Antonio Lanzavecchia

Antonio Lanzavecchia

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Antonio Lanzavecchia

Antonio Lanzavecchia

Publications by authors named "Antonio Lanzavecchia"

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Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles.

Sci Immunol 2019 11;4(41)

Laboratory of Applied Evolutionary Biology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.1126/sciimmunol.aay6125DOI Listing
November 2019

The Antibody Response to : Cues for Vaccine Design and the Discovery of Receptor-Based Antibodies.

Annu Rev Immunol 2019 04 19;37:225-246. Epub 2018 Dec 19.

Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland; email:

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http://dx.doi.org/10.1146/annurev-immunol-042617-053301DOI Listing
April 2019

Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations.

Cell Host Microbe 2019 Mar 19;25(3):367-376.e5. Epub 2019 Feb 19.

Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, USA; Center for Systems and Synthetic Biology, The University of Texas at Austin, Austin, TX 78712, USA; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417944PMC
March 2019

Publisher Correction: An immunoregulatory and tissue-residency program modulated by c-MAF in human T17 cells.

Nat Immunol 2019 01;20(1):109

Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland.

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http://www.nature.com/articles/s41590-018-0264-2
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http://dx.doi.org/10.1038/s41590-018-0264-2DOI Listing
January 2019

An immunoregulatory and tissue-residency program modulated by c-MAF in human T17 cells.

Nat Immunol 2018 10 10;19(10):1126-1136. Epub 2018 Sep 10.

Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland.

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http://www.nature.com/articles/s41590-018-0200-5
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http://dx.doi.org/10.1038/s41590-018-0200-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402560PMC
October 2018

Influenza hemagglutinin membrane anchor.

Proc Natl Acad Sci U S A 2018 10 17;115(40):10112-10117. Epub 2018 Sep 17.

Structural Biology of Disease Processes Laboratory, Francis Crick Institute, NW1 1AT London, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1810927115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176637PMC
October 2018

T cells in patients with narcolepsy target self-antigens of hypocretin neurons.

Nature 2018 10 19;562(7725):63-68. Epub 2018 Sep 19.

Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland.

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http://dx.doi.org/10.1038/s41586-018-0540-1DOI Listing
October 2018

Role of B cells in T cell responses in a mouse model of asthma.

J Allergy Clin Immunol 2018 04 7;141(4):1395-1410. Epub 2017 Sep 7.

Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594185PMC
April 2018

Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone.

Bone Res 2018 25;6:13. Epub 2018 Apr 25.

1Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Gaithersburg, MD USA.

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http://dx.doi.org/10.1038/s41413-018-0014-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916877PMC
April 2018

Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? T-Cell Heterogeneity, Plasticity, and Selection in Humans.

Cold Spring Harb Perspect Biol 2018 03 1;10(3). Epub 2018 Mar 1.

Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.

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http://dx.doi.org/10.1101/cshperspect.a029421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830897PMC
March 2018

Dissecting human antibody responses: useful, basic and surprising findings.

EMBO Mol Med 2018 03;10(3)

Institute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland.

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http://dx.doi.org/10.15252/emmm.201808879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840544PMC
March 2018

Tackling influenza with broadly neutralizing antibodies.

Curr Opin Virol 2017 06 18;24:60-69. Epub 2017 May 18.

Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.

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http://dx.doi.org/10.1016/j.coviro.2017.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102826PMC
June 2017

Social network architecture of human immune cells unveiled by quantitative proteomics.

Nat Immunol 2017 05 6;18(5):583-593. Epub 2017 Mar 6.

Experimental Systems Immunology, Max Planck Institute of Biochemistry, Bayern, Germany.

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http://dx.doi.org/10.1038/ni.3693DOI Listing
May 2017

Regulation of PfEMP1-VAR2CSA translation by a Plasmodium translation-enhancing factor.

Nat Microbiol 2017 May 8;2:17068. Epub 2017 May 8.

Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Box 280, Nobels väg 16, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1038/nmicrobiol.2017.68DOI Listing
May 2017

Rapid generation of a human monoclonal antibody to combat Middle East respiratory syndrome.

J Infect Public Health 2016 May-Jun;9(3):231-5. Epub 2016 Apr 19.

Microbiology Services Colindale, Public Health England, London NW9 5HT, United Kingdom.

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http://dx.doi.org/10.1016/j.jiph.2016.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102728PMC
January 2017

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity.

