Publications by authors named "Antonio Bertolotto"

100Publications

Proportion of alemtuzumab-treated patients converting from relapsing-remitting multiple sclerosis to secondary progressive multiple sclerosis over 6 years.

Mult Scler J Exp Transl Clin 2020 Oct-Dec;6(4):2055217320972137. Epub 2020 Dec 18.

Center of Clinical Neuroscience, Carl Gustav Carus University Hospital, Dresden, Germany Employees of Sanofi during study conduct and analysis.

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December 2020

Benign SARS-CoV-2 infection in MOG-antibodies associated disorder during tocilizumab treatment.

Mult Scler Relat Disord 2020 Nov 21;46:102592. Epub 2020 Oct 21.

Department of Rehabilitation, C.R.R.F. "Mons. L. Novarese", Loc. Trompone, Moncrivello, Italy. Electronic address:

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November 2020

Autologous Hematopoietic Stem Cell Transplantation (AHSCT): Standard of Care for Relapsing-Remitting Multiple Sclerosis Patients.

Neurol Ther 2020 Dec 16;9(2):197-203. Epub 2020 Jun 16.

SSD Terapia oncoematologica intensiva e trapianto CSE, AOU San Luigi Gonzaga, Dipartimento di Scienze Cliniche e Biologiche, University of Turin, Turin, Italy.

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December 2020

TNFAIP3 Deficiency Affects Monocytes, Monocytes-Derived Cells and Microglia in Mice.

Int J Mol Sci 2020 Apr 18;21(8). Epub 2020 Apr 18.

Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, 10043 Turin, Italy.

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April 2020

Acknowledgement to Authors, Referees and Readers 2019.

Neurol Ther 2019 Dec;8(2):513-515

University Hospital San Luigi Gonzaga, Turin, Italy.

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December 2019

NURR1 Impairment in Multiple Sclerosis.

Int J Mol Sci 2019 Sep 30;20(19). Epub 2019 Sep 30.

Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Orbassano, 10043 Turin, Italy.

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September 2019

NURR1 deficiency is associated to ADHD-like phenotypes in mice.

Transl Psychiatry 2019 08 27;9(1):207. Epub 2019 Aug 27.

Neuroscience Institute Cavalieri Ottolenghi (NICO) Orbassano (Turin), Orbassano, Italy.

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August 2019

Neurology and Therapy: Looking Back on 2018 and Forward to 2019.

Neurol Ther 2019 Jun 30;8(1):1-3. Epub 2019 Jan 30.

University Hospital San Luigi Gonzaga, Turin, Italy.

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June 2019

Rituximab-induced hypogammaglobulinemia in patients with neuromyelitis optica spectrum disorders.

Neurol Neuroimmunol Neuroinflamm 2018 Nov 13;5(6):e498. Epub 2018 Sep 13.

Neuroscience Institute Cavalieri Ottolenghi (NICO) (A.M., P.V., S.M., A. Balbo, A. Bertolotto, F.M., G.P.), Orbassano, Turin, Italy; Neurologia-CRESM (A.M., P.V., S.M., A. Balbo, A. Bertolotto, F.M., M.C.), AOU San Luigi Gonzaga, Orbassano, Turin, Italy; "Rita Levi Montalcini" Neuroscience Department (F.M., G.P.), University of Turin, TO, Italy; and Humanitas Hospital Gradenigo (A.D., M.L.), Turin, Italy.

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November 2018

Long-term disability progression in primary progressive multiple sclerosis: a 15-year study.

Brain 2017 Nov;140(11):2814-2819

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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November 2017

A Comprehensive Review on Copemyl.

Neurol Ther 2017 Dec 31;6(2):161-173. Epub 2017 Jul 31.

Multiple Sclerosis Study Center, ASST Valle Olona, Gallarate, VA, Italy.

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December 2017

Biological activity of glatiramer acetate on Treg and anti-inflammatory monocytes persists for more than 10years in responder multiple sclerosis patients.

Clin Immunol 2017 08 19;181:83-88. Epub 2017 Jun 19.

Neuroscience Institute Cavalieri Ottolenghi (NICO), Clinical Neurobiology Unit, Orbassano, Turin, Italy; AOU S. Luigi Gonzaga, Neurologia 2 - CReSM (Centro Riferimento Regionale Sclerosi Multipla), Orbassano, Turin, Italy.

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August 2017

Computerized posturography is more sensitive than clinical Romberg Test in detecting postural control impairment in minimally impaired Multiple Sclerosis patients.

