Antje Wick

Antje Wick

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Antje Wick

Publications by authors named "Antje Wick"

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Nonmeasurable Speckled Contrast-Enhancing Lesions Appearing During Course of Disease Are Associated With IDH Mutation in High-Grade Astrocytoma Patients.

Int J Radiat Oncol Biol Phys 2018 12 31;102(5):1472-1480. Epub 2018 Jul 31.

Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2018.07.2004DOI Listing
December 2018

Bevacizumab and temozolomide in patients with first recurrence of WHO grade II and III glioma, without 1p/19q co-deletion (TAVAREC): a randomised controlled phase 2 EORTC trial.

Lancet Oncol 2018 09 13;19(9):1170-1179. Epub 2018 Aug 13.

The Brain and Spine Institute (ICM), Sorbonne Université, The National Institute of Health and Medical Research (INSERM), National Centre for Scientific Research (CNRS), Public Assistance-Paris Hospitals (AP-HP), Hôpital Pitié-Salpêtrière, Paris, France.

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183036
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http://dx.doi.org/10.1016/S1470-2045(18)30362-0DOI Listing
September 2018

Location and Volume of MRI Artifacts in Patients With Implanted Sphenopalatine Ganglion Neurostimulators for Treatment of Chronic Cluster Headache.

Neuromodulation 2018 Sep 30. Epub 2018 Sep 30.

Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.

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http://doi.wiley.com/10.1111/ner.12861
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http://dx.doi.org/10.1111/ner.12861DOI Listing
September 2018

Treatment of glioblastoma in adults.

Ther Adv Neurol Disord 2018 25;11:1756286418790452. Epub 2018 Jul 25.

Neurology Clinic, University of Heidelberg, Clinical Cooperation Unit (CCU) Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1177/1756286418790452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071154PMC
July 2018

Neurofibromatosis and Schwannomatosis.

Semin Neurol 2018 02 16;38(1):73-85. Epub 2018 Mar 16.

Department of Neurology, University Hospital of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1055/s-0038-1627471DOI Listing
February 2018

Glioblastoma in elderly patients: solid conclusions built on shifting sand?

Neuro Oncol 2018 01;20(2):174-183

Neurology Clinic & German Consortium for Translational Cancer Research (DKTK), Heidelberg University Medical Center & DKFZ, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/nox133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777484PMC
January 2018

ID(H)entifying checkpoint inhibitor candidates among diffuse glioma.

Neuro Oncol 2017 Oct;19(11):1427-1428

Department of Neuropathology, University Hospital Heidelberg and Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research, German Cancer Research Center, Heidelberg, Germany; Neurology Clinic, University Hospital Heidelberg and Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/nox145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737517PMC
October 2017

Short-Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma.

N Engl J Med 2017 03;376(11):1027-1037

From Odette Cancer Centre, Sunnybrook Health Sciences Centre (J.R.P., A.S.) and Princess Margaret Cancer Centre (N.L., W.P.M.), Toronto, the Canadian Cancer Trials Group, Queens University, Kingston, ON (C.J.O., C.W., K.D.), University of Calgary, Calgary, AB (J.G.C.), University of Alberta, Edmonton (W.R.), Quality of Life Consulting, West Vancouver, BC (D.O.), Queen's University, Kingston General Hospital, Kingston, ON (J.P.R.), and Juravinski Cancer Centre, Hamilton, ON (H.H.) - all in Canada; Azienda Unità Sanitaria Locale- Istituto di Ricovero e Cura a Carattere Scientifico Istituto delle Scienze Neurologiche, Bologna (A.A.B., E.F.), and Fondazione Istituto Neurologico Carlo Besta, Milan (L. Fariselli) - both in Italy; University Hospital Gasthuisberg, Leuven, Belgium (J.M.); Peter MacCallum Cancer Centre, Melbourne, VIC (C.P.), University of Newcastle, Newcastle, NSW (M.F.), University of Queensland, Brisbane (M.F.), and Royal North Shore Hospital, Sydney (M.B.) - all in Australia; Saitama Medical University International Medical Center, Saitama, Japan (R.N.); Hôpital de la Pitié-Salpêtrière (F.L.-D., L. Feuvret), Paris, and Aix-Marseille University, Assistance Publique-Hôpitaux de Marseille, Centre Hospitalier Universitaire Timone, Marseilles (O.C.) - both in France; the European Organization for Research and Treatment of Cancer, Brussels (V.G.); the Neurology Clinic, University of Heidelberg, Heidelberg, Germany (A.W., W.W.); Tauranga Hospital, Tauranga, New Zealand (M.T.); and Maastricht University Medical Center and School for Oncology and Developmental Biology, Maastricht, the Netherlands (B.G.B.).