Cell 2016 Oct 13;167(3):829-842.e13. Epub 2016 Oct 13.

Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona 6500, Switzerland; Institute of Microbiology, ETH Zurich, Zurich 8093, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.09.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075284PMC
October 2016

Antibody-guided vaccine design: identification of protective epitopes.

Curr Opin Immunol 2016 08 22;41:62-67. Epub 2016 Jun 22.

Humabs BioMed, Via Mirasole 1, 6500 Bellinzona, Switzerland.

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http://dx.doi.org/10.1016/j.coi.2016.06.001DOI Listing
August 2016

Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells.

Nat Commun 2016 05 18;7:11541. Epub 2016 May 18.

Cellular Immunology Laboratory and Immune Regulation Laboratory, Institute for Research in Biomedicine, Università della Svizzera italiana, Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland.

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http://dx.doi.org/10.1038/ncomms11541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873938PMC
May 2016

SARS-like WIV1-CoV poised for human emergence.

Proc Natl Acad Sci U S A 2016 Mar 14;113(11):3048-53. Epub 2016 Mar 14.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079;

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http://dx.doi.org/10.1073/pnas.1517719113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801244PMC
March 2016

Serum Immunoglobulin A Cross-Strain Blockade of Human Noroviruses.

Open Forum Infect Dis 2015 Sep 1;2(3):ofv084. Epub 2015 Jul 1.

Department of Epidemiology , University of North Carolina , Chapel Hill.

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http://dx.doi.org/10.1093/ofid/ofv084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498284PMC
September 2015

Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus.

Proc Natl Acad Sci U S A 2015 Aug 27;112(33):10473-8. Epub 2015 Jul 27.

Immune Regulation Unit, Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland; Institute of Microbiology, Eidgenössische Technische Hochschule Zurich, 8093 Zurich, Switzerland

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http://dx.doi.org/10.1073/pnas.1510199112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547275PMC
August 2015

Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis.

Nat Commun 2015 Jun 16;6:7375. Epub 2015 Jun 16.

1] Institute for Research in Biomedicine (IRB), Bellinzona 6500, Switzerland [2] Institute of Microbiology, Eidgenössische Technische Hochschule (ETH), Zürich 8093, Switzerland.

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http://dx.doi.org/10.1038/ncomms8375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477037PMC
June 2015

Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: complete protection of rhesus monkeys from mucosal SHIV challenge.

Vaccine 2015 Apr 11;33(17):2086-95. Epub 2015 Mar 11.

Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX, USA; Southwest National Primate Research Center, San Antonio, TX, USA; Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.02.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411954PMC
April 2015

ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells.

Nat Commun 2015 Mar 16;6:6431. Epub 2015 Mar 16.

Institute for Research in Biomedicine, Università della Svizzera italiana, via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland.

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http://dx.doi.org/10.1038/ncomms7431DOI Listing
March 2015

Rapid development of broadly influenza neutralizing antibodies through redundant mutations.

Nature 2014 Dec 5;516(7531):418-22. Epub 2014 Oct 5.

1] Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland [2] Insitute for Microbiology, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland [3].

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http://dx.doi.org/10.1038/nature13764DOI Listing
December 2014

Antibody-driven design of a human cytomegalovirus gHgLpUL128L subunit vaccine that selectively elicits potent neutralizing antibodies.

Proc Natl Acad Sci U S A 2014 Dec 1;111(50):17965-70. Epub 2014 Dec 1.

Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland; Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland

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http://dx.doi.org/10.1073/pnas.1415310111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273412PMC
December 2014

Efficient Methods To Isolate Human Monoclonal Antibodies from Memory B Cells and Plasma Cells.

Microbiol Spectr 2014 Oct;2(5)

Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland.

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http://dx.doi.org/10.1128/microbiolspec.AID-0018-2014DOI Listing
October 2014

Within-host evolution results in antigenically distinct GII.4 noroviruses.

J Virol 2014 Jul 19;88(13):7244-55. Epub 2014 Mar 19.

Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1128/JVI.00203-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054459PMC
July 2014

Broadly neutralizing antiviral antibodies.

Annu Rev Immunol 2013 16;31:705-42. Epub 2013 Jan 16.

Institute for Research in Biomedicine IRB, 6500 Bellinzona, Switzerland.

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http://dx.doi.org/10.1146/annurev-immunol-032712-095916DOI Listing
June 2013

A functional BCR in human IgA and IgM plasma cells.

