Publications by authors named "Anthony W Segal"

64Publications

Variations in the Phagosomal Environment of Human Neutrophils and Mononuclear Phagocyte Subsets.

Front Immunol 2019 1;10:188. Epub 2019 Mar 1.

Division of Medicine, University College London, London, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2019.00188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405516PMC
January 2020

The role of neutrophils in the pathogenesis of Crohn's disease.

Authors:
Anthony W Segal

Eur J Clin Invest 2018 Nov;48 Suppl 2:e12983

Division of Medicine, University College London, London, UK.

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http://dx.doi.org/10.1111/eci.12983DOI Listing
November 2018

Corrigendum: An Exploration of Charge Compensating Ion Channels across the Phagocytic Vacuole of Neutrophils.

Front Pharmacol 2017 11;8:728. Epub 2017 Oct 11.

Division of Medicine, Centre for Molecular Medicine, University College London, London, United Kingdom.

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http://dx.doi.org/10.3389/fphar.2017.00728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641588PMC
October 2017

Imaging the Neutrophil Phagosome and Cytoplasm Using a Ratiometric pH Indicator.

J Vis Exp 2017 04 5(122). Epub 2017 Apr 5.

Centre for Molecular Medicine, Division of Medicine, University College London;

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http://dx.doi.org/10.3791/55107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564471PMC
April 2017

An Exploration of Charge Compensating Ion Channels across the Phagocytic Vacuole of Neutrophils.

Front Pharmacol 2017 28;8:94. Epub 2017 Feb 28.

Division of Medicine, Centre for Molecular Medicine, University College London London, UK.

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http://dx.doi.org/10.3389/fphar.2017.00094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329019PMC
February 2017

Making sense of the cause of Crohn's - a new look at an old disease.

Authors:
Anthony W Segal

F1000Res 2016 12;5:2510. Epub 2016 Oct 12.

University College London, London, WC1E 6BT, UK.

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http://dx.doi.org/10.12688/f1000research.9699.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224693PMC
October 2016

The NADPH Oxidase and Microbial Killing by Neutrophils, With a Particular Emphasis on the Proposed Antimicrobial Role of Myeloperoxidase within the Phagocytic Vacuole.

Microbiol Spectr 2016 08;4(4)

Division of Medicine, University College London, London WC1E 6JF, United Kingdom.

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http://dx.doi.org/10.1128/microbiolspec.MCHD-0018-2015DOI Listing
August 2016

A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF.

Gastroenterology 2016 10 1;151(4):710-723.e2. Epub 2016 Jul 1.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.06.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037012PMC
October 2016

Genetic Complexity of Crohn's Disease in Two Large Ashkenazi Jewish Families.

Gastroenterology 2016 10 1;151(4):698-709. Epub 2016 Jul 1.

Division of Medicine, University College London (UCL), London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.06.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643259PMC
October 2016

NADPH oxidases as electrochemical generators to produce ion fluxes and turgor in fungi, plants and humans.

Authors:
Anthony W Segal

Open Biol 2016 05 18;6(5). Epub 2016 May 18.

Division of Medicine, UCL, 5 University Street, London WC1E 6JJ, UK

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http://dx.doi.org/10.1098/rsob.160028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892433PMC
May 2016

Two CGD Families with a Hypomorphic Mutation in the Activation Domain of p67.

J Clin Cell Immunol 2014 Jun;5(3)

Departments of Pediatrics (Hematology/Oncology), Microbiology/Immunology, and Medical and Molecular Genetics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414043PMC
June 2014

Characterization of expression quantitative trait loci in the human colon.

Inflamm Bowel Dis 2015 Feb;21(2):251-6

*Medical Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom; †Division of Medicine, University College London, London, United Kingdom; ‡Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, London, United Kingdom; and §Eastman Dental Institute, University College London, London, United Kingdom.

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http://pdfs.journals.lww.com/ibdjournal/2015/02000/Character
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http://dx.doi.org/10.1097/MIB.0000000000000265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345969PMC
February 2015

Mucosal transcriptomics implicates under expression of BRINP3 in the pathogenesis of ulcerative colitis.