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http://dx.doi.org/10.1056/NEJMoa1611977DOI Listing
March 2017

Clinical parameters outweigh diffusion- and perfusion-derived MRI parameters in predicting survival in newly diagnosed glioblastoma.

Neuro Oncol 2016 12 13;18(12):1673-1679. Epub 2016 Jun 13.

Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany (S.B., P.K., O.E., D.B., L.W., M.B., A.R.); Division of Bioststatistics, German Cancer Research Center, Heidelberg, Germany (D.T.); Department of Neurology, University of Heidelberg Medical Center, Heidelberg, Germany (A.W., S.L., A.H., W.W.); Department of Neurology, Innsbruck Medical University, Innsbruck, Austria (M.N.); Department of Radiology, German Cancer Research Center, Heidelberg, Germany (H.S.).

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http://dx.doi.org/10.1093/neuonc/now122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744248PMC
December 2016

Radiogenomics of Glioblastoma: Machine Learning-based Classification of Molecular Characteristics by Using Multiparametric and Multiregional MR Imaging Features.

Radiology 2016 Dec 16;281(3):907-918. Epub 2016 Sep 16.

From the Department of Neuroradiology, University of Heidelberg Medical Center, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany (P.K., S.B., O.E., M.B.); German Cancer Research Center (DKFZ), Department of Radiology, Heidelberg, Germany (D.B., H.P.S., A.R.); Department of Neurology, Medical University Innsbruck, Austria (M.N.); Department of Neuropathology, University of Heidelberg Medical Center, Heidelberg, Germany (A.K., A.v.D., D.C.); German Cancer Consortium (DKTK), Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.K., A.v.D., D.C.); Division of Biostatistics, DKFZ, Heidelberg, Germany (M.S.); Neurology Clinic, University of Heidelberg Medical Center, Heidelberg, Germany (M.N., S.B., A.W., W.W.); Department of Radiation Oncology, University of Heidelberg Medical Center, Heidelberg, Germany (J.D.); Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.); Division of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg Medical Center, Heidelberg, Germany (C.H.M.); Department of Neurosurgery, University of Heidelberg Medical Center, Heidelberg, Germany (A.U.); Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany (D.J., S.P.); German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany (D.J., S.P.); Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany (S.P.); and German Cancer Consortium (DKTK), Clinical Cooperation Unit Neurooncology, DKFZ, Heidelberg, Germany (W.W.).

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http://dx.doi.org/10.1148/radiol.2016161382DOI Listing
December 2016

Long-term analysis of the NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with PCV or temozolomide.

Neuro Oncol 2016 11 1;18(11):1529-1537. Epub 2016 Jul 1.