Mult Scler Relat Disord 2017 May 23;14:51-55. Epub 2017 Mar 23.

2nd Neurology Department, Regional Multiple Sclerosis Centre, San Luigi Gonzaga Hospital, Orbassano, Italy; NICO, Neuroscience Institute Cavalieri Ottolenghi, San Luigi Gonzaga Hospital, Orbassano, Italy.

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May 2017

Rationale for Therapeutic Drug Monitoring of Biopharmaceuticals in Inflammatory Diseases.

Ther Drug Monit 2017 08;39(4):339-343

*Université François-Rabelais de Tours, CNRS UMR 7292, Tours, France; †Unit of Pharmacology-Toxicology, University Hospital, Tours, France; ‡Neurologia 2, Centro Riferimento Regionale Sclerosi Multipla (CReSM), Orbassano, Turin, Italy; §Neuroscience Institute Cavalieri Ottolenghi (NICO), San Luigi Hospital, Orbassano, Turin, Italy; ¶Department of Clinical Pharmacology, Tours University Hospital, Tours, France; ∥Unit of Immunology, La Paz University Hospital, Madrid, Spain; and ††Department of Rheumatology, Tours University Hospital, Tours, France.

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August 2017

Anal sphincter dysfunction in multiple sclerosis: an observation manometric study.

Open Med (Wars) 2016 25;11(1):509-517. Epub 2016 Nov 25.

University of Turin, Department of Oncology, School of Medicine, Teaching Hospital "San Luigi Gonzaga", Section of General Surgery, Orbassano, Turin, Italy.

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November 2016

A20 in Multiple Sclerosis and Parkinson's Disease: Clue to a Common Dysregulation of Anti-Inflammatory Pathways?

Neurotox Res 2017 Jul 23;32(1):1-7. Epub 2017 Mar 23.

Neurobiology Unit, Neurologia 2 - CReSM (Regional Referring Center Multiple Sclerosis), San Luigi Gonzaga University Hospital & Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano (TO), Italy.

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July 2017

Drug Efficacy Monitoring in Pharmacotherapy of Multiple Sclerosis With Biological Agents.

Ther Drug Monit 2017 08;39(4):350-355

*Neuroscience Institute Cavalieri Ottolenghi (NICO) and Neurology Department-Centro Riferimento Regionale Sclerosi Multipla (CReSM), San Luigi University Hospital, Turin, Italy; †CNRS, GICC UMR 7292, Université François-Rabelais de Tours, Tours, France; and ‡Sanquin Research and Landsteiner Laboratory, Department of Immunopathology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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August 2017

Detection of potassium channel KIR4.1 antibodies in Multiple Sclerosis patients.

J Immunol Methods 2017 06 12;445:53-58. Epub 2017 Mar 12.

Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Turin, Italy; Neurologia 2-CRESM, AOU San Luigi Gonzaga, Orbassano, Turin, Italy. Electronic address:

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June 2017

Biopharmaceuticals: Reference Products and Biosimilars to Treat Inflammatory Diseases.

Ther Drug Monit 2017 08;39(4):308-315

*Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Therapeutic and Diagnostic Antibodies, KU Leuven, Leuven, Belgium; †Division of Neurology and Multiple Sclerosis Regional Center, AOU San Luigi, Orbassano, Turin, Italy; and Departments of ‡Rheumatology and §Pharmacovigilance, Université François-Rabelais de Tours, Tours, France.

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August 2017

Aquaporin-4 antibody titration in NMO patients treated with rituximab: A retrospective study.

Neurol Neuroimmunol Neuroinflamm 2017 Mar 15;4(2):e317. Epub 2016 Dec 15.

Neuroscience Institute Cavalieri Ottolenghi (NICO) (P.V., F.M., L.G., A.B.) and Neurologia 2-CRESM (P.V., F.M., L.G., M.C., A.B.), AOU San Luigi Gonzaga, Orbassano, Turin, Italy.

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March 2017

High-Risk PML Patients Switching from Natalizumab to Alemtuzumab: an Observational Study.

Neurol Ther 2017 Jun 3;6(1):145-152. Epub 2016 Dec 3.

University Hospital San Luigi Gonzaga, SCDO Neurologia 2-Regional Multiple Sclerosis Center, Regione Gonzole 10, 10043, Orbassano, TO, Italy.

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June 2017

Erratum to: Altered NR4A Subfamily Gene Expression Level in Peripheral Blood of Parkinson's and Alzheimer's Disease Patients.

