol Res 2019 04 14;142:101. Epub 2019 Feb 14.

Division of Medicine, Azienda Ospedaliera Citta della Salute e della Scienza and Department of Medical Sciences, University of Turin corso AM Dogliotti 14, 10126 Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2019.02.012DOI Listing
April 2019

Screening for Gastric Cancer.

Am J Gastroenterol 2019 04;114(4):690

Department of Biotechnology Chemistry & Pharmacy, Siena, Italy.

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http://dx.doi.org/10.14309/ajg.0000000000000110DOI Listing
April 2019

Thrombosis of the Portal Venous System in Cirrhotic Patients.

Ann Hepatol 2018 10;17(6):1078-1080

Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.

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http://dx.doi.org/10.5604/01.3001.0012.7209DOI Listing
October 2018

Risk of Rebleeding After Hemostasis for Peptic Ulcer.

Dig Dis Sci 2019 01 16;64(1):281-282. Epub 2018 Nov 16.

National Mycobacterial Reference Unit National Mycobacterium Reference Laboratory (NMRL) Abernethy Building, Institute of Cell and Molecular Science (ICMS), 2 Newark Street, London, E1 2AT, UK.

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http://dx.doi.org/10.1007/s10620-018-5375-yDOI Listing
January 2019

Extragastric diseases correlated with Helicobacter pylori.

Helicobacter 2019 Feb 9;24(1):e12549. Epub 2018 Nov 9.

National Mycobacterium Reference Service-South (NMRS-S), Public Health England, London, UK.

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http://dx.doi.org/10.1111/hel.12549DOI Listing
February 2019

Delta hepatitis in resolved hepatitis B.

Eur J Gastroenterol Hepatol 2018 12;30(12):1528

Unit of Gastroenterology, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1097/MEG.0000000000001253DOI Listing
December 2018

Letter: proton pump inhibitors and the risk of hepatocellular carcinoma.

Aliment Pharmacol Ther 2018 11;48(10):1164-1165

Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1111/apt.14970DOI Listing
November 2018

Immune thrombocytopenic purpura and infections.

Intern Emerg Med 2018 10 20;13(7):1137. Epub 2018 Jul 20.

Department of Medical and Surgical Sciences, University of Bologna S. Orsola Hospital, Via Massarenti, 9, 40138, Bologna, Italy.

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http://dx.doi.org/10.1007/s11739-018-1908-9DOI Listing
October 2018

Containing the Costs of Recurrent Gastro-Duodenal Ulcer Bleeding.

Dig Dis 2018 23;36(4):269. Epub 2018 May 23.

Department of Medical Sciences, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1159/000488874DOI Listing
August 2018

Cancer Risk in Patients With Cystic Fibrosis.

Gastroenterology 2018 06 5;154(8):2282-2283. Epub 2018 May 5.

Department of Energy, Polytechnic of Turin, Torino, Italy.

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http://dx.doi.org/10.1053/j.gastro.2018.02.040DOI Listing
June 2018