Department of Neurology Clinic, University of Heidelberg, Heidelberg, Germany (W.W., A.W., M.P., B.W.); Clinical Cooperation Unit (CCU Neurooncology), German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany (W.W., B.W.); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (P.R., C.H., M.W.); Department of Neuropathology, Hannover Medical School, Hannover, Germany (C.H.); Department of Neurology, Regensburg University, Regensburg, Germany (P.H.); Department of Neurosurgery Clinic, Hannover Medical School, Hannover, Germany (M.N.); Department of Neurosurgery Clinic, Charité, Berlin, Germany (F.S., P.V.); Department of Neurosurgery, Heinrich Heine University, Düsseldorf, Germany (M.C.S.); Department of Neurology Clinic, Essen Medical Center, Essen, Germany (S.K.); Department of Neurosurgery Clinic, Saarland University, Homburg, Germany (R.K.); Department of Neurosurgery Clinic, University of Göttingen, Göttingen, Germany (F.S.); Department of Neurosurgery Clinic, University of Erlangen, Erlangen, Germany (I.E.); Department of Neurosurgery Clinic, University of Jena, Jena, Germany (R.K.); Department of Neurology Clinic, Cologne University, Cologne, Germany (N.G.); Department of Neurology Clinic, TU Munich, Munich, Germany (F.S.-G.); Department of Neuropathology, University of Heidelberg, Heidelberg, Germany (A.v.D.); CCU Neuropathology, (C.H., A.v.D.); CCU Brain Tumor Immunology, DKFZ, all Heidelberg, Germany (M.P.); Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany (G.R.); DKTK partner site Essen/Düsseldorf, Düsseldorf, Germany (G.R.), Department of General Neurology, Tübingen, Germany (W.W., A.W., F.S.-G., M.P., M.W.), Department of Radiation Oncology, Tübingen, Germany (M.B.), Department of Medical Biometry, University Hospital Tübingen, Tübingen, Germany (C.M.).

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http://dx.doi.org/10.1093/neuonc/now133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063521PMC
November 2016

Health-related quality of life in patients with high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.

Lancet Oncol 2016 Nov 27;17(11):1533-1542. Epub 2016 Sep 27.

Department of Medical Oncology and Cancer Centre, University Hospital Zurich, Zurich, Switzerland; Department of Radiation-Oncology (MAASTRO), Maastricht University Medical Centre (MUMC) and GROW (School for Oncology), Maastricht, Netherlands; Department of Radiation-Oncology, MediClin Robert-Janker-Clinic, Clinical Cooperation Unit Neuro-oncology, University Bonn Medical Centre, Bonn, Germany.

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http://dx.doi.org/10.1016/S1470-2045(16)30305-9DOI Listing
November 2016

Radiomic Profiling of Glioblastoma: Identifying an Imaging Predictor of Patient Survival with Improved Performance over Established Clinical and Radiologic Risk Models.

Radiology 2016 09 20;280(3):880-9. Epub 2016 Jun 20.

From the Department of Neuroradiology (P.K., S.B., O.E., M.B., A.R., D.B.) and Neurology Clinic (A.W., W.W.), University of Heidelberg Medical Center, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; Department of Medical Image Computing, Medical and Biological Informatics Division (M.G., K.H.M.H.), Department of Radiology (H.P.S., A.R., D.B.), and Clinical Neuro-oncology Cooperation Unit, German Cancer Consortium (DKTK) (W.W.), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://pubs.rsna.org/doi/10.1148/radiol.2016160845
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http://dx.doi.org/10.1148/radiol.2016160845DOI Listing
September 2016

Impact of tapering and discontinuation of bevacizumab in patients with progressive glioblastoma.

J Neurooncol 2016 09 15;129(3):533-539. Epub 2016 Jul 15.

Neurology Clinic & National Center for Tumor Disease, University of Heidelberg and German Cancer Research Center, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11060-016-2206-xDOI Listing
September 2016

MR Perfusion-derived Hemodynamic Parametric Response Mapping of Bevacizumab Efficacy in Recurrent Glioblastoma.

Radiology 2016 May 16;279(2):542-52. Epub 2015 Nov 16.

From the Departments of Neuroradiology (P.K., A.R., S.B., S.H., M.B., D.B.) and Neurology Clinic (A.W., W.W.), University of Heidelberg Medical Center, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R., H.P.S.); and German Cancer Consortium (DKTK), Clinical Cooperation Unit Neurooncology, DKFZ, Heidelberg, Germany (W.W.).