Blood 2013 May 2;121(20):4110-4. Epub 2013 Apr 2.

Institute for Research in Biomedicine, Bellinzona, Switzerland.

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http://dx.doi.org/10.1182/blood-2012-09-459289DOI Listing
May 2013

Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype.

Immunity 2013 Mar 14;38(3):596-605. Epub 2013 Mar 14.

Institute for Research in Biomedicine, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland.

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http://dx.doi.org/10.1016/j.immuni.2012.11.020DOI Listing
March 2013

Antibodies against neutralization epitopes of human cytomegalovirus gH/gL/pUL128-130-131 complex and virus spreading may correlate with virus control in vivo.

J Clin Immunol 2012 Dec 27;32(6):1324-31. Epub 2012 Jul 27.

Laboratori Sperimentali di Ricerca, Area Trapiantologica, Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy.

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http://www.cdfound.it/documenti/Antibodies_against_neutraliz
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http://link.springer.com/10.1007/s10875-012-9739-3
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http://dx.doi.org/10.1007/s10875-012-9739-3DOI Listing
December 2012

Immunogenetic mechanisms driving norovirus GII.4 antigenic variation.

PLoS Pathog 2012 17;8(5):e1002705. Epub 2012 May 17.

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1002705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355092PMC
November 2012

Human Th17 subsets.

Eur J Immunol 2012 Sep;42(9):2215-20

Institute for Research in Biomedicine, Cellular Immunology, Bellinzona, Switzerland.

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http://doi.wiley.com/10.1002/eji.201242741
Publisher Site
http://dx.doi.org/10.1002/eji.201242741DOI Listing
September 2012

T-cell trafficking in the central nervous system.

Immunol Rev 2012 Jul;248(1):216-27

Institute for Research in Biomedicine, Bellinzona, Switzerland.

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http://dx.doi.org/10.1111/j.1600-065X.2012.01140.xDOI Listing
July 2012

Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.

Nature 2012 Apr;484(7395):514-8

Institute for Research in Biomedicine, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland.

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http://dx.doi.org/10.1038/nature10957DOI Listing
April 2012

Ralph M. Steinman 1943-2011.

Cell 2011 Dec;147(6):1216-7

Institute for Research in Biomedicine, CH-6500 Bellinzona, Switzerland.

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http://dx.doi.org/10.1016/j.cell.2011.11.040DOI Listing
December 2011

Memory in disguise.

Nat Med 2011 Oct 11;17(10):1182-3. Epub 2011 Oct 11.

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http://dx.doi.org/10.1038/nm.2502DOI Listing
October 2011

High throughput cellular screens to interrogate the human T and B cell repertoires.

Curr Opin Immunol 2011 Jun 18;23(3):430-5. Epub 2011 May 18.

Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland.

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http://dx.doi.org/10.1016/j.coi.2011.04.006DOI Listing
June 2011

In-depth analysis of the antibody response of individuals exposed to primary dengue virus infection.

PLoS Negl Trop Dis 2011 Jun 21;5(6):e1188. Epub 2011 Jun 21.

Department of Microbiology and Immunology, and the Southeast Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1371/journal.pntd.0001188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119640PMC
June 2011

Dissecting the human immunologic memory for pathogens.

Immunol Rev 2011 Mar;240(1):40-51

Institute for Research in Biomedicine, Bellinzona, Switzerland.

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http://dx.doi.org/10.1111/j.1600-065X.2010.01000.xDOI Listing
March 2011

CD4+ CD25+ Treg regulate the contribution of CD8+ T-cell subsets in repopulation of the lymphopenic environment.

Eur J Immunol 2010 Dec 11;40(12):3478-88. Epub 2010 Nov 11.

Institute for Research in Biomedicine, Bellinzona, Switzerland.

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http://dx.doi.org/10.1002/eji.201040600DOI Listing
December 2010

Monocytes join the dendritic cell family.

Cell 2010 Oct;143(3):339-40

Institute for Research in Biomedicine, Bellinzona, Switzerland.

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http://dx.doi.org/10.1016/j.cell.2010.10.022DOI Listing
October 2010

From vaccines to memory and back.

Immunity 2010 Oct;33(4):451-63

Institute for Research in Biomedicine, CH-6500 Bellinzona, Switzerland.

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http://dx.doi.org/10.1016/j.immuni.2010.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760154PMC
October 2010