Neurotox Res 2017 02;31(2):317

Neurobiology Unit, Neurologia 2 - CReSM (Regional Referring Center of Multiple Sclerosis), Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin & AOU San Luigi Gonzaga, Regione Gonzole 10, 10043, Orbassano, TO, Italy.

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February 2017

Reversible disconnection syndrome in a case of acute tumefactive demyelinating lesion: a PET study.

Neurol Sci 2016 Dec 25;37(12):2019-2023. Epub 2016 Jul 25.

Department of Neuro-Oncology, University and A.O.U. City of Health and Science, Turin, Italy.

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December 2016

Decline of Neuropsychological Abilities in a Large Sample of Patients with Multiple Sclerosis: A Two-Year Longitudinal Study.

Front Hum Neurosci 2016 8;10:282. Epub 2016 Jun 8.

Faculty of Psychology, eCampus UniversityNovedrate, Italy; Department of Mental Health, Azienda Sanitaria Locale Torino 3Collegno, Italy.

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July 2016

Altered NR4A Subfamily Gene Expression Level in Peripheral Blood of Parkinson's and Alzheimer's Disease Patients.

Neurotox Res 2016 10 9;30(3):338-44. Epub 2016 May 9.

Neurobiology Unit, Neurologia 2 - CReSM (Regional Referring Center of Multiple Sclerosis), Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin & AOU San Luigi Gonzaga, Regione Gonzole, 10, 10043, Orbassano, TO, Italy.

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October 2016

A gene expression study denies the ability of 25 candidate biomarkers to predict the interferon-beta treatment response in multiple sclerosis patients.

J Neuroimmunol 2016 Mar 16;292:34-9. Epub 2016 Jan 16.

AOU San Luigi Gonzaga, Neurologia 2 - CReSM (Regional Referring Center of Multiple Sclerosis), Neurobiology Unit, Orbassano, TO, Italy; Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, TO, Italy. Electronic address:

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March 2016

Cytokine profiles show heterogeneity of interferon-β response in multiple sclerosis patients.

Neurol Neuroimmunol Neuroinflamm 2016 Apr 27;3(2):e202. Epub 2016 Jan 27.

Department of Neurology (H.H., A.M., M.H., D.R., F.D.), Medical University of Innsbruck, Austria; Department of Arthritis and Clinical Immunology (I.A., C.J.L., R.C.A.), Oklahoma Medical Research Foundation, Oklahoma City; Centro di Riferimento Regionale Sclerosi Multipla (A.B., S.N.), Neurologia 2, Azienda Ospedaliero Universitaria San Luigi Gonzaga, Orbassano, Turin, Italy; Centre d'Esclerosi Múltiple de Catalunya (Cemcat) (M.C., X.M.), Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Queen Mary University London (G.G.), Blizard Institute, Barts and The London School of Medicine and Dentistry, London, UK; Clinical Department of Neurology (M.G.), Allgemeines Krankenhaus Linz, Austria; Department of Neurology (M.K., F.F.), Medical University of Graz, Austria; Department of Neurology (J.K.), Vrije Universiteit Medical Center, Amsterdam, the Netherlands; Department of Biomedicines and Neurology (R.L.P.L., M.M.), Clinical Neuroimmunology, University of Basel, University Hospital Basel, Switzerland; Clinical Department of Neurology (F. Schautzer), Landeskrankenhaus Villach, Austria; Danish Multiple Sclerosis Center (F. Sellebjerg, P.S.S.), Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark; and Department of Neurology and Neurological Sciences (L.S.), Stanford University School of Medicine, CA.

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April 2016

Peculiar Cytological Cerebrospinal Fluid Pattern in a Case of Encephalomyelitis During Anti-Tumor Necrosis Factor-α Therapy.

Neurol Ther 2015 Jun 6;4(1):53-60. Epub 2015 Mar 6.

Neurologia 2-CRESM (Centro Riferimento Regionale Sclerosi Multipla), AOU San Luigi, Orbassano, Italy.

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June 2015

Nurr1 reduction influences the onset of chronic EAE in mice.

Inflamm Res 2015 Nov 4;64(11):841-4. Epub 2015 Sep 4.

AOU San Luigi Gonzaga, Neurobiology Unit, Neurologia 2, CReSM (Regional Referring Center of Multiple Sclerosis) and Neuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonzole, 10, 10043, Orbassano, TO, Italy.

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November 2015

Natalizumab treatment reduces L-selectin (CD62L) in CD4+ T cells.