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http://dx.doi.org/10.1148/radiol.2015151172DOI Listing
May 2016

Current status and future directions of anti-angiogenic therapy for gliomas.

Neuro Oncol 2016 Mar 12;18(3):315-28. Epub 2015 Oct 12.

Neurology Clinic and National Center for Tumor Diseases, University of Heidelberg and German Consortium for Translational Cancer Research, German Cancer Research Center, Heidelberg, Germany (W.W., M.P., A.W., A.H., F.W.); Department of Neuroradiology, University of Heidelberg and German Cancer Research Center, Heidelberg, Germany (A.R., M.B.).

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http://dx.doi.org/10.1093/neuonc/nov180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767238PMC
March 2016

Relative cerebral blood volume is a potential predictive imaging biomarker of bevacizumab efficacy in recurrent glioblastoma.

Neuro Oncol 2015 Aug 9;17(8):1139-47. Epub 2015 Mar 9.

Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany (P.K., S.B., S.H., M.B., A.R.); Neurology Clinic, University of Heidelberg Medical Center, Heidelberg, Germany (B.W., A.W., W.W.); German Cancer Consortium (DKTK), Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ, Heidelberg, Germany (B.W., W.W.); Department of Neurology, Medical University Innsbruck, Innsbruck, Austria (M.N.); Department of Radiology, DKFZ, Heidelberg, Germany (H.-P.S., A.R.).

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https://academic.oup.com/neuro-oncology/article-lookup/doi/1
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http://dx.doi.org/10.1093/neuonc/nov028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490872PMC
August 2015

Pseudoprogression in patients with glioblastoma: clinical relevance despite low incidence.

Neuro Oncol 2015 Jan 18;17(1):151-9. Epub 2014 Jul 18.

Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany (A.R., J.F., P.K., P.B., S.H., M.B.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R., H.-P.S.); Department of Neurooncology, Neurology Clinic and National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany (B.W., A.W., W.W.); German Cancer Consortium (DKTK) Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany (B.W., A.W., W.W.); Department of Neurology, Innsbruck Medical University, Innsbruck, Austria (M.N.).

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http://dx.doi.org/10.1093/neuonc/nou129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483046PMC
January 2015

Good maths is needed to understand CMV data in glioblastoma.

Int J Cancer 2014 Jun 26;134(12):2991-2. Epub 2013 Nov 26.

Department of Neurooncology Neurology Clinic & National Center for Tumor Diseases, University of Heidelberg & German Consortium of Translational Cancer Research (DKTK), Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany; Im Neuenheimer Feld 400, D-69120, Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.28614DOI Listing
June 2014

Towards optimizing the sequence of bevacizumab and nitrosoureas in recurrent malignant glioma.

J Neurooncol 2014 Mar 24;117(1):85-92. Epub 2014 Jan 24.

Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11060-013-1356-3DOI Listing
March 2014

Challenging cytomegalovirus data in glioblastoma.

Neuro Oncol 2014 Jan 18;16(1):165. Epub 2013 Dec 18.

Corresponding author: Wolfgang Wick, MD, Department of Neurooncology, Neurology Clinic & National Center for Tumor Diseases, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/not212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870834PMC
January 2014

Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma.

J Clin Oncol 2013 Sep 12;31(26):3212-8. Epub 2013 Aug 12.