Inflamm Bowel Dis 2014 Oct;20(10):1802-12

*Centre for Molecular Medicine, Division of Medicine, University College London, London, United Kingdom; †Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, London, United Kingdom; ‡Medical Genomics, UCL Cancer Institute, University College London, London, United Kingdom; §Division of Bioscience, University College London, London, United Kingdom; ‖Research Pathology and Advanced Diagnostics, UCL Cancer Institute, University College London, London, United Kingdom; and ¶Microbial Diseases, Eastman Dental Institute, University College London, London, United Kingdom.

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http://dx.doi.org/10.1097/MIB.0000000000000169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531309PMC
October 2014

What is wrong with granulocytes in inflammatory bowel diseases?

Dig Dis 2013 14;31(3-4):321-7. Epub 2013 Nov 14.

Division of Medicine, University College London, London, UK.

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http://dx.doi.org/10.1159/000354686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530493PMC
June 2014

Shotgun cholanomics of ileal fluid.

Biochimie 2013 Mar 14;95(3):461-3. Epub 2012 Sep 14.

Clinical Laboratory, The Second Hospital of Shandong University, Jinan, China.

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http://dx.doi.org/10.1016/j.biochi.2012.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529479PMC
March 2013

The neutrophil respiratory burst and bacterial digestion in Crohn's disease.

Dig Dis Sci 2011 May 9;56(5):1482-8. Epub 2010 Oct 9.

Department of Molecular Medicine, University College London, WC1E 6JJ, London, UK.

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http://dx.doi.org/10.1007/s10620-010-1426-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568317PMC
May 2011

Subcellular localisation of the p40phox component of NADPH oxidase involves direct interactions between the Phox homology domain and F-actin.

Int J Biochem Cell Biol 2010 Oct 15;42(10):1736-43. Epub 2010 Jul 15.

Department of Medicine, University College London, London, UK.

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http://dx.doi.org/10.1016/j.biocel.2010.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938475PMC
October 2010

Crohn's disease as an immunodeficiency.

Expert Rev Clin Immunol 2010 Jul;6(4):585-96

Department of Molecular Medicine, University College London, London, WC1E 6JJ, UK.

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http://dx.doi.org/10.1586/eci.10.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618314PMC
July 2010

CO binding and ligand discrimination in human myeloperoxidase.

Biochemistry 2010 Mar;49(10):2150-8

Centre for Molecular Medicine, Division of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK.

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http://dx.doi.org/10.1021/bi9021507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529485PMC
March 2010

The immunopathogenesis of Crohn's disease: a three-stage model.

Curr Opin Immunol 2009 Oct 8;21(5):506-13. Epub 2009 Aug 8.

Department of Medicine, UCL, 5 University Street, London WC1E 6JF, UK.

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http://dx.doi.org/10.1016/j.coi.2009.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529487PMC
October 2009

Crohn's disease: an immune deficiency state.

Clin Rev Allergy Immunol 2010 Feb;38(1):20-31

Department of Medicine, University College London, London, UK.

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http://dx.doi.org/10.1007/s12016-009-8133-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568313PMC
February 2010

Subproteome analysis of the neutrophil cytoskeleton.

Proteomics 2009 Apr;9(7):2037-49

Department of Medicine, Centre for Molecular Medicine, The Rayne Institute, University College London, London, UK.

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http://dx.doi.org/10.1002/pmic.200800674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261606PMC
April 2009

Inflammatory bowel disease in CGD reproduces the clinicopathological features of Crohn's disease.

Am J Gastroenterol 2009 Jan;104(1):117-24

Department of Medicine, University College London, London, UK.

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http://dx.doi.org/10.1038/ajg.2008.72DOI Listing
January 2009

Phagocyte dysfunction and inflammatory bowel disease.

Inflamm Bowel Dis 2008 Oct;14(10):1443-52

Department of Medicine, University College London, London, United Kingdom.

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http://dx.doi.org/10.1002/ibd.20449DOI Listing
October 2008

The function of the NADPH oxidase of phagocytes and its relationship to other NOXs in plants, invertebrates, and mammals.

Authors:
Anthony W Segal

Int J Biochem Cell Biol 2008 9;40(4):604-18. Epub 2007 Oct 9.