J Neuroinflammation 2015 Aug 12;12:146. Epub 2015 Aug 12.

Clinical Neurobiology Unit Neuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonzole 10, 10043, Orbassano, Turin, Italy.

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August 2015

Vitamin D Binding Protein Isoforms and Apolipoprotein E in Cerebrospinal Fluid as Prognostic Biomarkers of Multiple Sclerosis.

PLoS One 2015 5;10(6):e0129291. Epub 2015 Jun 5.

Neurology Unit 2 & Regional Referral Multiple Sclerosis Centre (CReSM), San Luigi University Hospital, Orbassano, Italy; Neuroscience Institute Cavalieri Ottolenghi (NICO), c/o San Luigi University Hospital, Orbassano, Italy.

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April 2016

Evaluation of the impact of neutralizing antibodies on IFNβ response.

Clin Chim Acta 2015 Sep 10;449:31-6. Epub 2015 Mar 10.

Neurologia 2-CRESM (Centro Riferimento Regionale Sclerosi Multipla), AOU San Luigi, Orbassano, Italy. Electronic address:

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September 2015

Quality of life and patient preferences: identification of subgroups of multiple sclerosis patients.

Qual Life Res 2015 Sep 26;24(9):2173-82. Epub 2015 Feb 26.

Psychology Department, University of Turin, Via Verdi 10, 10126, Turin, Italy,

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September 2015

Natalizumab discontinuation in patients with multiple sclerosis: Profiling risk and benefits at therapeutic crossroads.

Mult Scler 2015 Nov 19;21(13):1713-22. Epub 2015 Feb 19.

Department of Neurology and Psychiatry, Sapienza University, ItalyMS Centre, S. Antonio Abate Hospital, ItalyNeurologia 2 - CRESM (Centro Riferimento Regionale Sclerosi Multipla), University Hospital San Luigi Gonzaga, ItalyRegional Referring MS Center, Spedali Civili of Brescia, Montichiari Hospital, ItalyDepartment of Neurosciences Tor Vergata University, Italy/IRCCS Neuromed, ItalyDepartment of Neurosciences, S. Camillo-Forlanini Hospital, ItalyDepartment of Neurosciences, S. Camillo-Forlanini Hospital, ItalyNeurology Unit, Department Head and Neck, ASL 3 genovese, Genova, ItalyDepartment of Neurosciences Tor Vergata University, Italy/S. Lucia Foundation IRCCS, ItalyNeurologia 2 - CRESM (Centro Riferimento Regionale Sclerosi Multipla), University Hospital San Luigi Gonzaga, ItalyDepartment of Neurology and Psychiatry, Sapienza University, ItalyMS Centre, S. Antonio Abate Hospital, Italy.

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November 2015

Acute confusional state in HaNDL syndrome (transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis).

Neurol Sci 2015 Mar 3;36(3):477-8. Epub 2014 Dec 3.

Department of Experimental Medicine and Clinical Neuroscience, University of Palermo, Palermo, Italy,

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March 2015

CD19 mRNA quantification improves rituximab treatment-to-target approach: a proof of concept study.

J Neuroimmunol 2014 Dec 20;277(1-2):127-33. Epub 2014 Sep 20.

Clinical Neurobiology Unit, Regional Referring Multiple Sclerosis Centre (CRESM), Neuroscience Institute Cavalieri Ottolenghi (NICO), University Hospital San Luigi Gonzaga, Orbassano, Turin, Italy; Clinical Neurology Unit, Regional Referring Multiple Sclerosis Centre (CReSM), University Hospital San Luigi Gonzaga,Orbassano, Turin, Italy. Electronic address:

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December 2014

Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice.

PLoS One 2014 29;9(9):e108791. Epub 2014 Sep 29.

Neurobiology Unit, Neurologia 2 - CRESM (Regional Referring Center of Multiple Sclerosis), Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin and AOU San Luigi, Orbassano, Torino, Italy.

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September 2015

A new neurophysiological approach to assess central motor conduction damage to proximal and distal muscles of lower limbs.

Clin Neurophysiol 2014 Jan 16;125(1):133-41. Epub 2013 Jul 16.

2nd Neurology Unit and CReSM (Regional Referral Multiple Sclerosis Centre), AOU San Luigi Gonzaga, Orbassano, Torino, Italy.

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January 2014

Prevalence and significant determinants of post-traumatic stress disorder in a large sample of patients with multiple sclerosis.