Tracy T. Batchelor, Rakesh K. Jain, and Gregory Sorensen, Massachusetts General Hospital, Boston, MA; Paul Mulholland, University College London, London; Rao Gattamaneni, the Christie Foundation Trust Hospital, Manchester, United Kingdom; Bart Neyns, Universitair Ziekenhuis Brussel, Brussels, Belgium; L. Burt Nabors, University of Alabama at Birmingham, Birmingham, AL; Mario Campone, Centre Rene Gauducheau, Saint-Herblain, France; Antje Wick, University of Heidelberg, Heidelberg, Germany; Warren Mason, Princess Margaret Hospital, Toronto, Ontario, Canada; Tom Mikkelsen, Henry Ford Hospital, Detroit, MI; Surasak Phuphanich, Cedars-Sinai Medical Center, Los Angeles, CA; Lynn S. Ashby, Barrow Neurological Institute, Phoenix, AZ; John DeGroot, MD Anderson Cancer Center, Houston, TX; Lawrence Cher, Austin Health Cancer Services; Mark Rosenthal, Royal Melbourne Hospital, Melbourne, Australia; Franz Payer, Medical University, Graz, Austria; Juliane M. Jürgensmeier, John Xu, and Qi Liu, AstraZeneca, Wilmington, DE; and Martin van den Bent, Erasmus University Medical Center-Daniel den Hoed Cancer Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2012.47.2464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021043PMC
September 2013

Bevacizumab alone or in combination with irinotecan in recurrent WHO grade II and grade III gliomas.

Eur Neurol 2013 22;69(2):95-101. Epub 2012 Nov 22.

Department of Neurology, University Hospital Zurich, Zurich, Switzerland. katharina.seystahl @ usz.ch

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http://dx.doi.org/10.1159/000343811DOI Listing
August 2013

Patterns of progression in malignant glioma following anti-VEGF therapy: perceptions and evidence.

Curr Neurol Neurosci Rep 2011 Jun;11(3):305-12

Department of Neurooncology, University Clinic Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11910-011-0184-0DOI Listing
June 2011

Bevacizumab does not increase the risk of remote relapse in malignant glioma.

Ann Neurol 2011 Mar;69(3):586-92

Department of Neuro-oncology, University Clinic Heidelberg, Germany.

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http://dx.doi.org/10.1002/ana.22336DOI Listing
March 2011

Rechallenge with temozolomide in patients with recurrent gliomas.

J Neurol 2009 May 25;256(5):734-41. Epub 2009 Feb 25.

Department of Neurooncology, University of Heidelberg, Heidelberg, Germany.

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http://link.springer.com/10.1007/s00415-009-5006-9
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http://dx.doi.org/10.1007/s00415-009-5006-9DOI Listing
May 2009

A novel tool to analyze MRI recurrence patterns in glioblastoma.

Neuro Oncol 2008 Dec 31;10(6):1019-24. Epub 2008 Jul 31.

Department of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1215/15228517-2008-058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718999PMC
December 2008

Synergistic antiglioma activity of radiotherapy and enzastaurin.

Ann Neurol 2007 Feb;61(2):153-61

Laboratory of Molecular Neurooncology, Department of General Neurology and Hertie Institute for Clinical Brain Research, Eberhard-Karls-University of Tübingen, Germany.

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http://dx.doi.org/10.1002/ana.21057DOI Listing
February 2007

Chemotherapy-induced cell death in primary cerebellar granule neurons but not in astrocytes: in vitro paradigm of differential neurotoxicity.

J Neurochem 2004 Dec;91(5):1067-74

Laboratory of Molecular Neurodegeneration, Department of General Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02774.xDOI Listing
December 2004

Intracranial metastatic esthesioneuroblastoma responsive to temozolomide.

J Neurooncol 2004 Oct;70(1):73-5

Department of Neurology, University of Tübingen Medical School, Tübingen, Germany.

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October 2004

Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt.

J Neurosci 2002 Aug;22(15):6401-7

Laboratory of Neurodegeneration, Department of Neurology, University of Tübingen, 72076 Tübingen, Germany.

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http://dx.doi.org/20026672DOI Listing
August 2002

Prevention of irradiation-induced glioma cell invasion by temozolomide involves caspase 3 activity and cleavage of focal adhesion kinase.

Cancer Res 2002 Mar;62(6):1915-9

Laboratories of Molecular Neuro-Oncology, University of Tübingen, Medical School, D-72076 Tübingen, Germany.

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March 2002