Centre for Molecular Medicine, University College London, 5 University Street, London WC1E 6JJ, UK.

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http://dx.doi.org/10.1016/j.biocel.2007.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636181PMC
July 2008

How superoxide production by neutrophil leukocytes kills microbes.

Authors:
Anthony W Segal

Novartis Found Symp 2006 ;279:92-8; discussion 98-100, 216-9

Centre for Molecular Medicine, University College London, 5 University Street, London WC1E 6JJ, UK.

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March 2007

The role of grancalcin in adhesion of neutrophils.

Cell Immunol 2006 Apr 28;240(2):116-21. Epub 2006 Aug 28.

Centre for Molecular Medicine, Department of Medicine, The Rayne Institute, University College London, London WC1E 6JJ, UK.

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http://dx.doi.org/10.1016/j.cellimm.2006.07.004DOI Listing
April 2006

How neutrophils kill microbes.

Authors:
Anthony W Segal

Annu Rev Immunol 2005 ;23:197-223

Center for Molecular Medicine, University College London, London WC1E 6JJ, United Kingdom.

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http://dx.doi.org/10.1146/annurev.immunol.23.021704.115653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2092448PMC
June 2005

The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems.

Biochim Biophys Acta 2004 Jun;1657(1):1-22

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.bbabio.2004.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636547PMC
June 2004

Lipid rafts determine efficiency of NADPH oxidase activation in neutrophils.

FEBS Lett 2003 Aug;550(1-3):101-6

Department of Medicine, University College London, The Rayne Institute, 5 University Street, London WC1E 6JJ, UK.

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http://dx.doi.org/10.1016/s0014-5793(03)00845-7DOI Listing
August 2003

Reassessment of the microbicidal activity of reactive oxygen species and hypochlorous acid with reference to the phagocytic vacuole of the neutrophil granulocyte.

J Med Microbiol 2003 Aug;52(Pt 8):643-651

Centre for Molecular Medicine, University College London, 5 University Street, London WC1E 6JJ, UK 2Institute of Hygiene and Social Medicine, Leopold-Franzens-University of Innsbruck, A-6010 Innsbruck, Austria.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635949PMC
http://dx.doi.org/10.1099/jmm.0.05181-0DOI Listing
August 2003

Granulocyte function in grancalcin-deficient mice.

Mol Cell Biol 2003 Feb;23(3):826-30

Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, London W1T 4JF, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC140701PMC
http://dx.doi.org/10.1128/mcb.23.3.826-830.2003DOI Listing
February 2003

PX domain takes shape.

Curr Opin Hematol 2003 Jan;10(1):2-7

Department of Medicine, University College London, United Kingdom.

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http://dx.doi.org/10.1097/00062752-200301000-00002DOI Listing
January 2003

Catalase negative Staphylococcus aureus retain virulence in mouse model of chronic granulomatous disease.

FEBS Lett 2002 May;518(1-3):107-10

Centre for Molecular Medicine, The Rayne Institute, University College London, 5 University Street, WC1E 6JJ, London, UK.

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http://dx.doi.org/10.1016/s0014-5793(02)02658-3DOI Listing
May 2002

Killing activity of neutrophils is mediated through activation of proteases by K+ flux.

Nature 2002 Mar;416(6878):291-7

Centre for Molecular Medicine, University College London, 5 University Street, London WC1E 6JJ, UK.

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http://www.nature.com/articles/416291a
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http://dx.doi.org/10.1038/416291aDOI Listing
March 2002

Involvement of protein kinase D in Fc gamma-receptor activation of the NADPH oxidase in neutrophils.

Biochem J 2002 Apr;363(Pt 1):95-103

Centre for Molecular Medicine, Department of Medicine, University College London, The Rayne Institute, 5 University Street, London WC1E 6JJ, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222456PMC
http://dx.doi.org/10.1042/0264-6021:3630095DOI Listing
April 2002

Ym1 is a neutrophil granule protein that crystallizes in p47phox-deficient mice.

J Biol Chem 2002 Feb 3;277(7):5468-75. Epub 2001 Dec 3.

Department of Medicine, University College London, London WC1E 6JJ, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110635200DOI Listing
February 2002