J Clin Psychol Med Settings 2013 Jun;20(2):240-6

Department of Mental Health, San Luigi Gonzaga Hospital Medical School, University of Turin, ASL TO3, Regione Gonzole 10, 10043, Orbassano, TO, Italy.

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June 2013

Evaluation of a multiparametric immunofluorescence assay for standardization of neuromyelitis optica serology.

PLoS One 2012 12;7(6):e38896. Epub 2012 Jun 12.

Clinical Neurobiology Unit, Regional Referring Multiple Sclerosis Centre, University Hospital San Luigi Gonzaga, Orbassano, Turin, Italy.

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December 2012

Classification of individuals based on ex-vivo glatiramer acetate-induced interferon-γ and interleukin-4 response.

Mult Scler 2012 Oct 4;18(10):1484-92. Epub 2012 May 4.

Neuroscience Institute Cavalieri Ottolenghi, University Hospital San Luigi Gonzaga, Orbassano, TO, Italy.

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October 2012

A methodological reappraisal of non invasive high voltage electrical stimulation of lumbosacral nerve roots.

Clin Neurophysiol 2011 Oct 31;122(10):2071-80. Epub 2011 Mar 31.

II Neurological Department and Multiple Sclerosis Center, San Luigi Hospital, Orbassano, Turin, Italy.

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October 2011

Loss of braking signals during inflammation: a factor affecting the development and disease course of multiple sclerosis.

Arch Neurol 2011 Jul 14;68(7):879-88. Epub 2011 Mar 14.

Clinical Neurobiology Unit, Neuroscience Institute Cavalieri Ottolenghi, University Hospital San Luigi Gonzaga, Regione Gonzole 10, I-10043 Orbassano.

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July 2011

One-year evaluation of factors affecting the biological activity of interferon beta in multiple sclerosis patients.

J Neurol 2011 May 12;258(5):895-903. Epub 2010 Dec 12.

Neurologia 2, Centro Riferimento Regionale Sclerosi Multipla (CRESM), ASO S. Luigi Gonzaga, Regione Gonzole 10, 10043, Orbassano (Torino), Italy.

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May 2011

Characterization of two diesel fuel degrading microbial consortia enriched from a non acclimated, complex source of microorganisms.

Microb Cell Fact 2010 Feb 16;9:10. Epub 2010 Feb 16.

DICASM, Faculty of Engineering, University of Bologna, via Terracini 28, 40131 Bologna, Italy.

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February 2010

Clinical effect of neutralizing antibodies to interferon beta that persist long after cessation of therapy for multiple sclerosis.

Arch Neurol 2010 Apr 8;67(4):402-7. Epub 2010 Feb 8.

Department of Neurology, VU Medical Center, de Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands.

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April 2010

Implications of neutralising antibodies on therapeutic efficacy.

J Neurol Sci 2009 Feb;277 Suppl 1:S29-32

San Luigi Hospital, Orbassano, Turin, Italy.

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February 2009

Glatiramer acetate is a treatment option in neutralising antibodies to interferon-beta-positive patients.

Neurol Sci 2008 Sep;29 Suppl 2:S227-9

Centro di Riferimento Regionale Sclerosi Multipla e Neurobiologia Clinica, AOU S. Luigi Gonzaga, Regione Gonzole 10, 10043, Orbassano, TO, Italy.

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September 2008

Interferon-beta responders and non-responders. A biological approach.

Neurol Sci 2008 Sep;29 Suppl 2:S216-7

Centro Riferimento Regionale Sclerosi Multipla & Neurobiologia Clinica, AOU S. Luigi Gonzaga, Regione Gonzole 10, 10043, Orbassano, TO, Italy.

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September 2008

Acute myeloid leukemia induced by mitoxantrone treatment for aggressive multiple sclerosis.

Neurol Sci 2008 Jun 9;29(3):185-7. Epub 2008 Jul 9.

Centro di Riferimento Regionale Sclerosi Multipla & Neurobiologia Clinica, Aou S Luigi Gonzaga, Regione Gonzole 10, Orbassano TO, Italy.

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June 2008

Development of a bioassay for quantification of neutralising antibodies against human interferon-beta in mouse sera.

J Immunol Methods 2008 Jul 28;336(2):119-26. Epub 2008 Apr 28.

Centro di Riferimento Regionale Sclerosi Multipla (CReSM) & Neurobiologia Clinica, ASO S. Luigi Gonzaga, Orbassano (TO), Italy.

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July 2008